Conjecture / Kaposi's / linoleic acid / lipid liposome?

[ironj...@aol.com]

http://tinyurl.com/4cop8

Induced iron overload / hemosiderosis leads to hyperpigmentation of the
skin and in every other disease in which hyperpigmentation arises .. it
is treated with metal binding drugs / substances .. IE: kojic acid ,
resveratrol ,

In hemosiderosis induced pigmentation linoleic acid is used with
efficacy.

The ability of the body to use a 'drug' ... when .. 'topically' applied
is ENHANCED when the 'drug' is encapsulated in a lipid liposome ..

http://tinyurl.com/6grrt

Would / could linoleic acid BE .. 'natures own' .. lipid liposome .. AS
.. its' .. mode of operation .. ?
Could ? linoleic acid be ALREADY .. containing one of the synonyms ..
below ..?

Sodium phytate -

http://129.186.85.49/PathBinderH/pbout.php?term1=109402&term2=81496

Term 2: 'Calcium Phytate'
Synonyms included in the search: Inositol Hexakisphosphate, Inositol
Hexaphosphate, Phytate, Phytic Acid, Phytin, Sodium Phytate

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

[ironj...@aol.com]

The substance below just may well BE 'the' substance 'at work' in the
skin whitening effect of linoleic acid .. ?
Since phytic acid is present in most if not all vegetables / oils /
plants .. ?
So does linoleic acid form somewhat of a lipid liposome to fascilitate
the phytic acids entry to DO .. what .. it .. does .. ?
Form an iron chelate and therefore in theory may ALSO be able to enter
the body and form iron chelates and AGAIN .. now .. inhibit .. cancer
.. ?

Biochem J. 1993 Sep 15;294 ( Pt 3):929-34. Related Articles, Links

Inhibition of iron-catalysed hydroxyl radical formation by inositol
polyphosphates: a possible physiological function for myo-inositol
hexakisphosphate.

Hawkins PT, Poyner DR, Jackson TR, Letcher AJ, Lander DA, Irvine RF.

Department of Biochemistry, AFRC Institute of Animal Physiology and
Genetics Research, Babraham, Cambridge, U.K.

1. The ability of myo-inositol polyphosphates to inhibit iron-catalysed
hydroxyl radical formation was studied in a hypoxanthine/xanthine
oxidase system [Graf, Empson and Eaton (1987) J. Biol. Chem. 262,
11647-11650]. Fe3+ present in the assay reagents supported some radical
formation, and a standard assay, with 5 microM Fe3+ added, was used to
investigate the specificity of compounds which could inhibit radical
generation. 2. InsP6 (phytic acid) was able to inhibit radical
formation in this assay completely. In this respect it was similar to
the effects of the high affinity Fe3+ chelator Desferral, and
dissimilar to the effects of EDTA which, even at high concentrations,
still allowed detectable radical formation to take place. 3. The six
isomers of InsP5 were purified from an alkaline hydrolysate of InsP6
(four of them as two enantiomeric mixtures), and they were compared
with InsP6 in this assay. Ins(1,2,3,4,6)P5 and D/L-Ins(1,2,3,4,5)P5
were similar to InsP6 in that they caused a complete inhibition of
iron-catalysed radical formation at > 30 microM. Ins(1,3,4,5,6)P5 and
D/L-Ins(1,2,4,5,6)P5, however, were markedly less potent than InsP6,
and did not inhibit radical formation completely; even when
Ins(1,3,4,5,6)P5 was added up to 600 microM, significant radical
formation was still detected. Thus InsP5s lacking 2 or 1/3 phosphates
are in this respect qualitatively different from InsP6 and the other
InsP5s. 4. scyllo-Inositol hexakisphosphate was also tested, and
although it caused a greater inhibition than Ins(1,3,4,5,6)P5, it too
still allowed detectable free radical formation even at 600 microM. 5.
We conclude that the 1,2,3 (equatorial-axial-equatorial) phosphate
grouping in InsP6 has a conformation that uniquely provides a specific
interaction with iron to inhibit totally its ability to catalyse
hydroxyl radical formation; we suggest that a physiological function of
InsP6 might be to act as a 'safe' binding site for iron during its
transport through the cytosol or cellular organelles.

PMID: 8379947 [PubMed - indexed for MEDLINE]

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