Hi,
8 voices, with only an oscillator each should be no problem at all for an RP2040 running Mozzi. I have already made synths on similar chips (STM32 bluepill, which is single core, but around the same clock speed) with something like 16 voices, 4 osc each, and filters. The DAC might not be the best you could get for your money. RP2040 has native support for I2S (audio) DAC natively, there are a number of chips around there that should provide you 16bits audio for quite cheap (I think people have tried to work with the vs1053, I have been using PT8211 for now).
> I want to use a bit higher audio rate like 65khz
Support for this in Mozzi is still experimental, the default on this platform is 32k but nothing prevents it in theory.
Good luck with your project!