A 50 Hz magnetic field blocks melatonin-induced enhancement of junctional transfer in normal C3H/10T1/2 cells

1 view
Skip to first unread message

news....@googlemail.com

unread,
Oct 31, 2009, 3:35:36 AM10/31/09
to
Lest we forget about how much the EPA really is withholding from the
public!


Subject: EMF's & Melatonin....controller/neoplastic processes....US
EPA 1995

http://oas.oxfordjournals.org/5c/carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945/1792401924/Top/default/empty.gif/51696c6a3245726e532b634141387549?x
<http://oas.oxfordjournals.org/5c/carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945/1792401924/Top/default/empty.gif/51696c6a3245726e532b634141387549?x>
Subject: Melatonin....controller of neoplastic processes....EPA
# 1995...Blackman et al
#

# Oxford Journals <http://www.oxfordjournals.org/>
# Life Sciences
<http://www.oxfordjournals.org/subject/life_sciences//> &
Medicine <http://www.oxfordjournals.org/subject/medicine//>
# Carcinogenesis <http://carcin.oxfordjournals.org/>
# Volume 16, Number 12
<http://carcin.oxfordjournals.org/content/vol16/issue12/index.dtl>
# Pp. 2945-2949
This Article
Right arrow **Full Text* (PDF)
<http://carcin.oxfordjournals.org/cgi/reprint/16/12/2945> *
Right arrow *Alert me when this article is cited
<http://carcin.oxfordjournals.org/cgi/alerts/ctalert?alertType=citedby&addAlert=cited_by&saveAlert=no&cited_by_criteria_resid=carcin;16/12/2945&return_type=article&return_url=http%3A%2F%2Fcarcin.oxfordjournals.org%2Fcgi%2Fcontent%2Fabstract%2F16%2F12%2F2945>*

Right arrow *Alert me if a correction is posted
<http://carcin.oxfordjournals.org/cgi/alerts/ctalert?alertType=correction&addAlert=correction&saveAlert=no&correction_criteria_value=16/12/2945&return_type=article&return_url=http%3A%2F%2Fcarcin.oxfordjournals.org%2Fcgi%2Fcontent%2Fabstract%2F16%2F12%2F2945>*

Services
Right arrow *Email this article to a friend
<http://carcin.oxfordjournals.org/cgi/mailafriend?url=http%3A%2F%2Fcarcin.oxfordjournals.org%2Fcgi%2Fcontent%2Fabstract%2F16%2F12%2F2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H%2F10T1%2F2+cells>*

Right arrow *Similar articles in this journal
<http://carcin.oxfordjournals.org/cgi/search?qbe=carcin;16/12/2945&journalcode=carcin&minscore=5000>
*
Right arrow *Similar articles in PubMed
<http://carcin.oxfordjournals.org/cgi/external_ref?access_num=8603468&link_type=MED_NBRS>*

Right arrow *Alert me to new issues of the journal
<http://carcin.oxfordjournals.org/cgi/alerts/etoc>*
Right arrow *Add to My Personal Archive
<http://carcin.oxfordjournals.org/cgi/folders?action=addtofolder&wherefrom=JOURNALS&wrapped_id=carcin;16/12/2945>*

Right arrow *Download to citation manager
<http://carcin.oxfordjournals.org/cgi/citmgr?gca=carcin;16/12/2945>*
Right arrow *Search for citing articles in:
ISI Web of Science (21)
<http://carcin.oxfordjournals.org/cgi/external_ref?access_num=carcin%3B16%2F12%2F2945&link_type=ISI_Citing>
*
Right arrow *Request Permissions
<http://carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945#>*
Google Scholar
Right arrow *Articles by Ubeda, A.
<http://scholar.google.com/scholar?q=%22author%3AA.+author%3AUbeda%22>*
Right arrow *Articles by Blackman, C. F.
<http://scholar.google.com/scholar?q=%22author%3AC.%20F.+author%3ABlackman%22>*

Right arrow *Search for Related Content
<http://carcin.oxfordjournals.org/cgi/external_ref?access_num=http://carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945&link_type=GOOGLESCHOLARRELATED>*

PubMed
Right arrow *PubMed Citation
<http://carcin.oxfordjournals.org/cgi/external_ref?access_num=8603468&link_type=PUBMED>*

Right arrow *Articles by Ubeda, A.
<http://carcin.oxfordjournals.org/cgi/external_ref?access_num=Ubeda+A&link_type=AUTHORSEARCH>*

Right arrow *Articles by Blackman, C. F.
<http://carcin.oxfordjournals.org/cgi/external_ref?access_num=Blackman+CF&link_type=AUTHORSEARCH>*

