EMF RAPID and immune deficiency/Leukemia explains role of Bruton's Kinase activity

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Jul 7, 2008, 3:32:54 AM7/7/08
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SUBJECT: PROTEIN KINASES....WIRING PATTERN OF CELL SIGNALING
NETWORKS...2005

Dr. Fatih Uckun's very important results re EMF RAPID and immune
deficiency/Leukemia explains role of Bruton's Kinase activity.

Blood from my two grandsons diagnosed with "rare immune deficiencies"
(low IgG subclasses 1 and 3 - "no ICDM Code name" - my opinion:
"Acquired Immune Deficiency due to Toxic Electric Field Exposure" but
since can not use "AIDS," believe diagnosis should be labeled "Reactive
Immune Deficiency," was sent to Dr. Fatih Uckun on two separate
occasions. Dr. Uckun left the University of Minnesota soon after
completing his EMF RAPID work, and founded the Wayne Hughes Research
Institute with help from the NIH and DOD.

It is apparent from the study copied below that proteins can not carry
out their intended functions when signaling is continuously affected by
close, chronic, prolonged electric field exposures.

Take care - Joanne

Joanne C. Mueller
Guinea Pigs "R" Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota 55448-2127 USA
Phone: 763-755-6114
Email: jcmpe...@aol.com <mailto:jcmpe...@aol.com> (7-07-08)

WEBSITE: http://guineapigsrus.org

ARE YOU AND YOUR CHILDREN GUINEA PIGS? Letter 7-22-04 by Joanne Mueller
http://omega.twoday.net/stories/282050/



* * *

------------------------------------------------------------------------
From: JCMPelican
To: JCMPelican
Sent: 7/6/2008 1:59:32 P.M. Central Daylight Time
Subj: PROTEIN KINASES....wiring pattern of cell signaling
networks...2005


SCIENTISTS AND TECHNOLOGY PODCASTS - November 2005



Scientists Decipher "Wiring Pattern" Of Cell Signaling
Networkshttp://www.whatsnextnetwork.com/technology/index.php/2005/11/30/scientists_decipher_wiring_pattern_of_ce
<http://www.whatsnextnetwork.com/technology/index.php/2005/11/30/scientists_decipher_wiring_pattern_of_ce>

Categories: Medicine
<http://www.whatsnextnetwork.com/technology/index.php?cat=42>,
*Biology
<http://www.whatsnextnetwork.com/technology/index.php?cat=71>*
05:41:54 pm

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i <javascript:void(0);>

A team of scientists at Yale University has completed the first
comprehensive map of the proteins and kinase signaling network that
controls how cells of higher organisms operate, according to a
report this week in the journal Nature.

The study is a breakthrough in understanding mechanisms of how
proteins operate in different cell types under the control of master
regulator molecules called protein kinases. Although protein kinases
are already important targets of cancer drugs including Gleevec and
Herceptin, until recently, it has been difficult to identify the
proteins regulated by the kinases

A team of scientists at Yale University has completed the first
comprehensive map of the proteins and kinase signaling network that
controls how cells of higher organisms operate, according to a
report this week in the journal Nature.

The study is a breakthrough in understanding mechanisms of how
proteins operate in different cell types under the control of master
regulator molecules called protein kinases. Although protein kinases
are already important targets of cancer drugs including Gleevec and
Herceptin, until recently, it has been difficult to identify the
proteins regulated by the kinases.

[More:]

Led by Michael Snyder, Lewis B Cullman Professor of Molecular,
Cellular and Developmental Biology, these researchers focused on the
expression and relationship between proteins of the yeast cell
"proteome," or the proteins that are active in a cell.

Protein kinases act as regulator switches and modify their target
proteins by adding a phosphate group to them. This process, called
"phosphorylation," results in altered activity of the phosphorylated
protein. It is estimated that 30% of all proteins are regulated by
this process.

Using technology developed in Snyder's laboratory, graduate students
Jason Ptacek and Geeta Devgan used proteome microarrays to assay the
thousands of different proteins in a yeast cell for targets of the
protein kinases. The 82 unique kinases, representing the majority of
master regulators in the yeast cell, were tested separately with the
microarrays to determine which proteins were modified by each kinase.

From the wealth of information generated by these experiments
Snyder's team constructed a complex map of the regulatory networks
governing the functions and activities of the kinases in the yeast
cell. The map shows several distinct patterns.

"It was a little like having all the pieces of an airplane separated
out, and not knowing how those pieces function together to create an
airplane and make it fly," said Snyder. "We wanted to know how the
tens of thousands of proteins coordinate to carry out complex
processes such as growth, cell division and formation of complex
cell types such as brain cells and intestinal cells."

Over the past several years, a large volume of information on genes
in organisms as diverse as man, mouse, baker's yeast and viruses has
been generated. While genomic DNA is the blueprint, the encoded
proteins are the products that carry out the complex biological
functions of cells. Although scientists can predict from the DNA
what proteins are in the proteome of an organism, this study opens
the door to seeing how they are coordinated to work together.

"This insight into the regulation and integration of biological
networks has broad applications for basic science and clinical
research," said Snyder. "Biological networks determine the
development and function of organisms from the single-celled yeast
to man; aberrations in those networks signal disease."

Biological networks are typically conserved between species, meaning
that often the same type of protein carries out the same type of
function, whether it is in a yeast cell or a human cell. According
to Snyder, these findings in yeast are of immediate use for
understanding both human development from the fertilized egg to full
grown organism, and for drug discovery targeting human diseases.

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