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Okechukwu Ogah
Sep 8, 2023, 2:41:13 PM9/8/23
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Dr O.S Ogah. MBBS, MSc, PhD, MD, FWACP, FACP, FESC, FNCS
A. Senior Lecturer
Cardiology Unit, Department of Medicine,
Faculty of Clinical Sciences
College of Medicine,
University of Ibadan, NIGERIA
B. Honorary Consultant Physician/Cardiologist,
Cardiology Unit,
Department of Medicine
University College Hospital Ibadan, NIGERIA
PERSONAL POSTAL ADDRESS
P.O BOX 14343, UNIVERSITY OF IBADAN POST OFFICE
IBADAN, NIGERIA
C. Bernard Lown Visiting Scholar in Cardiovascular Health
Department of Global Health and Population
Harvard T.H. Chan School of Public Health
Email: oo...@hsph.harvard.edu
D. Adjunct Researcher,
Institute of Advanced Medical Research and Training (IAMRAT)
College of Medicine, University of Ibadan, NIGERIA
E. Affiliate Member,
The Hatter Institute for Cardiovascular Research in Africa (HICRA)
4th Floor Chris Barnard Building
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA
F. Past President,
Nigerian Cardiac Society
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"For with thee is the fountain of life: in thy light shall we see light." Psalm 36:9
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Diastolic Exercise Stress Testing in Heart Failure with Preserved Ejection Fraction–The DEST HF study
S Wernhart, A Goertz, J Hedderich, M Papathanasiou… - European Journal of Heart …, 2023
Abstract Background and Aims Pulmonary capillary wedge pressure (PAWP)≥
25mmHg during bicycle ergometry is recommended to uncover occult heart failure
with preserved ejection fraction. We hypothesized that PAWP increase would differ in …
25mmHg during bicycle ergometry is recommended to uncover occult heart failure
with preserved ejection fraction. We hypothesized that PAWP increase would differ in …
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Prevalence of Heart Failure With Preserved Ejection Fraction in Patients Undergoing Atrial Fibrillation Ablation Based on Resting and Post-Tachycardia Pacing Left …
P Chacko, S Bhuta, C Meenakshisundaram… - The American Journal of …, 2023
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are
frequent co-morbid conditions. In patients with symptomatic AF and preserved left
ventricular ejection fraction the clinical diagnosis of HFpEF may be difficult, as …
frequent co-morbid conditions. In patients with symptomatic AF and preserved left
ventricular ejection fraction the clinical diagnosis of HFpEF may be difficult, as …
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[HTML] Comparative value of dapagliflozin vs empagliflozin in patients with heart failure and preserved ejection fraction: A cost-effectiveness analysis
A Rane, RN Nechi, M Imam, CR Zoni, C Ndikumukiza… - Journal of Managed Care & …, 2023
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) imposes a
high disease burden on patients, primarily because of multimorbidity and frequent
hospitalizations. Recently, the American College of Cardiology Expert Consensus …
high disease burden on patients, primarily because of multimorbidity and frequent
hospitalizations. Recently, the American College of Cardiology Expert Consensus …
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Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction
KP Rommel, S Pagoulatou, KP Kresoja, S Rosch… - Circulation: Heart Failure, 2023
Background: Arterial stiffening contributes to hemodynamic derangements in heart
failure with preserved ejection fraction (HFpEF). We sought to investigate the impact
of renal denervation on pulsatile left ventricular loading in patients with HFpEF and …
failure with preserved ejection fraction (HFpEF). We sought to investigate the impact
of renal denervation on pulsatile left ventricular loading in patients with HFpEF and …
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Influence of background medical therapy on efficacy and safety of dapagliflozin in patients with heart failure with improved ejection fraction in the DELIVER trial
M Pabon, BL Claggett, X Wang, ZM Miao, S Chatur… - European Journal of Heart …, 2023
Abstract Aims The Dapagliflozin Evaluation to Improve the Lives of Patients with
Preserved Ejection Fraction Heart Failure (DELIVER) trial demonstrated the SGLT2i
dapagliflozin to be beneficial in patients with symptomatic heart failure with improved …
Preserved Ejection Fraction Heart Failure (DELIVER) trial demonstrated the SGLT2i
dapagliflozin to be beneficial in patients with symptomatic heart failure with improved …
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To Infinity and Beyond: Evolving Understanding of Peripartum Cardiomyopathy
MB Davis, K Sliwa - Heart Failure, 2023
Pregnancy-associated heart failure was first described as far back as the 1800s and
was formally labeled in 1971. 1 Despite this longstanding recognition, peripartum
cardiomyopathy (PPCM) remains an elusive diagnosis. Symptoms of heart failure …
was formally labeled in 1971. 1 Despite this longstanding recognition, peripartum
cardiomyopathy (PPCM) remains an elusive diagnosis. Symptoms of heart failure …
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Sex Differences in long‐term outcomes following acute heart failure hospitalization: Findings from the Get with The Guidelines‐Heart Failure Registry
N Keshvani, S Shah, I Ayodele, K Chiswell, B Alhanti… - European Journal of Heart …, 2023
Abstract Background and Aims Sex differences in long‐term outcomes following
hospitalization for heart failure (HF) across ejection fraction (EF) subtypes are not
well described. In this study, we evaluated the risk of mortality and re‐hospitalization …
hospitalization for heart failure (HF) across ejection fraction (EF) subtypes are not
well described. In this study, we evaluated the risk of mortality and re‐hospitalization …
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[HTML] Sodium-glucose cotransporter 2 inhibitors in frail, older people with type 2 diabetes and heart failure: do we have enough evidence to confidently support the use?
T Koufakis, MN Doumas, A Bargiota, K Kotsa… - Expert Review of Clinical …, 2023
Frailty is defined as “a state of increased vulnerability to endogenous and exogenous
stressors, due to age-related declines in physiologic reserve and function across
multiple physiologic systems”[1]. Frailty is more common as age increases but it is …
stressors, due to age-related declines in physiologic reserve and function across
multiple physiologic systems”[1]. Frailty is more common as age increases but it is …
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[PDF] Hospitalization for acute heart failure during non‐working hours impacts on long‐term mortality: the REPORT‐HF registry
S Katsanos, W Ouwerkerk, D Farmakis, SP Collins… - ESC heart failure, 2023
Aims Hospital admission during nighttime and off hours may affect the outcome of
patients with various cardiovascular conditions due to suboptimal resources and
personnel availability, but data for acute heart failure remain controversial. Therefore …
patients with various cardiovascular conditions due to suboptimal resources and
personnel availability, but data for acute heart failure remain controversial. Therefore …
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[HTML] Acute Changes on Left Atrial Function during Incremental Exercise in Patients with Heart Failure with Mildly Reduced Ejection Fraction: A Case-Control Study
MA Perrone, F Iellamo, V D'Antoni, A Gismondi… - Journal of Personalized …, 2023
Background: the aim of this study was to assess acute changes in left atrial (LA)
function during incremental aerobic exercise in patients with heart failure with mildly
reduced ejection fraction (HFmrEF) in comparison to healthy subjects (HS). Methods …
function during incremental aerobic exercise in patients with heart failure with mildly
reduced ejection fraction (HFmrEF) in comparison to healthy subjects (HS). Methods …
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Okechukwu Ogah
Sep 15, 2023, 2:08:02 AM9/15/23
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Timing of prescription of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers in patients hospitalized for acute heart failure with reduced/mildly …
T Ishii, Y Matsue, Y Matsunaga, K Iekushi, Y Homma… - Heart and Vessels, 2023
Although angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II
receptor blockers (ARBs) play critical roles in the treatment of heart failure with
reduced or mildly reduced ejection fraction (HFrEF/HFmrEF; left-ventricular ejection …
receptor blockers (ARBs) play critical roles in the treatment of heart failure with
reduced or mildly reduced ejection fraction (HFrEF/HFmrEF; left-ventricular ejection …
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Effect of sodium-glucose cotransporter 2 inhibitors on left atrial remodeling and prognosis in patients with type 2 diabetes and heart failure with reduced ejection …
S Yu, Y Sun, N Wang, X Lv, J Si, X Zhang, Y Zhang… - Journal of cardiovascular medicine …
Aims Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been found to
minimize hospitalization for heart failure and cardiovascular death. Cardiac reverse
remodeling may be a mechanism responsible for the favorable clinical efficacy of …
minimize hospitalization for heart failure and cardiovascular death. Cardiac reverse
remodeling may be a mechanism responsible for the favorable clinical efficacy of …
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Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by Acute Kidney Injury
AM Aklilu, S Kumar, Y Yamamoto, DG Moledina… - Kidney360
Background: While sodium-glucose cotransporter-2 inhibitor (SGLT2i) use during
acute heart failure (AHF) hospitalizations is associated with symptomatic
improvement, reduction in re-hospitalizations, and mortality, these medications are …
acute heart failure (AHF) hospitalizations is associated with symptomatic
improvement, reduction in re-hospitalizations, and mortality, these medications are …
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2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failureDeveloped by the task force for the diagnosis and …
TA McDonagh, M Metra, M Adamo, RS Gardner… - European Heart Journal
Patient Forum The content of this European Society of Cardiology (ESC) Focused
Update has been published for personal and educational use only. No commercial
use is authorized. No part of this document may be translated or reproduced in any …
Update has been published for personal and educational use only. No commercial
use is authorized. No part of this document may be translated or reproduced in any …
Okechukwu Ogah
Sep 21, 2023, 4:43:18 PM9/21/23
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The Role of Ablation-Based Rhythm Control in the Tangled Web of Atrial Fibrillation and Heart Failure
R Parkash, E O'Meara, ASL Tang - Circulation, 2023
Atrial fibrillation (AF) is a major global health problem with a population prevalence
of 1% to 2%. The Euro Heart Survey demonstrated that heart failure (HF) is present in
34% of patients with AF, and AF is present in 42% of patients with HF. Up to twothirds …
of 1% to 2%. The Euro Heart Survey demonstrated that heart failure (HF) is present in
34% of patients with AF, and AF is present in 42% of patients with HF. Up to twothirds …
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Malnutrition in heart failure with preserved ejection fraction
O Zainul, D Perry, M Pan, J Lau, K Zarzuela, R Kim… - Journal of the American …, 2023
Background Malnutrition may be an important geriatric condition in adults with heart
failure with preserved ejection fraction (HFpEF), but studies on its prevalence and
associated clinical outcomes are limited. The aim of this study was to determine if …
failure with preserved ejection fraction (HFpEF), but studies on its prevalence and
associated clinical outcomes are limited. The aim of this study was to determine if …
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Effects of Rhythm Control on Left Atrial Structure Remodeling in Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction
L Bai, J Si, Z Ding, X Zhang, Y Zhang, YL Xia, Y Liu - Frontiers in Cardiovascular Medicine
Background: The benefits of rhythm control for atrial fibrillation (AF) in heart failure
with preserved ejection fraction (HFpEF) have not been conclusively determined. We
assessed the effects of rhythm control on left atrial (LA) structure remodeling and …
with preserved ejection fraction (HFpEF) have not been conclusively determined. We
assessed the effects of rhythm control on left atrial (LA) structure remodeling and …
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Aetiology, ejection fraction and mortality in chronic heart failure: a mediation analysis
J Fritz, K Belovari, H Ulmer, MM Zaruba, M Messner… - Heart, 2023
Objective Clinical decision making in chronic heart failure (CHF) is based primarily
on left ventricular ejection fraction (LVEF), and only secondarily on aetiology of the
underlying disease. Our aim was to investigate the mediating role of LVEF in the …
on left ventricular ejection fraction (LVEF), and only secondarily on aetiology of the
underlying disease. Our aim was to investigate the mediating role of LVEF in the …
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[HTML] Global, regional, and national burden of hypertensive heart disease among older adults in 204 countries and territories between 1990 and 2019: a trend analysis
R Yang, X Zhang, J Bai, L Wang, W Wang, J Cai - Chinese Medical Journal, 2023
Background: Hypertensive heart disease (HHD) poses a public health challenge, but
data on its burden and trends among older adults are scarce. This study aimed to
identify trends in the burden of HHD among older adults between 1990 and 2019 at …
data on its burden and trends among older adults are scarce. This study aimed to
identify trends in the burden of HHD among older adults between 1990 and 2019 at …
Okechukwu Ogah
Sep 24, 2023, 6:01:00 AM9/24/23
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Hemoglobin to red cell distribution width ratio: A predictor of clinical outcome and diuretic response in patients with acute heart failure
H Chen, Z Zhen, Y Dong, C Liu, B Dong, R Xue - International Journal of Cardiology, 2023
Abstract Background Hemoglobin to Red Cell Distribution Width Ratio (HRR) is a
novel inflammatory marker in the prognostic assessment of tumors. Nevertheless, its
focus on the cardiovascular field is relatively limited, particularly regarding its …
novel inflammatory marker in the prognostic assessment of tumors. Nevertheless, its
focus on the cardiovascular field is relatively limited, particularly regarding its …
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[HTML] Effect of sacubitril/valsartan on cardiac remodeling compared with other renin–angiotensin system inhibitors: a difference-in-difference analysis of propensity-score …
E Carluccio, FL Dini, M Correale, G Dattilo, M Ciccarelli… - Clinical Research in …, 2023
Background In patients with heart failure with reduced ejection fraction (HFrEF),
treatment with sacubitril–valsartan (S/V) may reverse left ventricular remodeling
(rLVR). Whether this effect is superior to that induced by other renin–angiotensin …
treatment with sacubitril–valsartan (S/V) may reverse left ventricular remodeling
(rLVR). Whether this effect is superior to that induced by other renin–angiotensin …
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Sex Differences in Myocardial Histology, Gene Expression, and Myocardial Recovery in Recent-Onset Cardiomyopathy
A Koczo, A Rao, RC Starling, LT Cooper, GW Dec… - Heart Failure, 2023
ISSN 2213-1779/$36.00 demonstrated lower expression in women when compared
with men including TNFR1 (women 1.53%[IQR: 1.45%-1.76%] vs men 1.91%[IQR:
1.67%-2.17%]; P= 0.01), Fas receptor (women 0.26%[IQR: 0.23%-0.28%] vs men …
with men including TNFR1 (women 1.53%[IQR: 1.45%-1.76%] vs men 1.91%[IQR:
1.67%-2.17%]; P= 0.01), Fas receptor (women 0.26%[IQR: 0.23%-0.28%] vs men …
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[PDF] Use of SGLT2i and ARNi in patients with atrial fibrillation and heart failure in 2021-2022: an analysis of real-world data
A Alonso, AA Morris, AI Naimi, AB Alam, L Li… - medRxiv, 2023
Objective: To evaluate utilization of sodium-glucose cotransporter-2 inhibitors
(SGLT2i) and angiotensin receptor neprilysin inhibitors (ARNi) in patients with atrial
fibrillation (AF) and heart failure (HF). Methods: We analyzed the MarketScan …
(SGLT2i) and angiotensin receptor neprilysin inhibitors (ARNi) in patients with atrial
fibrillation (AF) and heart failure (HF). Methods: We analyzed the MarketScan …
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[HTML] Safety of Anticoagulation After Acute Ischemic Stroke in Patients With Atrial Fibrillation
U Fischer, M Koga, D Strbian, M Branca, S Abend…
Anticoagulation is beneficial in preventing recurrent stroke in patients with atrial
fibrillation, but the best timing for administration after acute ischemic stroke is
unclear. Clinicians worry about the specter of hemorrhagic transformation in the …
fibrillation, but the best timing for administration after acute ischemic stroke is
unclear. Clinicians worry about the specter of hemorrhagic transformation in the …
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Okechukwu Ogah
Sep 27, 2023, 9:38:07 PM9/27/23
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Pathophysiologic and Prognostic Importance of Cardiac Power Output Reserve in Heart Failure with Preserved Ejection Fraction
D Takizawa, T Harada, M Obokata, K Kagami… - European Heart Journal …, 2023
Aims Heart failure with preserved ejection fraction (HFpEF) is a syndrome
characterized by multiple cardiac reserve limitations during exercise. Cardiac power
output (CPO) is an index of global cardiac performance and can be estimated …
characterized by multiple cardiac reserve limitations during exercise. Cardiac power
output (CPO) is an index of global cardiac performance and can be estimated …
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[PDF] Recommendation for Appropriate Use of Sodium Glucose Cotransporter 2 Inhibitors in Treatment of Heart Failure
A Tanaka, K Kinugawa, K Kuwahara, H Ito, T Murohara… - Circulation Journal, 2023
Sodium glucose cotransporter 2 (SGLT2) inhibitors were approved in Japan in 2014
for the treatment of diabetes by inhibiting SGLT2 in the proximal tubule, which
increases urinary glucose excretion and lowers blood glucose levels. Cardiovascular …
for the treatment of diabetes by inhibiting SGLT2 in the proximal tubule, which
increases urinary glucose excretion and lowers blood glucose levels. Cardiovascular …
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Impact of sacubitril/valsartan and gliflozins on cardiac resynchronization therapy response in ischemic and non-ischemic heart failure patients
C Fonderico, V Pergola, D Faccenda, A Salucci… - International Journal of …, 2023
Aims Angiotensin receptor-neprilysin inhibitor (ARNi) and sodium-glucose co-
transporter 2 inhibitor (SGLT2i) improve outcomes in heart failure with reduced
ejection fraction (HFrEF) patients, however their effects in cardiac resynchronization …
transporter 2 inhibitor (SGLT2i) improve outcomes in heart failure with reduced
ejection fraction (HFrEF) patients, however their effects in cardiac resynchronization …
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Surgical pericardiotomy to treat heart failure with preserved ejection fraction: a first clinical study
BA Borlaug, HV Schaff, SJ Asirvatham, KE Koepp… - European Heart Journal, 2023
Patients with heart failure (HF) who have preserved ejection fraction (HFpEF) display
elevation in left ventricular (LV) filling pressures during exercise leading to dyspnoea
and increased morbidity and mortality. 1 High LV filling pressures in HFpEF are …
elevation in left ventricular (LV) filling pressures during exercise leading to dyspnoea
and increased morbidity and mortality. 1 High LV filling pressures in HFpEF are …
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USE OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS BY CARDIOLOGISTS SINCE THE RELEASE OF 2022 AHA/ACC/HFSA GUIDELINES FOR THE …
GR Grandhi, R Adhikari, E Tasdighi, AD Osei… - American Journal of …, 2023
Therapeutic Area Heart Failure Background Several studies have shown that most
patients who are eligible for an Sodium-glucose Cotransporter-2 inhibitor (SGLT2i)
are not receiving them and the proportion of prescriptions from cardiologists was very …
patients who are eligible for an Sodium-glucose Cotransporter-2 inhibitor (SGLT2i)
are not receiving them and the proportion of prescriptions from cardiologists was very …
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[HTML] Comparing Cardiovascular Outcomes and Costs of Perindopril-, Enalapril-or Losartan-Based Antihypertensive Regimens in South Africa: Real-World Medical Claims …
JR Snyman, F Gumedze, ESW Jones, OA Alaba… - Advances in Therapy, 2023
Methods Using a large, South African private health insurance claims database, we
identified patients with a hypertension diagnosis in January 2015 receiving standard
doses of perindopril, enalapril or losartan, alone or in combination with other agents …
identified patients with a hypertension diagnosis in January 2015 receiving standard
doses of perindopril, enalapril or losartan, alone or in combination with other agents …
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FINERENONE IN CHRONIC KIDNEY DISEASE AND TYPE 2 DIABETES: A FIDELITY ANALYSIS OF LEFT VENTRICULAR HYPERTROPHY
L Matavelli, G Filippatos, SD Anker, GL Bakris… - American Journal of …, 2023
Therapeutic Area Kidney Disease Background Left ventricular hypertrophy (LVH) is a
predictor of cardiovascular (CV) disease and associated morbidity and mortality.
Patients with chronic kidney disease (CKD), type 2 diabetes (T2D) have a higher …
predictor of cardiovascular (CV) disease and associated morbidity and mortality.
