Once a respected and brilliant cryogenicist, Dr. Victor Fries turned to a life of crime after his wife, Nora Fries, whom Victor had cryogenically froze to develop enough time to create a cure for her rare illness, was stolen away from him by his corrupt CEO, Ferris Boyle. In the confusion, Fries was drenched in the cryogenic chemicals that he had created to freeze Nora, which changed his metabolism. The result was Mr. Freeze, a cold-blooded villain who was motivated by the desire to save and cure his wife and kill anyone who would stand in his way.
On New Years Eve, Freeze eventually got his opportunity for revenge against his former employer, and allied himself with the criminal kingpin, the Penguin, and his gang with the promise of supplying them with cryogenic weapons. Though Boyle was eventually arrested and Nora was saved by Batman, Freeze regarded the hero as an adversary for stopping his revenge against Boyle and sending him to Arkham Island.
Continuing in his plans and attempts to cure his wife through crime over the years, Freeze rarely worked with other villains unless it furthered his research to save Nora. Within the confines of Arkham City, Freeze was blackmailed to perform the will of both the Joker and Hugo Strange under the threat of his wife's death. While he used his medical expertise to reluctantly aid those villains, Freeze's cold and dark rage only amplified as he made his own plans for revenge and ensure Nora's safety.
As a child, Victor Fries had an interest in cryogenics and a kind heart as well. He could not understand why people let their pets die when they could be preserved until a cure could be found for their diseases. As a result, Victor began to freeze the neighborhood pets, which lead to his parents to believe him to be mentally disturbed, and they sent him away to a reform school for help.
Victor discovered that Nora suffered from the terminal illness known as Huntington's Chorea. Desperate to save his wife, Victor placed Nora into cryogenic stasis. Ferris Boyle, his boss, learned of that and became interested in how he managed to successfully place her into cryogenic stasis. He then offered Victor a deal: Victor could work on GothCorp's secret cryogenic weapons program, and, in exchange, Ferris would fund a cure for Huntington's Chorea to save Nora.
Victor accepted the deal and began research for Boyle. Eventually, Victor discovered that Boyle had absolutely no intention of actually fulfilling his end of the bargain, so Victor decided to take matters into his own hands, and proceeded to secretly conduct his own research on the cure. During that time, Victor deprived himself of food and even sleep just to find a cure for Nora. Boyle eventually discovered that (ironically during the one time that Victor allowed himself to rest deeply enough to dream) and confronted Victor in his lab with accusations of corporate espionage, where he and his guards beat him and took Nora's capsule away. In the ensuing struggle, Victor and one of the security guards knocked over a prototype Cryogenic Cannon, which killed the other guard in the process. The resulting cryo vapors from the blast caused a chain reaction that caused the storage tank for the cryogenic chemicals to explode, which doused Victor and the surviving guard in the chemicals, and forced Boyle to flee the lab, leaving them for dead.
The chemicals that Victor and the guard were exposed to changed their metabolism. As a result, their bodies needed to be kept at subzero temperatures in order to survive. The guard attacked Fries and fled the lab, but his new physiology caused him to overheat and he died of a heat stroke in the normal room temperature. A dazed Victor witnessed the guard's death and realized that leaving his lab would be fatal, so he built a suit out of various prototypes in his lab in order to keep his core temperature at subzero.
Some time later, Freeze ended up allying himself with a gang that belonged to Oswald Cobblepot, better known as The Penguin, and promised them cryogenic weapons in exchange for their aid in capturing Boyle and helping him gain access to the GothCorp Cryogenics Lab. Freeze, alongside Penguin's Henchmen, stormed Wayne Manor during a presentation ceremony for Boyle on New Year's Eve and captured him. During that time, Freeze also froze Batman with enough cryogenic fluid to stun him, as he had no quarrel against him.
Upon reaching the Propellant Research Wing, Freeze got into an argument with Penguin, as Penguin wanted access to the lab in the belief that there were more powerful weapons in there. When Batman proceeded to encounter Freeze there, Freeze held Boyle hostage, and then proceeded to freeze the area into a thick sheet of ice, which encased the Penguin, and also cited that Batman's threats meant nothing to him, as he had "lost everything." Freeze then told Boyle to supply him with the security codes for Nora. When Boyle refused, he threatened to freeze him so that he could experience Nora's fate.
