Fwd: Recommended articles

[Okechukwu Ogah]

Dr O.S Ogah. MBBS, MSc, PhD, MD, FWACP, FACP, FESC, FNCS

A. Senior Lecturer

Cardiology Unit, Department of Medicine,

Faculty of Clinical Sciences

College of Medicine,

University of Ibadan, NIGERIA

B. Honorary Consultant Physician/Cardiologist,

Cardiology Unit,

Department of Medicine

University College Hospital Ibadan, NIGERIA

PERSONAL POSTAL ADDRESS

P.O BOX 14343, UNIVERSITY OF IBADAN  POST OFFICE

IBADAN, NIGERIA

Tel. +234 806 77 47 121
Fax. +1215-975-6817 (Electronic)
Emails: 

oso...@com.ui.edu.ng ,

osoga...@gmail.com

osoga...@yahoo.com

https://www.researchgate.net/profile/Okechukwu_Ogah4/contributions

C. Bernard Lown Visiting Scholar in Cardiovascular Health

Department of Global Health and Population

Harvard T.H. Chan School of Public Health

Email: oo...@hsph.harvard.edu

D. Adjunct Researcher,

Institute of Advanced Medical Research and Training (IAMRAT)

College of Medicine, University of Ibadan, NIGERIA

E. Affiliate Member,

The Hatter Institute for Cardiovascular Research in Africa (HICRA)

4th Floor Chris Barnard Building
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA

http://www.hatter.uct.ac.za/icra/about/staff/visiting-researchers

F. Past President,

Nigerian Cardiac Society

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"For with thee is the fountain of life: in thy light shall we see light." Psalm 36:9

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From: Google Scholar Alerts <scholarale...@google.com>
Date: Mon, Jul 3, 2023 at 7:28 AM
Subject: Recommended articles
To: <osoga...@gmail.com>

[HTML] Therapeutic effects on the development of heart failure with preserved ejection fraction by the sodium-glucose cotransporter 2 inhibitor dapagliflozin in type 2 diabetes

B Feng, P Yu, H Yu, B Qian, Y Li, K Sun, B Shi… - Diabetology & Metabolic …, 2023

Background Heart failure with preserved ejection fraction (HFpEF) is a common
disease with high morbidity and lacks effective treatment. We investigated the
protective effects of the long-term application of the sodium-glucose cotransporter 2 …

Global Longitudinal Strain Predicts Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction

A Brann, J Miller, E Eshraghian, JJ Park, B Greenberg - European Journal of Heart …, 2023

Abstract Aims Patients with HFpEF are at high risk for hospitalization and mortality
and many of these patients experience a deterioration in left ventricular ejection
fraction (LVEF) over time. Global longitudinal strain (GLS) is a sensitive marker of …

The efficacy and safety of sacubitril/valsartan in heart failure with reduced ejection fraction patients with hypotension

Y Takigami, S Ishii, Y Eda, M Yazaki, T Fujita, Y Iida… - Heart and Vessels, 2023

Despite previous studies showing that patients with low systolic blood pressure (sBP)
in heart failure with reduced ejection fraction (HFrEF) has a poor prognosis, it has
few treatment options. This study aimed to investigate the efficacy and safety of …

[PDF] Effects of sacubitril-valsartan in the treatment of chronic heart failure patients with end-stage renal disease undergoing dialysis

X Liu, L Huang, G Tse, T Liu, J Che - Clinical Cardiology, 2023

Background The data on the effects of the angiotensin receptor–neprilysin inhibitor
(ARNI) sacubitril-valsartan (LCZ696) in chronic heart failure (CHF) patients with end-
stage renal disease (ESRD) requiring dialysis are lacking. This study assessed the …

[PDF] Sex Differences in Prognosis of Heart Failure Due to Ischemic and Nonischemic Cardiomyopathy

AP Mansur, AC Pereira-Barretto, CH Del Carlo… - 2023

Background: Limited research has explored sex-specific differences in death
predictors of HF pa-tients with ischemic (iCMP) and nonischemic (niCMP)
cardiomyopathy. This study assessed sex differences in niCMP and iCMP prognosis …

Association of Body Mass Index and Abdominal Obesity with Incidence of Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction.

X Huang, X Liu, Y Jiang, Z Cao, M Wu, Z Chen, R Sun… - Current Medicinal Chemistry, 2023

Method A total of 2138 subjects without baseline AF were included in the trial.
Kaplan-Meier (KM) curves and Cox regression with hazard ratios (HRs) and
confidence intervals (CIs) were used to assess the incidence of AF with obesity. Of …

[HTML] Cost Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors Compared with Mineralocorticoid Receptor Antagonists among Patients with Heart Failure and a …

J Guo, MR Petersen, H Tang, LE Meece, H Shao… - Cardiovascular Innovations …, 2023

Objective: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are approved for heart
failure with reduced ejection fraction (HFrEF). However, their cost-effectiveness
remains unknown. We aimed to compare the cost-effectiveness of SGLT2i versus …

Anticoagulation Conundrum in Acute Ischemic Stroke with Atrial Fibrillation

K Uchino - New England Journal of Medicine, 2023

Decades ago, before the days of thrombolysis for ischemic stroke, many patients with
acute ischemic stroke routinely received anticoagulation therapy. This practice is
now less common, and the question is now when to start anticoagulation for long …

Sex differences in atrial fibrillation and associated complications in hypertensive patients with left ventricular hypertrophy: The LIFE study

JB Feinberg, EE Nielsen, SE Kjeldsen, RB Devereux… - American Journal of …, 2023

Background There is no consensus on whether biological differences account for the
higher risk of stroke seen in females compared to males with atrial fibrillation.
Methods Capitalising on The Losartan Intervention for Endpoint study, a multicenter …

Effectiveness and safety of Dabigatran 110 mg versus 150 mg for Stroke Prevention in Patients with Atrial Fibrillation at High Bleeding Risk

J An, TC Cheetham, T Luong, DT Lang, MS Lee… - Clinical Therapeutics, 2023

Purpose The effectiveness and tolerability of a reduced dose (110 mg) of dabigatran
versus the standard dose (150 mg) were evaluated in subgroups of patients with
atrial fibrillation (AF) at high bleeding risk. Methods Eligible patients were adults with …

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[Okechukwu Ogah]

Three-vessel coronary infusion of cardiosphere-derived cells for the treatment of heart failure with preserved ejection fraction in a pre-clinical pig model

R Gallet, JB Su, D Corboz, PM Chiaroni, A Bizé, J Dai… - Basic Research in …, 2023

Heart failure with preserved ejection fraction (HFpEF) is a major public health
concern. Its outcome is poor and, as of today, barely any treatments have been able
to decrease its morbidity or mortality. Cardiosphere-derived cells (CDCs) are heart …

[PDF] Sacubitril-Valsartan and Its Results for the Treatment of Heart Failure with Preserved and Mildly Reduced Ejection Fraction

LC Danzmann, F Forestiero, RF Catucci, N Tossetto - 2023

Background: The 2021 “Universal Definition of Heart Failure (HF)” Proposed the
following left ventricle ejection (LVEF) phenotype classification:≤ 40%; HF with
intermediate LVEF: between 41-49% and HF with preserved LVEF:≥ 50%. LVEF …

First-Phase Ejection Fraction and Long-Term Survival in Patients Who Underwent Transcatheter Aortic Valve Implantation

O Feder, D Zahler, Y Szekely, S Gefen, D Amsterdam… - The American Journal of …, 2023

Early recognition of deteriorating left ventricular function plays a key prognostic role
in patients with aortic stenosis (AS). First-phase ejection fraction (EF1), the ejection
fraction (EF) up to time of maximal contraction, has been suggested for detection of …

[PDF] A novel shared decision-making (SDM) tool for anticoagulation management in atrial fibrillation: protocol for a prospective, multicenter, cluster randomized controlled …

P Mangmang, C Zhang, L Shen, JJ Sha, H Shen… - 2023

Background: Atrial fibrillation (AF) is a common arrhythmia that requires
anticoagulation therapy to prevent stroke. However, there is still a significant under-
/over-treatment in stroke prevention for patients with AF. The adherence and the risk …

[Okechukwu Ogah]

fyi

[PDF] Positive airway pressure therapy adherence and health care resource use in patients with obstructive sleep apnea and heart failure with preserved ejection fraction

PA Cistulli, A Malhotra, KV Cole, AS Malik, JL Pépin… - Journal of the American …, 2023

Background Obstructive sleep apnea (OSA) is common in heart failure with
preserved ejection fraction (HFpEF). However, current evidence is equivocal
regarding the potential benefits of treating OSA with positive airway pressure (PAP) …

