Fwd: New: SMuRFless Hypothesis

[Okechukwu Ogah]

Professor Okechukwu .S Ogah. MBBS, MSc, PhD, MD, FWACP, FACP, FESC, FNCS

A. Professor of Medicine 

Cardiology Unit, Department of Medicine,

Faculty of Clinical Sciences

College of Medicine,

University of Ibadan, NIGERIA

B. Honorary Consultant Physician/Cardiologist,

Cardiology Unit,

Department of Medicine

University College Hospital Ibadan, NIGERIA

PERSONAL POSTAL ADDRESS

P.O BOX 14343, UNIVERSITY OF IBADAN  POST OFFICE

IBADAN, NIGERIA

Tel. +234 806 77 47 121
Fax. +1215-975-6817 (Electronic)
Emails: 

oso...@com.ui.edu.ng ,

osoga...@gmail.com

osoga...@yahoo.com

https://www.researchgate.net/profile/Okechukwu_Ogah4/contributions

C. Bernard Lown Visiting Scholar in Cardiovascular Health

Department of Global Health and Population

Harvard T.H. Chan School of Public Health

Email: oo...@hsph.harvard.edu

D. Adjunct Researcher,

Institute of Advanced Medical Research and Training (IAMRAT)

College of Medicine, University of Ibadan, NIGERIA

E. Affiliate Member,

The Hatter Institute for Cardiovascular Research in Africa (HICRA)

4th Floor Chris Barnard Building
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA

http://www.hatter.uct.ac.za/icra/about/staff/visiting-researchers

F. Past President,

Nigerian Cardiac Society

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"For with thee is the fountain of life: in thy light shall we see light." Psalm 36:9

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---------- Forwarded message ---------
From: American College of Cardiology Community <re...@docmatter.com>
Date: Mon, Mar 9, 2026 at 6:21 PM
Subject: New: SMuRFless Hypothesis
To: Okechukwu Samuel Ogah <osoga...@gmail.com>

From Dr. Hamza: The growing recognition of SMuRF-less myocardial infarction is challenging the traditional paradigm of coronary artery disease. Increasing attention is being directed toward non-traditional mechanisms, including systemic inflammation and genetic susceptibility. Biomarkers such as high-sensitivity C-reactive protein (hsCRP) and other inflammatory mediators are currently being explored to better understand the pathogenesis of MI in patients without conventional cardiovascular risk factors. In our single-center cohort of STEMI patients undergoing primary PCI, we explored an additional hypothesis: whether age and family history may offer clues to the biology of SMuRF-less disease. We observed two notable patterns: • Younger patients (≤45 years) appeared more likely to present with SMuRF-less STEMI. • Among patients with a family history of coronary artery disease, those without SMuRFs appeared more likely to demonstrate multi-vessel coronary disease. These findings suggest a hypothesis that younger age (<45 years) may act as an independent predictor of SMuRF-less STEMI, while family history may be associated with disease severity, likely reflecting a genetic predisposition that accelerates early-onset de novo atherosclerosis. Early development of atherosclerosis may result in a more diffuse and uniform plaque distribution across multiple coronary vessels, potentially increasing the likelihood of multi-vessel disease in SMuRF-less patients with a family history of CAD. What are your thoughts? Anfal Hamza MBBS Sheikh Zayed Medical College View Full Discussion You can also reply to this email to respond to Dr. Hamza Download the DocMatter app Unsubscribe Privacy Terms Support DocMatter Inc. © 2026 DocMatter Inc., 460 Brannan Street #77452, San Francisco, CA 94107