Seeking to Recruit Bioinformatics Post-Doc
Aleksandar Obradovic
Dear Colleagues,
Seeking to recruit a Postdoctoral Research Scientist in the lab of Dr. Aleksandar Obradovic at the Department of Medicine, Division of Experimental Therapeutics, Columbia University Irving Medical Center in New York, NY. Please share with anyone who may be interested.
Looking for an enthusiastic individual experienced in computational analysis of transcriptional data and interested in cancer immunotherapy research. The lab’s over-arching research goal is to identify mechanisms of resistance to immunotherapy treatment and prioritize combination-therapy approaches to overcome these mechanisms. This work builds on multiple datasets of bulk and single-cell RNA-Sequencing as well as multi-omic studies across clinical trials of immunotherapy in kidney, prostate, head and neck, as well as other tumor types. Ongoing work is highly collaborative with senior faculty in the Department of Systems Biology as well as the Center for Translational Immunology, and the lab maintains close connections to clinical collaborators running immunotherapy trials at Columbia, Fred Hutch, MSK, and Vanderbilt.
The ideal candidate should have a quantitative background (Bioinformatics, Computational Biology, Biostatistics, Statistics, Computer Science, or Applied Mathematics), be highly motivated to solve biological problems, and have experience analyzing large-scale transcriptomic data. A Ph.D. in computational biology, bioinformatics, statistics, biostatistics, computer science, or related area is preferred, but a Ph.D. in biology is also acceptable if the candidate has experience with quantitative methods. The candidate should have good knowledge of at least one programming language for implementing computational models and algorithms (R and/or python preferred), and familiarity with machine learning concepts. This position is a union position and has a starting salary of $60,000 (negotiable on interview). The candidate will be directly mentored and trained in computational techniques by Dr. Aleksandar Obradovic.
Research Projects and Directions will include the following:
- Developing and optimizing computational tools for analysis of single-nucleus and multi-modal single-cell data (scRNA-Seq, snRNA-Seq, CITE-Seq, TCR-Seq, and 10X Visium spatial transcriptomics)
- Generating and expanding on a Precision Medicine database of immunogenic drug effects (transcriptional effects of large-scale drug library on sorted immune cell types, immune effects of radiation therapy)
- Analysis of clinical trial data identifying shared characteristics of immunotherapy non-responders and matching resistance mechanisms to candidate drugs.
Application Instructions
If interested, please submit an application or inquiries by e-mail to Dr. Aleksandar Obradovic (azo...@cumc.columbia.edu). Please include a cover letter with a CV describing previous research, research interests, and future goals.
Aleksandar Obradovic, PhD
Associate Research Scientist, Department of Medicine, Division of Experimental Therapeutics, Columbia University Irving Medical Center