We also use (Google) Rich Snippets and this could be a problem.
…
<img name="mainphoto" pagespeed_lazy_src="/images/medium/product_10755_0.jpg" width="450" height="450" border="0" alt="Mukti Cleansing lotion - Dry, Mature, Sensitive Skin" itemprop="image" pagespeed_url_hash="230086851" src="/spacer.gif" onload="pagespeed.lazyLoadImages.loadIfVisible(this);">
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</div>
Note that for this particular example this is only a problem while the beacon is being called and not on later requests. Because the image is above the fold it is not tagged for lazy_load on subsequent requests. Any tagged images below the fold would be read incorrectly every time.
Matt, these 'microdata' attributes are read by Googlebot and other spiders during their normal spidering process. The best solution is probably to be able to skip images that have the itemprop attribute.