Does A New Study Really Show That Hydroxychloroquine Might Be
Effective Against Omicron?
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This means that SARS-CoV-2 has two ways to enter cells: from the
surface or via an endosome. The University of Glasgow study shows that
omicron has picked up mutations that improve its ability to enter our
cells via endosomes – and this is where hydroxychloroquine comes into
play.
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Using HCQ to stop omicron entering via endosomes would therefore only
marginally limit the virus from entering cells.
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https://www.iflscience.com/health-and-medicine/does-a-new-study-really-show-that-hydroxychloroquine-might-be-effective-against-omicron/>
In other words, HCQ can reduce replication via endosome means, but
Covid can kept on replicating on cells' membranes with ACE2 receptors.