[PDF] Incidence of atrial and ventricular arrhythmias in obese patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan

M Abumayyaleh, J Demmer, C Krack, C Pilsinger… - Diabetes, Obesity and …, 2023

Aim To compare clinical outcomes among patients with heart failure and reduced
ejection fraction (HFrEF) according to body mass index (BMI) after initiating treatment
with an angiotensin‐receptor neprilysin inhibitor (ARNI). Methods We gathered data …

Sodium–Glucose Cotransporter-2 Inhibitors: An Old Medication With New Indication in Heart Failure With Preserved Ejection Fraction

MT El Hussein, C Reeves - The Journal for Nurse Practitioners, 2023

Abstract Sodium–glucose cotransporter-2 (SGLT2) inhibitors are used for glycemic
control in patients with type 2 diabetes mellitus. Recent randomized controlled trials
have shown that SGLT2 inhibitors are effective treatments for heart failure (HF) …

The cost‐effectiveness of dapagliflozin in heart failure with preserved or mildly reduced ejection fraction: A European health‐economic analysis of the DELIVER trial

D Booth, JA Davis, P McEwan, SD Solomon… - European Journal of Heart …, 2023

Aims Determine the cost‐effectiveness of dapagliflozin, added to usual care, in
patients with heart failure (HF) with mildly reduced or preserved ejection fraction for
the UK, German and Spanish payers using detailed patient‐level data from the …

Long-term outcomes of women with peripartum cardiomyopathy having subsequent pregnancies

P Pachariyanon, H Bogabathina, K Jaisingh, M Modi… - Journal of the American …, 2023

Background Long-term maternal outcomes of subsequent pregnancies (SSPs) in
patients with peripartum cardiomyopathy (PPCM) have not been analyzed.
Objectives The goal of this study was to evaluate the long-term survival of SSPs in …

[HTML] Dapagliflozin and short-term changes on circulating antigen carbohydrate 125 in heart failure with reduced ejection fraction

M Amiguet, P Palau, E Domínguez, J Seller… - Scientific Reports, 2023

Abstract Circulating antigen carbohydrate 125 (CA125) has emerged as a proxy of
fluid overload in heart failure. This study aimed to evaluate the effect of dapagliflozin
on short-term CA125 levels in patients with stable heart failure with reduced ejection …

Safety of Subsequent Pregnancy After Recovery From Peripartum Cardiomyopathy

U Elkayam - Journal of the American College of Cardiology, 2023

Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy presenting with
heart failure secondary to left ventricular (LV) systolic dysfunction during pregnancy
or the postpartum period. 1 Although PPCM can be associated with important …

Rate-Adaptive Atrial Pacing for Heart Failure With Preserved Ejection Fraction—Reply

YNV Reddy, BA Borlaug - JAMA, 2023

To the Editor The recent RAPID-HF study1 explored the important concept of
supporting heart rate in patients with heart failure and chronotropic insufficiency.
Although the study reached a null conclusion, I believe it is important not to …

Circumferential Pulmonary Vein Isolation With vs Without Additional Low-Voltage-Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation: A Randomized …

H Chen, C Li, B Han, F Xiao, F Yi, Y Wei, C Jiang… - JAMA cardiology, 2023

Importance The overall success rate of circumferential pulmonary vein isolation
(CPVI) treatment in patients with paroxysmal atrial fibrillation (AF) remains
suboptimal, especially in older patients. Objective To explore the incremental benefit …

[Okechukwu Ogah]

[PDF] Interleukin‐1β Disruption Protects Male Mice From Heart Failure With Preserved Ejection Fraction Pathogenesis

BK Srinivas, A Bourdi, JD O'Regan, KD Malavalli… - Journal of the American …, 2023

Background Heart failure with preserved ejection fraction (HFpEF) is a significant
unmet need in cardiovascular medicine and remains an untreatable cardiovascular
disease. The role and mechanism of interleukin‐1β in HFpEF pathogenesis are …

[PDF] Sex Differences in the Effectiveness of Angiotensin‐Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Sacubitril–Valsartan for the Treatment of …

ZN Sohani, H Behlouli, CS de Moura, M Abrahamowicz… - Journal of the American …, 2023

Background PARAGON‐HF (Efficacy and Safety of LCZ696 Compared to Valsartan,
on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction)
suggested a potential benefit of sacubitril–valsartan in women with preserved …

[PDF] Impact of atrial fibrillation on cerebro‐cardiovascular outcome of heart failure with mildly‐reduced ejection fraction

N Li, Y Zhu, F Cheng, Y Chen, X Peng, M Wu, H Huang… - ESC Heart Failure, 2023

Aims Atrial fibrillation (AF) and heart failure (HF) often co‐exist and are closely
intertwined. The impact of AF on the outcome of patients with heart failure with mildly‐
reduced ejection fraction (HFmrEF) is not fully clear. This study aimed to investigate …

[HTML] Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

R Didier, L Garnier, G Duloquin, A Meloux, A Sagnard… - Stroke and Vascular …, 2023

Background Atrial cardiomyopathy (AC) is an emerging concept explaining the
pathophysiology of cardioembolic strokes in absence of atrial fibrillation (AF). A
definition based on the presence of electrical abnormality (P-wave terminal force in …

[PDF] So Much to Say on the Best of What's Around Regarding Sodium‐Glucose Cotransporter‐2 Inhibitors in Acute Myocardial Infarction

JT Nunes, JA Udell - Journal of the American Heart Association, 2023

Acute myocardial infarction (AMI) is a leading cause of morbidity and death
worldwide. Despite significant advancements in the management of AMI, patients
with diabetes continue to have a worse prognosis than those without diabetes. In …

[PDF] Prognostic Impact of Left Atrial Strain in Patients Hospitalized for Acute Heart Failure With Atrial Fibrillation

J Yamamoto, M Moroi, H Hayama, M Yamamoto… - Circulation Journal, 2023

Background: Patients with atrial fibrillation (AF) and heart failure (HF) have elevated
left ventricular end-diastolic pressure in addition to decreased left atrial (LA) function,
but there are few reports of useful prognostic indices that can be seen on …

[PDF] Association of Direct Oral Anticoagulation Management Strategies With Clinical Outcomes for Adults With Atrial Fibrillation

CG Derington, GK Goodrich, S Xu, NP Clark… - JAMA Network Open, 2023

Importance Anticoagulation management services (AMSs; ie, warfarin clinics) have
evolved to include patients treated with direct oral anticoagulants (DOACs), but it is
unknown whether DOAC therapy management services improve outcomes for …

Association of pre-hospital precipitating factors with short-and long-term outcomes of acute heart failure patients: A report from the WET-HF2 registry

YK Ichihara, Y Shiraishi, S Kohsaka, S Nakano… - International Journal of …, 2023

Background Interest in clinical course preceding heart failure (HF) exacerbation has
grown, with a greater emphasis placed on patients' clinical factors including
precipitant factor (PF). Large-scale studies with precise PF documentation and …

[PDF] Canagliflozin, Blood Pressure Variability, and Risk of Cardiovascular, Kidney, and Mortality Outcomes: Pooled Individual Participant Data From the CANVAS and …

RA Fletcher, C Arnott, P Rockenschaub, AE Schutte… - Journal of the American …, 2023

Background Sodium glucose cotransporter‐2 inhibitors reduce systolic blood
pressure (SBP), but whether they affect SBP variability is unknown. There also
remains uncertainty regarding the prognostic value of SBP variability for different …

[PDF] Risk of hospitalization with sodium‐glucose cotransporter‐2 inhibitors versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes lacking evidence of …

M Schechter, C Melzer Cohen, T Zelter, I Yanuv… - Diabetes, Obesity and …, 2023

2 METHODS The database includes over 2.2 million patients, and approximately 180
000 are in the diabetes registry, with a 99% yearly retention rate. Patients with T2D,
who initiated an SGLT2 inhibitor (empagliflozin or dapagliflozin) in an outpatient …

[Okechukwu Ogah]

[HTML] Dapagliflozin and short-term changes on circulating antigen carbohydrate 125 in heart failure with reduced ejection fraction

M Amiguet, P Palau, E Domínguez, J Seller… - Scientific Reports, 2023

Abstract Circulating antigen carbohydrate 125 (CA125) has emerged as a proxy of
fluid overload in heart failure. This study aimed to evaluate the effect of dapagliflozin
on short-term CA125 levels in patients with stable heart failure with reduced ejection …

