Both of my Macs running different OS versions and playing to different DAC's seem to have decided to emulate vinyl and are making faint pops and crackles. Mac #1 is my media server 2011 Mac Mini, upgraded with a 2TB SSD, running OS 10.13.6 and outputting from iTunes a saved ALAC file to PCM via USB-2 at 192kHz/24 bit to a Benchmark Media DAC-2L. One Album I really noticed this on was a recent recording from Hyperion, Homage to Godowsky which is quite quiet piano music. The problem is not in the DAC or the Krell Vanguard integrated amp, as I don't get the crackling on different digital sources. Just last night, I noticed I seem to be getting similar pops and crackles on Mac #2, my 2016 MacBook Pro, running OS 10.15.4. This time outputting from Music (the wrecked updated version of iTunes) via USB-C at 176 kHz/24 bit to a Chord Hugo 2 and then to Beyerdynamic T5P phones. This time I was streaming on Apple Music: Krystoff Penderecki Resurrection Piano Concerto.
"Icecast is a streaming media (audio/video) server which currently supports Ogg (Vorbis and Theora), Opus, WebM and MP3 streams.It can be used to create an Internet radio station or a privately running jukebox and many things in between. It is very versatile in that new formats can be added relatively easily and supports open standards for communication and interaction."
Construction of secretory cassettes of signal peptides and propeptide (SPK1-LEISS or SPKM19-LEISS) fused to target genes, (A) KRAS 68V-DTD or (B) wild-type KRAS (wtKRAS). The 9-residue anionic linker, LEISSTCDA, was placed immediately downstream of the C-terminal cleavage site of SPK1 to preserve the net negative charge of the first 10 MP protein as well as an enhancer for secretion. A six-histidine (6-His) tagged sequence was included at the C-terminal ends of target genes for protein detection. The REs (NcoI, KpnI, and SacI) used for directional cloning of the genes are shown.
My advice is moving to other operating systems (BSDs are all great, with OpenBSD and FreeBSD being the best in my humble opinion, Linux is a great choice too). If you want to run unpatched Windows workstations and servers I would suggest placing them in an air-gapped network. If energy-gapping is required for your projects then Windows is certainly not for you. Windows is ok for controlling some hardware that is not supported by other operating systems, and may be ok for running some tools that do not exist on other platforms, but it is certainly something I would not expose to the wild Internet, specially if patches are not being installed.