Hi,
Yes, it is possible. There is an example of this under "voronoi tesselation" on the
examples page, that includes that command with grains. To visualize it, you can plot exchcoupling either in the GUI, or save it to an OVF. You can also look to B_exch or Edens_exch.
In mumax3, exchange only affects nearest neighbors, so generally speaking it is sufficient to just change the coupling between regions(grains). However, in my past experience, simply lowering/turning off exchange may not decouple the grains as strongly as you might expect at first guess(there are still external fields, as well as magnetostatic interactions, intra grain exchange etc). Especially if there is not a lot of domain wall nucleation. Defects or varying parameters slightly between grains can help with this a bit.
However, you might find the new ext_grainboundaries feature useful if you want to create explicit grainboundary regions. There is an example
here. Whether it is 'better' I think depends on what experimental system you're trying to model, but it may help.
Best,
Josh L.