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Stomach stem cells in mice changed to insulin-producing cells?

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May 26, 2023, 11:19:51 AM5/26/23
May 25 2023

This treatment being researched in mice,
might be a future cure for humans, -but- it
remains in research on mice, unannounced
when it might be tried in humans.

The word "diabetics", used in the article, it's
referring to individuals with Islit (new super-
ior clarifying name for type 1 diabetes, indivi-
duals whose endogenous insulin production
is totally or near-totally lost) -and- possibly,
it may also be referring to persons with other ...

... Disparate High Glucose Conditions that
have severely reduced levels of endogenous
insulin production (it's estimated, for exam-
ple, that about 5% of individuals with Cellosis,
the new superior clarifying name for type 2
diabetes, use exogenous insulin, albeit many ...

... of them can reduce or eliminate their use
of exogenous insulin via diet & exercise &
using non-exogenous-insulin treatments).

Stem cells in the human stomach perform
the remarkable feat of regenerating intestinal
lining every 5 to 7 days, cells which produce

Researcher Joe Zhou has been working on
experimenting with producing insulin in the
mice stomach cells for 15 years. Despite
working on this for 15 years, the article says
they need to "optimize" their method increas-
ing the scale of insulin-producing cells & ...

... somehow (undisclosed) modifying the
cells to prevent the autoimmune attack
that caused Islit in most individuals who
have Islit. Mysterious how (or even if) they
can do that as researchers have not yet
come close to preventing Islit in humans ...

... who are vulnerable to an autoimmune
attack on their own beta cells.


Per the article, in 2021 there were 8.4 million
humans with Islit (a number lower than I'd
seen estimated elsewhere), & compared to
the total population in 2021 of 7.9 billion,
that's only 1/10th of 1% of the human popu-
lation. I'd never heard that the % with Islit ...

... was that low in the world. Perhaps this
article is mistaken with its 8.4 million fig-
ure. I don't know.


The study was published in Nature Cell
Biology on April 27 2023:

The abstract in that article doesn't men-
tion any research into how to stop the
autoimmune attack. None of the article
mentions whether or not the mice (re-
ferred to as "diabetic" mice) had auto-
immune-caused Islit & in the mice ...

... researched as to transplanting insulin-
producing stomach cells via the method
above, they only watched the mice for 6
months & didn't mention whether or not
they were Islit mice or how they got what-
ever Disparate High Glucose Condition ...

... they called diabetes. Were the mice
Islit mice that had autoimmune caused

Disappointing, the supposed promise of a
"cure" but missing critical details.

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~

Pro-Humanist FREELOVER, Insulinitis (Islit)
since age 5, got it in March 1961

C.ure I.nsulinitis A.ssociation

Glucose Anomalies Research regarding
Potential Cures / Improvements in Treatments
The Sooner The Better!

- - -

The old confusing way which all-too-often
involves folks using the diabetes / diabetic
words without a clarifier:

diabetes / diabetic without a clarifier,
diabetes / diabetic guessing required

- - -

Logic and reasoning behind ceasing using
diabetes & diabetic & reactive hypoglycemia
words and phrases, replacing all that with
vastly superior names, ending diabetes &
diabetic & reactive hypoglycemia confusion,
misleading, & misunderstanding:

Diabetes Bubble / Diabetes Bubble Burst

- - -

Disparate High Glucose Conditions,
DHGCs, 7 disparate categories of
unpreventability / nonreversibility
of all-but-one of the specific types
of DHGCs (thus far, research actively
trying to change that):

o 15 specific types of rapid-onset Insul-
initis (Islit), unpreventable & nonrevers-
ible (thus far), the overwhelming majority
with Islit have Insulitis Islit (sometimes
called type 1 diabetes, often confusingly
called diabetes with no clarifier)

14 specific types of Islit are not caused
by Insulitis, present in a small minority
of those with Islit.

o 1 specific type of slow-onset Islit, Latent
Autoimmune Islit, also unpreventable &
nonreversible (thus far) (sometimes called
latent autoimmune diabetes in adults, often
confusingly called diabetes with no clarifier)

o Preventable Cellosis is the only specific
type of DHGC that is preventable & revers-
ible (in many, sometimes it's called type 2
diabetes, often confusingly called diabetes
with no clarifier)

Risk for Preventable Cellosis, Hypertension,
& Cardiovascular Disease increases as one's
weight increases but BMI risk increases at
lower BMI levels in non-white individuals:

PreCellosis (often confusingly called pre-
diabetes with no clarifier) is the oft-times
preventable & reversible Cellosis precondi-
tion that all-too-often the overwhelming ma-
jority having it are unaware they have it

o 20 specific types of Cellosis, unpreven-
table & nonreversible (thus far, sometimes
called type 2 diabetes, all-too-often con-
fusingly called diabetes with no clarifier)

o 1 specific type of DHGC only occurring
in the late stage of impregnation in women,
a type that's transient but that increases
risk of later getting Cellosis, that ...

... condition called Gestational Cellosis
(sometimes called gestational diabetes,
sometimes confusingly called diabetes with
no clarifier).

o 11 specific types of Diminosis (new name
created in 2010 for a monogenic condition
> age 6 months that sometimes is called
maturity onset diabetes of the young, some-
times confusingly called diabetes with no
clarifier), unpreventable & non-reversible
(thus far).

o 12 specific types of Neonatal Diminosis
(new name created in 2010 for a monogenic
condition at age < or = 6 months that some-
times is called neonatal diabetes, sometimes
confusingly called diabetes with no ...

... clarifier), 8 types are permanent & unpre-
ventable & nonreversible (thus far); 4 specific
types are transient but can recur.

o 25 specific types of Ohiglucons (new name
created in 2010 for other diabetes mellitus,
but often confusingly called diabetes with
no clarifier).

23 specific types are totally unpreventable.

Hemochromatosis Ohiglucon, is only preventa-
ble if Hemochromatosis is found and treated
before it damages the pancreas.

Immunosuppressants Ohiglucon, caused after
a transplant with the required use of immun-
osuppressants, 50% is temporary, but if it
persists for over a year, most likely the condi-
tion is permanent.

If endogenous insulin production is near-totally
to totally lost & does not recover after immuno-
suppressants dosages reduced, it causes Im-
munosuppressants Islit.

- - -

A mostly Non-Glucose Anomaly, Insipidus, it's
also unpreventable & nonreversible (thus far):

o 6 specific types of Insipidus (new name
created in 2010 for diabetes insipidus, some-
times confusingly called diabetes with no clar-
ifier), 4 specific types don't include high glucose
& are unpreventable & nonreversible (thus far),
2 specific rare types do include high glucose &
are unpreventable & nonreversible (thus far).

- - -

The following condition is apart from the
diabetes confusion problem, but has confu-
sion issues of its own.

A Low Glucose Condition, Hut:

o The 21 specific types of Hut (new name
created in 2010 for Hypoglycemia Uncaused
by Treatments for High Glucose, often con-
fusingly called reactive hypoglycemia, con-
fusing in that it does not occur as a reac-
tion to treatment for High Glucose; one ...

... form sometimes called hyperinsulinism),
some specific types are preventable & rever-
sible, some aren't (thus far).

- - -

Stop Diabetes/Diabetic Confusion
with New Superior Clarifying Terms

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~

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