Wearing a new prototype XE Suit that was designed for extreme cold, Batman eventually caught up with the two men, and informed Freeze that he knew the truth about what Boyle did to him (having investigated the quarantined lab earlier while searching for components for a cryodrill to access the lab), tried to talk him out of committing more crimes as innocent people were getting hurt by his actions, and tried to tell him that Nora would not have wanted him to commit such actions. Fries considered Batman's words, but then decided to fight him instead, stated that his own emotions had been frozen from the same accident, and because Batman fought against him.
Batman overloaded the generators for Nora's tank, while Freeze froze the air and confronted Batman in the room. Throughout the battle, Nora's tank began reaching critical power due to the damage sustained earlier, which forced Freeze to break off from his attack on Batman in an attempt to save her. Batman sneaked up from underneath Freeze and disabled him, only for Boyle to take advantage of Freeze's battered condition to blast Batman with the Cryogenic Cannon, and intended to frame Freeze for everything.
Although Freeze attempted desperately to bargain with Boyle to save Nora, Boyle taunted him with letting him live long enough to see her go before he beat him with a pipe that he broke off from his suit. Breaking free of the ice, Batman managed to knock Boyle out, as well as told the former humanitarian to "take a seat" in disgust. After he restored power to Nora's capsule, Batman restored Freeze's suit, and also apologized to him for not giving him peace, and cited that he could, at least, give him justice. Freeze then ended up arrested alongside Boyle and Penguin, although he was imprisoned at Gotham General on watch, due to his severe condition. Freeze's condition acted as another reason for the reopening of Arkham Asylum.
Although he did not appear in the game himself, Freeze's Cell, which was in the same wing as Arkham's most deranged cases, could be seen at the Penitentiary at Arkham Asylum. The cell was scanned to unlock Freeze's biography, which revealed that he had escaped prior to the game and was also one of the Riddler's Riddles.
In Arkham City, Freeze was ultimately negotiated into entering the anarchist prison that was built right in the heart of Gotham City by Professor Hugo Strange under the promise of being incarcerated with Nora. Strange had taken Nora away from her previous location in order to entice Freeze to escape his holding cell within Arkham Asylum, but promised him the tools that he needed to cure her that were all arranged within the abandoned labs in the old GCPD Building at Amusement Mile. In return, Freeze developed a near limitless supply of medical serums for Strange to use within his inhumane experiments in the prison facility to research additional means of dominating the human brain and control the minds of select inmates in order to transform them into the TYGER Guards, the security force that patrolled Arkham City. However, with Nora nowhere in sight after several days, Freeze realized that Strange had used him and planned to storm Wonder Tower, Strange's base that overlooked the prison city, only to be captured by TYGER upon exiting the old GCPD Building.
Freeze then had his weapons confiscated, although not his suit, by the time that they reached Wonder Tower under Strange's orders. Strange commenced a meeting with Freeze due to their having "much in common," much to his TYGER Guard's hesitance, as they feared that he would still be dangerous as they didn't get a chance to remove his suit. Freeze was then brought in, who preferred to stand, and demanded to know why Strange had brought him to the prison. Strange replied that he wanted to know why Freeze had developed such a "frosty outlook" on life, but Freeze, already resentful that Strange had captured him, refused to answer, cited how his own suit was dangerous even without his weapons, and threatened to freeze the bone marrow of his legs and leave him in a presumably painful state of paralysis.
Strange, however, smugly told Victor that he wouldn't risk that, and revealed the reason why he wouldn't was because he had Nora in his custody, and then proceeded to give a threat that he would arrange for her death if Freeze attempted to harm him. Freeze then demanded for Nora's location, though Strange danced away from the question and tried to ask about his childhood. Freeze reluctantly explained his past after Strange proceeded to call a guard when he attempted to refuse, with Strange also inferred that Freeze was selfish and did not own up to his actions. Strange concluded the meeting by informing Freeze that he had delivered Nora to The Joker to be used as collateral to create a cure for his Titan blood poisoning, much to the former scientist's horror.
Strange eventually handed Freeze and his various equipment over to The Penguin and his henchmen, as Strange had everything that he needed from Victor and planned to additionally remove Joker as an obstacle in his plans by destroying the only known path towards any potential cure for the Titan Disease. Outnumbered and deprived of his suit and weapons, Freeze was easily overpowered by Penguin's Henchmen and was locked up within Cobblepot's sadistic Museum and base of operations in the Bowery.
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