Association of pre-hospital precipitating factors with short-and long-term outcomes of acute heart failure patients: A report from the WET-HF2 registry

YK Ichihara, Y Shiraishi, S Kohsaka, S Nakano… - International Journal of …, 2023

Background Interest in clinical course preceding heart failure (HF) exacerbation has
grown, with a greater emphasis placed on patients' clinical factors including
precipitant factor (PF). Large-scale studies with precise PF documentation and …

[HTML] Improving Blood Pressure Control in the United States: At the Heart of Million Hearts 2027

HK Wall, JS Wright, LA Fleisher, LS Sperling - 2023

Million Hearts, a national initiative co-led by the Centers for Disease Control and
Prevention (CDC) and the Centers for Medicare and Medicaid Services (CMS), was
launched in 2012 to focus and drive improvement on a small set of high-impact …

Heart failure with recovered ejection fraction in patients with non-ischemic cardiomyopathy–characteristics, outcomes, and long-term follow-up

Y Hammer, M Yosef, S Khalatbari, K Da Aaronson - Journal of Cardiac Failure, 2023

Background: Duration of recovery and long-term outcomes have not been well
described in a large cohort of patients with heart failure with recovered ejection
fraction (HFrecEF) due to nonischemic cardiomyopathy (NICM). The aim of the study …

The diuretic, natriuretic and chloride-regaining effects of oral acetazolamide as an add-on therapy for acute heart failure with volume overload. A single center …

A Kosiorek, S Urban, J Detyna, J Biegus, M Hurkacz… - Polish Archives of Internal …, 2023

The diuretic, natriuretic and chloride-regaining effects of oral acetazolamide as an
add-on therapy for acute heart failure with volume overload. A single center,
prospective, randomized study. - Abstract - Europe PMC Sign in | Create an account …

An Interesting Case of Peripartum Cardiomyopathy With Biventricular Thrombi

A Golden-Hart, G Stanger, H Mariam, C Kipson, L Sun… - Cureus, 2023

Peripartum cardiomyopathy (PPCM) is a cause of heart failure that develops within
five months postpartum. Biventricular thrombosis is a rare complication of PPCM with
only a few cases reported in the literature. Here, we report a case of PPCM with …

[HTML] Cardiac Resynchronization Therapy in Heart Failure in Sub-Saharan Africa Environment: Experience of the Principal Hospital of Dakar (Senegal)

K Dia, WN Mboup, DM Ba, SCT Ndao, MM Ka… - World Journal of …, 2023

Background: Heart failure is a major public health challenge in sub-Saharan Africa.
In patients with chronic Heart Failure and cardiac desynchrony, studies have
suggested that cardiac resynchronization, can improve cardiac function and the …

[Okechukwu Ogah]

Initiation of eplerenone or spironolactone, treatment adherence, and associated outcomes in patients with new-onset heart failure with reduced ejection fraction: a …

JE Larsson, C Denholt, JJ Thune, AA Raja, E Fosbøl… - European Heart Journal …, 2023

Background The mineralocorticoid receptor antagonists (MRAs) eplerenone and
spironolactone are beneficial in heart failure with reduced ejection fraction (HFrEF),
but have not been prospectively compared. We compared clinical outcomes, daily …

[HTML] Plasma angiopoietin-2 and its association with heart failure in patients with atrial fibrillation

AP Benz, Z Hijazi, J Lindbäck, SJ Connolly… - Europace, 2023

Background Several biomarkers are associated with clinical outcomes in patients
with atrial fibrillation (AF), but a causal relationship has not been established. This
study aimed to evaluate angiopoietin-2, a novel candidate biomarker of endothelial …

[HTML] Gender Differences in Atrial Fibrosis and Cardiomyopathy Assessed by Left Atrial Low-Voltage Areas During Catheter Ablation of Atrial Fibrillation

M Masuda, Y Matsuda, H Uematsu, A Sugino, H Ooka… - The American Journal of …, 2023

Atrial myocardial degeneration predisposes to atrial fibrillation (AF), ischemic stroke,
and heart failure. Studies suggest the presence of gender differences in atrial
myocardial degeneration. This study aimed to delineate gender differences in the …

[HTML] Prognostic Factors Associated with Acute Heart Failure in Patients Admitted for COVID-19: Analysis of the SEMI-COVID-19 Registry

M Méndez Bailón, N Lorenzo Villalba, J Garcia Onrubia… - Journal of Clinical Medicine, 2023

Introduction: Since the beginning of the COVID-19 pandemic in March 2020, an
intimate relationship between this disease and cardiovascular diseases has been
seen. However, few studies assess the development of heart failure during this …

Time-Varying Cardiovascular Effects of Sodium-Glucose Cotransporter Inhibitors in Patients With Heart Failure With Preserved Ejection Fraction

S Zahid, SU Khan - American Journal of Cardiology, 2023

Both the EMPEROR-Preserved (he Empagliflozin Outcome Trial in Patients with
Chronic Heart Failure with Preserved Ejection Fraction) and DELIVER (Dapagliflozin
Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart …

Effect of sodium-glucose co-transporter-2 inhibitor empagliflozin on disease progression in a patient with heart failure and preserved ejection fraction

F Málek - Vnitrni lekarstvi, 2023

Sodiumglucose co-transporter 2 inhibitors-gliflozins-have a scientific evidence on
efficacy in patients with heart failure regardless left ventricular ejection fraction.
Gliflozins They reduced combined endpoint of cardiovascular mortality and heart …

[HTML] Factors influencing blood pressure control in patients with atrial fibrillation and hypertension in Australian primary care

R Trivedi, S Marschner, T Shaw, H Min, J Yue, S Kazi… - Heart, 2023

Objective This study explored factors that may influence blood pressure (BP) control
in patients with atrial fibrillation (AF) with hypertension. Methods Cross-sectional
retrospective analysis of the MedicineInsight database which includes de-identified …

Risk of cardioembolic ischemic events and relation to atrial fibrillation/flutter in patients with arrhythmogenic cardiomyopathy during a long-term follow-up

E Toso, F De Lio, PP Bocchino, C Raineri, F Fioravanti… - International Journal of …, 2023

Structured abstract Background Arrhythmogenic cardiomyopathy (ACM) is an
inherited heart disease characterized by fibro-fatty replacement of myocardium.
Limited data is available concerning cardioembolic stroke. This study sought to …

[HTML] The aetiology and incidence of infective endocarditis in people living with rheumatic heart disease in tropical Australia

A Basaglia, K Kang, R Wilcox, A Lau, K McKenna… - European Journal of Clinical …, 2023

Purpose To define the incidence and microbiological aetiology of infective
endocarditis (IE) in patients with rheumatic heart disease (RHD) in tropical Australia.
Methods A retrospective study that examined all episodes of IE between January …

Usefulness of HANBAH Score in Japanese Patients With Acute Heart Failure

T Kaneko, N Kagiyama, Y Nakamura, T Dotare… - The American Journal of …, 2023

The HANBAH score is a novel simple risk score consisting of hemoglobin level, age,
sodium (N) level, blood urea nitrogen level, atrial fibrillation, and high-density
lipoprotein. We aimed to validate this score in an external population. This …

[Okechukwu Ogah]

The efficacy and safety of sacubitril/valsartan in heart failure with reduced ejection fraction patients with hypotension

Y Takigami, S Ishii, Y Eda, M Yazaki, T Fujita, Y Iida… - Heart and Vessels, 2023

Despite previous studies showing that patients with low systolic blood pressure (sBP)
in heart failure with reduced ejection fraction (HFrEF) has a poor prognosis, it has
few treatment options. This study aimed to investigate the efficacy and safety of …

[PDF] So Much to Say on the Best of What's Around Regarding Sodium‐Glucose Cotransporter‐2 Inhibitors in Acute Myocardial Infarction

JT Nunes, JA Udell - Journal of the American Heart Association, 2023

Acute myocardial infarction (AMI) is a leading cause of morbidity and death
worldwide. Despite significant advancements in the management of AMI, patients
with diabetes continue to have a worse prognosis than those without diabetes. In …

Atrial Myopathy and Ischemic Stroke in Heart Failure With Preserved Ejection Fraction

K Farhat, K Elkholey, ZUA Asad, S Stavrakis - The American Journal of Cardiology, 2023

Recent studies suggested an association between atrial myopathy and stroke
independent of atrial fibrillation (AF). We examined the hypothesis that atrial
myopathy may be associated with ischemic stroke in patients with heart failure with …

Heart Rate and Death and Hospitalization for Heart Failure in Patients with Persistent or Permanent Atrial Fibrillation: Insights from the ARISTOTLE Trial

