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Zocor May Reduce Exercise Benefits
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Don Roberto
May 17, 2013, 6:53:57 AM5/17/13
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Zocor May Reduce Exercise Benefits
Statins, the most widely prescribed drugs worldwide, are often suggested
to lower cholesterol and prevent heart disease in individuals with
obesity, diabetes and metabolic syndrome, which is a combination of
medical disorders including excess body fat and/or high levels of blood
pressure, blood sugar and/or cholesterol. However, University of
Missouri researchers found that simvastatin, a generic type of statin
previously sold under the brand name Zocor, hindered the positive
effects of exercise for obese and overweight adults.
"Fitness has proven to be the most significant predictor of longevity
and health because it protects people from a variety of chronic
diseases," said John Thyfault, an associate professor of nutrition and
exercise physiology at MU. "Daily physical activity is needed to
maintain or improve fitness, and thus improve health outcomes. However,
if patients start exercising and taking statins at the same time, it
seems that statins block the ability of exercise to improve their
fitness levels."
Thyfault says many cardiologists want to prescribe statins to all
patients over a certain age regardless of whether they have metabolic
syndrome; the drugs also are recommended for people with Type 2
diabetes. He recommends that cardiologists more closely weigh the
benefits and risks of statins given this new data about their effect on
exercise training.
"Statins have only been used for about 15-20 years, so we don't know
what the long-term effects of statins will be on aerobic fitness and
overall health," Thyfault said. "If the drugs cause complications with
improving or maintaining fitness, not everyone should be prescribed
statins."
Thyfault and his colleagues measured cardiorespiratory fitness in 37
previously sedentary, obese individuals ages 25-59 with low fitness
levels. The participants followed the same exercise regimen on the MU
campus for 12 weeks; 18 of the 37 people also took 40 mg of simvastatin
daily.
Statins significantly affected participants' exercise outcomes.
Participants in the exercise-only group increased their
cardiorespiratory fitness by an average of 10% compared to a 1.5%
increase among participants also prescribed statins. Additionally,
skeletal muscle mitochondrial content, the site where muscle cells turn
oxygen into energy, decreased by 4.5% in the group taking statins while
the exercise-only group had a 13% increase, a normal response following
exercise training.
Thyfault suggests that future research determine whether lower doses of
simvastatin or other types of statins similarly affect people's exercise
outcomes and thus their risk for diseases such as Type 2 diabetes.
Starting a statin regimen after exercising and obtaining a higher
fitness level may reduce the drugs' effects on fitness, he says.
Date: May 15, 2013
Source: University of Missouri
Statins, the most widely prescribed drugs worldwide, are often suggested
to lower cholesterol and prevent heart disease in individuals with
obesity, diabetes and metabolic syndrome, which is a combination of
medical disorders including excess body fat and/or high levels of blood
pressure, blood sugar and/or cholesterol. However, University of
Missouri researchers found that simvastatin, a generic type of statin
previously sold under the brand name Zocor, hindered the positive
effects of exercise for obese and overweight adults.
"Fitness has proven to be the most significant predictor of longevity
and health because it protects people from a variety of chronic
diseases," said John Thyfault, an associate professor of nutrition and
exercise physiology at MU. "Daily physical activity is needed to
maintain or improve fitness, and thus improve health outcomes. However,
if patients start exercising and taking statins at the same time, it
seems that statins block the ability of exercise to improve their
fitness levels."
Thyfault says many cardiologists want to prescribe statins to all
patients over a certain age regardless of whether they have metabolic
syndrome; the drugs also are recommended for people with Type 2
diabetes. He recommends that cardiologists more closely weigh the
benefits and risks of statins given this new data about their effect on
exercise training.
"Statins have only been used for about 15-20 years, so we don't know
what the long-term effects of statins will be on aerobic fitness and
overall health," Thyfault said. "If the drugs cause complications with
improving or maintaining fitness, not everyone should be prescribed
statins."
Thyfault and his colleagues measured cardiorespiratory fitness in 37
previously sedentary, obese individuals ages 25-59 with low fitness
levels. The participants followed the same exercise regimen on the MU
campus for 12 weeks; 18 of the 37 people also took 40 mg of simvastatin
daily.
Statins significantly affected participants' exercise outcomes.
Participants in the exercise-only group increased their
cardiorespiratory fitness by an average of 10% compared to a 1.5%
increase among participants also prescribed statins. Additionally,
skeletal muscle mitochondrial content, the site where muscle cells turn
oxygen into energy, decreased by 4.5% in the group taking statins while
the exercise-only group had a 13% increase, a normal response following
exercise training.
Thyfault suggests that future research determine whether lower doses of
simvastatin or other types of statins similarly affect people's exercise
outcomes and thus their risk for diseases such as Type 2 diabetes.
Starting a statin regimen after exercising and obtaining a higher
fitness level may reduce the drugs' effects on fitness, he says.
Date: May 15, 2013
Source: University of Missouri
mainframetech
May 17, 2013, 11:32:39 AM5/17/13
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Pro-Humanist FREELOVER
May 17, 2013, 12:03:05 PM5/17/13
to
- - -
On Friday, May 17, 2013 10:32:39 AM UTC-5, mainframetech wrote:
> On May 17, 6:53 am, Don Roberto <anothascreen...@aol.com> wrote:
> > Zocor May Reduce Exercise Benefits
> >
> http://www.telegraph.co.uk/health/healthnews/7481845/Health-warning-over-statin-taken-by-millions.html
>
> Chris
Complete article from that link [including
inserts, not part of orginal article, in
brackets]:
Simvastatin is taken by around three million
people [in Great Britain?] in order to lower
their cholesterol and reduce the risk of having
a heart attack.
However an analysis of clinical trial data in
America has found that high doses can cause
muscle damage and a rare condition which
induces kidney problems and may be fatal.
Patients were told not to stop taking simva-
statin but advised to talk to their doctor if
they have concerns.
The American medicines regulator, the Food
and Drug Administration, has issued a warning
to patients to be alert to signs of problems
when taking the 80mg daily dose of simva-
statin. It has also listed drugs that should
not be prescribed to those on high doses of
statins.
Muscle aches and damage are a known side
effect of all statins but the risks are generally
considered to be outweighed by the benefit
in reducing the risk of a heart attack.
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Pro-Humanist FREELOVER
C.ure I.nsulinitis A.ssociation
http://prohuman.net/cureinsulinitisassociation.htm
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