Patients with chronic kidney disease (CKD), type 2 diabetes (T2D) have a higher …
Okechukwu Ogah
Sep 28, 2023, 11:36:10 PM9/28/23
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[HTML] Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients
I Klobučar, L Vidović, I Arih, M Lechleitner… - Biomolecules, 2023
Considering the relationship between disease severity and the extent of metabolic
derangement in heart failure, we hypothesized that the serum levels of metabolites
may have prognostic value for 1-year mortality in acute heart failure (AHF). The AHF …
derangement in heart failure, we hypothesized that the serum levels of metabolites
may have prognostic value for 1-year mortality in acute heart failure (AHF). The AHF …
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[HTML] Characteristics of the right ventricle in left ventricular noncompaction with reduced ejection fraction in the light of dilated cardiomyopathy
Z Gregor, AR Kiss, K Grebur, Z Dohy, A Kovács… - Plos one, 2023
Background Reports of left ventricular noncompaction (LVNC) rarely include
descriptions of the right ventricle (RV). This study aimed to describe the
characteristics of the RV in LVNC patients with reduced LV function (LVNC-R) …
descriptions of the right ventricle (RV). This study aimed to describe the
characteristics of the RV in LVNC patients with reduced LV function (LVNC-R) …
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Sodium-Glucose CoTransporter-2 Inhibitor Among Patients with Cancer Therapy-Induced Left Ventricular Dysfunction
I Alfaris, A Ghandour, T Lopez-Fernandez, N Giannetti… - Canadian Journal of …, 2023
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have recently been shown to
improve clinical outcomes in patients with left ventricular (LV) dysfunction and heart
failure (HF). Originally designed to induce glucosuria in diabetic patients by targeting …
improve clinical outcomes in patients with left ventricular (LV) dysfunction and heart
failure (HF). Originally designed to induce glucosuria in diabetic patients by targeting …
Okechukwu Ogah
Oct 3, 2023, 5:09:19 PM10/3/23
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[PDF] Epicardial Adipose Tissue and Development of Atrial Fibrillation (AFIB) and Heart Failure With Preserved Ejection Fraction (HFpEF)
S Zain, T Shamshad, A Kabir, AA Khan - Cureus, 2023
Epicardial adipose tissue (EAT) has been associated with the development of many
cardiovascular abnormalities, of which the development of atrial fibrillation (AFIB) in
this group of patients is not an uncommon finding. Several mechanisms have been …
cardiovascular abnormalities, of which the development of atrial fibrillation (AFIB) in
this group of patients is not an uncommon finding. Several mechanisms have been …
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Hemoglobin to red cell distribution width ratio: A predictor of clinical outcome and diuretic response in patients with acute heart failure
H Chen, Z Zhen, Y Dong, C Liu, B Dong, R Xue - International Journal of Cardiology, 2023
Abstract Background Hemoglobin to Red Cell Distribution Width Ratio (HRR) is a
novel inflammatory marker in the prognostic assessment of tumors. Nevertheless, its
focus on the cardiovascular field is relatively limited, particularly regarding its …
novel inflammatory marker in the prognostic assessment of tumors. Nevertheless, its
focus on the cardiovascular field is relatively limited, particularly regarding its …
| | | |
Changes in Anticoagulation Practice in Subjects Admitted with Stroke Associated with Atrial Fibrillation, following introduction of Direct Oral Anticoagulants over 2013 …
J Harbison, J McCormack, O Brych, R Collins… - International Journal of …, 2023
Background. The adoption of Direct Oral Anticoagulants (DOACs) have changed
practice in prevention of stroke in Atrial Fibrillation (AF). We used Irish data national
data on stroke and anticoagulation therapy over 9 years to investigate changes in …
practice in prevention of stroke in Atrial Fibrillation (AF). We used Irish data national
data on stroke and anticoagulation therapy over 9 years to investigate changes in …
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[HTML] Trends and influence factors in the prevalence, awareness, treatment, and control of hypertension among US adults from 1999 to 2018
Z Fan, C Yang, J Zhang, Y Huang, Y Yang, P Zeng… - Plos one, 2023
Objective We aimed to describe the trends and influence factors in the prevalence,
awareness, treatment, and control of hypertension among US Adults from 1999 to
2018. Methods We utilized data from the National Health and Nutrition Examination …
awareness, treatment, and control of hypertension among US Adults from 1999 to
2018. Methods We utilized data from the National Health and Nutrition Examination …
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Calcium channel blocker and outcomes in patients with heart failure and mildly reduced and preserved ejection fraction
S Matsumoto, T Kondo, M Yang, RT Campbell… - European Journal of Heart …, 2023
Aims Patients with heart failure (HF) and mildly reduced ejection fraction (HFmrEF)
and preserved ejection fraction (HFpEF) are often treated with calcium channel
blockers (CCBs) although the safety of CCBs in these patients is uncertain. To …
and preserved ejection fraction (HFpEF) are often treated with calcium channel
blockers (CCBs) although the safety of CCBs in these patients is uncertain. To …
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Impact of COVID‐19 in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction Enrolled in the DELIVER Trial
AS Bhatt, MN Kosiborod, BL Claggett, ZM Miao… - European Journal of Heart …, 2023
Introduction COVID‐19 may affect clinical risk in patients with heart failure. DELIVER
began before and was conducted during the COVID‐19 pandemic. Objective We
evaluated the association between COVID‐19 and outcomes among DELIVER …
began before and was conducted during the COVID‐19 pandemic. Objective We
evaluated the association between COVID‐19 and outcomes among DELIVER …
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[PDF] Long‐term cumulative high‐sensitivity C‐reactive protein and mortality among patients with acute heart failure
L Zhang, G He, X Huo, A Tian, R Ji, B Pu, Y Peng - Journal of the American Heart …, 2023
Background Elevated hsCRP (high‐sensitivity C‐reactive protein) level is associated
with worse prognosis among patients hospitalized for heart failure. However, the
prognostic value of the long‐term cumulative hsCRP remains unknown. Methods …
with worse prognosis among patients hospitalized for heart failure. However, the
prognostic value of the long‐term cumulative hsCRP remains unknown. Methods …
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[PDF] Use of SGLT2i and ARNi in patients with atrial fibrillation and heart failure in 2021-2022: an analysis of real-world data
A Alonso, AA Morris, AI Naimi, AB Alam, L Li… - medRxiv, 2023
Objective: To evaluate utilization of sodium-glucose cotransporter-2 inhibitors
(SGLT2i) and angiotensin receptor neprilysin inhibitors (ARNi) in patients with atrial
fibrillation (AF) and heart failure (HF). Methods: We analyzed the MarketScan …
(SGLT2i) and angiotensin receptor neprilysin inhibitors (ARNi) in patients with atrial
fibrillation (AF) and heart failure (HF). Methods: We analyzed the MarketScan …
Okechukwu Ogah
Oct 6, 2023, 12:59:05 AM10/6/23
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Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction
S Gan, L Zhao, O Salman, Z Wang, C Ebert, JD Azzo… - The American Journal of …, 2023
Proteinuria is common in heart failure with preserved ejection fraction (HFpEF), but
its biologic correlates are poorly understood. We assessed the relation between 49
plasma proteins and the urinary protein/creatinine ratio (UPCR) in 365 participants in …
its biologic correlates are poorly understood. We assessed the relation between 49
plasma proteins and the urinary protein/creatinine ratio (UPCR) in 365 participants in …
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[HTML] Recommended assessment and management of sleep disordered breathing in patients with atrial fibrillation, hypertension and heart failure: Taiwan Society of …
PL Lee, YW Wu, HM Cheng, CY Wang, LP Chuang… - Journal of the Formosan …, 2023
Sleep disordered breathing (SDB) is highly prevalent and may be linked to
cardiovascular disease in a bidirectional manner. The Taiwan Society of Cardiology,
Taiwan Society of Sleep Medicine and Taiwan Society of Pulmonary and Critical …
cardiovascular disease in a bidirectional manner. The Taiwan Society of Cardiology,
Taiwan Society of Sleep Medicine and Taiwan Society of Pulmonary and Critical …
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[PDF] Exploring the Cardiovascular Benefits of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors: Expanding Horizons Beyond Diabetes Management
A Fatima, S Rasool, S Devi, M Talha, F Waqar, M Nasir… - Cureus, 2023
Globally, cardiovascular disease (CVD) continues to be the primary cause of
morbidity and mortality. The risk of cardiovascular disease is markedly increased in
individuals with type 2 diabetes mellitus (T2DM), making managing cardiovascular …
morbidity and mortality. The risk of cardiovascular disease is markedly increased in
individuals with type 2 diabetes mellitus (T2DM), making managing cardiovascular …
Okechukwu Ogah
Oct 8, 2023, 10:10:03 PM10/8/23
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Proteomic Profiling in Patients With Peripartum Cardiomyopathy: A Biomarker Study of the ESC EORP PPCM Registry
V Kodogo, C Viljoen, J Hoevelmann, G Chakafana… - JACC: Heart Failure, 2023
Background Peripartum cardiomyopathy (PPCM) remains an important cause of
maternal morbidity and mortality globally. The pathophysiology remains incompletely
understood, and the diagnosis is often missed or delayed. Objectives This study …
maternal morbidity and mortality globally. The pathophysiology remains incompletely
understood, and the diagnosis is often missed or delayed. Objectives This study …
| | | |
The value of using left ventricular pressure-strain loops to evaluate myocardial work in predicting heart failure with improved ejection fraction
T Li, Z Li, S Guo, S Jiang, Q Sun, Y Wu, J Tian - International Journal of Cardiology, 2023
Background The ultrasound left ventricular pressure-strain loop (LV PSL) was
applied to evaluate myocardial work in heart failure with improved ejection fraction
(HFimpEF) versus patients with persistent heart failure with reduced ejection fraction …
applied to evaluate myocardial work in heart failure with improved ejection fraction
(HFimpEF) versus patients with persistent heart failure with reduced ejection fraction …
| | | |
[HTML] Inequalities in care delivery and outcomes for myocardial infarction, heart failure, atrial fibrillation, and aortic stenosis in the United Kingdom
R Nadarajah, M Farooq, K Raveendra, YM Nakao… - The Lancet Regional Health …, 2023
Cardiovascular diseases are a leading cause of death and disability globally, with
inequalities in burden and care delivery evident in Europe. To address this
challenge, The Lancet Regional Health—Europe convened experts from a range of …
inequalities in burden and care delivery evident in Europe. To address this
challenge, The Lancet Regional Health—Europe convened experts from a range of …
| | | |
[PDF] Associations of Apixaban Dose With Safety and Effectiveness Outcomes in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
Y Xu, AR Chang, LA Inker, M McAdams-DeMarco… - Circulation, 2023
BACKGROUND: Recommendations for apixaban dosing on the basis of kidney
function are inconsistent between the US Food and Drug Administration and
European Medicines Agency for patients with atrial fibrillation. Optimal apixaban …
function are inconsistent between the US Food and Drug Administration and
European Medicines Agency for patients with atrial fibrillation. Optimal apixaban …
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[HTML] An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions
W Chua, VR Cardoso, E Guasch, MF Sinner, C Al-Taie… - Scientific Reports, 2023
Early detection of atrial fibrillation (AF) enables initiation of anticoagulation and early
rhythm control therapy to reduce stroke, cardiovascular death, and heart failure. In a
cross-sectional, observational study, we aimed to identify a combination of circulating …
rhythm control therapy to reduce stroke, cardiovascular death, and heart failure. In a
cross-sectional, observational study, we aimed to identify a combination of circulating …
| | | |
Predictors and prognostic implications of left ventricular ejection fraction trajectory improvement in the Spectrum of heart failure with reduced and mildly reduced …
J Si, Z Ding, Y Hu, X Zhang, Y Zhang, H Cao, Y Liu - Journal of Cardiology, 2023
Background The latest guidelines emphasize the significance of evaluating the left
ventricular ejection fraction (LVEF) trajectory in patients with heart failure (HF).
Because patients with HF with reduced ejection fraction (HFrEF) and HF with mildly …
ventricular ejection fraction (LVEF) trajectory in patients with heart failure (HF).
Because patients with HF with reduced ejection fraction (HFrEF) and HF with mildly …
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The Clinical Utility of Noninvasive Forrester Classification in Acute Heart Failure from PREDICT Study
T Takahashi, H Iwano, K Shibayama, T Kitai, H Tanaka… - The American Journal of …, 2023
The Forrester classification plays a crucial role in comprehending the underlying
pathophysiology of heart failure (HF) and is employed to categorize the severity and
predict the outcomes of patients with acute HF. Our objective was to assess the …
pathophysiology of heart failure (HF) and is employed to categorize the severity and
predict the outcomes of patients with acute HF. Our objective was to assess the …
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ACUTE RESPIRATORY DISTRESS IN THE PERIPARTUM PERIOD: AN UNUSUAL PRESENTATION OF TAKOTSUBO CARDIOMYOPATHY
C SHARMA - CHEST, 2023
DISCUSSION: This patient had no chronic pulmonary history and developed acute
hypoxic respiratory failure. She had a DVT but no RV dilatation to suggest significant
pulmonary embolism. She had acute onset left ventricular systolic dysfunction with …
hypoxic respiratory failure. She had a DVT but no RV dilatation to suggest significant
pulmonary embolism. She had acute onset left ventricular systolic dysfunction with …
| | | |
SHORTNESS OF BREATH WITH HIGH BLOOD PRESSURE IN THE IMMEDIATE POSTPARTUM PERIOD: PERIPARTUM CARDIOMYOPATHY POSING …
P WEERADDANA, D BHATTARAI, LN CUELLO… - CHEST, 2023
DISCUSSION: The etiology of PPCM is unclear but suggests viral myocarditis,
autoimmune disease, and excessive prolactin secretion. In our case, it was initially
suspected that the patient was suffering from eclampsia and magnesium sulfate was …
autoimmune disease, and excessive prolactin secretion. In our case, it was initially
suspected that the patient was suffering from eclampsia and magnesium sulfate was …
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[PDF] Sex-Related Differences in Long-term Outcomes across the Spectrum of Ejection Fraction in Heart Failure Patients
A Kawai, WET-HF investivators, Y Nagatomo… - medRxiv, 2023
Background: An important knowledge gap remains on sex-related differences in
heart failure (HF) management. Recently, it has been recognized that patients, and
particularly women, with supra-normal left ventricular ejection fraction (snLVEF) are …
heart failure (HF) management. Recently, it has been recognized that patients, and
particularly women, with supra-normal left ventricular ejection fraction (snLVEF) are …
Okechukwu Ogah
Oct 11, 2023, 4:25:58 AM10/11/23
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Informing understanding of coordination of care for patients with heart failure with preserved ejection fraction: a secondary qualitative analysis
R Brooman-White, T Blakeman, D McNab, C Deaton - BMJ Quality & Safety, 2023
Background Patients with heart failure with preserved ejection fraction (HFpEF) are a
complex and underserved group. They are commonly older patients with multiple
comorbidities, who rely on multiple healthcare services. Regional variation in …
complex and underserved group. They are commonly older patients with multiple
comorbidities, who rely on multiple healthcare services. Regional variation in …
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[HTML] High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction
Q Zhou, J Yang, H Tang, Z Guo, W Dong, Y Wang… - Cardiovascular Diabetology, 2023
The impact of insulin resistance on the prognosis of heart failure with preserved
ejection fraction (HFpEF) remains unknown. This study aimed to investigate the
association between the triglyceride-glucose (TyG) index, an easily calculated …
ejection fraction (HFpEF) remains unknown. This study aimed to investigate the
association between the triglyceride-glucose (TyG) index, an easily calculated …
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Pathophysiologic and Prognostic Importance of Cardiac Power Output Reserve in Heart Failure with Preserved Ejection Fraction
D Takizawa, T Harada, M Obokata, K Kagami… - European Heart Journal …, 2023
Aims Heart failure with preserved ejection fraction (HFpEF) is a syndrome
characterized by multiple cardiac reserve limitations during exercise. Cardiac power
output (CPO) is an index of global cardiac performance and can be estimated …
characterized by multiple cardiac reserve limitations during exercise. Cardiac power
output (CPO) is an index of global cardiac performance and can be estimated …
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Clinical outcomes with the use of sodium-glucose cotransporter-2 inhibitors in patients with atrial fibrillation and type 2 diabetes mellitus: a multicenter, real-world …
J Jang, SY Park, S Kim, SH Kim, YS Oh, YK Sa… - European Journal of …, 2023
Aim Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have been shown to
improve cardiovascular outcomes and reduce the incidence of atrial fibrillation (AF)
in patients with type 2 diabetes mellitus (T2DM). We investigated the clinical …
improve cardiovascular outcomes and reduce the incidence of atrial fibrillation (AF)
in patients with type 2 diabetes mellitus (T2DM). We investigated the clinical …
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[HTML] Cardiovascular protective effect of sodium-glucose cotransporter 2 inhibitors on patients with acute coronary syndrome and type 2 diabetes mellitus: a retrospective …
J Chen, J Chang, Q Shi, X Li, L Wang, H Zhao - BMC Cardiovascular Disorders, 2023
Acute coronary syndrome (ACS) remains the leading cause of death and disability
worldwide, especially when combined with type 2 diabetes mellitus (T2DM). Many
multicenter randomized controlled trials have established the cardiovascular benefits …
worldwide, especially when combined with type 2 diabetes mellitus (T2DM). Many
multicenter randomized controlled trials have established the cardiovascular benefits …
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Changes in Anticoagulation Practice in Subjects Admitted with Stroke Associated with Atrial Fibrillation, following introduction of Direct Oral Anticoagulants over 2013 …
J Harbison, J McCormack, O Brych, R Collins… - International Journal of …, 2023
Background. The adoption of Direct Oral Anticoagulants (DOACs) have changed
practice in prevention of stroke in Atrial Fibrillation (AF). We used Irish data national
data on stroke and anticoagulation therapy over 9 years to investigate changes in …
practice in prevention of stroke in Atrial Fibrillation (AF). We used Irish data national
data on stroke and anticoagulation therapy over 9 years to investigate changes in …
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[HTML] A 20-year population study of peripartum cardiomyopathy
AM Jackson, M Macartney, K Brooksbank, C Brown… - European Heart Journal, 2023
Abstract Background and Aims The epidemiology of peripartum cardiomyopathy
(PPCM) in Europe is poorly understood and data on long-term outcomes are lacking.
A retrospective, observational, population-level study of validated cases of PPCM in …
(PPCM) in Europe is poorly understood and data on long-term outcomes are lacking.
A retrospective, observational, population-level study of validated cases of PPCM in …
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THU338 Risks Of Stroke, Its Subtypes And Atrial Fibrillation Associated With Glucagon-like Peptide 1 Receptor Agonists Versus Sodium-glucose Cotransporter 2 …
D Lui, E Tang, T Wu, I Au, C Ho Lee, Y Cho Woo… - Journal of the Endocrine …, 2023
Abstract Disclosure: D. Lui: None. E. Tang: None. T. Wu: None. I. Au: None. C. Lee:
None. Y. Woo: None. KC Tan: None. C. Wong: None. Objectives: There are limited
data on head-to-head comparative risk of stroke between sodium-glucose …
None. Y. Woo: None. KC Tan: None. C. Wong: None. Objectives: There are limited
data on head-to-head comparative risk of stroke between sodium-glucose …
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Blood Pressure Control in a Diverse Population of Hypertensive Patients With Heart Failure
HM Nguyen, R Mahabaleshwarkar, S Nandkeolyar… - The American Journal of …, 2023
Hypertensive patients with heart failure (HF), with reduced or preserved ejection
fraction, belong to a vulnerable subset with high mortality risks. In HF patients, the
current clinical guideline recommends attaining a systolic blood pressure (BP)< 130 …
fraction, belong to a vulnerable subset with high mortality risks. In HF patients, the
current clinical guideline recommends attaining a systolic blood pressure (BP)< 130 …
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[HTML] Effect of Dapagliflozin on Patients with Rheumatic Heart Disease Mitral Stenosis
AA Asrial, R Reviono, S Soetrisno, BY Setianto… - Journal of Clinical Medicine, 2023
(1) Background: Mitral stenosis is the most common rheumatic heart disease (RHD).
