upadacitinib

[mark...@twc.com]

Simply because I keep seeing TV commercials for RINVOQ (upadacitinib), I looked up 

https://en.wikipedia.org/wiki/Upadacitinib 

The commercial instructs us on how to pronounce the commercial name (how else could you ask for it?), but doesn't pronounce the generic name, whose pronunciation is not obvious.  (It's 

Pronunciation	/juˌpædəˈsaɪtɪnɪb/ ew-PAD-ə-SY-ti-nib

.)

In reading this article, I was struck by chemical names like "the liver enzyme CYP3A4" and "substrates of CYP1A2, CYP2B6, CYP2C9, CYP2C19, or CYP2D6".  Don't these chemicals have "real" names?  Is the nomenclature of biochemicals so diverse that we have to use abbreviations and code numbering?  Yeah, maybe.  How many chemical names are possible?  How many can a human being memorize?

Incidentally, why do so many of these generic drug names end in "-b"?  Is there some system to  generic drug names?

-- Mark Spahn (West Seneca, NY)

[Matthew Schlecht]

On Mon, Jan 1, 2024 at 12:49 AM <mark...@twc.com> wrote:

Simply because I keep seeing TV commercials for RINVOQ (upadacitinib), I looked up 

https://en.wikipedia.org/wiki/Upadacitinib 

The commercial instructs us on how to pronounce the commercial name (how else could you ask for it?), but doesn't pronounce the generic name, whose pronunciation is not obvious.  (It's 

Pronunciation	/juˌpædəˈsaɪtɪnɪb/ ew-PAD-ə-SY-ti-nib

.)

Reference can be made to the USAN drug name pronunciation guide:

https://www.ama-assn.org/about/united-states-adopted-names/usan-drug-name-pronunciation-guide#:~:text=USAN%20drug%20name%20pronunciation%20guide%20%7C%20American%20Medical%20Association

 

In reading this article, I was struck by chemical names like "the liver enzyme CYP3A4" and "substrates of CYP1A2, CYP2B6, CYP2C9, CYP2C19, or CYP2D6".  Don't these chemicals have "real" names?  Is the nomenclature of biochemicals so diverse that we have to use abbreviations and code numbering?  Yeah, maybe.  How many chemical names are possible?  How many can a human being memorize?

So many questions?

CYP3A4 is an abbreviation for "Cytochrome P450 3A4".

For the uninitiated, the abbreviations can seem quite opaque, but for practitioners it would be boring and tedious to use the full names all the time.

Probably an infinite number of chemical names are possible, and no - no human can memorize all of them.

Could a human memorize all the possible first names for a baby girl or boy in English?

 

Incidentally, why do so many of these generic drug names end in "-b"?  Is there some system to  generic drug names?

See: https://accesspharmacy.mhmedical.com/content.aspx?bookid=1549&sectionid=93411751

Matthew

[mark...@twc.com]

Thanks for this information.

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