[Siberian Mouse M 45 Wmv
Oludare Padilla
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C. In the form of a mouse with ruby eyes, red enamel mouth and nose, the body entirely inlaid with oval split pearls, the fur very skillfully simulated with white champlev enamel, chased gold feet, fine gold wire eyebrows and whiskers, gold ears and gold wire mesh tail. M. Brass, shaped, with fixed barrel, the 5-wheel train terminating with a pinion pivoted in eccentric adjustable bushing for regulating the mouse's speed. The mainspring barrel is milled with four cams; one moves two levers up and down giving a very realistic motion to the animal's feet, the mouse moves via two small knurled steel wheels mounted on a pinion driven by the second wheel, two other cams at one point lift two levers protruding from the stomach which lifts the mouse and stops her, the last cam controls the head movement.Dim. Length 57 mm (130 with the tail), 25 mm thick at mid-body.
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Codon 12 of the K-ras gene is a generally recognized example of a mutational hot spot. By the approach of gel retardation and specific antibodies, a double-stranded oligonucleotide corresponding to the codon 12 region of the mouse K-ras gene (from 20 to 50 bp with respect to the exon 1 start) was found to be a site for cooperative binding of the transcription factors GATA-6 and NF-Y. GATA-6 and NF-Y were selectively activated with lung carcinogens 3-methylcholanthrene and nitrosoethylurea in mice of strains susceptible to lung tumorigenesis but not in animals of resistant strains. The interaction of GATA-6 and NF-Y with the codon 12 region of the K-ras gene is suggested to be involved in the mechanism of lung carcinogenesis.
The antiproliferative effect of the "early" protein E2 of the high-risk oncogenic human papillomavirus HPV16 on mouse testis tumors, which were induced by the intramuscular injection of HeLa cells, was discovered. The regression of tumors was maximum in the first 2 days after the oral vaccination with HPV16 E2 (500 mg per mouse) and then gradually decreased to the control variant. A typical monolayer of HeLa cells on the cultivation flask bottom, of which only 18% were functionally active, appeared after seeding testis tissue cells on DMEM medium.
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