Non-event based synaptic mechanism with NetPyNE

[Ernest Ho]

Hi,

I am just wondering if there is any way we can implement a synaptic mechanism on NetPyNE which is *not* based on discrete spike events of the pre-synaptic neurons, but rather on continuous variables such as pre-synaptic intracellular calcium concentration or pre-synaptic membrane potential? 

Thus, the mechanism is not going to have discrete triggers, but may have some sort of logistic functions to continuously update post-synpatic potentials based on what is happening pre-synaptically.

In NEURON parlance, we want to use POINTER in NMODL instead of netcon and  NET_RECEIVE.  How do we make that happen in NetPyNE?

Thanks,

Ernest

[Joe Graham]

Hi Ernest,

While NetPyNE doesn't currently have the ability to deal with synapses for continuous variables, anything that can be done in NEURON can be done in NetPyNE.  You can always modify your simulation after creating it by finding the appropriate NEURON objects in `sim.net`.

If you could share a functional example in NEURON of what you're trying to do, I'd be happy to help you get it working in NetPyNE.

Best wishes,

Joe