Inflammation and fibrosis are the primary pathophysiology, resulting in left atrial
stress and dysfunction. Dapagliflozin is a new heart failure treatment with anti …
Inflammation and fibrosis are the primary pathophysiology, resulting in left atrial
stress and dysfunction. Dapagliflozin is a new heart failure treatment with anti …
Okechukwu Ogah
Oct 15, 2023, 6:40:29 PM10/15/23
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Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction: Two Dishes—Same Ingredients
SS Khan, M Meyer - Heart Failure, 2023
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are
prevalent co-occurring conditions that share antecedent risk factors (ie, obesity and
hypertension), pathophysiology, and treatment goals (ie, to reduce symptoms and …
prevalent co-occurring conditions that share antecedent risk factors (ie, obesity and
hypertension), pathophysiology, and treatment goals (ie, to reduce symptoms and …
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Informing understanding of coordination of care for patients with heart failure with preserved ejection fraction: a secondary qualitative analysis
R Brooman-White, T Blakeman, D McNab, C Deaton - BMJ Quality & Safety, 2023
Background Patients with heart failure with preserved ejection fraction (HFpEF) are a
complex and underserved group. They are commonly older patients with multiple
comorbidities, who rely on multiple healthcare services. Regional variation in …
complex and underserved group. They are commonly older patients with multiple
comorbidities, who rely on multiple healthcare services. Regional variation in …
| | | |
[PDF] Recommendation for Appropriate Use of Sodium Glucose Cotransporter 2 Inhibitors in Treatment of Heart Failure
A Tanaka, K Kinugawa, K Kuwahara, H Ito, T Murohara… - Circulation Journal, 2023
Sodium glucose cotransporter 2 (SGLT2) inhibitors were approved in Japan in 2014
for the treatment of diabetes by inhibiting SGLT2 in the proximal tubule, which
increases urinary glucose excretion and lowers blood glucose levels. Cardiovascular …
for the treatment of diabetes by inhibiting SGLT2 in the proximal tubule, which
increases urinary glucose excretion and lowers blood glucose levels. Cardiovascular …
| | | |
The value of using left ventricular pressure-strain loops to evaluate myocardial work in predicting heart failure with improved ejection fraction
T Li, Z Li, S Guo, S Jiang, Q Sun, Y Wu, J Tian - International Journal of Cardiology, 2023
Background The ultrasound left ventricular pressure-strain loop (LV PSL) was
applied to evaluate myocardial work in heart failure with improved ejection fraction
(HFimpEF) versus patients with persistent heart failure with reduced ejection fraction …
applied to evaluate myocardial work in heart failure with improved ejection fraction
(HFimpEF) versus patients with persistent heart failure with reduced ejection fraction …
| | | |
[PDF] Utilization of sodium-glucose cotransporter 2 inhibitors on dry eye disease severity in patients with type 2 diabetes mellitus
YP Yao, PJ Yang, CY Lee, JY Huang, SF Yang, HY Lin - International Journal of …, 2023
Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors have protective effects
against various systemic diseases and neoplasms. This retrospective cohort study
evaluated the severity of dry eye disease (DED) in patients with type 2 diabetes …
against various systemic diseases and neoplasms. This retrospective cohort study
evaluated the severity of dry eye disease (DED) in patients with type 2 diabetes …
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[PDF] Echocardiographic multiparameter assessment for patients with heart failure with preserved ejection fraction and atrial fibrillation
L Qin, J Yang, F Xu - CARDIOVASCULAR JOURNAL OF AFRICA, 2023
We aimed to assess the echocardiographic parameters of cardiac structure and
function in patients with heart failure with preserved ejection fraction (HFpEF) and
atrial fibrillation (AF). Thirty-seven HFpEF patients with AF were selected, while 38 …
function in patients with heart failure with preserved ejection fraction (HFpEF) and
atrial fibrillation (AF). Thirty-seven HFpEF patients with AF were selected, while 38 …
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The Role of Ablation-Based Rhythm Control in the Tangled Web of Atrial Fibrillation and Heart Failure
R Parkash, E O'Meara, ASL Tang - Circulation, 2023
Atrial fibrillation (AF) is a major global health problem with a population prevalence
of 1% to 2%. The Euro Heart Survey demonstrated that heart failure (HF) is present in
34% of patients with AF, and AF is present in 42% of patients with HF. Up to twothirds …
of 1% to 2%. The Euro Heart Survey demonstrated that heart failure (HF) is present in
34% of patients with AF, and AF is present in 42% of patients with HF. Up to twothirds …
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Catheter Ablation for Atrial Fibrillation in Heart Failure—An Option to Defer Transplantation?
EF Lewis - New England Journal of Medicine, 2023
Patients with heart failure often have coexisting atrial fibrillation, and the incidence of
atrial fibrillation is higher among patients with more advanced heart failure (ranging
from 5% among those with New York Heart Association [NYHA] class I disease to …
atrial fibrillation is higher among patients with more advanced heart failure (ranging
from 5% among those with New York Heart Association [NYHA] class I disease to …
| | | |
[HTML] An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions
W Chua, VR Cardoso, E Guasch, MF Sinner, C Al-Taie… - Scientific Reports, 2023
Early detection of atrial fibrillation (AF) enables initiation of anticoagulation and early
rhythm control therapy to reduce stroke, cardiovascular death, and heart failure. In a
cross-sectional, observational study, we aimed to identify a combination of circulating …
rhythm control therapy to reduce stroke, cardiovascular death, and heart failure. In a
cross-sectional, observational study, we aimed to identify a combination of circulating …
Okechukwu Ogah
Oct 17, 2023, 4:41:01 PM10/17/23
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Date: Tue, 17 Oct 2023, 21:03
Subject: Recommended articles
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From: Google Scholar Alerts <scholarale...@google.com>
Date: Tue, 17 Oct 2023, 21:03
Subject: Recommended articles
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[HTML] Selvester QRS score is a predictor of mortality in heart failure with preserved ejection fraction
F Sivri, YK Icen, H Koca, M Coşkun, M Ardınç, O Deniz… - Arquivos Brasileiros de …, 2023
Abstract Background: The Selvester QRS (S-QRS) score on a 12-lead
electrocardiogram (ECG) is associated with both the amount of myocardial scar and
poor prognosis in myocardial infarction patients. However, its prognostic value in …
electrocardiogram (ECG) is associated with both the amount of myocardial scar and
poor prognosis in myocardial infarction patients. However, its prognostic value in …
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Left Atrial Decompression With the HeartMate3 in Heart Failure With Preserved Ejection Fraction: Virtual Fitting and Hemodynamic Analysis
X He, M Bender, C Gross, K Narayanaswamy, G Laufer… - ASAIO Journal
Effective treatment of heart failure with preserved ejection fraction (HFpEF) remains
an unmet medical need. Although left atrial decompression using mechanical
circulatory support devices was previously suggested, the heterogeneous HFpEF …
an unmet medical need. Although left atrial decompression using mechanical
circulatory support devices was previously suggested, the heterogeneous HFpEF …
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[HTML] Left Atrial Remodeling Related to Disproportionately Low B-Type Natriuretic Peptide in Acute Heart Failure Patients with Atrial Fibrillation
K Sakane, Y Kanzaki, T Okuno, S Nakayama… - The American Journal of …, 2023
The diagnostic performance of B-type natriuretic peptide (BNP) for acute heart failure
(HF) is impaired in patients with atrial fibrillation (AF). Increased AF burden in HF is
associated with left atrial (LA) remodeling. Recent studies have revealed that LA …
(HF) is impaired in patients with atrial fibrillation (AF). Increased AF burden in HF is
associated with left atrial (LA) remodeling. Recent studies have revealed that LA …
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The Effects of Sacubitril/Valsartan Compared to Olmesartan on the Blood Pressure and Glucolipid Metabolism in DM Patients with Primary Hypertension
S Zhang, Z Yin, ZF Li, WJ Zhang, YG Sui, YL Xu… - Cardiovascular Drugs and …, 2023
Purpose Given the beneficial effects of sacubitril/valsartan on blood pressure
generally, this study investigates its antihypertension effects in diabetes mellitus
(DM) patients with primary hypertension specifically, and the effect of …
generally, this study investigates its antihypertension effects in diabetes mellitus
(DM) patients with primary hypertension specifically, and the effect of …
| | | |
Anaesthesia and peripartum cardiomyopathy
K Chapman, F Njue, M Rucklidge - BJA Education, 2023
The 2010 position statement of the European Society of Cardiology defines PPCM as
an 'idiopathic cardiomyopathy that causes heart failure secondary to left ventricular
(LV) systolic dysfunction and occurs towards the end of pregnancy, or in the months …
an 'idiopathic cardiomyopathy that causes heart failure secondary to left ventricular
(LV) systolic dysfunction and occurs towards the end of pregnancy, or in the months …
| | | |
[HTML] Heart Failure Epidemiology and Outcomes Statistics A Report of the Heart Failure Society of America
B Bozkurt, T Ahmad, K Alexander, WL Baker… - Journal of Cardiac Failure, 2023
Heart Failure Epidemiology and Outcomes Statistics A Report of the Heart Failure
Society of America - Journal of Cardiac Failure Skip to Main Content Advertisement
Journal of Cardiac Failure Home Submit Log in Register Log in Submit Log in …
Society of America - Journal of Cardiac Failure Skip to Main Content Advertisement
Journal of Cardiac Failure Home Submit Log in Register Log in Submit Log in …
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Pathophysiological insights into machine learning-based subphenotypes of acute heart failure with preserved ejection fraction
Y Sotomi, S Tamaki, S Hikoso, D Nakatani, K Okada… - Heart, 2023
Objective The heterogeneous pathophysiology of the diverse heart failure with
preserved ejection fraction (HFpEF) phenotypes needs to be examined. We aim to
assess differences in the biomarkers among the phenotypes of HFpEF and …
preserved ejection fraction (HFpEF) phenotypes needs to be examined. We aim to
assess differences in the biomarkers among the phenotypes of HFpEF and …
| | | |
Anticoagulation in people with atrial fibrillation after intracranial haemorrhage
S Uchiyama - The Lancet Neurology, 2023
For people with atrial fibrillation, anticoagulation can reduce the risk of stroke by
approximately two-thirds. However, their risk of bleeding is high, causing a dilemma
for clinicians on whether to prescribe anticoagulants or not when managing these …
approximately two-thirds. However, their risk of bleeding is high, causing a dilemma
for clinicians on whether to prescribe anticoagulants or not when managing these …
| | | |
Outcomes at one year in women with peripartum cardiomyopathy: findings from the ESC EORP PPCM Registry.
AM Jackson, J Bauersachs, MC Petrie, P van der Meer… - European Journal of Heart …, 2023
Aims There are few prospective reports of 1-year outcomes for women with
peripartum cardiomyopathy (PPCM). We report findings from the European Society of
Cardiology EURObservational Research Programme PPCM Registry. Methods and …
peripartum cardiomyopathy (PPCM). We report findings from the European Society of
Cardiology EURObservational Research Programme PPCM Registry. Methods and …
| | | |
[PDF] Aims: We sought to conduct a meta-analysis to evaluate the efficacy and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with heart failure (HF) …
S Vallabhajosyula, M Bansal, A Mehta, HA Cheema… - 2023
Aims: We sought to conduct a meta-analysis to evaluate the efficacy and safety of
sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with heart failure (HF)
with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction …
sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with heart failure (HF)
with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction …
| | | |
Okechukwu Ogah
Oct 20, 2023, 12:17:44 AM10/20/23
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[PDF] Systemic Effects of Homoarginine Supplementation on Arginine Metabolizing Enzymes in Rats with Heart Failure with Preserved Ejection Fraction
P Büttner, S Werner, J Böttner, S Ossmann… - International Journal of …, 2023
A restoration of low homoarginine (hArg) levels in obese ZSF1 rats (O-ZSF1) before
(S1-ZSF1) and after (S2-ZSF1) the manifestation of heart failure with preserved
ejection fraction (HFpEF) did not affect the worsening of cardiac HFpEF …
(S1-ZSF1) and after (S2-ZSF1) the manifestation of heart failure with preserved
ejection fraction (HFpEF) did not affect the worsening of cardiac HFpEF …
| | | |
Association of activin A and postpartum blood pressure in peripartum cardiomyopathy
A Koczo, A Marino, VB Polsinelli, R Alharethi, J Damp… - Pregnancy Hypertension, 2023
Background Activin A has been implicated in the pathogenesis of patients with
chronic hypertension and heart failure as well as patients with hypertensive
disorders of pregnancy (HDP). Whether activin A correlates with blood pressure in …
chronic hypertension and heart failure as well as patients with hypertensive
disorders of pregnancy (HDP). Whether activin A correlates with blood pressure in …
| | | |
[HTML] Data-efficient machine learning methods in the ME-TIME study: rationale and design of a longitudinal study to detect atrial fibrillation and heart failure from wearables
A Naseri, D Tax, P van der Harst, M Reinders… - … Digital Health Journal, 2023
Background Smartwatches enable continuous and non-invasive time series
monitoring of cardiovascular biomarkers like heart rate (from photoplethysmograms),
step counter, skin temperature, etcetera, as such they have a promise in assisting in …
monitoring of cardiovascular biomarkers like heart rate (from photoplethysmograms),
step counter, skin temperature, etcetera, as such they have a promise in assisting in …
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[PDF] Dapagliflozin and Apparent Treatment-Resistant Hypertension in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The DELIVER Trial
JW Ostrominski, M Vaduganathan, S Selvaraj… - Circulation, 2023
BACKGROUND: Apparent treatment-resistant hypertension (aTRH) is prevalent and
associated with adverse outcomes in heart failure with mildly reduced or preserved
ejection fraction. Less is known about the potential role of sodium-glucose co …
associated with adverse outcomes in heart failure with mildly reduced or preserved
ejection fraction. Less is known about the potential role of sodium-glucose co …
| | | |
Winding Down the Storm: Could Empagliflozin's Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?
SA Gómez-Ochoa, LZ Rojas, LE Echeverría - Cardiovascular Drugs and Therapy, 2023
Dear Editor, In a recent issue of Cardiovascular Drugs and Therapy, Peng and
colleagues published an insightful study entitled “Empagliflozin Ameliorates Ouabain-
Induced Na+ and Ca2+ Dysregulations in Ventricular Myocytes in an Na+ …
colleagues published an insightful study entitled “Empagliflozin Ameliorates Ouabain-
Induced Na+ and Ca2+ Dysregulations in Ventricular Myocytes in an Na+ …
| | | |
[PDF] Cardiovascular Protection Beyond Blood Pressure Control in Hypertension
R Gupta
Cardiovascular diseases, especially coronary heart disease (CHD) and stroke are
the most important cause of death and disability in patients with hypertension.
Hypertension management includes risk stratification of these patients into high …
the most important cause of death and disability in patients with hypertension.
Hypertension management includes risk stratification of these patients into high …
| | | |
Role of ejection fraction in patients at risk for advanced heart failure: insights from the HELP-HF registry
M Pagnesi, CM Lombardi, C Tedino, M Chiarito… - ESC heart failure
Aims Patients with heart failure (HF) with reduced ejection fraction (EF)(HFrEF),
mildly reduced EF (HFmrEF), and preserved EF (HFpEF) may all progress to
advanced HF, but the impact of EF in the advanced setting is not well established …
mildly reduced EF (HFmrEF), and preserved EF (HFpEF) may all progress to
advanced HF, but the impact of EF in the advanced setting is not well established …
| | | |
SGLT2 inhibitors on top of intravenous iron in patients with heart failure and iron deficiency: any incremental effect?
G Savarese, J Butler, P Ponikowki, SD Anker - European journal of heart failure
SGLT2 inhibitors on top of intravenous iron in patients with heart failure and iron
deficiency: any incremental effect? SGLT2 inhibitors on top of intravenous iron in patients
with heart failure and iron deficiency: any incremental effect? Eur J Heart Fail. 2023 Oct …
deficiency: any incremental effect? SGLT2 inhibitors on top of intravenous iron in patients
with heart failure and iron deficiency: any incremental effect? Eur J Heart Fail. 2023 Oct …
Okechukwu Ogah
Oct 22, 2023, 4:06:04 PM10/22/23
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[PDF] Impact of adherence to guideline‐directed therapy on risk of death in HF patients across an ejection fraction spectrum
X Chen, Y Kang, U Dahlström, M Fu - ESC Heart Failure, 2023
Aims How different degrees of adherence to guideline‐directed medical therapy
(GDMT) affect mortality risk in patients with heart failure (HF) in a real‐world clinical
setting is poorly understood. This study sought to investigate how different levels of …
(GDMT) affect mortality risk in patients with heart failure (HF) in a real‐world clinical
setting is poorly understood. This study sought to investigate how different levels of …
| | | |
Electrocardiogram-based deep learning model to screen peripartum cardiomyopathy
YM JUNG, K Sora, JM SON, HS LEE, GI HAN… - American Journal of Obstetrics & …
Background Peripartum cardiomyopathy, one of the most fatal conditions during
delivery, results in heart failure secondary to left ventricular systolic dysfunction. Left
ventricular dysfunction can result in abnormalities in electrocardiography. However …
delivery, results in heart failure secondary to left ventricular systolic dysfunction. Left
ventricular dysfunction can result in abnormalities in electrocardiography. However …
| | | |
[PDF] Blood pressure control in hypertensive sleep apnea patients of the ESADA cohort-effects of PAP and antihypertensive medication
S Svedmyr, J Hedner, S Bailly, F Fanfulla, H Hein… - European Heart Journal …, 2023
Introduction We analysed longitudinal blood pressure data from hypertensive
Obstructive Sleep Apnea (OSA) patients from the European Sleep Apnea Database
(ESADA) cohort. The study investigated the interaction between positive airway …
Obstructive Sleep Apnea (OSA) patients from the European Sleep Apnea Database
(ESADA) cohort. The study investigated the interaction between positive airway …
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Orthostatic Hypotension, Hypertension Treatment, and Cardiovascular Disease: An Individual Participant Meta-Analysis
SP Juraschek, JR Hu, JL Cluett, AM Ishak, C Mita… - JAMA, 2023
Importance There are ongoing concerns about the benefits of intensive vs standard
blood pressure (BP) treatment among adults with orthostatic hypotension or standing
hypotension. Objective To determine the effect of a lower BP treatment goal or active …
blood pressure (BP) treatment among adults with orthostatic hypotension or standing
hypotension. Objective To determine the effect of a lower BP treatment goal or active …
| | | |
MUSCLE SYMPATHETIC EXCITATORY RESPONSES TO DYNAMIC ONE-LEG CYCLING EXERCISE ARE AUGMENTED IN HEART FAILURE WITH PRESERVED …
M Badrov, T Tobushi, C Notarius, E Keys, D Cherney… - Canadian Journal of …, 2023
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SGLT-2 Inhibition in Heart Failure with Mildly Reduced and Pre-served Ejection Fraction
P Meyer, N Poku, E Massie
Okechukwu Ogah
Oct 27, 2023, 5:00:54 AM10/27/23
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fyi
[PDF] Body Mass Index (BMI) and BMI Variability are Risk Factors for Heart Failure with Preserved and Reduced Ejection Fraction in a Longitudinal Cohort Study Using Real …
Z Yu, Y Chen, M Zhang, N Feng, T Ryan, NC Schloot… - medRxiv, 2023
Objective: The aim of this study is to evaluate the differential impact of BMI and long-
term intra-individual BMI variability on the risk of developing heart failure with
preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction …
term intra-individual BMI variability on the risk of developing heart failure with
preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction …
| | | |
Mortality and heart failure admission following mitral valve surgery for mitral regurgitation among patients with versus without a history of atrial fibrillation: A nationwide …
HT Due, JK Petersen, E Havers-Borgersen… - The American Journal of …, 2023
Aims To examine the associated rate of 3-year mortality and heart failure (HF)
admission in patients undergoing mitral valve replacement/repair (MVR) for mitral
regurgitation (MR) with and without a history of atrial fibrillation (AF). Methods and …
admission in patients undergoing mitral valve replacement/repair (MVR) for mitral
regurgitation (MR) with and without a history of atrial fibrillation (AF). Methods and …
| | | |
New insights in acute heart failure
A Asakage, A Mebazaa, B Denau - La Presse Médicale, 2023
Acute heart failure (AHF) is a clinical complex disease and a worldwide issue due to
its inconsistent diagnosis and poor prognosis. The cornerstone of pathophysiology of
AHF is systemic venous congestion, which is led by the underlying structural and …
its inconsistent diagnosis and poor prognosis. The cornerstone of pathophysiology of
AHF is systemic venous congestion, which is led by the underlying structural and …
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[HTML] Correlation analysis between lung ultrasound scores and pulmonary arterial systolic pressure in patients with acute heart failure admitted to the emergency intensive …
P Xu, B Nasr, L Li, W Huang, W Liu, X Wang - Journal of Intensive Medicine, 2023
Background No convenient, inexpensive, and non-invasive screening tools exist to
identify pulmonary hypertension (PH)-left heart disease (LHD) patients during the
early stages of the disease course. This study investigated whether different methods …
identify pulmonary hypertension (PH)-left heart disease (LHD) patients during the
early stages of the disease course. This study investigated whether different methods …
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The Diagnostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy: Novel ECG Signs
L Calò, C Crescenzi, A Martino, M Casella, F Romeo… - JACC: Clinical …, 2023
Background Electrocardiographic (ECG) findings in arrhythmogenic left ventricular
cardiomyopathy (ALVC) are limited to small case series. Objectives This study aimed
to analyze the ECG characteristics of ALVC patients and to correlate ECG with …
cardiomyopathy (ALVC) are limited to small case series. Objectives This study aimed
to analyze the ECG characteristics of ALVC patients and to correlate ECG with …
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Stress Echocardiography in Dilated Nonischemic Cardiomyopathy
J Čelutkienė, E Picano - Stress Echocardiography, 2023
Echocardiography is a key technique in dilated nonischemic cardiomyopathy since
serial examinations are needed in these patients from the sub-clinical, early phase to
the overt heart failure. The required information is not limited to left ventricular …
serial examinations are needed in these patients from the sub-clinical, early phase to
the overt heart failure. The required information is not limited to left ventricular …
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TAH AS A SUCCESSFUL BRIDGE-TO-TRANSPLANT IN A PATIENT WITH LEFT VENTRICULAR NONCOMPACTION CARDIOMYOPATHY
K BABU, G PRABHU, K SHAH, G PRABHU - CHEST, 2023
DISCUSSION: Our patient's decreased cardiac output in the setting of LVNC
presented with multiple large thrombi in the LV cavity ultimately leading to VT storm.
