GT
Your misinformation above is bordering on or has already crossed into libel.
Henry N Fox Chapel
Henry N Fox Chapel
Henry N Fox Chapel
Every one who posted threads on this newsgroup did it for a
reason. So before you start bashing other people, take a good
look at yourself.
If you don't like this posts, then don't read it. It is just
that easy. Don't you have better things to do, get a life?
-->Bob, I'll take you up on your suggestion. My sources have been posts on this
-->board and the Money Talk BB as well as the Barron's article (and basic
-->knowledge about hormones and receptors). I really did get E-Mail from the
-->FDA suggesting concern, but it was more in terms of science than FDA approval
-->and certainly did not indicate that an investigation was imminent or
-->likely. (The concern was not official or even from someone who would
-->be involved or recommending such an investigation. It was strictly scientist
-->to scientist).
-->My prediction of an investigation stems from knowledge about
-->how powerful hormones are (or drugs that interact with their recptors)
-->and the parallels between Ethocyn Essence and Renova (and it was the Renova
-->approval that attracted my attention to CHTL). The personal attacks by
-->CHTL supporters (including threat of legal action for calling ethocyn a
hormone,
-->computer checks of bank accounts, notification of the University of
Pittsburgh
-->about abuse of computer account, inside information, membership in a large
-->group of short sellers, being a large group, and on and on) that has kept
-->my attention. I originally said that Ethocyn Essence would do well if it
-->really worked because there were definite disadvantages associated with
-->tretinoin (the active ingredient in Renova). I'll call to get info about
-->data that shows that Ethocyn Essence is better than Essence and see how
-->strong the "scientically proven" data is. From what I've seen thus far,
-->there's plenty of room for improvement, but I certainly have not done an
-->in depth analysis of the underlying data and I have no information indicating
-->that an FDA investigation is imminent or even being considered (although I
-->do think that JNJ could make a good argument after they were fined for
-->making off label claims and conducted an approved FDA trial).
-->
-->Henry N Fox Chapel
Is it just me, or has the tone of Mr. Niman dramatically changed in this
latest post? Now it seems he has _almost_ outrightly admitted that the FDA
will most likely _not_intervene. Interesting turnabout.
Yet, the price of CHTL's stock dipped again to around 8.5 on Wednesday.
Not stablizing _even_ after the conference call of last Friday _and_ the
earnings projection released Tuesday. This does not bode will for CHTL's
credibility.
What more can Chantel do to buttress its stock price?
Lance
Economics & Philosophy Major
Henry N Fox Chapel
Henry N Fox Chapel
PRODIGY(R) interactive personal service 01/25 9:33 AM
Board: MONEY TALK
Topic: STOCKS A-M
Subject: CHANTAL UPDATE
To: ALL Date: 01/25
From: WPSW77A HERBERT LANDON Time: 4:50 AM
I hate to add more personal insults to a topic that has already
deterioated, but since Henry has so prolifically defiled Chantal, I
think everyone should have an understanding of Henry's motives. Henry
obviously has a very significant financial interest in Ligand. He has
posted excessively about Ligand on AOL, Prodigy and the Internet.
LIGAND IS HIS TRUE INTEREST.
Henry's motivation in Chantal has been very confusing to me
so I read most of his notes on prodigy. The following
notes from Prodigy show his main interest:
Subject: JOHNSON & JOHNSON To: ALL
Date: 01/03
From: JJFT14A HENRY NIMAN
Time: 8:37 AM
Yesterday, after the close, JNJ announced the approval of
its wrinkle cream, Renova. This is another Vitamin-A
derivative (retinoid) and just adds to the approved uses of
such compounds. The active ingredient, tretinoid, is an
all trans-retinoid and it is the same active ingredient
found in Retin-A (made by JNJ) and Vesanoid (made by Roche
for treating acute promyelocytic leukemia). A related
compound made by Roche, (iso-tretinoid, Accutane), like
Retin-A is also used for treating psoriasis and acne. AGN
also has a related retinoid, tazarotene approved for
treating psoriasis and acne. LGND and AGN's new company,
Allergan Ligand Retinoid Therapeutics (ALRIZ) are working
on 2nd and 3rd generation retinoids. These compounds have
more selective binding and many also bind to RXRs. These
compounds should be more active for chronic conditions
since they do not induce their own inactivating metabolism
and have fewer adverse reations and side effects. ALRT1057
and LGD1069 are already in advanced clinical trials for a
wide range of conditions. ALRT550 is related to enter the
clinic this year. Over 1400 retinoids have been screened
and many others are in pre-clinical testing phases.
