Cancer PPT Questions

[Liz McMahon]

For those that wanted the answers to the cancer powerpoint practice questions:

Slide 40: Tumor suppressor genes are usually thought of as: 

C. Recessive in nature, acting to suppress cell growth and proliferation

Slide 41-42: Is this a balanced or unbalanced translocation?  Balanced

What chromosomes are involved? 9 and 22

Are the breaks in the short arm or the long arm? Long arm Is this likely to be a constitutional change or an acquired change? Acquired

How could you check? Bone marrow karyotype

If it's an acquired change, does the translocation pose a risk to any children she may conceive after treatment? NO

If it is a constitutional change, would you expect this patient to have birth defects and/or mental retardation? No because it’s balanced

If constitutional, does the translocation pose a risk to future conceptions? Yes

Slide 43: The inborn cytogenetic (i.e. constitutional chromosomal disorder that predisposes to breast cancer is:

C. 47, XXY (Klinefelter syndrom)