We suspect that this was likely caused by embolization of thrombi into the coronary …
presented with multiple large thrombi in the LV cavity ultimately leading to VT storm.
We suspect that this was likely caused by embolization of thrombi into the coronary …
Okechukwu Ogah
Nov 1, 2023, 2:44:41 AM11/1/23
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NLRP3-inflammasome inhibition by MCC950 attenuates cardiac and pulmonary artery remodelling in heart failure with preserved ejection fraction
X Cheng, H Zhao, X Wen, G Li, S Guo, D Zhang - Life Sciences, 2023
Aims The purpose of this study was to evaluate the role of the NLRP3-inflammasome
in heart failure with preserved ejection fraction (HFpEF). Main methods Serum
inflammatory cytokines were detected in patients with heart failure. Correlation …
in heart failure with preserved ejection fraction (HFpEF). Main methods Serum
inflammatory cytokines were detected in patients with heart failure. Correlation …
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Identifying Barriers to Initiation of Sodium-Glucose Cotransporter-2 Inhibitor Therapy in Patients Hospitalized With Heart Failure With Reduced Ejection Fraction …
JB Pierce, GC Fonarow, SJ Greene - JAMA Cardiology
In Reply We thank Sadaniantz et al for their interest in our recent article. 1 We agree
that our findings suggest concerning disparities in sodium-glucose cotransporter-2
inhibitor (SGLT2i) use in heart failure with reduced ejection fraction (HFrEF) across …
that our findings suggest concerning disparities in sodium-glucose cotransporter-2
inhibitor (SGLT2i) use in heart failure with reduced ejection fraction (HFrEF) across …
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[HTML] The Mounting Evidence for Permissive Hypercreatinemia in Acute Heart Failure: Adding Sodium Glucose Cotransporter Inhibitors to the List
E Macedo, N Wettersten - Kidney360, 2023
Sodium/glucose cotransporter 2 inhibitors (SGLT2is) have been a pharmacologic
breakthrough in the management of CKD and heart failure (HF). However, with their
relative newness in clinical use, these agents are frequently held because of …
breakthrough in the management of CKD and heart failure (HF). However, with their
relative newness in clinical use, these agents are frequently held because of …
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[PDF] Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence: Clinical validation in real-time and large databases
S Olaisen, E Smistad, T Espeland, J Hu, D Pasdeloup… - European Heart Journal …, 2023
Background and aims Echocardiography is a cornerstone in cardiac imaging and left
ventricular (LV) ejection fraction (EF) is a key parameter for patient management.
Recent advances in artificial intelligence (AI) have enabled fully automatic …
ventricular (LV) ejection fraction (EF) is a key parameter for patient management.
Recent advances in artificial intelligence (AI) have enabled fully automatic …
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Mortality and heart failure admission following mitral valve surgery for mitral regurgitation among patients with versus without a history of atrial fibrillation: A nationwide …
HT Due, JK Petersen, E Havers-Borgersen… - The American Journal of …, 2023
Aims To examine the associated rate of 3-year mortality and heart failure (HF)
admission in patients undergoing mitral valve replacement/repair (MVR) for mitral
regurgitation (MR) with and without a history of atrial fibrillation (AF). Methods and …
admission in patients undergoing mitral valve replacement/repair (MVR) for mitral
regurgitation (MR) with and without a history of atrial fibrillation (AF). Methods and …
| | | |
Peripartum cardiomyopathy in Europe: new insights from the UK
C Viljoen, J Hoevelmann, K Sliwa - European Heart Journal, 2023
Peripartum cardiomyopathy (PPCM) is an idiopathic form of dilated cardiomyopathy,
characterized by a reduced left ventricular ejection fraction (LVEF) of< 45%, which
manifests towards the end of the third trimester of pregnancy or within the first months …
characterized by a reduced left ventricular ejection fraction (LVEF) of< 45%, which
manifests towards the end of the third trimester of pregnancy or within the first months …
| | | |
AM Jackson, M Macartney, K Brooksbank, C Brown… - European Heart Journal, 2023
The epidemiology of peripartum cardiomyopathy (PPCM) in Europe is poorly
understood and data on long-term outcomes are lacking. A retrospective,
understood and data on long-term outcomes are lacking. A retrospective,
observational, population-level study of validated cases of PPCM in Scotland from …
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Association Between Race, Cardiology Care, and the Receipt of Guideline-Directed Medical Therapy in Peripartum Cardiomyopathy
IK Bolakale-Rufai, SM Knapp, AE Johnson, LP Brewer… - Journal of Racial and Ethnic …, 2023
Background Black patients with peripartum cardiomyopathy (PPCM) have
disproportionately worse outcomes than White patients, possibly related to variable
involvement of cardiovascular specialists in their clinical care. We sought to …
disproportionately worse outcomes than White patients, possibly related to variable
involvement of cardiovascular specialists in their clinical care. We sought to …
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[HTML] Dapagliflozin-Induced Myocardial Flow Reserve Improvement is not Associated with HDL Ability to Stimulate Endothelial Nitric Oxide Production
U Capece, C Pavanello, F Cinti, L Leccisotti, T Mezza… - Diabetes Therapy, 2023
Abstract Background Sodium-glucose cotransporter-2 (SGLT2) inhibitors have
shown controversial results in modulating plasma lipids in clinical trials. Most studies
found slight increases in high-density lipoprotein (HDL) cholesterol but few have …
shown controversial results in modulating plasma lipids in clinical trials. Most studies
found slight increases in high-density lipoprotein (HDL) cholesterol but few have …
| | | |
Hypotension in heart failure is less harmful if associated with high or increasing doses of heart failure medication: Insights from the Swedish Heart Failure Registry
N Girerd, S Coiro, L Benson, G Savarese, U Dahlström… - European Journal of Heart Failure
Background Heart failure (HF) medication may reduce blood pressure (BP). Low BP
is associated with worse outcomes but how this association is modified by HF
medication has not been studied. We evaluated the association between BP and …
is associated with worse outcomes but how this association is modified by HF
medication has not been studied. We evaluated the association between BP and …
| | | |
Jayne Ajuluchukwu
Nov 1, 2023, 6:14:32 AM11/1/23
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Interesting insights. Appreciated
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Okechukwu Ogah
Nov 6, 2023, 9:11:04 AM11/6/23
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[HTML] Utilization of sodium-glucose cotransporter 2 inhibitors on dry eye disease severity in patients with type 2 diabetes mellitus
YP Yao, PJ Yang, CY Lee, JY Huang, SF Yang, HY Lin - International Journal of …, 2023
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have protective effects against
various systemic diseases and neoplasms. This retrospective cohort study evaluated
various systemic diseases and neoplasms. This retrospective cohort study evaluated
the severity of dry eye disease (DED) in patients with type 2 diabetes mellitus (T2DM) …
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[PDF] Race, Hypertensive Disorders of Pregnancy and Outcomes in Peripartum Cardiomyopathy
VB Polsinelli, A Koczo, AE Johnson, U Elkayam… - medRxiv, 2023
Introduction: Black women with peripartum cardiomyopathy (PPCM) have a high
prevalence of hypertensive disorders of pregnancy (HDP) and worse clinical
outcomes compared with other races. We examined the role of HDP and race on …
prevalence of hypertensive disorders of pregnancy (HDP) and worse clinical
outcomes compared with other races. We examined the role of HDP and race on …
| | | |
[PDF] Acute effect of atrial fibrillation on circulating natriuretic peptides: the influence of heart rate, rhythm irregularity, and left atrial pressure overload
P Stojadinovic, D Wichterle, M Fukunaga, P Peichl… - The American Journal of …, 2023
Plasma natriuretic peptides (NPs) are increased in patients with atrial fibrillation (AF)
compared with the patients with sinus rhythm. This study investigated whether this
phenomenon is intrinsic to heart rhythm irregularity and independent of the heart rate …
compared with the patients with sinus rhythm. This study investigated whether this
phenomenon is intrinsic to heart rhythm irregularity and independent of the heart rate …
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Left Atrial Strain in Acute Heart Failure: Clinical and Prognostic Insights
M Barki, M Losito, MM Caracciolo, T Sugimoto… - European Heart Journal …, 2023
Aims In acute heart failure (AHF), the consequences of impaired left atrial (LA)
mechanics are not well understood. We aimed to define the clinical trajectory of LA
mechanics by left atrial strain (LAS) analysis. Methods and Results 85 consecutive …
mechanics are not well understood. We aimed to define the clinical trajectory of LA
mechanics by left atrial strain (LAS) analysis. Methods and Results 85 consecutive …
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[HTML] Benefit of Catheter Ablation for Atrial Fibrillation in Heart Failure Patients with Different Etiologies
S Long, Y Sun, X Xiao, Z Wang, W Sun, L Gao, Y Xia… - Journal of Cardiovascular …, 2023
(1) Background: A plethora of studies have elucidated the safety and efficacy of
catheter ablation (CA) for patients afflicted with atrial fibrillation (AF) and concomitant
reduction in left ventricular ejection fraction (LVEF). Nevertheless, the literature on …
catheter ablation (CA) for patients afflicted with atrial fibrillation (AF) and concomitant
reduction in left ventricular ejection fraction (LVEF). Nevertheless, the literature on …
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[HTML] Blood pressure in atrial fibrillation and in sinus rhythm during ambulatory blood pressure monitoring: data from the TEMPLAR project
K Lundwall, T Kahan, S Omboni - Hypertension Research, 2023
The coexistence of hypertension and atrial fibrillation (AF) is common and accounts
for a worse prognosis. Uncertainties exist regarding blood pressure (BP)
measurements in AF patients by automated oscillometric devices. The Microlife …
for a worse prognosis. Uncertainties exist regarding blood pressure (BP)
measurements in AF patients by automated oscillometric devices. The Microlife …
| | | |
[PDF] Left ventricular noncompaction cardiomyopathy and myocardial bridging association: A coincidence or a usual association?
A Couissi, S Obeidat, AM Boutaleb, R Habbal - Journal of the Saudi Heart Association, 2023
Left ventricular non compaction (LVNC) is a rare congenital disease. It occurs due to
an arrest of the myocardial fibers compaction during embryogenesis. Myocardial
bridge (MB) is a coronary anomaly in which the myocardium covers segments of the …
an arrest of the myocardial fibers compaction during embryogenesis. Myocardial
bridge (MB) is a coronary anomaly in which the myocardium covers segments of the …
Okechukwu Ogah
Nov 7, 2023, 8:26:56 PM11/7/23
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X He, M Bender, C Gross, K Narayanaswamy, G Laufer… - ASAIO Journal, 2023
Effective treatment of heart failure with preserved ejection fraction (HFpEF) remains
an unmet medical need. Although left atrial decompression using mechanical
circulatory support devices was previously suggested, the heterogeneous HFpEF …
an unmet medical need. Although left atrial decompression using mechanical
circulatory support devices was previously suggested, the heterogeneous HFpEF …
| | | |
[PDF] The short‐term effects of sacubitril/valsartan therapy on myocardial oxygen consumption and energetic efficiency of cardiac work in heart failure with reduced ejection …
SV Nesterov, J Räty, W Nammas, T Maaniitty, X Galloo… - European Journal of Heart Failure
Aims We sought to evaluate the mechanism of angiotensin‐converting enzyme
inhibitor (ARNI) sacubitril/valsartan therapy and compare it with a valsartan‐only
control group in HFrEF patients. Methods and results The study was a phase IV …
inhibitor (ARNI) sacubitril/valsartan therapy and compare it with a valsartan‐only
control group in HFrEF patients. Methods and results The study was a phase IV …
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[PDF] Echocardiographic multiparameter assessment for patients with heart failure with preserved ejection fraction and atrial fibrillation
L Qin, J Yang, F Xu - CARDIOVASCULAR JOURNAL OF AFRICA, 2023
We aimed to assess the echocardiographic parameters of cardiac structure and
function in patients with heart failure with preserved ejection fraction (HFpEF) and
atrial fibrillation (AF). Thirty-seven HFpEF patients with AF were selected, while 38 …
function in patients with heart failure with preserved ejection fraction (HFpEF) and
atrial fibrillation (AF). Thirty-seven HFpEF patients with AF were selected, while 38 …
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[HTML] Study Protocol for the Pleiotropic Effects of Sodium–Glucose Cotransporter 2 Inhibitor on Organ-Specific Sympathetic Nerve Activity and Insulin Sensitivity in …
Y Takeshita, C Nomura, H Murai, Y Mukai, T Hirai… - Diabetes Therapy, 2023
Introduction Hyperinsulinemia and hyperglycemia are associated with exaggerated
systemic sympathetic nerve activity (SNA) in patients with type 2 diabetes. Sodium–
glucose cotransporter 2 (SGLT2) inhibitors lower insulin levels, whereas …
systemic sympathetic nerve activity (SNA) in patients with type 2 diabetes. Sodium–
glucose cotransporter 2 (SGLT2) inhibitors lower insulin levels, whereas …
| | | |
Mortality and heart failure admission following mitral valve surgery for mitral regurgitation among patients with versus without a history of atrial fibrillation: A nationwide …
HT Due, JK Petersen, E Havers-Borgersen… - The American Journal of …, 2023
Aims To examine the associated rate of 3-year mortality and heart failure (HF)
admission in patients undergoing mitral valve replacement/repair (MVR) for mitral
regurgitation (MR) with and without a history of atrial fibrillation (AF). Methods and …
admission in patients undergoing mitral valve replacement/repair (MVR) for mitral
regurgitation (MR) with and without a history of atrial fibrillation (AF). Methods and …
| | | |
[HTML] Longitudinal Trajectory Modeling to Assess Adherence to Sacubitril/Valsartan among Patients with Heart Failure
S Mucherino, AL Dima, E Coscioni, MG Vassallo… - Pharmaceutics, 2023
Medication adherence in chronic conditions is a long-term process. Modeling
longitudinal trajectories using routinely collected prescription data is a promising
method for describing adherence patterns and identifying at-risk groups. The study …
longitudinal trajectories using routinely collected prescription data is a promising
method for describing adherence patterns and identifying at-risk groups. The study …
| | | |
Clinical Outcomes by Sex After Pulsed Field Ablation of Atrial Fibrillation
MK Turagam, P Neuzil, B Schmidt, T Reichlin, K Neven… - JAMA Cardiology, 2023
Importance Previous studies evaluating the association of patient sex with clinical
outcomes using conventional thermal ablative modalities for atrial fibrillation (AF)
such as radiofrequency or cryoablation are controversial due to mixed results …
outcomes using conventional thermal ablative modalities for atrial fibrillation (AF)
such as radiofrequency or cryoablation are controversial due to mixed results …
| | | |
Discriminative ability of left ventricular strain in mildly reduced ejection fraction heart failure
FP Chung, TF Chao, AS Lee, KT Sung, WH Huang… - JACC: Advances, 2023
Background Left ventricular (LV) systolic strain is presumably a more sensitive
myocardial indicator than LV ejection fraction (LVEF). Data regarding the use of LV
strain in clinical risk stratification and in identifying angiotensin receptor-neprilysin …
myocardial indicator than LV ejection fraction (LVEF). Data regarding the use of LV
strain in clinical risk stratification and in identifying angiotensin receptor-neprilysin …
| | | |
The clinical outcomes of dapagliflozin in patients with acute heart failure: A randomized controlled trial (DAPA-RESPONSE-AHF)
AN Emara, M Wadie, NO Mansour, MEE Shams - European Journal of Pharmacology, 2023
Aims Dapagliflozin may confer additional decongestive and natriuretic benefits to
patients with acute heart failure (AHF). Nonetheless, this hypothesis was not
clinically examined. This study aimed primarily to investigate the effect of …
patients with acute heart failure (AHF). Nonetheless, this hypothesis was not
clinically examined. This study aimed primarily to investigate the effect of …
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Development and validation of a sensitive and simple LC-MS/MS method for simultaneous quantitation of valsartan, sacubitril and sacubitrilat in pediatric population
Q Yang, P Cao, Y Lv, H Peng, X Zhai - Journal of Pharmaceutical and Biomedical …, 2023
Pediatric heart failure (HF) is an important clinical disease with high hospitalization
rates, morbidity, mortality and medical costs. Sacubitril/valsartan (also known as
Entresto), was approved for the treatment of adult HF and is recently used in …
rates, morbidity, mortality and medical costs. Sacubitril/valsartan (also known as
Entresto), was approved for the treatment of adult HF and is recently used in …
Okechukwu Ogah
Nov 15, 2023, 1:20:30 AM11/15/23
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[PDF] Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental Heart Failure with Preserved Ejection Fraction
S Smolgovsky, AL Bayer, K Kaur, E Sanders… - The Journal of Clinical …, 2023
Heart Failure with Preserved Ejection Fraction (HFpEF) is a widespread syndrome
with limited therapeutic options and poorly understood immune-pathophysiology.
Using a two-hit preclinical model of cardiometabolic HFpEF that induces obesity and …
with limited therapeutic options and poorly understood immune-pathophysiology.
Using a two-hit preclinical model of cardiometabolic HFpEF that induces obesity and …
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[HTML] Dapagliflozin Attenuates Heart Failure With Preserved Ejection Fraction Remodeling and Dysfunction by Elevating β-Hydroxybutyrate–activated Citrate Synthase
X Zhang, N Wang, P Fu, Y An, F Sun, C Wang, X Han… - Journal of Cardiovascular …, 2023
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent, accounting
for 50% of all heart failure patients, and is associated with significant mortality.
Sodium–glucose cotransporter subtype inhibitor (SGLT2i) is recommended in the …
for 50% of all heart failure patients, and is associated with significant mortality.