Selective receptor retinoids already identified in
ALRT's prospectus include ALRT521, ALRT792, ALRT379,
ALRT121, and ALRT620. Of course there are many more
anatagonists and agonist not yet publically named.
PRODIGY(R) interactive personal service - Date: 01/25 Time:
2:00 AMBoard: MONEY TALKTopic: STOCKS A-M
Subject: LIGAND NEWS
To: URTD64A JUDY MULDAWER Date: 01/03
From: JJFT14A HENRY NIMAN Time: 9:44 AM
Judy, It will be interesting to see what the JNJ
announcement does to CHTL. The move was quite impressive,
but long term effects will probably determine which product
is best (and LGND should look good long term). The H&Q
conference is just around the corner, so I think LGND will
make a run at 12.
Henry N Fox Chapel 1/3/96 9:41AM ET
PRODIGY(R) interactive personal service -
Date: 01/25
From: JJFT14A HENRY NIMAN
Time: 2:03 AM
Chris, I have just been watching CHTL from the sidelines
because I don't put them in the Biotech category (which
is all I know anything about). FDA approvals are getting
easier, but they still take time and require hard
PRODIGY(R) interactive personal service 01/25 9:34 AM
Board: MONEY TALK
Topic: STOCKS A-M
Subject: CHANTAL UPDATE
To: WPSW77A HERBERT LANDON Date: 01/25
From: JJFT14A HENRY NIMAN Time: 6:22 AM
Herb, I have posted on LGND long before CHTL (I think
there are few who read the Biotech posts who do not know
about my interest in LGND - if you set your clock back a
couple of months, you can see the LGND topics which I
started). I have also posted under CHTL the fact that I
considered JNJ and other big pharms LGND's competition
(not CHTL although the RetinA post attracted my attention
to the CHTL threads). I also noted that although they
competed with LGND, they also had alliances with them.
PFE, GLX, AGN, ABT, AHP, SBE, and Sankyo in Japan all have
equity positions in LGND and Strategic Alliance programs.
Any wrinkle applications are in the distant future. LGND
and ALRIZ retinoids are in advanced clinical trials for
cancer. ALRIZ just started a psoriasis trial. However,
ALL of LGND or ALRIZ drugs go through the FDA as drugs.
They are hormones or analogs and act through hormone
receptors (as does ethocyn and tretinoin). I am very
familiar with hormone, analog, and receptor interactions.
I started LGND's parent company, Progenx, which was
involved in cancer diagnostics using monoclonal antibodies.
However, I currently am just an interested stockholder
(although LGND holds the rights to my patents).
Henry N Fox Chapel 1/25/96 6:00AM ET
PRODIGY(R) interactive personal service 01/25 9:32 AM
Board: MONEY TALK
Topic: STOCKS A-M
Subject: CHANTAL UPDATE
To: WPSW77A HERBERT LANDON Date: 01/25
From: WPSW77A HERBERT LANDON Time: 4:50 AM
(continued)
scientific data. I suspect that CHTL doesn't have the
expertise or clinical connections, but I really don't
follow them other than notice how far the price has come so
I can't say for sure. As far as LGND and ALRIZ
are concerned, I am fairly confident that their retinoids
will have wrinkle applications and they will be safer and
more effective then Retin-A (or other trans-retinoids).
JNJ and Roche have taken awhile to get these products
approved (for cancer and wrinkles) and I suspect that they
work, but there is room for improvement. LGND (with ALRIZ
and AGN) have the corner on the 2nd and 3rd generation
retinoid market. There are three known receptors for
retinoic acid (RARs) and three for related receptors
(RXRs). LGND uses all six receptors to screen compounds.
RAR binding induces cell differentiation and RXR binding
induces programed cell death. The ones that bind to RXRs
are cis-retinoic acids and they do not induce their own
inactivating metabolism (as the trans compounds do) nor do
they have severe side effects (they may even help
cholesterol levels when taken orally). LGND's partner for
the retinoids is AGN and they specialize in skin and eye
disease. Their retinoid (identified before the LGND
alliance) has been approved for eczyma and acne and I would
think that they would tackle the wrinkle market, especially
after the Retin-A approval. ALRT1057 has already entered
the clinic in a psoriasis or eczyma trial and it's strong
suit is limited side effects for chronic conditions. I
don't have a good feel about what CHTL's price should be.