D Vinereanu, DM Wojdyla, JH Alexander, RD Lopes… - American Heart Journal, 2023

Rate control is fundamental in the treatment of patients with atrial fibrillation (AF). The
independent association of heart rate with outcomes and range of heart rate
associated with best outcomes remains uncertain. We assessed the relationship …

DASH-HF Study: A Pragmatic Quality Improvement Randomized Implementation Trial for Patients With Heart Failure With Reduced Ejection Fraction

A Verma, GC Fonarow, JJ Hsu, CA Jackevicius… - Circulation: Heart Failure, 2023

BACKGROUND: Heart failure is a prevailing diagnosis of hospitalization and
readmission within 6 months, and nearly a quarter of these patients die within a year.
Guideline-directed medication therapies reduce risk of mortality by 73% over 2 years; …

[PDF] Effect of Health-Education Intervention on Knowledge Level and Motivation of Hypertension Prevention among Pre-Hypertensive Market Traders in Lagos State

OO Oyerinde, IO Okesiji, AM Amosu - KIU Journal of Social Sciences, 2023

Hypertension is a long-term medical disorder in which blood pressure in the arteries
remains abnormally high (Naish & Court, 2014). Majority of the time, high blood
pressure is asymptomatic (Ayogu, Ezeh & Okafor, 2021). Nevertheless, persistent …

[Okechukwu Ogah]

Left Ventricular Gene Expression in Heart Failure With Preserved Ejection Fraction—Profibrotic and Proinflammatory Pathways and Genes

B Ye, AD Bradshaw, JE Abrahante, JA Dragon… - Circulation: Heart Failure, 2023

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is
increasingly prevalent and has few treatments. The molecular mechanisms and
resultant signaling pathways that underlie the development of HFpEF are poorly …

Association of atrial fibrillation with survival in patients with low-flow low-gradient aortic stenosis with preserved ejection fraction undergoing TAVI

M Nakase, D Tomii, D Heg, F Praz, S Stortecky, J Lanz… - European Heart Journal …, 2023

Aims There is limited evidence on the prognostic significance of atrial fibrillation (AF)
in patients with low flow, low gradient aortic stenosis with preserved ejection fraction
(LFLG-pEF AS). We aimed to evaluate the recovery of stroke volume after …

[HTML] The Relationship between the MAGGIC Score and Cardiorenal Syndrome in Patients with Acute Decompensated Heart Failure with Reduced Ejection Fraction

O Dogan, HA Barman, A Atıcı, AO Ebeoglu, ME Gokce… - Acta Cardiologica Sinica, 2023

Background The Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) is a
scoring system that is easy to use in outpatient clinics or at the bedside, and was
developed to predict the survival of heart failure patients after hospitalization …

[HTML] Cardioprotective efficacy of Xin-shu-bao tablet in heart failure with reduced ejection fraction by modulating THBD/ARRB1/FGF1/STIM1 signaling

F Zhang, X Xu, J Hou, H Xiao, F Guo, X Li, H Yang - Biomedicine & Pharmacotherapy, 2023

Traditional Chinese medicine offer unique advantages in mitigating and preventing
early or intermediate stage for treating heart failure (HF). The purpose of this study
was to assess the in vivo therapeutic efficacy of Xin-shu-bao (XSB) at different stages …

Dapagliflozin in the treatment of heart failure with preserved ejection fraction

T Švarcová - Vnitrni lekarstvi, 2023

We present obese patient with numerous comorbidities in this case report, who's
treatment of heart failure with preserved ejection fraction (HF PEF) has been
managed in our office for several years. The treatment was limited by the patient's …

[PDF] Changes in Heart Rate after Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation and Sinus Bradycardia

J Liu, F Sun, J Sun, Y Ba, W Zhao, Z Zhang, L Liu… - International Heart Journal, 2023

This study aimed to evaluate the effect of circumferential pulmonary vein isolation
(CPVI) on autonomic nervous function and prognosis in patients with paroxysmal
atrial fibrillation (AF) with or without sinus bradycardia. A total of 66 patients with …

Effects of sodium-glucose cotransporter 2 inhibitors on iron metabolism in a contemporary cohort of patients affected by chronic heart failure with reduced ejection …

A Piccoli - 2023

Background. Sodium/glucose cotransporter 2 inhibitors (SGLT2i) have modified
heart failure's therapy and prognosis. Their contribution to cardiac reverse
remodeling and the merging effects on iron metabolism could be the substrate of the …

[HTML] Association of carbohydrate antigen 125 on the response to dapagliflozin in patients with heart failure

KF Docherty, K McDowell, P Welsh, J Osmanska… - Journal of the American …, 2023

Background Elevated circulating carbohydrate antigen 125 (CA125) is a marker of
congestion and a predictor of outcomes in acute heart failure (HF). Less is known
about CA125 in chronic ambulatory HF with reduced ejection fraction. Objectives …

[HTML] The arrhythmogenic cardiomyopathy phenotype associated with PKP2 c. 1211dup variant

TA Bos, SRD Piers, MW Wessels, AC Houweling… - Netherlands Heart Journal, 2023

Background The arrhythmogenic cardiomyopathy (ACM) phenotype, with life-
threatening ventricular arrhythmias and heart failure, varies according to genetic
aetiology. We aimed to characterise the phenotype associated with the variant c …

[PDF] Heart Failure and Comorbidities in Patients Evaluated for Cardiovascular Surgery in a Tertiary Hospital in Nigeria

PO Njoku, NC Mbadiwe, EC Ejim, BC Anisiuba… - Nigerian Journal of …, 2023

Heart Failure and Comorbidities in Patients Evaluated for Cardiovascular Surgery in a
Tertiary Hospital in Nigeria Page 1 Abstract Original Article INTRODuCTION Heart
failure (HF) is a complex clinical syndrome with reduced ability of the heart to pump …

[Okechukwu Ogah]

Comparative effectiveness of sodium‐glucose cotransporter‐2 inhibitors among patients with heart failure with preserved ejection fraction

M Riaz, SM Smith, EA Dietrich, DE Winchester, J Guo… - … : The Journal of Human …, 2023

Background Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended
by the American Heart Association for management of heart failure with preserved
ejection fraction (HFpEF), but little is known about their in‐class comparative …

[HTML] Dapagliflozin and short-term changes on circulating antigen carbohydrate 125 in heart failure with reduced ejection fraction

M Amiguet, P Palau, E Domínguez, J Seller… - Scientific Reports, 2023

Abstract Circulating antigen carbohydrate 125 (CA125) has emerged as a proxy of
fluid overload in heart failure. This study aimed to evaluate the effect of dapagliflozin

on short-term CA125 levels in patients with stable heart failure with reduced ejection …

Projected clinical benefits of dapagliflozin in patients with heart failure with preserved ejection fraction

M Montero-Pérez-Barquero, C Escobar-Cervantes… - Future Cardiology, 2023

Aims: To address the projected clinical benefits of dapagliflozin among patients with
heart failure (HF) with mildly reduced ejection fraction (HFmrEF) and preserved
ejection fraction (HFpEF). Methods: A multicenter, prospective, cohort study of …

Long-term outcomes of women with peripartum cardiomyopathy having subsequent pregnancies

P Pachariyanon, H Bogabathina, K Jaisingh, M Modi… - Journal of the American …, 2023

Background Long-term maternal outcomes of subsequent pregnancies (SSPs) in
patients with peripartum cardiomyopathy (PPCM) have not been analyzed.
Objectives The goal of this study was to evaluate the long-term survival of SSPs in …

Atrial fibrillation burden and atrial shunt therapy in heart failure with preserved ejection fraction

RB Patel, VY Reddy, J Komtebedde, SW Wegerich… - JACC: Heart Failure, 2023

Background Atrial fibrillation (AF) is a common comorbidity in patients with heart
failure with preserved ejection fraction (HFpEF) and in heart failure with mildly
reduced ejection fraction (HFmrEF). Objectives This study sought to describe AF …

Circumferential Pulmonary Vein Isolation With vs Without Additional Low-Voltage-Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation: A Randomized …

H Chen, C Li, B Han, F Xiao, F Yi, Y Wei, C Jiang… - JAMA cardiology, 2023

Importance The overall success rate of circumferential pulmonary vein isolation
(CPVI) treatment in patients with paroxysmal atrial fibrillation (AF) remains
suboptimal, especially in older patients. Objective To explore the incremental benefit …

Remote patient management of heart failure across the ejection fraction spectrum: A prespecified analysis of the TIM‐HF2 trial