Sodium–glucose cotransporter subtype inhibitor (SGLT2i) is recommended in the …
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Prognostic impact of acute decompensated heart failure in patients with heart failure and mildly reduced ejection fraction
A Schmitt, T Schupp, M Reinhardt, N Abel, F Lau… - European Heart Journal …, 2023
Objective This study sought to determine the prognostic impact of acute
decompensated heart failure (ADHF) in patients with heart failure with mildly reduced
ejection fraction (HFmrEF). Background ADHF is a major complication in patients …
decompensated heart failure (ADHF) in patients with heart failure with mildly reduced
ejection fraction (HFmrEF). Background ADHF is a major complication in patients …
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[PDF] Morbidity and mortality of acute heart failure patients stratified by mitral regurgitation in the Arabian Gulf: Observations from the Gulf acute heart failure registry (Gulf …
L AlObaid, R Rajan, M Al Jarallah, R Dashti… - Heliyon, 2023
This study aimed to evaluate the clinical outcomes of patients with acute heart failure
(AHF) stratified by mitral regurgitation (MR) in the Arabian Gulf. Patients from the Gulf
CARE registry were identified from 47 hospitals in seven Arabian Gulf countries …
(AHF) stratified by mitral regurgitation (MR) in the Arabian Gulf. Patients from the Gulf
CARE registry were identified from 47 hospitals in seven Arabian Gulf countries …
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Peripartum cardiomyopathy delivery hospitalization and postpartum readmission trends, risk factors, and outcomes
H Azad, T Wen, NA Bello, WA Booker, S Purisch… - Pregnancy Hypertension, 2023
Objective To evaluate risk for peripartum cardiomyopathy during delivery and
postpartum hospitalizations, and analyze associated trends, risk factors, and clinical
outcomes. Methods The 2010–2020 Nationwide Readmissions Database was used …
postpartum hospitalizations, and analyze associated trends, risk factors, and clinical
outcomes. Methods The 2010–2020 Nationwide Readmissions Database was used …
| | | |
[PDF] Hypertrophic Cardiomyopathy Predicts Thromboembolism and Heart Failure in Patients With Nonvalvular Atrial Fibrillation―A Prospective Analysis From the Hokuriku …
T Tsuda, K Hayashi, T Kato, T Kusayama, Y Nakagawa… - Circulation Journal, 2023
Background: The prognostic effect of concomitant hypertrophic cardiomyopathy
(HCM) on adverse events in patients with atrial fibrillation (AF) has not been
evaluated in a multicenter prospective cohort study in Japan. Methods and Results …
(HCM) on adverse events in patients with atrial fibrillation (AF) has not been
evaluated in a multicenter prospective cohort study in Japan. Methods and Results …
| | | |
Impact of in-hospital initiation of sodium-glucose cotransporter-2 inhibitors in patients with heart failure and reduced ejection fraction
L Burgos, F Ballari, A Spaccavento, B Ricciardi… - European Heart Journal, 2023
Introduction Safety and early clinical benefit make sodium-glucose cotransporter-2
inhibitor (SGLT-2i) therapy suitable for in-hospital initiation in patients with heart
failure and reduced ejection fraction (HFrEF). Despite randomized controlled trials …
inhibitor (SGLT-2i) therapy suitable for in-hospital initiation in patients with heart
failure and reduced ejection fraction (HFrEF). Despite randomized controlled trials …
| | | |
Effects of dapagliflozin in heart failure with preserved ejection fraction and chronic obstructive pulmonary disease: an analysis of the DELIVER trial
J Butt, H Lu, T Kondo, E Bachus, RA De Boer… - European Heart Journal, 2023
Introduction Chronic obstructive pulmonary disease (COPD) is a common
comorbidity in heart failure (HF) with preserved ejection fraction (HFpEF) and
associated with worse outcomes. Purpose We investigated the relationship between …
comorbidity in heart failure (HF) with preserved ejection fraction (HFpEF) and
associated with worse outcomes. Purpose We investigated the relationship between …
| | | |
Short term effect of sodium glucose cotransporter 2 inhibitors and sacubitril/valsartan on comprehensive geriatric assessment and oxidative stress in elderly with …
G Armentaro, M Magurno, V Cassano, CA Pastura… - European Heart Journal, 2023
Abstract Background Sodium Glucose Cotransporter 2 inhibitors (SGLT2i) and
Sacubitril/Valsartan (Sac/Val) have improved clinical prognosis in patients affected
by heart failure (HF) with reduced ejection fraction (HFrEF). Cognitive impairment …
Sacubitril/Valsartan (Sac/Val) have improved clinical prognosis in patients affected
by heart failure (HF) with reduced ejection fraction (HFrEF). Cognitive impairment …
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Heart failure in Africa: challenges of dealing with a heterogeneous syndrome in a heterogeneous continent
N Jessen, AO Mocumbi, K Sliwa - 2023
Heart failure (HF) is an evolving syndrome. In developed countries,
echocardiographic-based studies suggest that the true prevalence is double of the
1%–2% generally found in the adult population. Furthermore, recent studies indicate …
echocardiographic-based studies suggest that the true prevalence is double of the
1%–2% generally found in the adult population. Furthermore, recent studies indicate …
Okechukwu Ogah
Nov 21, 2023, 5:48:14 PM11/21/23
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[PDF] Socio-economic factors determine maternal and neonatal outcomes in women with peripartum cardiomyopathy: A study of the ESC EORP PPCM registry
K Sliwa, P van der Meer, C Viljoen, AM Jackson… - International Journal of Cardiology
Background Peripartum cardiomyopathy (PPCM) is a global disease with substantial
morbidity and mortality. The aim of this study was to analyze to what extent
socioeconomic factors were associated with maternal and neonatal outcomes …
morbidity and mortality. The aim of this study was to analyze to what extent
socioeconomic factors were associated with maternal and neonatal outcomes …
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[HTML] Anticoagulation with edoxaban in patients with long Atrial High-Rate Episodes≥ 24 hours
N Becher, T Toennis, E Bertaglia… - European Heart Journal, 2023
Abstract Background and Aims Patients with long atrial high-rate episodes (AHRE)≥
24 hours and stroke risk factors are often treated with anticoagulation for stroke
prevention. Anticoagulation has never been compared to no anticoagulation in these …
24 hours and stroke risk factors are often treated with anticoagulation for stroke
prevention. Anticoagulation has never been compared to no anticoagulation in these …
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[HTML] Prevention of cerebral thromboembolism by oral anticoagulation with dabigatran after pulmonary vein isolation for atrial fibrillation: the ODIn-AF trial
JW Schrickel, T Beiert, M Linhart, JA Luetkens… - Clinical Research in …, 2023
Background and objectives Long-term oral anticoagulation (OAC) following
successful catheter ablation of atrial fibrillation (AF) remains controversial.
Prospective data are missing. The ODIn-AF study aimed to evaluate the effect of OAC …
successful catheter ablation of atrial fibrillation (AF) remains controversial.
Prospective data are missing. The ODIn-AF study aimed to evaluate the effect of OAC …
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[HTML] Protocol: Evaluating the implementation of a dynamic digital application to enable community-based decentralisation of rheumatic heart disease case management in …
NW Minja, J Pulle, J Rwebembera, SR de Loizaga… - BMJ Open, 2023
Introduction Rheumatic heart disease (RHD) affects over 39 million people
worldwide, the majority in low-income and middle-income countries. Secondary
antibiotic prophylaxis (SAP), given every 3–4 weeks can improve outcomes …
worldwide, the majority in low-income and middle-income countries. Secondary
antibiotic prophylaxis (SAP), given every 3–4 weeks can improve outcomes …
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[PDF] Subcutaneous infusion of high-dose benzathine penicillin G is safe, tolerable, and suitable for less-frequent dosing for rheumatic heart disease secondary prophylaxis …
J Kado, S Salman, TK Hla, S Enkel, R Henderson… - Antimicrobial Agents and …, 2023
Since 1955, the recommended strategy for rheumatic heart disease (RHD)
secondary prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)]
injections administered intramuscularly every 4 weeks. Due to dosing frequency …
secondary prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)]
injections administered intramuscularly every 4 weeks. Due to dosing frequency …
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[HTML] Blood pressure in atrial fibrillation and in sinus rhythm during ambulatory blood pressure monitoring: data from the TEMPLAR project
K Lundwall, T Kahan, S Omboni - Hypertension Research, 2023
The coexistence of hypertension and atrial fibrillation (AF) is common and accounts
for a worse prognosis. Uncertainties exist regarding blood pressure (BP)
measurements in AF patients by automated oscillometric devices. The Microlife …
for a worse prognosis. Uncertainties exist regarding blood pressure (BP)
measurements in AF patients by automated oscillometric devices. The Microlife …
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Effect of Intensive Blood Pressure Control on Kidney Outcomes: Long-Term Electronic Health Record–Based Post-trial Follow-Up of SPRINT
PE Drawz, KM Lenoir, NK Rai, A Rastogi, CD Chu… - Clinical Journal of the …, 2023
Background: Intensive blood pressure (BP) lowering in SPRINT produced acute
decreases in kidney function and higher risk for acute kidney injury. We evaluated
the effect of intensive BP lowering on long-term changes in kidney function using trial …
decreases in kidney function and higher risk for acute kidney injury. We evaluated
the effect of intensive BP lowering on long-term changes in kidney function using trial …
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Multiparameter Right Ventricular Dysfunction Predicts Worse Prognosis in Heart Failure With Preserved Ejection Fraction-Lessons From the PARAGON-HF Trial
H Lu, RM Inciardi, M Abanda, AM Shah, M Cikes… - Circulation, 2023
Introduction: Impaired tricuspid annular plane systolic excursion (TAPSE), fractional
area change (FAC) and right ventricular free wall longitudinal strain (RVFWLS) have
been individually associated with a worse prognosis in patients with heart failure with …
area change (FAC) and right ventricular free wall longitudinal strain (RVFWLS) have
been individually associated with a worse prognosis in patients with heart failure with …
Okechukwu Ogah
Nov 29, 2023, 2:06:05 AM11/29/23
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Prognostic value of left atrial reverse remodelling in heart failure with preserved ejection fraction
Y Sun, Q Fu, G Tse, L Bai, J Liu, H He, S Zhao, M Tse… - Journal of Cardiovascular …, 2023
Objectives Left atrial reverse remodelling (LARR) reflects an improvement in the
function or structure. However, it is unclear whether the presence of LARR is
associated with better outcomes in patients with heart failure with preserved ejection …
function or structure. However, it is unclear whether the presence of LARR is
associated with better outcomes in patients with heart failure with preserved ejection …
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M Barki, M Losito, MM Caracciolo, T Sugimoto… - European Heart Journal …, 2023
Aims In acute heart failure (AHF), the consequences of impaired left atrial (LA)
mechanics are not well understood. We aimed to define the clinical trajectory of LA
mechanics by left atrial strain (LAS) analysis. Methods and Results 85 consecutive …
mechanics are not well understood. We aimed to define the clinical trajectory of LA
mechanics by left atrial strain (LAS) analysis. Methods and Results 85 consecutive …
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Effect of Eplerenone on Cardiac Reverse Remodeling in Patients With Acute Heart Failure: A Sub-Analysis of the Earlier Randomized Double-Blind Trial
S Ito, M Asakura, M Kitakaze - Circulation, 2023
Background: Activation of the renin-angiotensin-aldosterone system promotes left
ventricular (LV) remodeling and dysfunction. In the EARLIER trial, we reported that
the early initiation of eplerenone in patients with acute heart failure (AHF) reduced re …
ventricular (LV) remodeling and dysfunction. In the EARLIER trial, we reported that
the early initiation of eplerenone in patients with acute heart failure (AHF) reduced re …
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Biomarker Profile of Patients With Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction or Reduced Ejection Fraction: Insights From the ARISTOTLE …
T Pol, J Lindbäck, JH Alexander, C Granger, RD Lopes… - Circulation, 2023
Introduction: Heart failure with preserved ejection fraction (HFpEF) is a poorly
understood entity with phenotypic differences to heart failure with reduced ejection
fraction (HFrEF). To shed light on the potential pathophysiological difference …
understood entity with phenotypic differences to heart failure with reduced ejection
fraction (HFrEF). To shed light on the potential pathophysiological difference …
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Cost-Effectiveness of Sacubitril-Valsartan in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction With a Recent Worsening Heart Failure …
N Dixit, K Truong, B Ziaeian, GC Fonarow - Circulation, 2023
Background: In a pooled analysis of the PARAGON-HF and PARAGLIDE-HF trials,
sacubitril-valsartan was effective in the treatment of heart failure with mildly reduced
or preserved ejection fraction (HFmrEF/HFpEF) in patients who experienced a recent …
sacubitril-valsartan was effective in the treatment of heart failure with mildly reduced
or preserved ejection fraction (HFmrEF/HFpEF) in patients who experienced a recent …
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H Lu, RM Inciardi, M Abanda, AM Shah, M Cikes… - Circulation, 2023
Introduction: Right ventricular dysfunction (RVD) is a major prognostic factor in
patients with heart failure with preserved ejection fraction (HFpEF), however
determinants of RVD in HFpEF are not well described. Although sex-specific …
patients with heart failure with preserved ejection fraction (HFpEF), however
determinants of RVD in HFpEF are not well described. Although sex-specific …
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Early vs. Late Transcatheter Aortic Valve Replacement in Acute Heart Failure Hospitalizations: National Inpatient Sample (2015-2020)
A Hashem, A Khalouf, MS Mohamed, M Ismayl… - Circulation, 2023
Introduction: Data on clinical outcomes of early transcatheter aortic valve
replacement (TAVR)(< 48 hours) compared to late (≥ 48 hours) TAVR in patients
hospitalized with acute heart failure (AHF) and aortic stenosis (AS) remains limited …
replacement (TAVR)(< 48 hours) compared to late (≥ 48 hours) TAVR in patients
hospitalized with acute heart failure (AHF) and aortic stenosis (AS) remains limited …
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Age-Related Echocardiographic Characteristics in Patients With Heart Failure With Preserved Ejection Fraction in PARAGON-HF
X Wang, H Skali, M Cikes, O Vardeny, CS Lam… - Circulation, 2023
Introduction: Heart failure with preserved ejection fraction (HFpEF) may have
different characteristics by age groups. Aim Compare clinical and echocardiographic
characteristics in patients with HFpEF enrolled in the PARAGON-HF …
different characteristics by age groups. Aim Compare clinical and echocardiographic
characteristics in patients with HFpEF enrolled in the PARAGON-HF …
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Effect of Torsemide vs Furosemide After Discharge for Acute Heart Failure Across the Spectrum of Left Ventricular Ejection Fraction: Observations From Transform-HF
CJ Kapelios, SJ Greene, RJ Mentz, U Ikeaba… - Circulation, 2023
Introduction: TRANSFORM-HF trial showed no significant difference in mortality or
hospitalization outcomes in patients randomized to torsemide (T) versus furosemide
(F) following a heart failure (HF) hospitalization (HFH). However, outcomes and …
hospitalization outcomes in patients randomized to torsemide (T) versus furosemide
(F) following a heart failure (HF) hospitalization (HFH). However, outcomes and …
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Obesity is Associated With Greater Intensity of Guideline Recommended Therapy in Patients With Heart Failure With Reduced Ejection Fraction in the CHAMP-HF …
MS Khan, TJ Fendler, J Butler, AD Devore… - Circulation, 2023
Introduction: Despite the importance of guideline-directed medical therapy (GDMT) in
heart failure with reduced ejection fraction (HFrEF), treatment disparities by sex, race
and age have been described. We hypothesized obesity might also be associated …
heart failure with reduced ejection fraction (HFrEF), treatment disparities by sex, race
and age have been described. We hypothesized obesity might also be associated …
Jayne Ajuluchukwu
Nov 29, 2023, 4:53:31 AM11/29/23
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Very interesting publications. Thanks for sharing.JNA
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Okechukwu Ogah
Nov 30, 2023, 2:19:03 PM11/30/23
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fyi
[PDF] Empagliflozin cost‐effectiveness analysis in Japanese heart failure with mildly reduced and preserved ejection fraction
H Tsutsui, H Sakamaki, S Momomura, Y Sakata… - ESC Heart Failure, 2023
Aims Empagliflozin, a sodium‐glucose co‐transporter 2 inhibitor, was shown to be
effective in patients with heart failure with preserved ejection fraction (HFpEF) in the
EMPEROR‐Preserved trial. The present study aims to evaluate the cost …
effective in patients with heart failure with preserved ejection fraction (HFpEF) in the
EMPEROR‐Preserved trial. The present study aims to evaluate the cost …
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[HTML] DAPagliflozin for the attenuation of albuminuria in Patients with hEaRt failure and type 2 diabetes (DAPPER study): a multicentre, randomised, open-label, parallel …
F Yoshihara, M Imazu, I Sakuma, Y Hiroi, H Hara… - eClinicalMedicine, 2023
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the urinary
albumin-to-creatinine ratio (UACR) in patients with elevated levels of albuminuria in
the presence or absence of heart failure (HF) or type 2 diabetes mellitus (T2D) …
albumin-to-creatinine ratio (UACR) in patients with elevated levels of albuminuria in
the presence or absence of heart failure (HF) or type 2 diabetes mellitus (T2D) …
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Impact of Treatment with Sacubitril/Valsartan on Erectile Dysfunction in Patients with Heart Failure with Reduced Ejection Fraction
HA Barman, O Dogan, S Tanyolaç, A Atıcı, HO Arabaci… - The American Journal of …, 2023
Abstract Sacubitril/valsartan (S/V), an angiotensin receptor-neprilysin inhibitor
(ARNI), has been shown to reduce the risk of cardiovascular death or heart failure
hospitalization and improve symptoms among patients with chronic heart failure with …
(ARNI), has been shown to reduce the risk of cardiovascular death or heart failure
hospitalization and improve symptoms among patients with chronic heart failure with …
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[HTML] Assessing left atrial intramyocardial fat infiltration from computerized tomography angiography in patients with atrial fibrillation
A Saglietto, G Falasconi, D Soto-Iglesias, P Francia… - Europace, 2023
Background Epicardial adipose tissue might promote atrial fibrillation (AF) in several
ways, including infiltrating the underlying atrial myocardium. However, the role of this
potential mechanism has been poorly investigated. Aim Aim of the present study is to …
ways, including infiltrating the underlying atrial myocardium. However, the role of this
potential mechanism has been poorly investigated. Aim Aim of the present study is to …
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NT-proBNP After Discharge in Patients With Decompensated Heart Failure and Preserved Left Ventricle Ejection Fraction: The NICE Study
D Pascual Figal, A Gallego Navarro… - Circulation, 2023
Introduction: In hospitalized patients with heart failure (HF), the transition period after
discharge is associated with high risk of adverse events. The impact of monitoring
natriuretic peptides (NP) in patients with preserved LVEF (HFpEF) has not …
discharge is associated with high risk of adverse events. The impact of monitoring
natriuretic peptides (NP) in patients with preserved LVEF (HFpEF) has not …
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Sodium-glucose cotransporter 2 inhibitors are associated with reduced risk of mortality and readmissions in heart failure
P Karlström, A Pivodic, U Dahlström, M Fu - ESC heart failure
Aims Compelling evidence from randomized trials has shown that sodium-glucose
cotransporter 2 inhibitors (SGLT2is) are effective in heart failure (HF) across the
spectrum of left ventricular ejection fractions. However, there are very few studies …
cotransporter 2 inhibitors (SGLT2is) are effective in heart failure (HF) across the
spectrum of left ventricular ejection fractions. However, there are very few studies …
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Impact of atrial fibrillation on heart failure in patients treated with anthracycline chemotherapy
T Onoue, Y Kang, B Lefebvre, AM Smith, S Denduluri… - The American Journal of …, 2023
BACKGROUND: Atrial fibrillation (AF) and anthracyclines are known risk factors for
heart failure (HF). The magnitude of the effect of pre-existing AF (pre-anthracycline
AF) and newly developed AF (post-anthracycline AF) in patients treated with …
heart failure (HF). The magnitude of the effect of pre-existing AF (pre-anthracycline
AF) and newly developed AF (post-anthracycline AF) in patients treated with …
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[HTML] Prevention of cerebral thromboembolism by oral anticoagulation with dabigatran after pulmonary vein isolation for atrial fibrillation: the ODIn-AF trial
JW Schrickel, T Beiert, M Linhart, JA Luetkens… - Clinical Research in …, 2023
Background and objectives Long-term oral anticoagulation (OAC) following
successful catheter ablation of atrial fibrillation (AF) remains controversial.
Prospective data are missing. The ODIn-AF study aimed to evaluate the effect of OAC …
successful catheter ablation of atrial fibrillation (AF) remains controversial.
