Vaccine experiments

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John Scudamore

Jul 7, 1997, 3:00:00 AM7/7/97

Down's babies used in vaccine experiments
by VICTORIA MACDONALD Health Correspondent Sunday Times (UK)July 6,

BABIES and young children with Down's syndrome were used as guinea pigs
by British doctors in 1960 to test an experimental vaccine for measles.
The Sunday Telegraph has learnt that the children, who were living in
institutions for the "severely subnormal" were subjected to the
experiments because the doctors said it was "useful" having them in
hospital where they could watch over them for adverse reactions.
One of the children died seven days after being vaccinated from a common
side-effect of measles, but the doctors described it as coincidental in
their report.
Llewellyn Smith, Labour MP for Blaenau Gwent, said last night that he
would press for an adjournment debate tomorrow. Mr Smith, who has
campaigned for two years on behalf of children damaged by vaccines, said
that to use mentally handicapped children as guinea pigs was "to say the
least scandalous. It is totally unacceptable in any society which calls
itself civilised. There must be an inquiry into how this could have
happened. I do not see how it could have been justified."
Only two of the doctors who did the experiments at the Fountain Hospital
in Tooting, south London, and at Queen Mary's Hospital, Carshalton,
Surrey, are still alive.
Dr Inez Aldous, retired in Ipswich, said: "The benefits were tremendous
with these children living in very poor circumstances, and measles was a
Professor Neville Butler, of the International Centre for Child Studies,
in Bristol, said: "It was neither here nor there that they were Down's
syndrome children." He could not remember much about the tests except
that he did not think there was more chance of a Down's syndrome child
suffering a reaction than any other child. "The makers of the vaccine
had thought it was all right. Certainly I do not think it would be done
today on children who are mentally retarded." He added: "The measles
vaccine has reduced the number of children dying throughout the world
and you could argue that without trials like that people would never
have known what to do."
The research was uncovered in an investigation by Richard Barr, a
solicitor with Dawbarns, who is represent-ing families of children said
to have been damaged by the measles, mumps and rubella combined vaccine.
Mr Barr has been trying to find out what safety tests were done on the
measles vaccine given to millions of children.
Dr Andrew Wakefield, of the Royal Free Hospital, London, who fears the
measles vaccine can lead to children developing Crohn's disease, a
serious inflammatory bowel disorder, and autism, said he was shocked by
the 1960 experiment.
"This is both a practical and an ethical issue. You cannot extrapolate
from brain-damaged children to normal infants," he said. "The question
you have to ask is can we apply the same standards now as to then? I do
not see why not."
Dr Richard Nicholson, editor of the Bulletin of Medical Ethics, said:
"People try to say that you cannot apply the same ethical standards
today as you could in the 1960s. You have to do research with proper
safeguards in place and the safeguard was there in 1960 but it was
largely ignored by doctors."
The research involved 77 children aged between one and 11. They were
described by the doctors as severely subnormal "in the imbecile and
idiot range". 56 of the children were given one of three live measles
vaccines. The others remained unvaccinated as "controls".
Most of the children developed mild measles with fever and a rash. Nine
had marked reactions including broncho-pneumonia and photophobia, a
reaction to light. One boy, said to be severely mentally retarded with a
history of epilepsy, died on the seventh day. A post-mortem examination
revealed broncho-pneumonia and appendicitis.
The results of the research led to the Medical Research Council's
Vaccine Commit-tee creating a trial of the safety and efficacy of the
measles vaccine in 1963. This is seen as one of the defini-tive vaccine
studies upon which vaccine policy is based.
The trial was arranged in 32 areas throughout Britain and involved
36,000 children from 10 months to two years of age. But adverse effects
were only monitored for three weeks. Nine months after the trial began
the measles vaccine was offered to all unvaccinated children.
In October 1988, the combined measles, mumps and rubella vaccination was
offered for the first time. The measles component was based on the 1960
and 1963 study. Although the vaccine used today is weaker than doses
used on the children in 1960, researchers believe this does not mean
that it cannot cause underlying, long-term health conditions.
Jackie Fletcher, who set up the organisation JABS after her son was
damaged after vaccination, said: "The more I go into this the more
horrific it becomes."
Gavin Smith, now 15, received the measles vaccine when he was 30 months
old. When he was six he developed SSPE, a rare fatal swell-ing of the
brain caused by persistent measles infection.
His parents Yvonne and Phil, of Edlington in Doncas-ter, were told by
Gavin's consultant that it was caused by the measles vaccine. He is
totally paralysed and has already lived several years longer than
expected. Mrs Smith said: "These studies are disturbing. Nobody told as
then that there might be any problems."
The Department of Health refused to answer any questions on the ethics
of using children with Down's syndrome to experiment on.
It said the Joint Committee on Vaccination and Immunisation, an
independent committee which advises the Government, had looked at the
measles vaccine three times in the last two years and found no evidence
to question its safety.

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