Seems simple enough. You need an OPC server to talk to which that tool allows you to create using node.js - this would live along side the NR server. Could be on the same platform if it has enough grunt, otherwise you'd need another platform to run that.
Then you'd need to create a client for NR. You would need to understand the client part of that library to work out how to implement that in a series of NR nodes. I would imagine it working in a similar way to the MQTT nodes though I've not looked too deeply into it.
In fact, it all looks quite similar to the concepts in MQTT except that MQTT seems at first glance rather simpler to use though that might be due to the excellent work already put into NR for MQTT use :) Also worth noting that MQTT has the option of a websockets interface which makes for some interesting options in web apps.