Prospective data are missing. The ODIn-AF study aimed to evaluate the effect of OAC …
Okechukwu Ogah
Dec 5, 2023, 8:32:06 AM12/5/23
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Heart failure with preserved ejection fraction risk is associated with prevalence and severity of obstructive sleep apnea
JE Connolly, MV Genuardi, JI Mora, SB Prenner - Journal of Clinical Sleep Medicine, 2023
Study Objectives: While heart failure with preserved ejection fraction (HFpEF) is
associated with the presence of obstructive sleep apnea (OSA), few studies have
examined the association between scoring systems used to predict HFpEF risk, such …
associated with the presence of obstructive sleep apnea (OSA), few studies have
examined the association between scoring systems used to predict HFpEF risk, such …
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β-blockers may be detrimental in frail patients with heart failure with preserved ejection fraction
S Hikoso, H Kida, A Sunaga, D Nakatani, K Okada… - Clinical Research in …, 2023
Background The effectiveness of β-blocker in patients with heart failure with
preserved ejection fraction (HFpEF) remains to be determined. We aimed to clarify
the association between the use of β-blocker and prognosis according to the status …
preserved ejection fraction (HFpEF) remains to be determined. We aimed to clarify
the association between the use of β-blocker and prognosis according to the status …
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Peripheral blood microRNA-21 as a predictive biomarker for heart failure with preserved ejection fraction in old hypertensives
M Marketou, J Kontaraki, E Zacharis, S Maragkoudakis… - American Journal of …, 2023
BACKGROUND Heart failure with preserved ejection fraction (HFpEF) is a major
health issue with high morbidity and mortality. The epidemiology and the factors that
cause HFpEF have not been fully clarified, while accurate predictive biomarkers are …
health issue with high morbidity and mortality. The epidemiology and the factors that
cause HFpEF have not been fully clarified, while accurate predictive biomarkers are …
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First-phase ejection fraction to predict adverse outcomes in patients with heart failure
C Jin, G Chen, C Zhao, Y Wu, L Song, T Zhao, Y Xie… - International Journal of …, 2023
Background First-phase ejection fraction (EF1) is a novel measurement of early left
ventricular systolic dysfunction. We investigate its prognostic value in patients with
heart failure (HF). Methods and results Patients with HF were prospectively enrolled …
ventricular systolic dysfunction. We investigate its prognostic value in patients with
heart failure (HF). Methods and results Patients with HF were prospectively enrolled …
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[HTML] Salvianolic acid A alleviates heart failure with preserved ejection fraction via regulating TLR/Myd88/TRAF/NF-κB and p38MAPK/CREB signaling pathways
A Dawuti, S Sun, R Wang, D Gong, R Liu, D Kong… - Biomedicine & …, 2023
Heart failure with preserved ejection fraction (HFpEF) is a morbid, fatal, and common
syndrome for which lack of evidence-based therapies. Salvianolic acid A (SAA), a
major active ingredient of Salvia miltiorrhiza Burge, has shown potential to protect …
syndrome for which lack of evidence-based therapies. Salvianolic acid A (SAA), a
major active ingredient of Salvia miltiorrhiza Burge, has shown potential to protect …
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Factors associated with the uric acid‐lowering effects of sodium‐glucose cotransporter‐2 inhibition in patients with type 2 diabetes: Insights from the randomized …
Y Saito, A Tanaka, T Imai, SI Miura, M Ajioka… - Diabetes, Obesity and …, 2023
2 METHODS This was a sub-analysis of the PROTECT study, a multicentre,
randomized, open-label trial, conducted to examine if ipragliflozin therapy delays the
progression of carotid intima-media thickness in patients with type 2 diabetes …
randomized, open-label trial, conducted to examine if ipragliflozin therapy delays the
progression of carotid intima-media thickness in patients with type 2 diabetes …
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Impact of Treatment with Sacubitril/Valsartan on Erectile Dysfunction in Patients with Heart Failure with Reduced Ejection Fraction
HA Barman, O Dogan, S Tanyolaç, A Atıcı, HO Arabaci… - The American Journal of …, 2023
Abstract Sacubitril/valsartan (S/V), an angiotensin receptor-neprilysin inhibitor
(ARNI), has been shown to reduce the risk of cardiovascular death or heart failure
hospitalization and improve symptoms among patients with chronic heart failure with …
(ARNI), has been shown to reduce the risk of cardiovascular death or heart failure
hospitalization and improve symptoms among patients with chronic heart failure with …
| | | |
[PDF] Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure
S James, D Erlinge, RF Storey, DK McGuire… - NEJM Evidence, 2023
Background In patients with acute myocardial infarction (MI), therapies that could
further reduce the risk of adverse cardiovascular and metabolic outcomes are
needed. Methods In this international registry-based, randomized, double-blind trial …
further reduce the risk of adverse cardiovascular and metabolic outcomes are
needed. Methods In this international registry-based, randomized, double-blind trial …
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[PDF] Efficacy and Safety of Sacubitril/Valsartan in Japanese Patients With Heart Failure According to Baseline Systolic Blood Pressure―Results From a Subgroup Analysis …
H Tsutsui, S Momomura, Y Saito, H Ito, K Yamamoto… - Circulation Journal, 2023
Background: Lower systolic blood pressure (SBP) is known to be associated with
poor prognosis in heart failure (HF). We evaluated the efficacy and safety of
sacubitril/valsartan according to baseline SBP tertiles in Japanese patients from the …
poor prognosis in heart failure (HF). We evaluated the efficacy and safety of
sacubitril/valsartan according to baseline SBP tertiles in Japanese patients from the …
Okechukwu Ogah
Dec 9, 2023, 4:11:35 AM12/9/23
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[PDF] Clinical predictors of right ventricular dysfunction and association with adverse outcomes in peripartum cardiomyopathy
TF Imran, F Ataklte, M Khalid, D Lopez, D Mohebali… - ESC Heart Failure, 2023
Aims We sought to identify factors associated with right ventricular (RV) dysfunction
and elevated pulmonary artery systolic pressure (PASP) and association with
adverse outcomes in peripartum cardiomyopathy (PPCM). Methods and results We …
and elevated pulmonary artery systolic pressure (PASP) and association with
adverse outcomes in peripartum cardiomyopathy (PPCM). Methods and results We …
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Dapagliflozin downregulates G protein-coupled receptor Kinase-2 and upregulates regulator of g protein signaling-4 in adrenals to exert sympatholysis in heart failure
A Lymperopoulos, G Del Calvo, T Baggio Lopez… - European Heart Journal, 2023
Dapagliflozin is a sodium-glucose co-transporter (SGLT)-2 inhibitor with beneficial
cardiovascular effects independent of its anti-diabetic actions. Among these is
sympatholysis, ie, norepinephrine (NE) lowering which is beneficial in chronic …
cardiovascular effects independent of its anti-diabetic actions. Among these is
sympatholysis, ie, norepinephrine (NE) lowering which is beneficial in chronic …
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[HTML] Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients
I Klobučar, H Hinteregger, M Lechleitner, M Trbušić… - Biomedicines, 2023
Very little is known about the association between individual serum free fatty acids
(FFAs) and clinical and laboratory parameters (indicators of heart failure severity) in
acute heart failure (AHF) patients. Here, the baseline serum levels of FFAs, 16: 0 …
(FFAs) and clinical and laboratory parameters (indicators of heart failure severity) in
acute heart failure (AHF) patients. Here, the baseline serum levels of FFAs, 16: 0 …
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[HTML] On-vs. Off-Pump CABG in Heart Failure Patients with Reduced Ejection Fraction (HFrEF): A Multicenter Analysis
CJ Rustenbach, S Reichert, M Radwan, I Doll… - Biomedicines, 2023
Objective: This study aimed to compare postoperative outcomes and 30-day mortality
in patients with reduced ejection fraction (< 40%) who underwent isolated coronary
artery bypass grafting (CABG) with (ONCAB) and without (OPCAB) the use of …
in patients with reduced ejection fraction (< 40%) who underwent isolated coronary
artery bypass grafting (CABG) with (ONCAB) and without (OPCAB) the use of …
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Association between coronary microcirculatory resistance, left atrial strain and heart failure with preserved ejection fraction in patents with ischemia and non …
J Legutko, P Szolc, L Niewiara, M Stapor, P Kleczynski… - European Heart Journal, 2023
Background Coronary microvascular dysfunction (CMD) plays an important role in
the pathogenesis of ischemia and non-obstructive coronary arteries (MINOCA) and
heart failure with preserved ejection fraction (HFpEF). Left atrial strain (LAS) …
the pathogenesis of ischemia and non-obstructive coronary arteries (MINOCA) and
heart failure with preserved ejection fraction (HFpEF). Left atrial strain (LAS) …
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The association between dapagliflozin use and the risk of post contrast acute kidney injury in patients with type 2 diabetes and chronic kidney disease: a propensity …
T Liu, X Jian, L Li, S Chu, Z Fan - Kidney & Blood Pressure Research, 2023
Introduction This study aimed to investigate the effect of dapagliflozin in preventing
post contrast acute kidney injury (PC-AKI) in patients with type 2 diabetes (T2DM)
and chronic kidney disease (CKD) who underwent an elective coronary procedure …
post contrast acute kidney injury (PC-AKI) in patients with type 2 diabetes (T2DM)
and chronic kidney disease (CKD) who underwent an elective coronary procedure …
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Enhanced central sympathetic tone induces heart failure with a preserved ejection fraction (HFpEF) in rats
SS Nandi, K Katsurada, M Moulton, H Zheng, KP Patel - Frontiers in Physiology
Heart failure with a preserved ejection fraction (HFpEF) is a heterogenous clinical
syndrome characterized by diastolic dysfunction, concentric cardiac left ventricular
(LV) hypertrophy, myocardial fibrosis with a preserved systolic function. However, the …
syndrome characterized by diastolic dysfunction, concentric cardiac left ventricular
(LV) hypertrophy, myocardial fibrosis with a preserved systolic function. However, the …
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Bilateral Cardiac Sympathetic Denervation for Refractory Multifocal Premature Ventricular Contractions in Patients With Nonischemic Cardiomyopathy
A Ahmed, R Charate, D Bawa, R Ghazal, J Garg… - JACC: Clinical …, 2023
Background Bilateral cardiac sympathetic denervation (BCSD) for refractory life-
threatening ventricular arrhythmias is a neuromodulatory intervention targeting
sympathetically driven focal or re-entrant ventricular arrhythmias. Objectives This …
threatening ventricular arrhythmias is a neuromodulatory intervention targeting
sympathetically driven focal or re-entrant ventricular arrhythmias. Objectives This …
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[HTML] Resistant Hypertension and Related Outcomes in a Cohort of Patients with Cardiorenal Multimorbidity Hospitalized in an Internal Medicine Ward
A Gigante, R Cianci, C Brigato, M Melena, E Acquaviva… - High Blood Pressure & …, 2023
Introduction Resistant hypertension (RH) is characterized by the failure to reach a
goal blood pressure despite the administration of three medications at maximally
tolerated doses, one of which being a diuretic. RH can be observed in a variety of …
goal blood pressure despite the administration of three medications at maximally
tolerated doses, one of which being a diuretic. RH can be observed in a variety of …
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Efficacy of sacubitril and valsartan combined with bisoprolol in the treatment of chronic heart failure and its effect on N-terminal pro-brain natriuretic peptide level
L ZHANG, L JIANG, L ZHANG - Chinese Journal of Primary Medicine and Pharmacy, 2023
Objective: To investigate the clinical efficacy of sacubitril and valsartan combined
with bisoprolol in the treatment of chronic heart failure and its effect on N-terminal pro-
brain natriuretic peptide (NT-pro BNP) level. Methods: The clinical data of 89 patients …
with bisoprolol in the treatment of chronic heart failure and its effect on N-terminal pro-
brain natriuretic peptide (NT-pro BNP) level. Methods: The clinical data of 89 patients …
Okechukwu Ogah
Dec 12, 2023, 11:09:14 AM12/12/23
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Subject: Recommended articles
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From: Google Scholar Alerts <scholarale...@google.com>
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Impact of Empagliflozin on Insulin Use in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) and Type 2 Diabetes: Sub-Analysis from EMPEROR …
JB Green, J Butler, J Rosenstock, ET Committees - American Heart Journal, 2024
Aim We assessed the impact of empagliflozin on insulin requirement, and outcomes
according to insulin use in patients with heart failure with preserved ejection fraction
(HFpEF). Methods Of 5988 patients randomised to empagliflozin or placebo, 2938 …
according to insulin use in patients with heart failure with preserved ejection fraction
(HFpEF). Methods Of 5988 patients randomised to empagliflozin or placebo, 2938 …
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[HTML] Echocardiography and Electrocardiography in Detecting Atrial Cardiomyopathy: A Promising Path to Predicting Atrial Fibrillation
D Gentille-Lorente, A Hernández-Pinilla… - Journal of Clinical Medicine, 2023
(1) Background: Atrial cardiomyopathy constitutes an intrinsically prothrombotic atrial
substrate that may promote AF and thromboembolic events, especially stroke,
independently of the arrhythmia. Atrial reservoir strain is the echocardiography …
substrate that may promote AF and thromboembolic events, especially stroke,
independently of the arrhythmia. Atrial reservoir strain is the echocardiography …
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[HTML] Impact of Atrial Fibrillation on Heart Failure with Preserved Ejection Fraction: An Observational Cross-sectional Study from Western India
MH Shastri, V Vinod, HP Mistry, VM Rathod, NV Gohil… - APIK Journal of Internal …, 2023
Background: Both atrial fibrillation (AF) and heart failure with preserved ejection
fraction (HFpEF) commonly coexist with overlapping symptoms, risk factors, and
shared pathophysiology. Both conditions independently impact left atrial volume …
fraction (HFpEF) commonly coexist with overlapping symptoms, risk factors, and
shared pathophysiology. Both conditions independently impact left atrial volume …
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[PDF] REAL WORLD EXPERIENCE OF SAFETY AND EFFICACY OF DAPAGLIFLOZIN IN PATIENTS WITH HEART FAILURE AND PRESERVED EJECTION FRACTION …
VA Mishra, AB Kinare, SK Tripathi, MS Siddiqui, S Soni - Int J Acad Med Pharm, 2023
Background: The prevalence of heart failure with mildly reduced or preserved
ejection fraction (HFpEF) markedly increases with age, with older individuals
disproportionately facing excess risk for mortality and hospitalization. To determine …
ejection fraction (HFpEF) markedly increases with age, with older individuals
disproportionately facing excess risk for mortality and hospitalization. To determine …
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[HTML] Coronary Flow Reserve Changes after Angiotensin Receptor–Neprilysin Inhibitor Treatment in Heart Failure with Reduced Ejection Fraction
EB Karaayvaz, G Güz - Acta Cardiologica Sinica, 2023
Background Sacubitril/valsartan has been shown to reduce hospital admissions and
even mortality for heart failure. In heart failure and acute coronary syndrome, the
effects of sacubitril/valsartan have been studied, but the effect on coronary artery flow …
even mortality for heart failure. In heart failure and acute coronary syndrome, the
effects of sacubitril/valsartan have been studied, but the effect on coronary artery flow …
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Dapagliflozin-entresto protected kidney from renal hypertension via downregulating cell-stress signaling and upregulating SIRT1/PGC-1α/Mfn2-medicated …
SF Ko, CC Yang, PH Sung, BC Cheng, PL Shao… - Experimental Biology and …, 2023
This study tested whether combined dapagliflozin and entresto would be superior to
mere one therapy on protecting the residual renal function and integrity of kidney
parenchyma in hypertensive kidney disease (HKD) rat. In vitro results showed that …
mere one therapy on protecting the residual renal function and integrity of kidney
parenchyma in hypertensive kidney disease (HKD) rat. In vitro results showed that …
| | | |
[HTML] Anticoagulation with edoxaban in patients with long Atrial High-Rate Episodes≥ 24 hours
N Becher, T Toennis, E Bertaglia… - European Heart Journal, 2023
Abstract Background and Aims Patients with long atrial high-rate episodes (AHRE)≥
24 hours and stroke risk factors are often treated with anticoagulation for stroke
prevention. Anticoagulation has never been compared to no anticoagulation in these …
24 hours and stroke risk factors are often treated with anticoagulation for stroke
prevention. Anticoagulation has never been compared to no anticoagulation in these …
| | | |
Prevalence and Predictors of Subclinical Cardiomyopathy in Patients With Type 2 Diabetes in a Health System
A Nagori, MW Segar, N Keshvani, L Patel, KV Patel… - Journal of Diabetes Science …, 2023
Introduction: Diabetic cardiomyopathy (DbCM) is characterized by subclinical
abnormalities in cardiac structure/function and is associated with a higher risk of
overt heart failure (HF). However, there are limited data on optimal strategies to …
abnormalities in cardiac structure/function and is associated with a higher risk of
overt heart failure (HF). However, there are limited data on optimal strategies to …
| | | |
[PDF] Effect of Dapagliflozin Versus Placebo on Symptoms and 6-Minute Walk Distance in Patients With Heart Failure: The DETERMINE Randomized Clinical Trials
JJV McMurray, KF Docherty, RA de Boer… - Circulation, 2023
BACKGROUND: Sodium-glucose cotransporter 2 inhibitors reduce the risk of
worsening heart failure (HF) and cardiovascular death in patients with HF
irrespective of left ventricular ejection fraction. It is important to determine whether …
worsening heart failure (HF) and cardiovascular death in patients with HF
irrespective of left ventricular ejection fraction. It is important to determine whether …
| | | |
European Society of Cardiology guidelines and 1 year outcomes of acute heart failure treatment in Central Asia and Europe.
T Abdurashidova, M Müller, S Schukraft, N Soborun… - ESC Heart Failure, 2023
Aims Outcomes reported for patients with hospitalization for acute heart failure (AHF)
treatment vary worldwide. Ethnicity-associated characteristics may explain this
observation. This observational study compares characteristics and 1-year outcomes …
treatment vary worldwide. Ethnicity-associated characteristics may explain this
observation. This observational study compares characteristics and 1-year outcomes …
Okechukwu Ogah
Dec 21, 2023, 1:43:25 AM12/21/23
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[HTML] Epicardial Adipose Tissue in Obese Heart Failure With Preserved Ejection Fraction: The Evidence Grows
M Obokata, K Kagami - JACC: Advances, 2023
Obesity has reached epidemic proportions in most of the westernized countries;
currently, 40% of adults in the United States are obese. It is projected that 1 in 2
American adults will be obese by 2030. 1 Obesity is substantially common in patients …
currently, 40% of adults in the United States are obese. It is projected that 1 in 2
American adults will be obese by 2030. 1 Obesity is substantially common in patients …
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[HTML] Rationale and Design of the PACE HFpEF Trial: Physiologic Accelerated Pacing as a Holistic Treatment of Heart Failure with Preserved Ejection Fraction
N Habel, M Infeld, J Bernknopf, M Meyer, D Lustgarten - Heart Rhythm O2, 2023
Background In heart failure with preserved ejection fraction (HFpEF), it has been
assumed that pharmacologic heart rate suppression should provide clinical benefits
through an increase in diastolic filling time. Contrary to this assumption, heart rate …
assumed that pharmacologic heart rate suppression should provide clinical benefits
through an increase in diastolic filling time. Contrary to this assumption, heart rate …
| | | |
[PDF] Comparing Efficacy and Safety Between Patients With Atrial Fibrillation Taking Direct Oral Anticoagulants or Warfarin After Direct Oral Anticoagulant Failure
MT Hsieh, CH Liu, SH Lin, PY Lin, YM Chang… - Journal of the American …, 2023
Background An increased risk of recurrent stroke is noted in patients with atrial
fibrillation despite direct oral anticoagulant (DOAC) use. We investigated the efficacy
and safety of treatment with each of 4 different DOACs or warfarin after DOAC failure …
fibrillation despite direct oral anticoagulant (DOAC) use. We investigated the efficacy
and safety of treatment with each of 4 different DOACs or warfarin after DOAC failure …
| | | |
[PDF] Impact of Sacubitril/valsartan on cardiac and systemic hypoxia in chronic heart failure
H Nougué, F Picard, A Cohen-Solal, D Logeart… - iScience, 2023
In heart failure patients with reduced ejection fraction, Sacubitril/valsartan (S/V)
increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via
miR-30a in vitro. Using a cohort of 73 HFrEF patients who were transitioned from …
increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via
miR-30a in vitro. Using a cohort of 73 HFrEF patients who were transitioned from …
| | | |
The real-world safety of sacubitril/valsartan among older adults (≥ 75): A pharmacovigilance study from the FDA data
TT Lerman, N Greenberg, B Fishman, A Goldman… - International Journal of …, 2023
Background Heart failure is a major cause of morbidity and mortality among older
adults. Sacubitril-Valsartan (Sac/Val) has been shown to improve patients' outcomes;
however, its safety profile among older adults has not been adequately examined …
adults. Sacubitril-Valsartan (Sac/Val) has been shown to improve patients' outcomes;
however, its safety profile among older adults has not been adequately examined …
| | | |
[HTML] Effects of 3-month dapagliflozin on left atrial function in treatment-naïve patients with type 2 diabetes mellitus: assessment using 4-dimensional echocardiography
M Zhang, L Sun, X Wu, Y Qin, M Lin, X Ding, W Zhu… - Hellenic Journal of …, 2023
Background The sodium-glucose transporter-2 (SGLT-2) inhibitor dapagliflozin can
improve left ventricular (LV) performance in patients with type 2 diabetes mellitus
(T2DM). However, the effects on left atrial (LA) function in treatment-naïve T2DM …
improve left ventricular (LV) performance in patients with type 2 diabetes mellitus
(T2DM). However, the effects on left atrial (LA) function in treatment-naïve T2DM …
| | | |
[HTML] Heart failure, investigator-reported sleep apnea and dapagliflozin: A patient-level pooled meta-analysis of DAPA-HF and DELIVER
JH Butt, K Jering, RA de Boer, BL Claggett, AS Desai… - Journal of Cardiac Failure, 2023
Background Sleep apnea is more common in patients with heart failure (HF) than in
the general population, but little is known about its association with clinical outcomes
in different HF phenotypes or how it might modify the effect of HF therapy. Objectives …
the general population, but little is known about its association with clinical outcomes
in different HF phenotypes or how it might modify the effect of HF therapy. Objectives …
| | | |
Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice
J Fielitz, N Dörmann, E Hammer, K Struckmann… - Frontiers in Cardiovascular …
Background: A metabolic shift from fatty acid (FAO) to glucose oxidation (GO) occurs
during cardiac hypertrophy (LVH) and heart failure with reduced ejection fraction
(HFrEF), which is mediated by PGC-1α and PPARα. While the transcription factor EB …
during cardiac hypertrophy (LVH) and heart failure with reduced ejection fraction
(HFrEF), which is mediated by PGC-1α and PPARα. While the transcription factor EB …
| | | |
[HTML] Ambulatory blood pressure monitoring with atrial fibrillation detection algorithm: two birds with one stone
A Kollias, KG Kyriakoulis, GS Stergiou - Hypertension Research, 2023
Blood pressure (BP) measurement in the presence of atrial fibrillation (AF) is
considered as difficult and uncertain due to the increased beat-to-beat BP variability
(BPV) which renders even the gold standard manual auscultatory method …
considered as difficult and uncertain due to the increased beat-to-beat BP variability
(BPV) which renders even the gold standard manual auscultatory method …
Okechukwu Ogah
Dec 25, 2023, 11:11:21 AM12/25/23
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Heart failure with preserved ejection fraction in patients with moderate/severe aortic stenosis: what harms our patients most?
