Human pancreas on a chip & Cystic Fibrosis Ohiglucon

[Pro-Humanist FREELOVER]

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Excerpt from Diabetes Bubble / Diabetes
Bubble Burst:
https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

...

Cystic Fibrosis Ohiglucon - unique, with
similarities to some aspects of Cellosis,
& differing similarities to a few aspects
of Insulinitis, it's different enough to
list this as a unique specific type of
Other High Glucose Condition (Ohiglucon):

1 in 2500 are born with Cystic Fibrosis;
of those with Cystic Fibrosis, Cystic
Fibrosis Ohiglucon is present in

- 2% of children,

- 19% of adolescents,

and

- 40% to 50% of adults

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Excerpts [with clarifying inserts, not part
of original article, included in brackets]:

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July 16 2019

Human pancreas on a chip could help identify
possible cause of [Cystic Fibrosis Ohiglucon]
https://www.news-medical.net/news/20190716/Human-pancreas-on-a-chip-could-help-identify-possible-cause-of-CF-Related-Diabetes.aspx
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Scientists created human pancreas on a chip
that allowed them to identify the possible
cause of [Cystic Fibrosis Ohiglucon].

It may be feasible to also use the small two-
chambered device, which features bioengineered
human pancreatic organoids to study the causes
of [Islit (Insulinitis), new superior clarifying
name for near-total to total loss of endogenous
insulin] and [Cellosis, new superior clarifying ...

... name for hampered glucose lowering often re-
sulting from insulin resistance caused by life-
style issues (old name: type 2 diabetes)] ... .

First, however, the scientists want to see if
their device can help people with Cystic Fibrosis;
a genetic lung disease caused by a mutation in the
CFTR gene. The mutation leads to a water and salt
imbalance on cell surfaces that clogs the lungs
with thick mucus.

As people with Cystic Fibrosis get older, they
become increasingly at risk for [Cystic Fibrosis
Ohiglucon (see above)] ... . Making matters worse
is that until now there hasn't been an effective
way to study [Cystic Fibrosis Ohiglucon] in the
lab to look for better treatments.

Mouse models of Cystic Fibrosis don't faithfully
recreate [Cystic Fibrosis Ohiglucon] in the lab,
and it wasn't possible to study the disease at
the depth we achieved in this study.

"Our technology closely resembles the human pan-
creas and potentially may help us find therapeutic
measures to manage glucose imbalance in people with
Cystic Fibrosis, which is linked to increased ill-
ness and death."

The in vitro chip technology can be used to study
[Cystic Fibrosis Ohiglucon] and glucose imbalance
in specific individuals with the condition, creat-
ing the potential for diagnosing different disease
manifestations on a highly personalized basis.

The chip can help assay variability in the glucose
measures of different people, determine correlation
of glucose levels with the CFTR [gene] mutation type,
and test small-molecule interventions.

Chipping away at CFTR [gene] conundrum

Although mutations in the CFTR gene are known to
cause cystic fibrosis, its role in [Cystic Fibrosis
Ohiglucon] is unclear.

To answer that question, the researchers started by
isolating pancreatic ductal epithelial cells and pan-
creatic islets donated by surgical patients.

The ductal organoids were cultured in a transparent
dual-chamber called a microfluidic device, which con-
tained specific biochemical solutions to generate the
pancreas-on-a-chip.

Ductal epithelial cells were cultured in the top cham-
ber and pancreatic islet cells were in the bottom cham-
ber, separated by a thin layer of porous membrane that
allowed the different chambers to interact.

The cells grew and expanded into three-dimensional pan-
creatic organs that mimicked cell-to-cell communications
and fluid exchange, similar to the function of a natur-
ally developed human pancreas.

When the researchers tested pancreas-on-a-chip by dis-
rupting CFTR gene expression, it impaired cell-to cell
communication, fluid exchange and negatively affected
endocrine function.

This caused an insulin deficiency and recreated the
[Cystic Fibrosis Ohiglucon] disease process similar to
that observed in the pancreas of a person.

Researchers said this confirmed that the CFTR gene has
a direct role in regulating insulin secretion and caus-
ing [Cystic Fibrosis Ohiglucon] in people with Cystic
Fibrosis.

Microfluidic devices have existed since 1979. But inno-
vations in their design and functionality, especially
since the advent of organoid technology, now allow re-
searchers to bioengineer human organ tissues and mimic
the function of natural organs in a laboratory setting.

Next steps

The research team ... now will use the devices in a pilot
study to test FDA-approved drugs that modulate CFTR gene
expression. The goal will be to determine how well differ-
ent CFTR drugs can slow or reverse lab-simulated [Cystic
Fibrosis Ohiglucon].

Source: Cincinnati Children's Hospital Medical Center

Journal reference: Nature Communications.
Patient-derived pancreas-on-a-chip to
model cystic fibrosis-related disorders.
https://www.nature.com/articles/s41467-019-11178-w

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diabetes

Confusing? Think about it.

Which disparate condition(s) is(are)
actually being referred to?

Islit, Latent Autoimmune Islit,
Cellosis, Gestational Cellosis,
Diminosis, Neonatal Diminosis,
Ohiglucon,
Insipidus, Hut
https://www.memecreator.org/static/images/memes/4927657.jpg

Diabetes Bubble / Diabetes Bubble Burst
Super! https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

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Pro-Humanist FREELOVER

Insulitis Islit (abbreviation for
Insulinitis, near-total to total
loss of endogenous insulin) since
age 5, March, 1961 CE

C.ure I.nsulinitis A.ssociation
Ideal! https://prohuman.net/cureinsulinitisassociation.htm

Glucose Anomalies Research regarding
Potential Cures / Improvements in Treatments
Great! https://prohuman.net/glucoseanomaliesresearch.htm

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