If their compound works and doesn't have long term
complications, I think it can do well against
Retin-A. However, JNJ has lots of money and a good
reputation so it should be quite a battle. However, I
think the 2nd and 3rd generation reinoids will blow away
Retin-A. I have a dematologist friend who perscribes
Retin-A, but he's longon LGND and ALRIZ.
Henry N Fox Chapel 1/4/96 3:47PM ET
I believe these notes show Henry's allegiance to
Ligand. He is hoping that Ligand will provide an effective
wrinkle cream in the future. Chantal is a threat to
Ligand's ability in this market.
I hope this helps.
Herb
: Do you guys really believe that Henry Niman is concerned with the
: science of ethocyn? Oh, don't speak so high of his science integrity.
: Do you have any clue whatthe gentleman is doing for a living? He said a
: few days ago that he did his postdoct in The Scripps Research
: Institutein the 80s. I think he also did his post-degree research in
: somewhere New York in the early 90s, now he ended up in U of Pitt. in
: the Department of Epidemiology. A few days ago, he wrote a damned long
: story on how the faculty in U of Pitt. finance their budget in a tone
: as if he is a faculty! No way. If anyone is interested in what this man
* The rest of the above meaningless stuff deleted*
Dude; You act like you started CHTL yourself. Be logical in your
responses not emotional. Reading the above makes you and CHTL look worse.
Talk stocks or science (in this case) or don't talk at all.
I am not picking Henry's side; I don't give two shits about CHTL after
reading what their business is but please don't bring anger into a
logical discussion.
Cheers
--
_/\_
_\ /_
\_ _/
||
C A N A D A
DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA$DNA
Shahram Mori
Program in Molecular Biology
Department of Chemistry and Biochemistry Box 3C
New Mexico State University
Las Cruces NM
88003
RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA$RNA
Henry N Fox Chapel
Obviously Jack Martin has stepped over the line. However you uploaded
the post onto AOL with some additional comments. You seem to have
either also stepped over the line or are very close. I'll let you
know what I find out about cyberstalking. There could be some very interesting
investigations.
Henry N Fox Chapel
>Henry, I have no intention to stalk you. The post from Prodigy I placed on
>the internet newsgroup without comment.
>In the AOL version, I preceded the post by saying: "Also Henry Niman gets
>mentioned" without further comment.
Stalk Henry-?! No. Stalk me.
Henry is much too busy, and I'd really hate to see him distracted from his
biotech Posts, LGND, etc. updates over this nonsense. Enough.
I'm serious--don't bother him; I've got enough free disks from America
Online to send you guys to AOL Hell while looking forward to the trip.
Be advised.
P. Howard
>>Henry, I have no intention to stalk you. The post from Prodigy I placed on
>>the internet newsgroup without comment.
>>In the AOL version, I preceded the post by saying: "Also Henry Niman gets
>>mentioned" without further comment.
>Stalk Henry-?! No. Stalk me.
>Henry is much too busy, and I'd really hate to see him distracted from >his
>biotech Posts, LGND, etc. updates over this nonsense. Enough.
>I'm serious--don't bother him; I've got enough free disks from America
>Online to send you guys to AOL Hell while looking forward to the trip.
>Be advised.
>P. Howard
You should talk to Henry and tell him not to be distracted from Biotechs updates, particularly on LGND (BTW, I have no negative feel=
ings on LGND), ask him to make more fantasy projections on what LGND can do in, say, 5 or 10 years!
I can promise you that I won't bother him any more, if he can spare his nonsenses for himself!
Regards.
Henry N Fox Chapel
I hope to hear from you soon. I need another biotech company to invest.
I just got out of MABXA with a nice project. I don't know why this
stock is going up without any news so I rather have a bird in hand than
two in the bush. Thanks for bringing MABXA to my attention.
Currently, I am looking at DNAP. The historical chart looks very nice.
Do you know this company at all?
Hope to hear from you soon. Please reply.
Bao
Henry N Fox Chapel
Thanks for your comment about DNAP. I got in some and am watching it
closely. I think this recent agreement which guarantees DNAP's R&D for
the next 10 years will help the company alot.
Thanks again Henry.
Bao