MW Bergmann - European Heart Journal-Cardiovascular Imaging, 2023
Elderly patients have a high risk of developing heart failure (HF); measurement of the
heart failure biomarker N-terminal pro-brainnatriuretic-peptide establishes the
diagnosis followed by echocardiography to define HFrEF/HFmrEF or HFpEF …
heart failure biomarker N-terminal pro-brainnatriuretic-peptide establishes the
diagnosis followed by echocardiography to define HFrEF/HFmrEF or HFpEF …
| | | |
[HTML] Clinical characteristics and outcomes of patients hospitalized with heart failure with preserved ejection fraction and low NT-proBNP levels
YY Chen, L Liang, PC Tian, JY Feng, LY Huang… - Medicine, 2023
The aim of this study was to investigate the clinical characteristics and prognosis of
patients hospitalized with heart failure with preserved ejection fraction (HFpEF) and
low N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Seven hundred …
patients hospitalized with heart failure with preserved ejection fraction (HFpEF) and
low N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Seven hundred …
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Quantitative metrics of the LV trabeculated layer by cardiac CT and cardiac MRI in patients with suspected noncompaction cardiomyopathy
A Manohar, DM Vigneault, DH Kwon, K Caliskan… - European Radiology, 2023
Objectives To compare cardiac computed tomography (CCT) and cardiac magnetic
resonance (CMR) for the quantitative assessment of the left ventricular (LV)
trabeculated layer in patients with suspected noncompaction cardiomyopathy …
resonance (CMR) for the quantitative assessment of the left ventricular (LV)
trabeculated layer in patients with suspected noncompaction cardiomyopathy …
| | | |
[HTML] ΔRDW Could Predict Major Adverse Cardiovascular Events in Patients with Heart Failure with Reduced Ejection Fraction After Sacubitril/Valsartan Treatment
J Wang, J Zhao, Q Lin, X Xu, K Jiang, Y Li - International Journal of General Medicine, 2023
Objective This study aimed to evaluate the association between red blood cell
distribution width (RDW) changes and major adverse cardiovascular event (MACE)
occurrences during sacubitril/valsartan treatment in patients with heart failure with …
distribution width (RDW) changes and major adverse cardiovascular event (MACE)
occurrences during sacubitril/valsartan treatment in patients with heart failure with …
| | | |
Prognostic Impact of Repeated NT-proBNP Measurements in Patients With Heart Failure With Reduced Ejection Fraction
MA Fuery, ES Leifer, MD Samsky, S Sen, CM O'Connor… - JACC: Heart Failure, 2023
Background Although clinical studies have demonstrated the association between a
single N-terminal pro–B-type natriuretic peptide (NT-proBNP) measurement and
clinical outcomes in chronic heart failure, the biomarker is frequently measured …
single N-terminal pro–B-type natriuretic peptide (NT-proBNP) measurement and
clinical outcomes in chronic heart failure, the biomarker is frequently measured …
| | | |
[PDF] Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure
Z Zhang, J Vlcek, V Pauly, N Hesse, J Bauer… - European Journal of Clinical …, 2023
Background Atrial fibrillation (AF) is the most common arrhythmia and is associated
with considerable morbidity and mortality. Ischaemic heart failure (IHF) remains one
of the most common causes of AF in clinical practice. However, ischaemia‐mediated …
with considerable morbidity and mortality. Ischaemic heart failure (IHF) remains one
of the most common causes of AF in clinical practice. However, ischaemia‐mediated …
| | | |
Irreversible myocardial injury attenuates the benefits of sacubitril/valsartan in heart failure patients
HM Choi, IC Hwang, HJ Choi, YE Yoon, HJ Lee… - International Journal of …, 2023
Background Despite the established benefits of angiotensin receptor-neprilysin
inhibitor (ARNI) in heart failure with reduced ejection fraction (HFrEF) across various
etiologies, there are controversies regarding the effects of ARNI in patients with …
inhibitor (ARNI) in heart failure with reduced ejection fraction (HFrEF) across various
etiologies, there are controversies regarding the effects of ARNI in patients with …
| | | |
Clinical and genetic characteristics of catecholaminergic polymorphic ventricular tachycardia combined with left ventricular non-compaction
B Xu, J Yang, F Liu, T Lv, K Li, Y Yuan, S Li, Y Liu… - Cardiology in the Young, 2023
Background: Catecholaminergic polymorphic ventricular tachycardia is an ion
channelopathy, caused by mutations in genes coding for calcium-handling proteins.
It can coexist with left ventricular non-compaction. We aim to investigate the clinical …
channelopathy, caused by mutations in genes coding for calcium-handling proteins.
It can coexist with left ventricular non-compaction. We aim to investigate the clinical …
| | | |
[HTML] Patent Ductus Arteriosus from Diagnosis to Surgical Closure: 10 Years Experience at Federal Medical Centre Abeokuta, Ogun State, Nigeria
CC Uzodimma, MK Yusuf, SB Sanni, AJ Olugbemi… - Open Access Library …, 2023
Introduction: Patent ductus arteriosus is a common congenital heart defect. PDA
accounts for 10%-22% of CHD in various studies conducted in Nigeria. The addition
of the paediatric cardiology sub-specialty unit at Federal Medical Centre Abeokuta …
accounts for 10%-22% of CHD in various studies conducted in Nigeria. The addition
of the paediatric cardiology sub-specialty unit at Federal Medical Centre Abeokuta …
| | | |
[HTML] Involvement of plasminogen activator inhibitor-1 in p300/p53-mediated age-related atrial fibrosis
Y Lai, J He, X Gao, D Peng, H Zhou, Y Xu, X Luo… - PeerJ, 2023
Abstract Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic
system, is also intimately involved in the fibrosis. Although PAI-1 may be involved in
the occurrence of atrial fibrillation (AF) and thrombosis in the elderly, but whether it …
system, is also intimately involved in the fibrosis. Although PAI-1 may be involved in
the occurrence of atrial fibrillation (AF) and thrombosis in the elderly, but whether it …
| | | |
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[HTML] Comment on “Importance of epicardial adipose tissue as a predictor of heart failure with preserved ejection fraction”
X Qin, C Yu - Revista da Associação Médica Brasileira, 2023
Dear Editor, We read the recent study performed by Ateş et al1. with great interest,
which underscores the importance of epicardial adipose tissue as a predictor for
heart failure with preserved ejection fraction. The research highlights the pivotal role …
which underscores the importance of epicardial adipose tissue as a predictor for
heart failure with preserved ejection fraction. The research highlights the pivotal role …
| | | |
Impact of Empagliflozin on Insulin Use in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) and Type 2 Diabetes: Sub-Analysis from EMPEROR …
JB Green, J Butler, J Rosenstock, ET Committees - American Heart Journal, 2024
Aim We assessed the impact of empagliflozin on insulin requirement, and outcomes
according to insulin use in patients with heart failure with preserved ejection fraction
(HFpEF). Methods Of 5988 patients randomised to empagliflozin or placebo, 2938 …
according to insulin use in patients with heart failure with preserved ejection fraction
(HFpEF). Methods Of 5988 patients randomised to empagliflozin or placebo, 2938 …
| | | |
Efficacy and safety of sacubitril/valsartan after six months in patients with heart failure with reduced ejection fraction and asymptomatic hypotension
WU An-Hu, LIN Zong-Wei, Y Zhuo-Hao, H ZHANG… - Journal of Geriatric …, 2023
BACKGROUND It is not clear whether sacubitril/valsartan is beneficial for patients
with heart failure (HF) with reduced ejection fraction (HFrEF) and low systolic blood
pressure (SBP). This study aimed to investigate the efficacy and tolerability of …
with heart failure (HF) with reduced ejection fraction (HFrEF) and low systolic blood
pressure (SBP). This study aimed to investigate the efficacy and tolerability of …
| | | |
[HTML] The Impact of Positive Inotropic Therapy on Hemodynamics and Organ Function in Acute Heart Failure: A Differentiated View
J Cheko, N Patsalis, J Kreutz, D Divchev, G Chatzis… - Journal of Personalized …, 2023
Background: Little is known about the impact of treatment with inotropic drugs on the
interaction of hemodynamics, biomarkers, and end-organ function in patients with
acute decompensated heart failure (HF) of different origins and heart rhythms …
interaction of hemodynamics, biomarkers, and end-organ function in patients with
acute decompensated heart failure (HF) of different origins and heart rhythms …
| | | |
[HTML] Oral anticoagulation after atrial fibrillation catheter ablation: benefits and risks
K Kanaoka, T Nishida, Y Iwanaga, M Nakai… - European Heart Journal, 2023
Abstract Background and Aims Few recent large-scale studies have evaluated the
risks and benefits of continuing oral anticoagulant (OAC) therapy after catheter
ablation (CA) for atrial fibrillation (AF). This study evaluated the status of continuation …
risks and benefits of continuing oral anticoagulant (OAC) therapy after catheter
ablation (CA) for atrial fibrillation (AF). This study evaluated the status of continuation …
| | | |
[HTML] Renal Denervation in the Treatment of Resistant Hypertension and Difficult-to-Control Hypertension–Consensus Document of the Croatian Hypertension League …
B Jelaković, D Perkov, K Barišić, N Bukal, L Gellineo… - Vascular Health and Risk …, 2023
Renal denervation (RDN) as a method of treating arterial hypertension (AH) was
introduced in Croatia in 2012. A multidisciplinary team and a network of hospitals
that diagnose and treat patients with severe forms of AH were established, and a …
introduced in Croatia in 2012. A multidisciplinary team and a network of hospitals
that diagnose and treat patients with severe forms of AH were established, and a …
| | | |
Are device-detected atrial high-rate episodes a risk marker for stroke?
P Hanna, E Buch, K Shivkumar - Nature Cardiovascular Research, 2023
Continuous cardiac rhythm monitoring via cardiac implantable electronic devices
finds an increased number of patients with asymptomatic atrial fibrillation. Yet, not all
patients with device-detected atrial high-rate episodes are alike. Fine-tuning risk …
finds an increased number of patients with asymptomatic atrial fibrillation. Yet, not all
patients with device-detected atrial high-rate episodes are alike. Fine-tuning risk …
| | | |
Worsening renal function and the plasma B-type natriuretic peptide in prognosis of patients with acute heart failure
D ZHAO, W WEI, D PENG, Z XIANG, S RONG - Clinical Medicine of China, 2023
Objective: To analyze the effects of different plasma B-type natriuretic peptide (BNP)
changes on worsening renal function (WRF) on 1-year all-cause mortality in patients
with acute heart failure (AHF). Methods: The clinical data of 399 patients with AHF …
changes on worsening renal function (WRF) on 1-year all-cause mortality in patients
with acute heart failure (AHF). Methods: The clinical data of 399 patients with AHF …
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Pulmonary hypertension due to left heart disease: First validation of the 2022 definitions in a prospective study, the PH-HF multicenter study
C Fauvel, E Berthelot, F Bauer, JC Eicher, P De Groote… - Archives of Cardiovascular …, 2024
Introduction The 2022 European guidelines changed the hemodynamic definition of
post-capillary pulmonary hypertension (pcPH) in heart failure (HF) lowering the level
of mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance …
post-capillary pulmonary hypertension (pcPH) in heart failure (HF) lowering the level
of mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance …
Okechukwu Ogah
Dec 28, 2023, 1:56:10 PM12/28/23
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[HTML] Impact of sodium glucose co-transporter-2 inhibitors on left atrial functions in patients with type-2 diabetes and heart failure with mildly reduced ejection fraction
SB El-Saied, WS El-Sherbeny, SI El-sharkawy - IJC Heart & Vasculature, 2024
Background We aimed to assess the impact of adding sodium glucose co-
transporters-2 inhibitors (SGLT-2I) on cardiac remodeling in type 2 diabetic patients
with heart failure with mildly reduced ejection fraction (HFmrEF) that had been under …
transporters-2 inhibitors (SGLT-2I) on cardiac remodeling in type 2 diabetic patients
with heart failure with mildly reduced ejection fraction (HFmrEF) that had been under …
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CO41 Long-Term Clinical Outcomes in People with Heart Failure with Preserved Ejection Fraction (HFpEF) Treated with Standard Care
L Sun, V Dayer, RN Hansen, Y Du, T Williamson… - Value in Health, 2023
Objectives To model clinical outcomes in a cohort of patients with symptomatic
HFpEF over a lifetime horizon. Methods We constructed a Markov model with health
states for stable HF, HF hospitalization, and death to follow a cohort of patients with …
HFpEF over a lifetime horizon. Methods We constructed a Markov model with health
states for stable HF, HF hospitalization, and death to follow a cohort of patients with …
| | | |
Role of cardiopulmonary ultrasound in predicting the occurrence of heart failure with preserved ejection fraction in patients with acute myocardial infarction
R TIAN, W ZHU, Q CAI, Y QIN, M LIN, S JIN, W ZHANG… - Chinese Journal of …, 2023
Objective: To evaluate the left ventricular diastolic function and pulmonary
congestion in patients with acute myocardial infarction (AMI) with preserved left
ventricular ejection fraction (LVEF) by cardiopulmonary ultrasound (CPUS), and to …
congestion in patients with acute myocardial infarction (AMI) with preserved left
ventricular ejection fraction (LVEF) by cardiopulmonary ultrasound (CPUS), and to …
| | | |
[PDF] Management of nocturnal hypertension: An expert consensus document from Chinese Hypertension League
J Liu, Y Li, X Zhang, P Bu, X Du, L Fang, Y Feng, Y Guo… - The Journal of Clinical …, 2023
Nocturnal hypertension is highly prevalent among Chinese and Asian populations,
which is mainly attributed to high salt intake and high salt sensitivity. Nocturnal
hypertension increases the risk of cardiovascular and all‐cause mortality …
which is mainly attributed to high salt intake and high salt sensitivity. Nocturnal
hypertension increases the risk of cardiovascular and all‐cause mortality …
Okechukwu Ogah
Dec 30, 2023, 7:50:05 AM12/30/23
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[HTML] Net clinical benefit of oral anticoagulants in Asian patients with atrial fibrillation based on a CHA2DS2-VASc score
K Methavigul, P Chichareon, A Yindeengam… - BMC Cardiovascular …, 2023
This study was conducted to assess the net clinical benefit (NCB) for oral
anticoagulant (OAC) in atrial fibrillation (AF) patients according to the CHA2DS2-
VASc score. Patients with AF were prospectively recruited in the COOL AF Thailand …
anticoagulant (OAC) in atrial fibrillation (AF) patients according to the CHA2DS2-
VASc score. Patients with AF were prospectively recruited in the COOL AF Thailand …
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[PDF] Post-myocardial infarction heart failure with reduced ejection fraction in older patients: a prospective multicentre study in Vietnam
NTH Phan, HT Nguyen, VH Vu - 2023
Background Heart failure (HF) is a common complication of myocardial infarction (MI)
in older adults. However, data on the incidence of and risk factors for post-MI HF with
reduced ejection fraction (HFrEF) are limited, especially among older Asian …
in older adults. However, data on the incidence of and risk factors for post-MI HF with
reduced ejection fraction (HFrEF) are limited, especially among older Asian …
| | | |
[PDF] Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial
S von Haehling, W Doehner, R Evertz, T Garfias-Veitl… - Global Cardiology, 2023
Background: Iron deficiency is highly prevalent in patients with heart failure and has
well established diagnostic criteria. Its occurrence is associated with reduced quality
of life, exercise capacity and increased hospitalization rates and mortality. The …
well established diagnostic criteria. Its occurrence is associated with reduced quality
of life, exercise capacity and increased hospitalization rates and mortality. The …
| | | |
[HTML] Effects of 3-month dapagliflozin on left atrial function in treatment-naïve patients with type 2 diabetes mellitus: assessment using 4-dimensional echocardiography
M Zhang, L Sun, X Wu, Y Qin, M Lin, X Ding, W Zhu… - Hellenic Journal of …, 2023
Background The sodium-glucose transporter-2 (SGLT-2) inhibitor dapagliflozin can
improve left ventricular (LV) performance in patients with type 2 diabetes mellitus
(T2DM). However, the effects on left atrial (LA) function in treatment-naïve T2DM …
improve left ventricular (LV) performance in patients with type 2 diabetes mellitus
(T2DM). However, the effects on left atrial (LA) function in treatment-naïve T2DM …
| | | |
[HTML] Evaluation of organized atrial arrhythmias after cryptogenic stroke
NVK Pothineni, U Batnyam, H Schwennesen, A Tierney… - Heart Rhythm O2, 2023
Background Long-term rhythm monitoring to detect atrial fibrillation (AF) following a
cryptogenic stroke (CS) is well established. However, the burden of organized atrial
arrhythmias in this population is not well defined. Objective To assess the incidence …
cryptogenic stroke (CS) is well established. However, the burden of organized atrial
arrhythmias in this population is not well defined. Objective To assess the incidence …
| | | |
[HTML] Involvement of plasminogen activator inhibitor-1 in p300/p53-mediated age-related atrial fibrosis
Y Lai, J He, X Gao, D Peng, H Zhou, Y Xu, X Luo… - PeerJ, 2023
Abstract Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic
system, is also intimately involved in the fibrosis. Although PAI-1 may be involved in
the occurrence of atrial fibrillation (AF) and thrombosis in the elderly, but whether it …
system, is also intimately involved in the fibrosis. Although PAI-1 may be involved in
the occurrence of atrial fibrillation (AF) and thrombosis in the elderly, but whether it …
| | | |
[In Press] Prior anticoagulation and bridging thrombolysis improve outcomes in patients with atrial fibrillation undergoing endovascular thrombectomy for anterior …
L Lin, C Blair, J Fu, DJ Cordato, C Cappelen-Smith… - Journal of …, 2023
Background: Where stroke occurs with pre-existing atrial fibrillation (AF) studies
validating the safety and efficacy of bridging thrombolysis, and the use of
endovascular thrombectomy (EVT) in the setting of prior anticoagulation, are limited …
validating the safety and efficacy of bridging thrombolysis, and the use of
endovascular thrombectomy (EVT) in the setting of prior anticoagulation, are limited …
| | | |
[PDF] Development and validation of a diagnostic model for ischemic cardiomyopathy with Artificial Neural Network by bioinformatic analysis
T Naman, S Aimaier, R Abuduhalike, A Abudouwayiti… - 2023
Background Ischemic cardiomyopathy (ICM) is a significant global health concern
caused by high morbidity and mortality. In addition, no previous study has reported
the diagnostic biomarkers in ICM. Objective The presentstudy is aimed at …
caused by high morbidity and mortality. In addition, no previous study has reported
the diagnostic biomarkers in ICM. Objective The presentstudy is aimed at …
Okechukwu Ogah
Jan 6, 2024, 6:33:12 AM1/6/24
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Impact of Empagliflozin on Insulin Use in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) and Type 2 Diabetes: Sub-Analysis from EMPEROR …
JB Green, J Butler, J Rosenstock, ET Committees - American Heart Journal, 2024
Aim We assessed the impact of empagliflozin on insulin requirement, and outcomes
according to insulin use in patients with heart failure with preserved ejection fraction
(HFpEF). Methods Of 5988 patients randomised to empagliflozin or placebo, 2938 …
according to insulin use in patients with heart failure with preserved ejection fraction
(HFpEF). Methods Of 5988 patients randomised to empagliflozin or placebo, 2938 …
| | | |
Incidence and progression of atrial fibrillation in patients with and without heart failure using mineralocorticoid receptor antagonists: a meta-analysis
T Sampaio Rodrigues, LJ Garcia Quarto, SC Nogueira… - Clinical Research in …, 2024
Abstract Background Mineralocorticoid receptor antagonists (MRAs) have emerged
as potential therapy to target the underlying arrhythmogenic substrate in atrial
fibrillation (AF). Nevertheless, there have been inconsistent results on the impact of …
as potential therapy to target the underlying arrhythmogenic substrate in atrial
fibrillation (AF). Nevertheless, there have been inconsistent results on the impact of …
| | | |
Dapagliflozin in patients with myocardial infarction without diabetes or prior heart failure
S James, RF Storey, J Oldgren - 2024
In recent years improvements in the prognosis of patients with acute myocardial
infarction have slowed, with limited new treatment options and continued high risk of
cardiovascular and metabolic events. The Dapagliflozin in myocardial infarction …
infarction have slowed, with limited new treatment options and continued high risk of
cardiovascular and metabolic events. The Dapagliflozin in myocardial infarction …
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[HTML] Could admission level of uric acid predict total diuretic dose in acute heart failure?