F Kerwagen, K Koehler, E Vettorazzi, V Stangl… - European Journal of Heart Failure

Aims The benefit of non‐invasive remote patient management (RPM) for patients
with heart failure (HF) has been demonstrated. We evaluated the effect of left
ventricular ejection fraction (EF) on treatment outcomes in the TIM‐HF2 (Telemedical …

Safety of Subsequent Pregnancy After Recovery From Peripartum Cardiomyopathy

U Elkayam - Journal of the American College of Cardiology, 2023

Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy presenting with
heart failure secondary to left ventricular (LV) systolic dysfunction during pregnancy
or the postpartum period. 1 Although PPCM can be associated with important …

[PDF] So Much to Say on the Best of What's Around Regarding Sodium‐Glucose Cotransporter‐2 Inhibitors in Acute Myocardial Infarction

JT Nunes, JA Udell - Journal of the American Heart Association, 2023

Acute myocardial infarction (AMI) is a leading cause of morbidity and death
worldwide. Despite significant advancements in the management of AMI, patients
with diabetes continue to have a worse prognosis than those without diabetes. In …

[Okechukwu Ogah]

Serum Proteomic Analysis of Peripartum Cardiomyopathy Reveals Distinctive Dysregulation of Inflammatory and Cholesterol Metabolism Pathways

JP Lovell, K Bermea, J Yu, S Rousseau, CD Cohen… - JACC: Heart Failure, 2023

Background The pathophysiology of peripartum cardiomyopathy (PPCM) and its
distinctive biological features remain incompletely understood. High-throughput
serum proteomic profiling, a powerful tool to gain insights into the pathophysiology of …

Association of atrial fibrillation with survival in patients with low-flow low-gradient aortic stenosis with preserved ejection fraction undergoing TAVI

M Nakase, D Tomii, D Heg, F Praz, S Stortecky, J Lanz… - European Heart Journal …, 2023

Aims There is limited evidence on the prognostic significance of atrial fibrillation (AF)
in patients with low flow, low gradient aortic stenosis with preserved ejection fraction
(LFLG-pEF AS). We aimed to evaluate the recovery of stroke volume after …

[HTML] Protocol: Rationale and design of the NEO-NORMAL-AF study examination of the usefulness of implantable loop recorder for arrhythmia detection including atrial …

J Sugiura, S Kasama, T Ueda, T Nishida, H Kawata… - Open Heart, 2023

Protocol: Rationale and design of the NEO-NORMAL-AF study examination of the
usefulness of implantable loop recorder for arrhythmia detection including atrial
fibrillation in heart failure with non-reduced ejection fraction cases: a pilot study - PMC …

Different right ventricular dysfunction and pulmonary coupling in acute heart failure according to the left ventricular ejection fraction

P Alberto, C Alessandra, P Filippo, V Francesca… - Progress in Cardiovascular …, 2023

Background Right ventricular (RV) dysfunction and pulmonary uncoupling are two
acknowledged features associated with poor outcome, however few data defined RV
adaptation across the different left ventricular ejection fraction (EF) cut-off …

[PDF] Increased Left Atrial Stiffness is Significantly Associated with Paroxysmal Atrial Fibrillation in Diabetic Patients

DA Arnautu, SF Arnautu, MC Tomescu, S Luca… - … , Metabolic Syndrome and …, 2023

Purpose Atrial fibrillation (AF) and diabetes mellitus (DM) are common pathogenic
diseases. Diabetes is an independent risk factor for AF, and coexisting AF is a risk
factor for the diabetic pa-tient's progression. The purpose of this study was to see if …

Peripartum Cardiomyopathy

A Hesson, MB Davis - Contemporary Topics in Cardio-Obstetrics, 2023

Peripartum cardiomyopathy (PPCM) is a diagnosis of exclusion manifesting as acute
systolic heart failure towards the end of pregnancy or in the months that follow.
Elevated BNP or NT-proBNP and echocardiogram with evidence of systolic …

[PDF] Expert opinion of the Heart Failure Association of the Polish Society of Cardiology, the College of Family Physicians in Poland, and the Polish Society of Family …

J Nessler, K Krawczyk, P Leszek, P Rubiś, P Rozentryt… - Kardiologia Polska (Polish …, 2023

Despite advances in the treatment of heart failure (HF), the rate of hospitalisation for
exacerbations of the disease remains high. One of the underlying reasons is that
recommended guidelines for the management of HF are still too rarely followed in …

Dapagliflozin ameliorates sepsis-induced heart injury by inhibiting cardiomyocyte apoptosis and electrical remodeling through the PI3K/Akt pathway

X Han, X Liu, X Zhao, X Wang, Y Sun, C Qu, J Liang… - European Journal of …, 2023

Background Sepsis-induced heart injury is one of the leading causes of circulation
disorders worldwide. Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor
mainly used for controlling blood glucose, has been shown to exert a protective effect …

[ekpe ekpe]

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[Jayne Ajuluchukwu]

Congratulations Dr Ogah for being the First Lecturer of the Professor JJAndy Guest Lecture series. I know the lecture and delivery will be excellent. I don't think I noticed a zoom link for online participants. 

Looking forward to a clarification and the lecture. 

JNA

To view this discussion on the web visit https://groups.google.com/d/msgid/nigerian-cardiac-society/2065705665.418032.1691400304694%40mail.yahoo.com.

[Basil Okeahialam]

I congratulate pROF J. J.ANDY, one of my guardian angels. God willing and my busy Tuesday clinic permitting, I shall join virtually.

Prof B N Okeahialam 

To view this discussion on the web visit https://groups.google.com/d/msgid/nigerian-cardiac-society/2065705665.418032.1691400304694%40mail.yahoo.com.

[Okechukwu Ogah]

[HTML] Telmisartan versus EnalapRil In heart failure with redUced ejection fraction patients with Moderately impaired kidney Functions; randomized controlled trial:“TRIUMF …

A Samir, S Aboel-Naga, A Shehata, M Abdelhamid - The Egyptian Heart Journal, 2023

When heart failure with reduced ejection fraction (HFrEF) and chronic kidney disease
(CKD) co-exist, Renin angiotensin-aldosterone system inhibitors (RAASi) are often
underutilized for the fear of worsening renal function (WRF). Telmisartan is a RAASi …

[PDF] Comparative Outcomes of a Transthyretin Amyloid Cardiomyopathy Cohort Versus Patients With Heart Failure With Preserved Ejection Fraction Enrolled in the …

MM Kim, M Prasad, Y Burton, CM Kolseth, Y Zhao… - Journal of the American …, 2023

Background Transthyretin cardiac amyloidosis (ATTR‐CM), found in 6% to 15% of
cohorts with heart failure with preserved ejection fraction, has long been considered
a rare disease with poor prognosis. New treatments have made it one of the few …

Utilization rates and predictors of sodium glucose cotransporter 2 inhibitor use in patients with heart failure with or without type 2 diabetes

GM Ray, SR Bermudez, JR Anderson, AJ Bos - American Journal of Health-System …, 2023

Disclaimer In an effort to expedite the publication of articles, AJHP is posting
manuscripts online as soon as possible after acceptance. Accepted manuscripts
have been peer-reviewed and copyedited, but are posted online before technical …

[HTML] Right Atrial Phasic Function in Heart Failure with Preserved Ejection Fraction: Cardiac Magnetic Resonance Feature Tracking and Outcomes

R Schönbauer, F Hana, F Duca, M Koschutnik, C Donà… - Journal of Clinical Medicine, 2023

Background: This study sought to investigate the prognostic impact of right atrial (RA)
size and function in patients with heart failure with preserved ejection fraction
(HFpEF) in sinus rhythm (SR) and atrial fibrillation (AF). Methods: Consecutive …

Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction

A Alogna, KE Koepp, M Sabbah, JME Netto… - JACC: Heart Failure, 2023

Abstract Background Interleukin (IL)-6 is a central inflammatory mediator and
potential therapeutic target in heart failure (HF). Prior studies have shown that IL-6
concentrations are elevated in patients with HF, but much fewer data are available in …

Ischemic Etiology in Advanced Heart Failure: Insight from the HELP-HF Registry

A Villaschi, M Pagnesi, D Stolfo, L Baldetti… - The American Journal of …, 2023

In patients with advanced heart failure (HF), defined according to the presence of at
least one I-NEED-HELP criterium, the updated 2018 Heart Failure Association of the
European Society of Cardiology (HFA-ESC) criteria for advanced HF identify a …

