M-vroc Viscometer

[Lane Stefano]

m-VROC II is the next generation of leading semi-automated, small sample viscometer. Capable of the most demanding applications including small sample protein therapeutics, m-VROC II features the widest dynamic range viscosity measurement with as little as 10 microliters of sample. The m-VROC II allows you to get the most out of your samples with the ability to retest and reuse a single sample for multiple measurements.

With VROC Technology, RheoSense took the standard principles of rheometry and created a dynamic micro-sample viscometer by adding microfluidics while reducing the size of the device with MEMS (micro-electrical mechanical systems) manufacturing. The result was a new platform which offers capabilities that are well beyond the limits of conventional viscometers in not only the sample volumes required, but the measurement range and precision.

Our all inclusive support package covers four chip repairs or calibrations, an onsite inspection of your instrument, three onsite visits, unlimited remote support, and unlimited mail in repairs for your instrument.

Our mid-tier support package covers two chip repairs or calibrations, an onsite inspection of your instrument, two onsite and remote training sessions, and unlimited mail in repairs to your instrument.

Our viscometers have redefined the way viscosity is measured with the benefit of VROC technology. All RheoSense viscometers require only small sample volume, control from low to very high shear rates, and measure true viscosity of Newtonian and non-Newtonian liquids. Select your viscometer! Let's dig into the details.

LinkedIn and 3rd parties use essential and non-essential cookies to provide, secure, analyze and improve our Services, and to show you relevant ads (including professional and job ads) on and off LinkedIn. Learn more in our Cookie Policy.

We're still not out of the pandemic, but it's time to slowly return back to your lab. It may not be an everyday in person thing but you are now responsible for setting up all of your equipment and you need to start running experiments.

You recently purchased a RheoSense m-VROC, a small sample viscometer. With the optional temperature controller that enables you to control temperatures between 4 - 70 C, you may have received one to two shipment boxes roughly around 24" x 18" x 16" to 17" x 17" x 17". Unbox the viscometer and water bath.

m-VROC should be in the 24" box and you should keep the custom made foam and ideally the shipping box in the future for shipping back for service or recalibration. Take the foam out and set your viscometer on a leveled lab bench with at least two plugs (ideally three - the third for your laptop) readily available to use on the lab wall. If you have the optional temperature controller, please open the 17" box and set the water bath on the equal level as your viscometer. We also recommend keeping the custom foam and box for any future shipments. (For customers who do not prefer this, we also do sell the packaging in the future if ever needed).

The viscometer and temperature controller will each need a plug to start. Make sure they are plugged in and use a acceptable lab computer (ideally Windows 10) to install and navigate the software. (Visit our customer portal for access to latest release notes and more goodies).

The syringe jacket may need to be installed in the viscometer itself but don't worry, it comes with the tool (like Ikea furniture) and instructions can be found on the manual - it's definitely easier than putting together furniture, don't worry. Once the syringe jacket is on, you can connect your chip and turn on the unit. A successful connection with your viscometer and laptop should be indicated on the software and will allow you to input measurement parameters to begin your sample testing.

Load your sample using a new syringe and peek union and needle (twisted on to your syringe). Once successfully drawn, make sure your syringe doesn't show any visible bubbles by tilting the syringe vertically and flipping it. Once the sample is ready, carefully insert the syringe into the chip inlet and twist the syringe into place. When properly installed, the syringe should sit quite nicely in the syringe jacket. Lock the black pusher block on the right side of the pump THEN open the chip valve by turning the valve to the left and close the syringe jacket. (It is important to do in this order).

August 18, 2009 - RheoSense introduce the m-VROC viscometer, an enclosed system complete with all the required hardware providing a high degree of accuracy and reproducibility.The m-VROC requires the smallest sample volume of 50 microliter which is the target for protein and other biological formulations.The unit is very user friendly and easy to set up and the portable design allows the system to be implemented on or off the process line.An improved, optional temperature-control (via an external circulating water bath) is provided. An optional purge air supply (connected through an external source) prevents condensation inside the chamber when operating at low temperatures.With the versatility of a wide measurement range (0.1 to 100k cP viscosity) and high shear rates, the m-VROC is capable of analyzing virtually any liquid viscosity value. The m-VROC will meet the stringent R&D or QC requirements of most applications.

