CD52 May Enable the Overwhelming #1 Cause of Insulinitis to be Turned Off

[Pro-Humanist FREELOVER]

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Insulinitis (old name: type 1 diabetes), the
overwhelming cause in most (but not all)
cases is an autoimmune attack on beta
cells, said attack which destroys all -or-
close to all insulin production. In some
with Insulinitis, other causes (like severe
pancreatitis, pancreatic cancer, or pan-
creatic wound) can cause the loss of
all or almost all insulin production.

For most with Insulinitis, the following
may deactivate the autoimmune attack,
if it works in humans as well as it has
in animal models. If so, it could act as
a preventative -and- it's unclear the
extent to which other measures would
be needed to restore beta cells once
the autoimmune attack has been muted.

In any case, for those with the autoim-
mune caused type of Insulinitis, CD52
may become a critical part of stopping
the autoimmune attack, and a key part
of any cure which enables a restora-
tion of insulin production in those who
lost their insulin production due to an
autoimmune attack.

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May 20, 2013
http://medicalxpress.com/news/2013-05-immune-protein-diabetes-tracks.html
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Excerpts [with inserts, not part of original
article, included in brackets]:

... Professor Harrison said CD52 held great
promise as a therapeutic agent for preventing
and treating autoimmune diseases such as
... [Insulinitis].

"Immune suppression by CD52 is a previously
undiscovered mechanism that the body uses
to regulate itself, and protect itself against
excessive or damaging immune responses,"
Professor Harrison said.

"We are excited about the prospect of devel-
oping this discovery to clinical trials as soon
as possible, to see if CD52 can be used to
prevent and treat ... [Insulinitis] and other
autoimmune diseases.

...

CD52 appears to play a dominant role in con-
trolling or suppressing immune activity in the
early stages of the immune response, Profes-
sor Harrison said. "We identified a specialised
population of immune cells (T cells) that carry
high levels of CD52, which they release to
dampen the activity of other T cells and pre-
vent uncontrolled immune responses," Profes-
sor Harrison said.

"The cells act as an early 'braking' mechanism."
Professor Harrison said his goal is to prevent
and ultimately cure ... [Insulinitis]. "In animal
models we can prevent and cure ... [Insulinitis],"
Professor Harrison said. "I am hopeful that
these results will be translatable into humans,
hopefully in the not-too-distant future."

...

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Dr. Harrison Video on CD52
(2 minutes, 41 seconds)
http://www.youtube.com/watch?v=IwtphdQL6co
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- - - end excerpts - - -

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Pro-Humanist FREELOVER
C.ure I.nsulinitis A.ssociation
http://prohuman.net/cureinsulinitisassociation.htm
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[vittyguy]

By which microb is the insulin infected, as the "itis" ending suggests?

[Pro-Humanist FREELOVER]

On Monday, May 20, 2013 1:15:19 PM UTC-5, vitty guy wrote:

> By which microb is the insulin infected, as the "itis" ending suggests?

See Insulitis for details on the primary
cause of the type of Insulinitis which is
present in the overwhelming majority
of those of us with the condition, but
not all, from Merriam-Webster:

Insulitis
http://www.merriam-webster.com/medical/insulitis
invasion of the pancreatic islets of Langerhans
by lymphocytes that produces an inflammatory
or autoimmune response and results in destruc-
tion of the beta cells of the pancreas

See itis for a definition of that suffix, from
Merriam-Webster

itis
http://www.merriam-webster.com/medical/itis?show=0&t=1369102983
a disease characterized by inflammation <arthritis,
tendinitis and all those other itises—Sports Illustrated>

See itis for a definition of that suffix, from
dictionary.com

itis
http://dictionary.reference.com/browse/itis
a suffix used in pathological terms that denote
inflammation of an organ and hence, in extended
senses, nouns denoting abnormal states or condi-
tions, excesses, tendencies, obsessions, etc. (tele-
phonitis; baseballitis).

So, in Insulinitis, you have the Insulitis causality
which is the overwhelming cause of the condi-
tion, although notably, other causes (like severe
pancreatitis, pancreatic cancer, pancreatic
wound) can result in the total or near-total
loss of insulin production, requiring exogenous
insulin to survive, the obsession which every-
one with Insulinitis, regardless of causality, is
forced to engage in in order to survive.

For further details, see

What is Insulinitis?
http://prohuman.net/insulinitis.htm

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For another article on CD52 [with an
insert in brackets which is not part of
the original title], see

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May 20, 2013

[Insulinitis] May Be Reversible
With Immune Suppressor Protein
http://www.medicalnewstoday.com/articles/260762.php