Topping Off the Pill Box: Dapagliflozin, Heart Failure, and Polypharmacy

JJ Park, B Greenberg - Heart Failure, 2023

In the current era of advanced medical standards, there is a justifiable expectation
among people to have access to effective treatments for their various ailments. When
immediate solutions are not available to treat a medical condition, dedicated …

[HTML] Tricuspid Regurgitation Velocity and Mean Pressure Gradient for the Prediction of Pulmonary Hypertension According to the New Hemodynamic Definition

GE Mandoli, F Landra, B Chiantini, C Sciaccaluga… - Diagnostics, 2023

Background: The hemodynamic definition of PH has recently been revised with
unchanged threshold of peak tricuspid regurgitation velocity (TRV). The aim of this
study was to evaluate the predictive accuracy of peak TRV for PH based on the new …

Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke

EL Stulberg, BRE Harris, AR Zheutlin, A Delic… - Neurology, 2023

Background/Objective It is unclear if blood pressure variability's (BPV) association
with worse outcomes is unique to stroke patients or a risk factor among all critically-ill
patients. We (1) determined if BPV differed between stroke and non-stroke …

[Okechukwu Ogah]

fyi

[HTML] A novel mouse model of heart failure with preserved ejection fraction after chronic kidney disease induced by retinol through JAK/STAT pathway

B Liu, A Shalamu, Z Pei, L Liu, Z Wei, Y Qu, S Song… - International Journal of …, 2023

Heart failure is the leading cardiovascular comorbidity in chronic kidney disease
(CKD) patients. Among the types of heart failure according to ejection fraction, heart
failure with preserved ejection fraction (HFpEF) is the most common type of heart …

[HTML] Lifeday coverage of oral anticoagulants and one-year relative survival in patients with atrial fibrillation: a population-based study in Estonia

P Pauklin, T Marandi, M Kals, T Ainla, K Martinson… - BMC Cardiovascular …, 2023

Routine oral anticoagulation (OAC) is recommended for almost all high-risk patients
with atrial fibrillation, yet registries show that OACs are still underused. Our aim was
to study the lifeday coverage (LDC) of OAC prescriptions and its relationship with …

Prevention and treatment of diuretic resistance in acute heart failure: when to use which combination of diuretics?

P Martens, J Testani, K Damman - European Heart Journal, 2023

For decades, guidance on the titration of diuretic therapy in acute heart failure (AHF)
has been based upon expert opinion. This is due to the lack of practice-changing
randomized controlled trials (RCTs) beyond those such as the DOSE trial testing …

Can a best practice advisory improve anticoagulation prescribing to reduce stroke risk in patients with atrial fibrillation?

MH Eckman, R Wise, C Knochelmann, R Mardis… - Journal of Cardiology, 2023

Background Atrial fibrillation (AF) is the most common cardiac rhythm disorder and a
risk factor for stroke. Randomized trials have demonstrated that anticoagulation can
reduce strokes in AF patients. Yet, widespread underutilization of this therapy …

Effect of pharmacological heart failure drugs and gene therapy on Danon's cardiomyopathy

D Yadin, T Guetta, Z Petrover, R Alcalai, J Seidman… - Biochemical Pharmacology, 2023

Danon disease is an X-linked genetic disease resulting from LAMP2 mutations
leading to defective lysosomal function. Heart failure is the main causes of morbidity
and mortality. Mice with an LAMP2-exon-6-deletion (L2 Δ6), develop cardiac …

[HTML] CA125, Galectin-3 and FGF-23 are interrelated in heart failure with reduced ejection fraction

D Gruson, D Maisin, AC Pouleur, SA Ann… - EJIFCC, 2023

Background Carbohydrate Antigen 125 (CA125) is the most widely used biomarker
in ovarian cancer screening. In patients with heart failure (HF), increased levels of
CA125 have been observed and related to disease severity. Our objective was to …

Resistant hypertension, catecholamine excess, left ventricular hypertrophy and systolic dysfunction: hypertensive cardiomyopathy?

A Gould, I Ambrosini, PG Masci, RJ Mcnally… - Journal of Human …, 2023

Raised catecholamines in patients with hypertension might represent a feature of
pheochromocytoma/paraganglioma or be ascribed to several other conditions whose
differential diagnosis is often challenging in clinical practice. In these patients …

Early prediction of ventricular fibrillation using electrocardiographic characteristics in prehospital suspected ST-segment elevation myocardial infarction: a case …

A Tanguay, J Lebon, D Hébert - Canadian Journal of Emergency Medicine, 2023

Purpose Our objective was to determine characteristics of electrocardiograms (ECG)
that predict ventricular fibrillation (VF) among prehospital patients with suspected ST-
segment elevation myocardial infarction (STEMI) in Québec. Methods We performed …

Blood pressure control and antihypertensive medication use after discharge and prognosis of ischemic stroke

M Shi, Y Liu, S Wang, R Wang, P Yang, Y Peng… - Journal of Hypertension

Objective: To investigate the effect of consistently blood pressure (BP) control status
after discharge on adverse clinical outcomes among ischemic stroke (IS) patients.
Methods: Three thousand, four hundred and six acute IS patients were included and …

[Okechukwu Ogah]

[HTML] Blood Immune Cell Alterations in Patients with Hypertensive Left Ventricular Hypertrophy and Heart Failure with Preserved Ejection Fraction

A Ovchinnikov, A Filatova, A Potekhina, T Arefieva… - Journal of Cardiovascular …, 2023

(1) Background: Chronic inflammation and fibrosis are key players in cardiac
remodeling associated with left ventricular hypertrophy (LVH) and heart failure with a
preserved ejection fraction (HFpEF). Monocytes and T-helpers (Th) are involved in …

Diastolic Exercise Stress Testing in Heart Failure with Preserved Ejection Fraction–The DEST HF study

S Wernhart, A Goertz, J Hedderich, M Papathanasiou… - European Journal of Heart Failure

Abstract Background and Aims Pulmonary capillary wedge pressure (PAWP)≥
25mmHg during bicycle ergometry is recommended to uncover occult heart failure
with preserved ejection fraction. We hypothesized that PAWP increase would differ in …

[HTML] Left Ventricular Noncompaction Masquerading as Hypertrophic Nonobstructive Cardiomyopathy

PR Veedu, V Haridasan, GR Nair, G Subramanian - 2023

A 61-year-old male with no significant medical history presented with dyspnea on
exertion for the past 3 months. Clinical examination findings and electrocardiogram
showed sinus rhythm and left ventricular hypertrophy. The chest X-ray and basic …

[HTML] Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study

Z Zhang, L Li, Z Hu, L Zhou, Z Zhang, Y Xiong, Y Yao - BMC Medical Genomics, 2023

Observational studies have suggested a close association between atrial fibrillation
(AF) and heart failure (HF), yet the causal effect remains uncertain. In this study, we
employed a bidirectional Mendelian randomization analysis to investigate the causal …

[HTML] Sodium-glucose cotransporter 2 inhibitors in frail, older people with type 2 diabetes and heart failure: do we have enough evidence to confidently support the use?

T Koufakis, MN Doumas, A Bargiota, K Kotsa… - Expert Review of Clinical …, 2023

Frailty is defined as “a state of increased vulnerability to endogenous and exogenous
stressors, due to age-related declines in physiologic reserve and function across
multiple physiologic systems”[1]. Frailty is more common as age increases but it is …

[HTML] A “Grasp Heart” Situation: Managing Heart Failure with Reduced Ejection Fraction in Primary Adrenal Insufficiency

MAM Stumpf, MQ Almeida - Arquivos Brasileiros de Cardiologia, 2023

Primary adrenal insufficiency (PAI) is a well-established risk factor for ischemic heart
disease, the most prevalent cause of heart failure. Treatment of patients with heart
failure with reduced ejection fraction (HFrEF) and PAI is debatable. Here, we briefly …

[HTML] A novel mutation in the TTN gene resulted in left ventricular noncompaction: a case report and literature review

S Tian, H Liang, X Li, B Cao, L Feng, L Wang - BMC Cardiovascular Disorders, 2023

Left ventricular noncompaction (LVNC) is a specific type of cardiomyopathy
characterized by coarse trabeculae and interspersed trabecular crypts within the
ventricles. Clinical presentation varies widely and may be nonsignificant or may …

Post-COVID-19 Peripartum Cardiomyopathy: Experience from a Large Tertiary Referral Center

S Yaniv-Salem, L Dym, L Nesher, D Zahger, A Shalev… - The Israel Medical …, 2023

Background Peripartum cardiomyopathy (PPCM) is a rare but potentially devastating
complication of pregnancy. Although the pathophysiology of PPCM is not fully
understood, there are known risk factors for developing PPCM, which are maternal …