The m-VROCTM is offered in four sensor specifications (A, B, C, and D) to maximize the viscosity range for scientists and engineers with varying viscosity measurement needs. The B sensor is our general use viscometer. Our A, C, and D sensors are designed for more specialized applications.

m-VROCTM characterizes rheological properties of liquids, enabling cost-effective flow management through smart process quantification. Flow management through viscosity measurement is essential in the production of various complex liquids. Our technology quantifies "true" flow properties, whereas many existing products give a qualitative indication of "apparent" properties.

Founded in 2001, we have become the leader in biotechnology, pharmaceutical, and the emerging protein therapeutics industries. RheoSense instruments have been rigorously tested, approved, and adopted worldwide by Fortune Global 500 companies and leading research universities.

VROC initium is the leading automatic viscometer that measures true viscosity with the highest accuracy and repeatability. Its superior resolution makes it possible to measure hydrodynamic size and to quantify particle-particle interactions and protein stability

The m-VROC II is the next generation of leading automated microfluidic viscometer. Capable of the most demanding applications including small sample protein therapeutics, m-VROC II features the widest dynamic range (high shear rate viscosity measurements up to 2,020,000 s-1) with as little as 15 microliters of sample.

The second generation m-VROC also measures viscosity with the highest accuracy (2% of reading) and repeatability (0.5% of reading), but is now equipped with sample retrieval and recovery. Sample retrieval refers to the reversal of flow to refill the test syringe with a portion of the loaded volume. The retrieval process allows for more extensive testing on a single loaded sample volume which can include multiple repeats, shear rates, and temperatures. Sample recovery involves a final retrieval of the entire volume back into the test syringe so that the sample can be retained for further testing.

The measuring cell contains a rectangular slit flow channel constructed of borosilicate glass, with a uniform cross-sectional area. The sample is injected at a constant flow rate though the flow channel where multiple pressure sensors mounted within the base monitor the pressure drop from the inlet to the outlet. The pressure drop is correlated with the shear-stress at the boundary wall. The shear rate and shear stress are directly related to the geometry of the rectangular slit and the flow rate which allow for viscosity measurements.

Unlike the previous model, the m-VROC II does not require any external temperature control device, since the temperature is controlled in the cell block and chip using a Peltier thermal regulator. The instrument also is supplied with a chip cleaning station, so you can clean the chips quite fast and easy.

The m-VROC II comes equipped with an intuitive software, allowing users to easily save and load protocols, perform shear rate and temperature sweeps, export data into PDF/Excel, and apply non-Newtonian corrections with the push of a button. This software is also 21 CFR part 11 compliant, providing multi-level user access (standard user, IT admin, super admin etc.) and ensuring data integrity, preventing users from potentially manipulating your data.

Understanding the viscosity is a crucial aspect of manufacturing operations in many industries worldwide. In order to fulfill customer demands of product consistency and quality, viscosity measurement becomes even more important.

Additional problems are that current viscometers require larger amount of sample volume and limited to narrow shear rates. Larger volume requirements make viscosity measurement very difficult for precious samples and even larger volume of cleaning solution needs to be consumed after test. Limited (or no) shear rate accessibility from these viscometers makes it impossible to characterize properly the liquid flow behavior during fast processes such as printing, coating, inkjetting, and spraying.

In addition to the ability of measuring true viscosity, small measuring cell of VROC enables viscosity measurement for small sample volume (as small as 50 microliters) and viscosity measurement at high shear rates. The VROC chip has been used to measure wide range of liquids and viscosities.

Pharmaceutical companies have increasingly focused on developing high-concentration protein therapeutics that enable patients to treat themselves at home by self injection. However, the formulation of therapeutic proteins has many challenges.

3a8082e126