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First things first: You may be asking yourself, "What is ketamine?" Well,
it was once used mainly as an anesthetic on battlefields and in operating
rooms. Now this medication is gaining ground as a promising treatment for
cases of major depression, which is the leading cause of disability
worldwide. In the US, recent estimates show 16 million adults had an
episode of major depression in the course of a year. Suicide rates rose
substantially between 1999 and 2016, increasing by more than 30% in 25
states. Because of its rapid action, ketamine could have a role to play in
helping to prevent suicide.

Why is ketamine exciting for treating depression?

When an individual responds to ketamine, it can rapidly reduce suicidality
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depression. Ketamine also can be effective for treating depression combined
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What you know about ketamine

A much lower dose of ketamine is given for depression compared with the
dose necessary for anesthesia.Like opioids, ketamine has addictive
properties. It’s important to understand this when weighing risks and
benefits. If you have a history of substance abuse –– such as alcohol or
drugs –– it’s especially important for you and your doctor to consider
whether ketamine is a good option for you.
When IV (racemic) ketamine works, people usually respond to it within one
to three infusions. If a person has no response at all, further infusions
are unlikely to help. Instead, it’s probably best to try other treatments
for depression.

People who experience some relief from depression within one to three
ketamine treatments are probably likely to extend these positive effects if
the treatment is repeated several more times. The subsequent sessions may
help prolong the effects of ketamine, rather than achieving further
dramatic relief of symptoms. There are no standard guidelines for this.
Many studies offer eight treatments initially (acute phase). After this,
patient and doctor decide whether to taper or stop ketamine treatments or
continue treatments at longer intervals.

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