Well firstly, for security you should run it as a non-root user.
"DO NOT USE THIS SERVER IN A PRODUCTION SETTING. It has not gone through security audits or performance tests. (And that’s how it’s gonna stay. We’re in the business of making Web frameworks, not Web servers, so improving this server to be able to handle a production environment is outside the scope of Django.)"
Making a systemd service is a sensible thing to do, so I'd just follow what /etc/supervisor/conf.d/netbox.conf does:
[program:netbox]
command = gunicorn -c /opt/netbox/gunicorn_config.py netbox.wsgi
directory = /opt/netbox/netbox/
user = www-data