Extra-Low-Frequency Magnetic Fields alter Cancer
Cells through Metabolic Restriction
Ying Li1,2 and Paul Héroux1,2
1 InVitroPlus Laboratory, Department of Surgery, Royal
Victoria Hospital, Montreal, Canada.
2 Department of Epidemiology, Biostatistics and Occupational
Health, McGill University, Montreal, Canada.
Contact: Dr. Paul Héroux, Faculty of Medicine, McGill
University, Montreal, Canada,
H3A 1A3. 1-514-398-6988 paul....@mcgill.ca
BACKGROUND: Biological effects of extra-low-frequency (ELF)
magnetic fields (MF) have lacked a credible mechanism of
interaction between MFs and living material.
OBJECTIVES: Examine the effect of ELF-MFs on cancer cells.
METHODS: Five cancer cell lines were exposed to ELF-MFs within
the range of 0.025 to 5 μT, and the cells were examined for
karyotype changes after 6 days.
RESULTS: All cancer cells lines lost chromosomes from MF
exposure, with a mostly flat dose-response. Constant MF
exposures for three weeks allow a rising return to the
baseline, unperturbed karyotypes. From this point, small MF
increases or decreases are again capable of inducing karyotype
contractions. Our data suggests that the karyotype
contractions are caused by MF interference with mitochondria’s
ATP synthase (ATPS), compensated by the action of
AMP-activated protein kinase (AMPK). The effects of MFs are
similar to those of the ATPS inhibitor oligomycin. They are
amplified by metformin, an AMPK stimulator, and attenuated by
resistin, an AMPK inhibitor. Over environmental MFs,
karyotype contractions of various cancer cell lines show
exceptionally wide and flat dose-responses, except for those
of erythro-leukemia cells, which display a progressive rise
from 0.025 to 0.4 μT.
CONCLUSIONS: The biological effects of MFs are connected to an
alteration in the structure of water that impedes the flux of
protons in ATPS channels. These results may be environmentally
important, in view of the central roles played in
human physiology by ATPS and AMPK, particularly in their links
to diabetes, cancer and longevity.
Keywords: Magnetic field; Extra-Low-Frequency; ATP Synthase
Informant: André Fauteux