Social Bookmarking
http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H/10T1/2+cells+--+Ubeda+et+al.+16+(12):+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CITEULIKE
<http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H%2F10T1%2F2+cells+--+Ubeda+et+al.+16+%2812%29%3A+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CITEULIKE>
http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H/10T1/2+cells+--+Ubeda+et+al.+16+(12):+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CONNOTEA
<http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H%2F10T1%2F2+cells+--+Ubeda+et+al.+16+%2812%29%3A+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CONNOTEA>
http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H/10T1/2+cells+--+Ubeda+et+al.+16+(12):+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=DEL_ICIO_US
<http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H%2F10T1%2F2+cells+--+Ubeda+et+al.+16+%2812%29%3A+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=DEL_ICIO_US>

What's this?
<http://www.oxfordjournals.org/help/features/index.html#socialbookmarking>


© 1995 Oxford University Press
<http://carcin.oxfordjournals.org/misc/terms.shtml>

------------------------------------------------------------------------


research-article


A 50 Hz magnetic field blocks melatonin-induced enhancement of
junctional transfer in normal C3H/10T1/2 cells

*Alejandro Ubeda^ 1 ^ 3 , M. Angeles Trillo^ 1 , Dennis E. House^ 2
and Carl F. Blackman^ 2 *

^1 Hospital Ramón y Cajal, Dept Investigation, 28034 Madrid, Spain
^2 * US Environmental Protection Agency, Research Triangle Park, NC
27711, USA *

^3 To whom correspondence should be addressed

There is strong evidence that pineal melatonin is involved in^
controlling neoplastic processes. We have reported that
physiological,^ but not pharmacological or sub physiological,
concentrations^ of melatonin enhance intercellular communication in
normal C3H/10T1/2^ fibroblasts. Gap junctional intercellular
communication intervenes^ in the control of cell proliferation and
differentiation, and^ seems to play a crucial role in suppression of
tumor promotion.^ A number of /in vivo/ studies have shown that
extremely low frequency^ (ELF) magnetic fields (MF) can act as
cancer promoters or co-promoters.^ /In vitro/, 60 Hz MF have been
reported to block melatonin-induced^ inhibition of cell
proliferation in human breast cancer cells.^ The mechanisms
responsible for the observed interactions of^ MF at the cellular
level remain unknown. In the present study^ melatonin was added to
confluent fibroblasts at a concentration^ of 10^–10 M. Twenty-seven
hours later, a fluorescent dye^ was scrapeloaded into groups of
cells and the transfer of the^ dye to adjacent cells through gap
junctions was quantified.^ Under these conditions melatonin induced
a significant increase^ of dye transfer; this increase was not
observed when the cultures^ were exposed to the MF for 30 min before
the scrape-load assay^ was performed. This finding reinforces
previously reported results^ suggesting that the /in vivo/
oncostatic action of melatonin could^ be exerted, in part, through
modulation of the levels of gap^ junctional intercellular
communication. Also, the data indicate^ that ELF-MF could counteract
the melatonin-induced enhancement^ of junctional transfer.^


http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H/10T1/2+cells+--+Ubeda+et+al.+16+(12):+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CITEULIKE
CiteULike
<http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H%2F10T1%2F2+cells+--+Ubeda+et+al.+16+%2812%29%3A+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CITEULIKE> http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H/10T1/2+cells+--+Ubeda+et+al.+16+(12):+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CONNOTEA
Connotea
<http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H%2F10T1%2F2+cells+--+Ubeda+et+al.+16+%2812%29%3A+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=CONNOTEA> http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H/10T1/2+cells+--+Ubeda+et+al.+16+(12):+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=DEL_ICIO_US
Del.icio.us
<http://carcin.oxfordjournals.org/cgi/external_ref?tag_url=http://carcin.oxfordjournals.org/cgi/content/long/16/12/2945&title=A+50+Hz+magnetic+field+blocks+melatonin-induced+enhancement+of+junctional+transfer+in+normal+C3H%2F10T1%2F2+cells+--+Ubeda+et+al.+16+%2812%29%3A+2945+--+Carcinogenesis&doi=10.1093/carcin/16.12.2945&link_type=DEL_ICIO_US>
What's this?
<http://carcin.oxfordjournals.org/help/social_bookmarks.dtl>

http://carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945


--------


Chick embryo development can be irreversibly altered by early
exposure to weak extremely-low-frequency magnetic fields

If you click on this page on: Similar articles in PubMed

Its really impressive to read all that !

Ubeda and All have shown in 1994 a terrific study with only 1
microTesla !
See: http://www.ncbi.nlm.nih.gov/pubmed/7802707

Mayday, mayday, mayday...

Philippe Hug
Chairman of ARA
Switzerland


[ http://omega.twoday.net/search?q=magnetic+field
http://omega.twoday.net/search?q=exposure
http://omega.twoday.net/search?q=low-frequency
http://omega.twoday.net/search?q=C3H
http://omega.twoday.net/search?q=chick+embryo
http://omega.twoday.net/search?q=melatonin
http://omega.twoday.net/search?q=neoplastic
http://omega.twoday.net/search?q=Carl+Blackman
http://omega.twoday.net/search?q=Philippe+Hug ]

Reply all
Reply to author
Forward
0 new messages