That can happen momentarily when a graceful restart of Apache is done as Apache allows the child worker processes which are proxying requests to mod_wgsi daemon processes to hang around until all requests on a HTTP connection are handled.
It comes about because the socket path has a generation number in it. Every time you restart Apache the generation number goes up one. Thus an older child worker created for a prior generation will be trying to connect to a socket path which no longer exists, because the mod_wsgi daemon processes for that older generation have been killed and replaced with those corresponding to next generation.
This is a self protection mechanism to ensure that old child worker process that still haven't been killed and which are running against Apache configuration for an older generation, are not able to connect to daemon process running with a newer Apache configuration. Allowing them to would produce undefined results, errors or potential security issues.
Thus, so long as transitory, it is normal.
Can you confirm whether do a graceful restart of Apache?
It could also happen with a normal restart, but you would have to be quite lucky for it to happen in that case.
Graham