Metastases remain the leading cause of cancer-related mortality. The oligometastasis hypothesis postulates that a spectrum of metastatic spread exists and that some patients with a limited burden of metastases can be cured with ablative therapy. Over the past decade, substantial advances in systemic therapies have resulted in considerable improvements in the outcomes of patients with metastatic cancers, warranting re-examination of the oligometastatic paradigm and the role of local ablative therapies within the context of the improved therapeutic responses, shifting patterns of disease recurrence and possible synergy with systemic treatments. Herein, we reframe the oligometastatic phenotype as a dynamic state for which locally ablative, metastasis-directed therapy improves clinical outcomes, including by prolonging survival and increasing cure rates. Important risk factors defining the metastatic spectrum are highlighted that inform both staging and therapy. Finally, we synthesize the literature on combining local therapies with modern systemic treatments, identifying general themes to optimally integrate ablative therapies in this context.
Basket making is among one of the oldest crafts practiced by Native peoples, including the Salish, Pend d'Oreille, and Kootenai. From historic through modern times, basket making is an artistic expression as well as a practical item used to carry just about anything. At the Maker Truck, visitors explore how to make a cedar bark basket without actually using cedar bark. With special guest role model and tribal elder Eva Boyd, students also explore how to make a Sally Bag.
Standardized octave and one-third octave bands are ubiquitous in modern acoustical measurements, such that the particular way they divide the spectrum might reasonably be assumed to be self-evident. Yet when Hans Thilo was granted the patent for the first octave band analyzer in 1937, this division was anything but certain. In the ensuing years, many systems proliferated, with different center frequencies employed between airborne noise and vibration, source and absorption measurements, and even American and European practitioners. This presentation traces the multiple systems in play from Wallace Sabine's early experiments with organ pipes up through the dominant standard today based upon preferred numbers. Though the large majority of these systems have long since been abandoned, their ghosts are still occasionally encountered, haunting compliance studies beholden to legacy noise ordinances, and muddling the definitions of metrics such as speech interference level (SIL), which were originally defined using older octave bands.
The History Program at Winston-Salem State University is designed to inspire and challenge students to critically evaluate the world around them and to explain the complexity and diversity of human experiences, activities, affairs, ideas, and institutions over time. This experience and knowledge is necessary to understand the world as it has been shaped in the present and to plan for the future, as history opens up the entirety of documented human experience. Students in the history program use their knowledge of the past to engage with the world around them through research, analysis, and communication in order to create a new generation of informed and critically thinking citizens committed to social justice and equity and well able to express that commitment. To further this end, the history curriculum offers a wide spectrum of courses in African American, U.S., Africa and the African Diaspora, Europe, and wider world history; in the pre-modern and modern eras; in cultural, economic, intellectual, political, religious and social history; and in the specialized areas of applied history, the history of war and society, urban history, and the history of science.
Studying history at Winston-Salem State means reading, writing, working with others in a supportive academic environment, inside and outside the classroom. It means understanding the past, present, and future through both traditional historical methodology, and theories, and interdisciplinary means as well. History students here do scholarly research, develop written and verbal communication skills, and are able to understand issues that affect the world around us and to not only think about those issues critically but also to communicate those thoughts to others.
The history program prepares graduates to pursue graduate studies in a variety of fields such as history, divinity, law, and education. Additionally, our program provides all students with analytical skills necessary for a wide range of jobs and occupations. Many history majors have gone on to successful careers as journalists, writers, and many other creative and professional occupations. A history major teaches the student to empathize and understand how people in the past lived, thought, and acted across a wide spectrum of cultures, and as such instills empathy and creativity, which are important to many fields.
Our Special Fields involve the application of the full spectrum of core historical competencies within a narrower field of study. In this sense, they are designed to prepare you to undertake independent research for yourself by showing you how practicing historians work with sources, historiographies, methodologies, and concepts within a particular specialism.
Hong Kong has often been understood as an 'in-between' place at the edge of Britain and China, its past and present sovereigns. But can we understand this city beyond the edge of two empires, and as something more than an 'in-between' place? Exploring the history of Hong Kong from the early 1800s to the present day, this unit offers new avenues in understanding the city, by situating it within the frameworks of urban and global history. The overall aim of this unit is to understand key issues in the modern history of Hong Kong, and its place in the globalising world. We will analyse how international socio-political trends shaped the city's urban landscape, public debates, identity politics, economic development, and civil society. We will also examine how the city played a key role in global networks of migration, trade, and information, and the active agency of its multiracial population in such networks.
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