Actually, pin 22 is HVOUT1 and 23 is data out. This
might produce some whoopsies. Generally, a freshly soldered PCB shouldn't arc even at full 220 VDC, but as time passes, moisture and dust accumulates and increases the chance for current leaking into low voltage section. It's an oversight in my opinion, there are empty pins, so there could easily be an NC pin between all HV and LV pins.
For the less-than-desirable section - I am not super knowledgeable in the Microchip portfolio, but the 1 mA parts listed above are a good start.
I personally would put the classic 74141 in this section, but I guess that being a nixie specific part it does not deserve such harsh treatment. I'd add a note about up to 25 mA current draw of one in the paragraph about this part, as for a direct drive 6 digit clock this totals to a significant amount.