Some time ago I read that it would be good practice to let each
cathode lit at maximum rated current for about 2 minutes, I can't find
that page no more so I am not too sure about the reasoning behind it.
If metal sputters are a cause of the problem, it could more likely
show up in these first 2 minutes of maximum drive I guess.
Putting the tubes in sockets would be an advantage in this case. I am
actually surprised how easy it is to change a faulty (or broken) tube,
it takes less effort than I had expected. It's quite easy to heat up
all the legs together, take the tube out and then use some wick to
empty the holes. Crucial here is to use a solder that has lots of
flux. My board setup is different from yours, so sockets would simply
not fit.
Michel