router for stimulator

[kemal]

Hi Users,

I am trying to build my own stimulator setup with slight modifications. I am stucked at switching circuit to be placed between preamp and stimulator. I could not clearly get the solution in NeuroRighter schematics. I guess i should use a 60 channel switch to turn the preamp connection off when applying stimulation. Does anyone have an advice ?

Kemal,

Best 

[Jon Newman]

Hi Kemal,

We use and 8x8 array of analog muxes to deliver stimuli. This components, called 'stimulus modules' were a component of Daniel Wagenaar's RACS stimulation system. See the 'other PCBs' section of this page

https://sites.google.com/site/neurorighter/download-neurorighter-pcbs

You can get the design from Daniel. Additionally, if you search this mailing list, you will find a second design that has been provided by Jon Erickson, which also works nicely.

Jon

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Jonathan Newman

Postdoctoral Fellow, MIT

http://www.mit.edu/~jpnewman/

[Jon Erickson]

Kemal, 

Just to clarify,,are you talking about stimulus blanking circuitry, or just the standard stimulus modules Jon N. described in his reply?

On Wednesday, August 26, 2015, Jon Newman <jpne...@mit.edu> wrote:

Hi Kemal,

We use and 8x8 array of analog muxes to deliver stimuli. This components, called 'stimulus modules' were a component of Daniel Wagenaar's RACS stimulation system. See the 'other PCBs' section of this page

download neurorighter pcbs | neurorighter

You can get the design from Daniel. Additionally, if you search this mailing list, you will find a second design that has been provided by Jon Erickson, which also works nicely.

Jon

On Tue, Aug 25, 2015 at 4:00 PM, kemal <fkema...@gmail.com> wrote:

Hi Users,

I am trying to build my own stimulator setup with slight modifications. I am stucked at switching circuit to be placed between preamp and stimulator. I could not clearly get the solution in NeuroRighter schematics. I guess i should use a 60 channel switch to turn the preamp connection off when applying stimulation. Does anyone have an advice ?

Kemal,

Best 

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Jonathan Newman

Postdoctoral Fellow, MIT

http://www.mit.edu/~jpnewman/

[kemal]

Thanks, but i am using a plexon headstage and preamp for recording. So, i cannot adapt mentioned stimulus modules. I guess i should switch on and off the connection between headstage and preamp when recording and applying stimuli respectively.

I am intending to build a circuit of 4x16 analog muxes in a similar way with Wagenaar's. However i do not know how you switch between recording from and giving stimulus to an electrode (or more than one) ?

Best

[Jon Erickson]

At least with the mcs 1060 + neuro righter system I know and love, unless you have a stimulus blanking circuit, you will be simultaneously recording from all channels while stimulating a single one. This means you will record a huge stimulus artifact on the stimulus channel and smaller artifacts on non stimulus channels. Note that the salpa algorithm was designed to clean up the latter...typically can see spikes a few msec after stimulus delivery. 

[Riley Zeller-Townson]

Kemal - as Jon mentioned, NeuroRighter gets along fine by using a stimulation circuit that momentarily opens up the connection between the stimulus generator and the electrodes, while recording the entire time.  Thus, you don't need to add switches to turn off recording, though you will effectively need switches to turn on stimulation.  I've never used the plexon system before, however, so I can't speak to how well it will be able to hold up to recording a stimulus waveform. Figure 1b of Wagenaar's paper on RACS <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570177/pdf/nihms-50046.pdf> should be all the switching you need.  

--

Riley Zeller-Townson

PhD student, Potter lab

Laboratory for Neuroengineering

Georgia Tech/Emory University

Atlanta, GA, USA

[kemal]

Hi,

Besides the stimulation artifacts when simultaneously recording, i am also concerned with the fact that whether i might harm the amplifier or not - if i apply for instance a 1 volt peak to peak biphasic voltage stimulus having 1 msec period ?
Because it is a huge amplitude compared to spike or lfp levels as well as its frequency spectrum coincides with the preamp's bandwidth. So, shouldn't i add a switch ?

Best


25 Ağustos 2015 Salı 23:00:22 UTC+3 tarihinde kemal yazdı:

[Riley Zeller-Townson]

That will depend on your preamp.  I suggest looking at the specs, or call up support at plexon and see if you can find a maximum range for safe operation.  With the MCS preamps, applying a standard stimulus waveforms (1 vpp, for instance) to the electrodes while the preamp is connected has never been a problem, so I anticipate you should be fine, but definitely check first!

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[kemal]

 Hi,

 I would like to thank for all your contributions.
 I sould check plexon preamp's specs right now.

 Best,

 Kemal

25 Ağustos 2015 Salı 23:00:22 UTC+3 tarihinde kemal yazdı:

Hi Users,