Q
How to convert a library of linear precursors into a library of macrocycles?
A.
Sketch the reaction in the
molecule editor with a special bond (dotted) which means
anything between R1-R2
![](https://groups.google.com/group/molsoft-icm-forum/attach/8b1f47b09c942/Auto%20Generated%20Inline%20Image%201?part=0.1&view=1)
- The bond can be added using 'Distance Bond' tool in the editor.
-
Save the reaction to a chemical table
- Read in your precursors sdf file
- Then you can just apply this reaction (Right Click on the reaction and select Apply Reaction)
to your data.
- A new chemical table will be made containing the macrocycles.