[PDF] Real‐world risk of cardiovascular diseases in patients with type 2 diabetes associated with sodium–glucose cotransporter 2 inhibitors in comparison with metformin: A …

T Horii, Y Oikawa, A Shimada, K Mihara - Journal of Diabetes Investigation, 2023

We aimed to compare the effects of cardiovascular disease risk in Japanese patients
with type 2 diabetes on sodium–glucose cotransporter 2 inhibitors (SGLT2Is) or
metformin. This retrospective, real‐world cohort study was carried out using a claims …

Sacubitril/valsartan improves exercise performance in patients with heart failure: a dose-dependent effect

I Mattavelli, M Mapelli, E Salvioni, S Paolillo… - European Journal of …, 2023

Abstract Funding Acknowledgements Type of funding sources: None. Background
Sacubitril/Valsartan therapy has become a cornerstone of heart failure with reduced
ejection fraction (HFrEF) pharmacological therapy due to its positive prognostic …

[Okechukwu Ogah]

To Infinity and Beyond: Evolving Understanding of Peripartum Cardiomyopathy

MB Davis, K Sliwa - Heart Failure, 2023

Pregnancy-associated heart failure was first described as far back as the 1800s and
was formally labeled in 1971. 1 Despite this longstanding recognition, peripartum
cardiomyopathy (PPCM) remains an elusive diagnosis. Symptoms of heart failure …

[HTML] Protocol: Rationale and design of the NEO-NORMAL-AF study examination of the usefulness of implantable loop recorder for arrhythmia detection including atrial …

J Sugiura, S Kasama, T Ueda, T Nishida, H Kawata… - Open Heart, 2023

Protocol: Rationale and design of the NEO-NORMAL-AF study examination of the
usefulness of implantable loop recorder for arrhythmia detection including atrial
fibrillation in heart failure with non-reduced ejection fraction cases: a pilot study - PMC …

Randomized controlled trial of urinE chemiStry guided aCute heArt faiLure treATmEnt (ESCALATE): Rationale and design

ZL Cox, HK Siddiqi, LW Stevenson, B Bales, JH Han… - American Heart Journal, 2023

Diuresis to achieve decongestion is a central aim of therapy in patients hospitalized
for acute decompensated heart failure (ADHF). While multiple clinical trials have
investigated initial diuretic strategies for a designated period of time, there is a …

Improving Risk Stratification of Sudden Death in Cardiomyopathy: Can Magnetic Resonance Help Beyond Ejection Fraction?

CAA Chahal, MY Khanji - Cardiovascular Imaging, 2023

Despite the enormous strides made with improved mortality and morbidity with
cardiovascular prevention, sudden cardiac arrest (SCA) affects over 3 million
individuals per annum worldwide. 1-3 SCA can lead to sudden cardiac death (SCD) …

Diagnosis and Management of Patients with Left Ventricular Hypertrophy: Role of Multimodality Cardiac Imaging. A Scientific Statement of the Heart Failure …

B Moura, A Aimo, A Al‐Mohammad, K Keramida… - European Journal of Heart Failure

Left ventricular (LV) hypertrophy consists in an increased LV wall thickness. LV
hypertrophy can be either secondary, in response to pressure or volume overload, or
primary, ie, not explained solely by abnormal loading conditions. Primary LV …

Sacubitril–Valsartan in Heart Failure: The Hard Sell of Spending More to Save Later

R Samson, TH Le Jemtel - American Journal of Cardiology, 2023

The economic burden of heart failure (HF) care to the health care system and
patients is immense. The annual cost of HF in the United States is nearly $31 billion
and is projected to exceed $70 billion by the year 2030. 1 From a health care system …

[Okechukwu Ogah]

[PDF] Comparative Outcomes of a Transthyretin Amyloid Cardiomyopathy Cohort Versus Patients With Heart Failure With Preserved Ejection Fraction Enrolled in the …

MM Kim, M Prasad, Y Burton, CM Kolseth, Y Zhao… - Journal of the American …, 2023

Background Transthyretin cardiac amyloidosis (ATTR‐CM), found in 6% to 15% of
cohorts with heart failure with preserved ejection fraction, has long been considered
a rare disease with poor prognosis. New treatments have made it one of the few …

Aortic Valve Replacement in Patients With ESRD and Heart Failure With Reduced Ejection Fraction

ED Warner, J Riley, M Liotta, C Pritting, Y Brailovsky… - The American Journal of …, 2023

Transcatheter aortic valve replacement (TAVR) has become the standard of care for
the treatment of all patients with calcific aortic stenosis. Patients with end-stage renal
disease (ESRD) on hemodialysis were excluded from participation in many of the …

[HTML] Echocardiographic determination of right ventricular volumes and ejection fraction: Validation of a truncated cone and rhomboid pyramid formula

G Al Ateah, A Kirschfink, M Frick, M Almalla, M Becker… - PloS one, 2023

Background Echocardiographic assessment of right ventricular (RV) measurements
may be challenging. The aim of this study was to develop a formula for calculation of
RV volumes and function based on measurements of linear dimensions by 2 …

[HTML] Acute Changes on Left Atrial Function during Incremental Exercise in Patients with Heart Failure with Mildly Reduced Ejection Fraction: A Case-Control Study

MA Perrone, F Iellamo, V D'Antoni, A Gismondi… - Journal of Personalized …, 2023

Background: the aim of this study was to assess acute changes in left atrial (LA)
function during incremental aerobic exercise in patients with heart failure with mildly
reduced ejection fraction (HFmrEF) in comparison to healthy subjects (HS). Methods …

Cost-Effectiveness Analysis of Pharmacogenomics (PGx)-Based Warfarin, Apixaban, and Rivaroxaban Versus Standard Warfarin for the Management of Atrial …

A Hafeez, LE Cipriano, RB Kim, GS Zaric, UI Schwarz… - PharmacoEconomics, 2023

Objective To assess the cost-effectiveness of pharmacogenomics (PGx)-based
warfarin (ie, warfarin dosing following genetic testing), apixaban, and rivaroxaban
oral anticoagulation versus standard warfarin for the treatment of newly diagnosed …

[HTML] Catheter Ablation of Atrial Fibrillation in Adult Congenital Heart Disease: Procedural Characteristics and Outcomes

TY Hu, C Janga, M Amin, NY Tan, DO Hodge… - Circulation: Arrhythmia and …, 2023

BACKGROUND: The outcomes of catheter ablation for atrial fibrillation in adults with
congenital heart disease are not well described. METHODS: In a retrospective study
of adult patients with congenital heart disease who underwent catheter ablation for …

[HTML] Intravenous ferric carboxymaltose for iron repletion following acute heart failure in patients with and without diabetes: a subgroup analysis of the randomized AFFIRM …

G Rosano, P Ponikowski, C Vitale, SD Anker, J Butler… - Cardiovascular Diabetology, 2023

In AFFIRM-AHF, treatment of iron deficiency with intravenous ferric carboxymaltose
(FCM) reduced the risk of heart failure (HF) hospitalization and improved quality of
life (QoL) vs placebo in patients stabilized following an acute HF (AHF) episode, with …

[PDF] Left Atrial Appendage Closure in Patients with Atrial Fibrillation and Acute Ischemic Stroke Despite Anticoagulation

A Abramovitz Fouks, S Yaghi, MH Selim, E Gokcal… - medRxiv, 2023

Background: The occurrence of acute ischemic stroke (AIS) while regularly using oral
anticoagulants (OAC) is an increasingly recognized problem among nonvalvular
atrial fibrillation (NVAF) patients. Due to the high risk of AIS recurrence (reported 5.3 …

[PDF] The effects of sodium-glucose cotransporter 2 inhibitors beyond the cardio-renal-metabolic spectrum: Will gliflozins have a different fate than statins?