M Chenaghlou, S Hamzehzadeh, A Norouzi, H Sahrai… - BMC Cardiovascular …, 2024
Recent studies have shown that increases in serum UA levels are associated with
adverse clinical outcomes in patients with chronic heart failure (CHF); the aim of this
study was to determine the relationship between serum uric acid and total diuretic …
adverse clinical outcomes in patients with chronic heart failure (CHF); the aim of this
study was to determine the relationship between serum uric acid and total diuretic …
| | | |
A treatment algorithm for ischemic cardiomyopathy
R De Caterina, R Liga - Vascular Pharmacology, 2024
Abstract Treatment of ischemic cardiomyopathy has been the focus of increased
attention by cardiologists due to recent evidence of an important outcome study
comparing percutaneous coronary intervention (PCI) plus optimal medical treatment …
attention by cardiologists due to recent evidence of an important outcome study
comparing percutaneous coronary intervention (PCI) plus optimal medical treatment …
Okechukwu Ogah
Jan 9, 2024, 2:29:02 PM1/9/24
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Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction
AM Troy, D Normukhamedova, D Grothe, A Momen… - American Journal of …, 2024
Heart failure with preserved ejection fraction (HFpEF) afflicts over half of all heart
failure patients and is a debilitating and fatal syndrome affecting post-menopausal
women more than any other demographic. This bias towards older females calls into …
failure patients and is a debilitating and fatal syndrome affecting post-menopausal
women more than any other demographic. This bias towards older females calls into …
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Impaired Cardiopulmonary Baroreflex Function and Altered Cardiovascular Responses to Hypovolemia in Patients with Heart Failure with Preserved Ejection Fraction
JK Alpenglow, K Bunsawat, MA Francisco, JC Craig… - Journal of Applied …, 2024
Heart failure with preserved ejection fraction (HFpEF) is associated with autonomic
imbalance which may be related to baroreflex dysfunction. Thus, we tested the
hypothesis that central and peripheral hemodynamic responses to baroreflex …
imbalance which may be related to baroreflex dysfunction. Thus, we tested the
hypothesis that central and peripheral hemodynamic responses to baroreflex …
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[HTML] Blood pressure lowering effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA)
S Toyoda - Hypertension Research, 2024
Two classes of antidiabetic agents, sodium-glucose cotransporter 2 inhibitors
(SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA), have recently
emerged as hypoglycemic agents with superior cardiorenal protective effects. This …
(SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA), have recently
emerged as hypoglycemic agents with superior cardiorenal protective effects. This …
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[HTML] Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF)
S Cho, K Dadson, HK Sung, O Ayansola… - Biomedicine & …, 2024
Aims Adiponectin has been shown to mediate cardioprotective effects and levels are
typically reduced in patients with cardiometabolic disease. Hence, there has been
intense interest in developing adiponectin-based therapeutics. The aim of this …
typically reduced in patients with cardiometabolic disease. Hence, there has been
intense interest in developing adiponectin-based therapeutics. The aim of this …
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[HTML] Rivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease
R Kreutz, G Deray, J Floege, M Gwechenberger… - JACC: Advances, 2024
Background Treatment with vitamin K antagonists (VKAs) has been linked to
worsening of kidney function in patients with atrial fibrillation (AF). Objectives
XARENO (Factor XA-inhibition in RENal patients with non-valvular atrial fibrillation …
worsening of kidney function in patients with atrial fibrillation (AF). Objectives
XARENO (Factor XA-inhibition in RENal patients with non-valvular atrial fibrillation …
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Cardiac MR Imaging in Left Ventricular Noncompaction
V Arora - Case-based Atlas of Cardiac Imaging, 2024
Left ventricular noncompaction is a rare entity characterized by hypertrabeculated
myocardium with adjacent deep intertrabecular recesses in communication with the
left ventricular cavity. This anatomical organization of prominent trabeculations …
myocardium with adjacent deep intertrabecular recesses in communication with the
left ventricular cavity. This anatomical organization of prominent trabeculations …
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2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis …
TF Members, TA McDonagh, M Metra, M Adamo… - European journal of heart failure
Document Reviewers: Rudolf A. de Boer (CPG Review Co-ordinator)(Netherlands),
P. Christian Schulze (CPG Review Co-ordinator)(Germany), Elena Arbelo (Spain),
Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger …
P. Christian Schulze (CPG Review Co-ordinator)(Germany), Elena Arbelo (Spain),
Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger …
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[PDF] Development and validation of a diagnostic model for ischemic cardiomyopathy with Artificial Neural Network by bioinformatic analysis
T Naman, S Aimaier, R Abuduhalike, A Abudouwayiti… - 2023
Background Ischemic cardiomyopathy (ICM) is a significant global health concern
caused by high morbidity and mortality. In addition, no previous study has reported
the diagnostic biomarkers in ICM. Objective The presentstudy is aimed at …
caused by high morbidity and mortality. In addition, no previous study has reported
the diagnostic biomarkers in ICM. Objective The presentstudy is aimed at …
Okechukwu Ogah
Jan 11, 2024, 4:51:24 PM1/11/24
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[HTML] Seeking synergy for novel weight-and glucose-lowering pharmacotherapy and exercise training in heart failure patients with preserved ejection fraction
T Kambic, CJ Lavie, TMH Eijsvogels - 2024
Heart failure (HF) with preserved ejection fraction (HFpEF; EF> 50%) accounts for
more than 50% of new HF diagnoses, and the prevalence is increasing due to the
ageing population and the rising prevalence of obesity. 1, 2 Heart failure with …
more than 50% of new HF diagnoses, and the prevalence is increasing due to the
ageing population and the rising prevalence of obesity. 1, 2 Heart failure with …
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[HTML] Costs and Cardiovascular Benefits of a Fourth-Generation Synchronous Telehealth Program on Mortality and Cardiovascular Outcomes for Patients With Atrial …
HY Chang, HW Wu, CS Hung, YH Chen, CC Huang… - Journal of Medical Internet …, 2024
Background The prevalence of atrial fibrillation (AF) continues to increase in modern
aging society. Patients with AF are at high risk for multiple adverse cardiovascular
events, including heart failure, stroke, and mortality. Improved medical care is …
aging society. Patients with AF are at high risk for multiple adverse cardiovascular
events, including heart failure, stroke, and mortality. Improved medical care is …
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[HTML] The Impact of Positive Inotropic Therapy on Hemodynamics and Organ Function in Acute Heart Failure: A Differentiated View
J Cheko, N Patsalis, J Kreutz, D Divchev, G Chatzis… - Journal of Personalized …, 2023
Background: Little is known about the impact of treatment with inotropic drugs on the
interaction of hemodynamics, biomarkers, and end-organ function in patients with
acute decompensated heart failure (HF) of different origins and heart rhythms …
interaction of hemodynamics, biomarkers, and end-organ function in patients with
acute decompensated heart failure (HF) of different origins and heart rhythms …
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[PDF] Oral anticoagulation therapy in patients with atrial fibrillation at high risk of bleeding: Clinical characteristics and treatment strategies based on data from the Polish …
M Maciorowska, B Uziębło-Życzkowska… - Kardiologia Polska (Polish …, 2023
Background: Oral anticoagulant (OAC) therapy in patients with atrial fibrillation (AF),
despite its benefits, is associated with hemorrhagic complications. Aims: To evaluate
the clinical characteristics of patients with AF at high risk of bleeding, the frequency of …
despite its benefits, is associated with hemorrhagic complications. Aims: To evaluate
the clinical characteristics of patients with AF at high risk of bleeding, the frequency of …
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[HTML] Concealed Inherited Cardiomyopathies Detected in Cardio-Oncology Screening
R Lorca, I Pascual, M Fernandez, R Alvarez-Velasco… - Journal of Clinical Medicine, 2023
Introduction: Basal cardiovascular risk assessment in cardio-oncology is essential.
Integrating clinical information, ECG and transthoracic echocardiogram can identify
concealed inherited cardiomyopathies (ICMPs) with potential added risk of …
Integrating clinical information, ECG and transthoracic echocardiogram can identify
concealed inherited cardiomyopathies (ICMPs) with potential added risk of …
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[HTML] Sacubitril/valsartan reduces proteasome activation and cardiomyocyte area in an experimental mouse model of hypertrophy
M Meyer-Jens, K Wenzel, K Grube, J Rüdebusch… - Journal of Molecular and …, 2024
Abstract Sacubitril/valsartan (Sac/Val) belongs to the group of angiotensin receptor–
neprilysin inhibitors and has been used in the treatment of heart failure (HF) for
several years. The mechanisms that mediate the beneficial effects of Sac/Val are not …
neprilysin inhibitors and has been used in the treatment of heart failure (HF) for
several years. The mechanisms that mediate the beneficial effects of Sac/Val are not …
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[PDF] AI-powered Coronary Artery Calcium Scans (AI-CAC) Enables Prediction of Heart Failure and Outperforms NT-proBNP: The Multi-Ethnic Study of Atherosclerosis
M Naghavi, AP Reeves, MJ Budoff, D Li, K Atlas… - medRxiv, 2024
Introduction: Coronary artery calcium (CAC) scans contain useful information beyond
the Agatston CAC score that is not currently reported. We recently reported that
artificial intelligence (AI)-enabled cardiac chambers volumetry in CAC scans (AI …
the Agatston CAC score that is not currently reported. We recently reported that
artificial intelligence (AI)-enabled cardiac chambers volumetry in CAC scans (AI …
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[HTML] Time in target range of systolic blood pressure and clinical outcomes in atrial fibrillation patients: results of the COOL-AF registry
R Krittayaphong, P Chichareon, C Komoltri… - Scientific Reports, 2024
We aimed to investigate the relationship between time in target range of systolic
blood pressure (SBP-TTr) and clinical outcomes in patients with atrial fibrillation (AF).
We analyzed the results from multicenter AF registry in Thailand. Blood pressure was …
blood pressure (SBP-TTr) and clinical outcomes in patients with atrial fibrillation (AF).
We analyzed the results from multicenter AF registry in Thailand. Blood pressure was …
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[PDF] Is Blood Pressure Measurement Performed During the Examination? Is it Standardized?
Ş Ulusoy - Hypertension (HT), 2024
Hypertension (HT) is one of the most important diseases encountered in our
professional lives and one with a number of particularly significant characteristics.
The first of these is its relatively high prevalence in the community. Although rates …
professional lives and one with a number of particularly significant characteristics.
The first of these is its relatively high prevalence in the community. Although rates …
Okechukwu Ogah
Jan 13, 2024, 11:31:40 AM1/13/24
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Revascularization for Patients With Heart Failure With Preserved Ejection Fraction and Coronary Artery Disease
M Fu, Y Wang, X Han, S Yuan, Y Liu, J Qian, J Zhou… - The American Journal of …, 2024
Coronary artery disease (CAD) is one of the main causes of heart failure (HF) with
preserved ejection fraction (HFpEF). The efficacy of revascularization therapy in
patients with HFpEF and CAD, however, remains unclear. Patients who underwent …
preserved ejection fraction (HFpEF). The efficacy of revascularization therapy in
patients with HFpEF and CAD, however, remains unclear. Patients who underwent …
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[PDF] The increasing importance of the ablation therapy in patients with atrial fibrillation and heart failure with preserved ejection fraction
E Akşit, U Küçük, G Taylan - Europace, 2024
We read with great interest the article by Xie et al. regarding the results of atrial
fibrillation (AF) ablation in patients with heart failure (HF) with preserved ejection
fraction (HFpEF). 1 In their study, based on a large cohort of patients with HFpEF …
fibrillation (AF) ablation in patients with heart failure (HF) with preserved ejection
fraction (HFpEF). 1 In their study, based on a large cohort of patients with HFpEF …
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In Heart Failure With Preserved Ejection Fraction Muscle Sympathetic Nerve Activity Is Augmented At Rest And During Exercise
MB Badrov, T Tobushi, CF Notarius, E Keys, JS Floras - Journal of Cardiac Failure, 2024
Introduction In heart failure (HF), both sympathetic excess and diminished exercise
capacity predict disease progression and survival. In HF with reduced ejection
fraction, elevated muscle sympathetic nerve activity (MSNA), evident both at rest and …
capacity predict disease progression and survival. In HF with reduced ejection
fraction, elevated muscle sympathetic nerve activity (MSNA), evident both at rest and …
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Effects Of Sodium-Glucose Cotransporter-2 Inhibitors On Pulmonary Pressures In Heart Failure With Preserved Ejection Fraction Using Pulmonary Artery Remote …
J Nickol, R Zolty - Journal of Cardiac Failure, 2024
Introduction Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have emerged as a
mainstay in therapy for all classes of heart failure. Heart failure with preserved
ejection fraction (HFpEF), a class that was previously devoid of many treatment …
mainstay in therapy for all classes of heart failure. Heart failure with preserved
ejection fraction (HFpEF), a class that was previously devoid of many treatment …
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[PDF] Left Ventricular Noncompaction Cardiomyopathy in 2 Siblings With Underlying Tetralogy of Fallot: A Case Report
R Abbaszadeh, F Naderi, H Tatari, YT Tabar
Tetralogy of Fallot (TOF) is one of the most common congenital heart diseases.
Family recurrence provides strong evidence for the involvement of a genetic
component in the susceptibility to TOF. The role of genetic factors is supported by the …
Family recurrence provides strong evidence for the involvement of a genetic
component in the susceptibility to TOF. The role of genetic factors is supported by the …
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Personalized Diuretic Therapy in Acute Heart Failure: The Holy Grail?
JM ter Maaten, LEEC Zonneveld - Heart Failure, 2024
The hallmark of acute heart failure (AHF) is congestion, and the primary treatment of
these patients is aimed at restoring euvolemia by administration of loop diuretic
agents. 1 In recent decades, the treatment of AHF has not altered substantially …
these patients is aimed at restoring euvolemia by administration of loop diuretic
agents. 1 In recent decades, the treatment of AHF has not altered substantially …
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The two different profiles in heart failure with preserved ejection fraction and type 2 diabetes mellitus: ischemic and diabetic
JC Arévalo Lorido, J Carretero Gómez, A Conde Martel… - Current Medical Research …, 2024
Objective Two profiles of patients with heart failure with preserved ejection fraction
(HFpEF) and type 2 diabetes mellitus (T2DM) can be discerned: those with ischemic
and those with diabetic cardiomyopathy (DMC). We aim to analyze clinical …
(HFpEF) and type 2 diabetes mellitus (T2DM) can be discerned: those with ischemic
and those with diabetic cardiomyopathy (DMC). We aim to analyze clinical …
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Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: Rationale, Design, and Lead-in Phase Results of the …
M Fudim, S Litwin, BA Borlaug, RC Mohan, MJ Price… - Journal of Cardiac Failure, 2024
Introduction Splanchnic vasoconstriction augments transfer of blood volume from the
abdomen into the thorax, which may increase filling pressures and hemodynamic
congestion in patients with noncompliant hearts. Therapeutic interruption of …
abdomen into the thorax, which may increase filling pressures and hemodynamic
congestion in patients with noncompliant hearts. Therapeutic interruption of …
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[HTML] Age and Sex Disparities in Blood Pressure Control and Therapeutic Inertia: Impact of a Quality Improvement Program
O Myers, T Markossian, B Probst, G Hiura, K Habicht… - American Journal of …, 2024
Objective Hypertension quality improvement programs reduce uncontrolled blood
pressure (BP) but impact may differ by sex and age. Methods This study examined
uncontrolled BP, defined as a BP≥ 140/90 mmHg, and therapeutic inertia, defined …
pressure (BP) but impact may differ by sex and age. Methods This study examined
uncontrolled BP, defined as a BP≥ 140/90 mmHg, and therapeutic inertia, defined …
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HERMES: Effects Of Ziltivekimab Versus Placebo On Morbidity And Mortality In Patients With Heart Failure With Mildly Reduced Or Preserved Ejection Fraction And …
M Petrie, B Borlaug, K Buchholtz, A Ducharme… - Journal of Cardiac Failure, 2024
Background-Inflammation is a central pathophysiological process in heart failure with
preserved (HFpEF) and mildly reduced ejection fraction (HFmrEF). Il-6, a pro-
inflammatory cytokine, is an independent risk factor for adverse outcomes in HFpEF …
preserved (HFpEF) and mildly reduced ejection fraction (HFmrEF). Il-6, a pro-
inflammatory cytokine, is an independent risk factor for adverse outcomes in HFpEF …
| | | |
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Okechukwu Ogah
Jan 20, 2024, 7:48:42 AM1/20/24
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[HTML] Diagnostic and Prognostic Value of Aminoterminal Prohormone of Brain Natriuretic Peptide in Heart Failure with Mildly Reduced Ejection Fraction Stratified by the …
T Schupp, M Abumayyaleh, K Weidner, F Lau… - Journal of Clinical Medicine, 2024
Limited data concerning the diagnostic and prognostic value of blood-derived
biomarkers in heart failure with mildly reduced ejection fraction (HFmrEF) is
available. This study investigates the diagnostic and prognostic value of …
biomarkers in heart failure with mildly reduced ejection fraction (HFmrEF) is
available. This study investigates the diagnostic and prognostic value of …
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[HTML] Prognostic Implications of Septal Hypertrophy in Patients with Heart Failure with Mildly Reduced Ejection Fraction
N Abel, T Schupp, M Abumayyaleh, A Schmitt… - Journal of Clinical Medicine, 2024
Cardiac remodeling is frequently observed in patients with heart failure (HF) and
serves as an indicator of disease progression and severity. Septal hypertrophy
represents an aspect of remodeling that can be easily assessed via an …
serves as an indicator of disease progression and severity. Septal hypertrophy
represents an aspect of remodeling that can be easily assessed via an …
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[PDF] Educational status affects prognosis of patients with heart failure with reduced ejection fraction: A post‐hoc analysis from the WARCEF trial
B Corica, GF Romiti, AH Simoni, DA Mei, T Bucci… - European Journal of Clinical …, 2024
Aims The influence of social determinants of health (SDOH) on the prognosis of
Heart Failure and reduced Ejection Fraction (HFrEF) is increasingly reported. We aim
to evaluate the contribution of educational status on outcomes in patients with HFrEF …
Heart Failure and reduced Ejection Fraction (HFrEF) is increasingly reported. We aim
to evaluate the contribution of educational status on outcomes in patients with HFrEF …
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[HTML] Spot urine sodium as a marker of urine dilution and decongestive abilities in acute heart failure
M Guzik, G Iwanek, M Fudim, R Zymliński, D Marciniak… - Scientific Reports, 2024
The decongestion ability in response to diuretic treatment plays a crucial role in the
treatment of acute heart failure. This effectiveness is evaluated through the
assessment of sodium concentration and urine volume, which are also treatment …
treatment of acute heart failure. This effectiveness is evaluated through the
assessment of sodium concentration and urine volume, which are also treatment …
| | | |
Treatment with dapagliflozin increases FGF-21 gene expression and reduces triglycerides content in myocardial tissue of genetically obese mice
A Di Vincenzo, M Crescenzi, M Granzotto, M Vecchiato… - Journal of Endocrinological …, 2024
Background The association between obesity and some cardiovascular
complications such as heart failure (HF) is well established, and drugs affecting
adiposity are supposed to be promising treatments for these conditions. The sodium …
complications such as heart failure (HF) is well established, and drugs affecting
adiposity are supposed to be promising treatments for these conditions. The sodium …
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Prediction of Cardiac Death in Patients with Hypertrophic Cardiomyopathy Using Plasma Adipokine Levels
K Akita, K Hasegawa, MA Fifer, A Tower-Rader, J Jung… - Nutrition, Metabolism and …
Abstract Backgrounds and Aims Hypertrophic cardiomyopathy (HCM) causes cardiac
death through both sudden cardiac death (SCD) and death due to heart failure (HF).
Although adipokines lead to adverse cardiac remodeling in HCM, the prognostic …
death through both sudden cardiac death (SCD) and death due to heart failure (HF).
Although adipokines lead to adverse cardiac remodeling in HCM, the prognostic …
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Seasonal variation in ambulatory blood pressure control in patients on clinic blood pressure-guided antihypertensive treatment
XF Ye, XY Wang, QF Huang, CS Sheng, Y Li, JG Wang - Journal of Hypertension, 2024
Background: We investigated seasonal variation in ambulatory blood pressure
control in hypertensive patients on clinic blood pressure-guided antihypertensive
treatment. Methods: The study participants were hypertensive patients enrolled in an …
control in hypertensive patients on clinic blood pressure-guided antihypertensive
treatment. Methods: The study participants were hypertensive patients enrolled in an …
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[PDF] Impact of sacubitril/valsartan on cardiac and systemic hypoxia in chronic heart failure
F Picard, A Cohen-Solal, D Logeart, N Launay
In heart failure patients with reduced ejection fraction, Sacubitril/valsartan (S/V)
increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via
miR-30a in vitro. Using a cohort of 73 HFrEF patients who were transitioned from …
increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via
miR-30a in vitro. Using a cohort of 73 HFrEF patients who were transitioned from …
| | | |
[PDF] Is Blood Pressure Measurement Performed During the Examination? Is it Standardized?
Ş Ulusoy - Hypertension (HT), 2024
Hypertension (HT) is one of the most important diseases encountered in our
professional lives and one with a number of particularly significant characteristics.
The first of these is its relatively high prevalence in the community. Although rates …
professional lives and one with a number of particularly significant characteristics.
The first of these is its relatively high prevalence in the community. Although rates …
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