Don’t use mod_wsgi-standalone package on PyPi. That is a special case variant of the mod_wsgi package that also installs its own Apache, you don’t need that. Use ‘pip install mod_wsgi’ instead and they will all use the existing Apache installation. None of them modify the original Apache installation as a separate configuration is generated each time you run mod_wsgi-express. So just run ‘pip install mod_wsgi’ into the virtual environments for the different Python versions you want.
As to integrating with the main Apache on a system, you run each mod_wsgi-express instance you want, and then set up the main Apache installation to proxy to each. Thus the main Apache accepts the requests first for everything.
For details on setting up proxy (ignore that mentions docker), see:
As to having the separate mod_wsgi-express instances run as daemons, see section 'Running mod_wsgi-express as root’ in:
This explains how you can generate a script for running as managed daemon. You then need to integrate execution of that into whatever startup system your operating system uses. Eg., systemd, init.d etc.