T Koufakis, V Tsimihodimos, S Metallidis, K Kotsa… - Expert Opinion on …, 2023

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) originally emerged as drugs for
the treatment of type 2 diabetes (T2D). However, they soon proved to exert
remarkable cardioprotective and renoprotective actions, leading to their licensed use …

[HTML] Lifeday coverage of oral anticoagulants and one-year relative survival in patients with atrial fibrillation: a population-based study in Estonia

P Pauklin, T Marandi, M Kals, T Ainla, K Martinson… - BMC Cardiovascular …, 2023

Routine oral anticoagulation (OAC) is recommended for almost all high-risk patients
with atrial fibrillation, yet registries show that OACs are still underused. Our aim was
to study the lifeday coverage (LDC) of OAC prescriptions and its relationship with …

[Okechukwu Ogah]

[HTML] Value of the HFA-PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the inflammatory myopathy population

Y Shi, H Zhang, Z Qiu, Y Chen, X Su, H Chi, T Feng… - Arthritis Research & …, 2023

The HFA-PEFF score has been validated to hold great diagnostic and prognostic
utility for heart failure with preserved ejection fraction (HFpEF). Idiopathic
inflammatory myopathy (IIM) is recognized as one of the potential etiologies …

Atrial Myopathy and Ischemic Stroke in Heart Failure With Preserved Ejection Fraction

K Farhat, K Elkholey, ZUA Asad, S Stavrakis - The American Journal of Cardiology, 2023

Recent studies suggested an association between atrial myopathy and stroke
independent of atrial fibrillation (AF). We examined the hypothesis that atrial

myopathy may be associated with ischemic stroke in patients with heart failure with …

Impact of Coronary Artery Disease in Women With Newly Diagnosed Heart Failure and Reduced Ejection Fraction

RR Nielsen, N Anker, N Stødkilde-Jørgensen… - JACC: Heart Failure, 2023

Background The representation of women in heart failure studies has been
inadequate, resulting in a knowledge gap regarding the prognostic impact of
coronary artery disease (CAD) on all-cause mortality in women with newly …

[HTML] Shared decision making for anticoagulation reduces anxiety and improves adherence in patients with atrial fibrillation

HH Chiu, SL Chang, HM Cheng, TF Chao, YJ Lin… - BMC Medical Informatics …, 2023

Treatment with oral anticoagulants (OACs) could prevent stroke in atrial fibrillation
(AF), but side effects developed due to OACs may cause patients anxiety during
decision making. This study aimed to investigate whether shared decision making …

Sodium–glucose co-transporter 2 inhibitors and mineralocorticoid receptor antagonists synergism in heart failure: it takes two to tango

J Bauersachs, S Soltani - European Heart Journal, 2023

Synergistic effects of MRA and SGLT2i in HF: Key beneficial effects (+) of
mineralocorticoid receptor antagonists (MRA) and sodium–glucose co-transporter
inhibitors (SGLT2i) on relevant cardiovascular outcomes in heart failure (HF) as well …

[HTML] Clinical features of heart failure with normal ejection fraction: insights from the ASIAN-HF Registry

K Teramoto, W Ouwerkerk, WT Tay, J Tromp, THK Teng… - JACC: Asia, 2023

Background Heart failure and left ventricular ejection fraction in the normal range
(HFnEF)(left ventricular ejection fraction [LVEF] of≥ 55% for men and≥ 60% for
women) is understudied. Objectives The authors aimed to characterize patients with …

[HTML] Glycaemic control and insulin therapy are significant confounders of the obesity paradox in patients with heart failure and diabetes mellitus

H Fröhlich, A Bossmeyer, S Kazmi, KM Goode… - Clinical Research in …, 2023

Background A high body mass index (BMI) confers a paradoxical survival benefit in
patients with heart failure (HF) or diabetes mellitus (DM). There is, however,
controversy whether an obesity paradox is also present in patients with HF and …

[PDF] Systolic Blood Pressure Time in Target Range and Incident Atrial Fibrillation in Patients With Hypertension: Insights From the SPRINT Trial

J Wang, C Jiang, S Li, Z Wang, Y Wang, Y Lai, Z Wang… - Hypertension, 2023

BACKGROUND: Systolic blood pressure (SBP) time in target range (TTR) indicates
the mean value, exposure time, and variability in blood pressure over time. The
prognostic value of SBP TTR for incident atrial fibrillation (AF) in patients with …

Sacubitril/Valsartan versus Valsartan in Regressing Myocardial Fibrosis in Hypertension: A Prospective, Randomized, Open-label, Blinded Endpoint Clinical Trial …

V Lee, Q Zheng, DF Toh, CJ Pua, JA Bryant, CH Lee… - Frontiers in Cardiovascular …

Background: Diffuse interstitial myocardial fibrosis is a key common pathological
manifestation in hypertensive heart disease (HHD) progressing to heart failure (HF).
Angiotensin receptor-neprilysin inhibitors (ARNi), now a front-line treatment for HF …

[Okechukwu Ogah]

The immunology of heart failure with preserved ejection fraction

CD Smart, MS Madhur - Clinical Science, 2023

Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority
of new heart failure diagnoses and continues to increase in prevalence in the United
States. Importantly, HFpEF is a highly morbid, heterogeneous syndrome lacking …

[PDF] Outpatient Worsening Among Patients With Mildly Reduced and Preserved Ejection Fraction Heart Failure in the DELIVER Trial

S Chatur, M Vaduganathan, BL Claggett… - Circulation, 2023

Background: Hospitalization is recognized as a sentinel event in the disease
trajectory of patients with heart failure (HF), but not all patients experiencing clinical
decompensation are ultimately hospitalized. Outpatient intensification of diuretics is …

[PDF] Long-Term Treatment With Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction―Open-Label Extension of the …

H Tsutsui, S Momomura, Y Saito, H Ito, K Yamamoto… - Circulation Journal, 2023

Background: The PARALLEL-HF study assessed the efficacy and safety of
sacubitril/valsartan vs. enalapril in Japanese patients with chronic heart failure with
reduced ejection fraction (HFrEF). This open-label extension (OLE) assessed long …

[HTML] Time to Benefit of Sodium-Glucose Cotransporter-2 Inhibitors Among Patients With Heart Failure

KY Chen, Z Nie, R Shi, D Yu, Q Wang, F Shao, G Wu… - JAMA Network Open, 2023

Importance Emerging evidence has consistently demonstrated that sodium-glucose
cotransporter 2 (SGLT2) inhibitors reduce the risk of heart failure (HF) hospitalization
and cardiovascular (CV) death among patients with HF. However, it remains unclear …

[PDF] Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients With Atrial Fibrillation on Direct-Acting Oral Anticoagulants

R Aggarwal, CT Ruff, S Virdone, S Perreault… - Circulation, 2023

BACKGROUND: Current clinical decision tools for assessing bleeding risk in
individuals with atrial fibrillation (AF) have limited performance and were developed
for individuals treated with warfarin. This study develops and validates a clinical risk …

[PDF] Risk factors and outcomes associated with heart failure with preserved and reduced ejection fraction in persons with chronic kidney disease

N Bansal, LR Zelnick, R Scherzer, MM Estrella… - medRxiv, 2023

Background: Heart failure (HF) is associated with poor outcomes in persons with
chronic kidney disease (CKD). This study aimed to examine associations of incident
preserved (HFpEF) versus reduced (HFrEF) ejection fraction (EF) with risk of …

[HTML] Association of insulin use with LV remodeling and clinical outcomes in diabetic patients with heart failure and reduced ejection fraction: assessed by cardiac MRI

K Shi, G Zhang, H Fu, S Huang, HY Xu, Y Gao, R Shi… - Cardiovascular Diabetology, 2023

Insulin is commonly used in type 2 diabetes mellitus (T2DM) to achieve glycemic
control. However, recent evidence showed that insulin use is associated with poor
outcomes in the context of heart failure (HF). Since heart failure with reduced ejection …

Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity

MN Kosiborod, SZ Abildstrøm, BA Borlaug, J Butler… - New England Journal of …, 2023

Background Heart failure with preserved ejection fraction is increasing in prevalence
and is associated with a high symptom burden and functional impairment, especially
in persons with obesity. No therapies have been approved to target obesity-related …

[HTML] Does Heterogeneity Exist in Treatment Associations with Renin-Angiotensin-System Inhibitors or Beta-blockers According to Phenotype Clusters in Heart Failure with …

A Uijl, S Koudstaal, D Stolfo, U Dahlström, I Vaartjes… - Journal of Cardiac Failure, 2023

Aims To explore the association between use of renin-angiotensin-system inhibitors
(RASi) and beta-blockers, with mortality/morbidity in 5 previously identified clusters of
patients with heart failure and preserved ejection fraction (HFpEF). Methods and …

[PDF] Blinded Withdrawal of Long-Term Randomized Treatment With Empagliflozin or Placebo in Patients With Heart Failure

M Packer, J Butler, C Zeller, SJ Pocock, M Brueckmann… - Circulation, 2023

BACKGROUND: It is not known whether the benefits of sodium-glucose
cotransporter 2 inhibitors in heart failure persist after years of therapy. METHODS: In
the EMPEROR-Reduced (Empagliflozin Outcome Trials in Chronic Heart Failure …