Running:
sudo systemctl disable apache2
should be fine and enough to stop it running.
When using mod_wsgi-express you aren't relying on the existing Apache instance for the system to be running, only that the Apache packages are installed. That is, is uses the same Apache binary, include files, libraries and modules, but not the same Apache configuration. So unless you use the system Apache for some other reason, you should disable it in systemd so it doesn't start. Just do not uninstall the Apache using apt-get.
Graham