What's It Like to Have a Fully Functional Pancreas?

[_]

- - -

Well, don't have much in the way of memories
before I got Islit (Insulinitis, near-total to total
loss of endogenous insulin) in March, 1961,
but I'd wager it was sweet, as in heavenly.

Hopefully, some day all of us with any of 5 of
the non-transient non-reversible Disparate
High Glucose Conditions (DHGCs) will know
what it's like again, when THE CURE for each
one of our DHGCs arrives.

Some of us, those with Preventable Cellosis
(the preventable type of type 2 diabetes) can
return to that with diet / exercise / weight loss
or gastric bypass surgery, but the risk is that
won't last if what led to having Cellosis returns
again.

Some, those with transient Gestational Cellosis
(gestational diabetes) will once again know what
it's like to have a fully functional pancreas after
giving birth, though having had Gestational Cel-
losis increases the risk of later getting Cellosis.

Most of us with any of over 80 specific types of
DHGCs, we can only dream of what it's like to
have a fully functional pancreas.

Recently, I linked to an article with many differ-
ent reports of what it's like to have a fully func-
tional pancreas, varying in their accounts, reflec-
ting differences in large part due to the manner
in which continuous glucose monitors have im-
proved from 2009 to 2019 (the years in those
reports):
https://www.levelshealth.com/blog/what-should-my-glucose-levels-be-ultimate-guide

For the latest, here's an impressive recent study,
April 25 2019, of Dexcom G6 glucose levels in
153 individuals who have no DHGC, age 7 to 80.
https://scholar.google.com/scholar_url?url=https://academic.oup.com/jcem/article-pdf/104/10/4356/33391651/jc.2018-02763.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=H7VOYJz4CKWO6rQPzNu3iAY&scisig=AAGBfm33swcoXccjDG92mseRsRDu6G0_dQ

That's a PDF file, if that link doesn't work, the article
may be accessed from
https://academic.oup.com/jcem/article/104/10/4356/5479355

Tables display revealing details, but for a thorough
understanding of all 153 individuals' glucose levels,
refer to the following information in Table 2:

% of glucose levels > 180 mg/dL ... 0%
% of glucose levels 160.1 to 180 mg/dl ... 3/10ths of 1%
% of glucose levels 140.1 to 160 mg/dl ... 2.1%
% of glucose levels 70 to 140 mg/dl ... 96%
% of glucose levels 70 to 120 mg/dl ... 89%
% of glucose levels 60 to 69.9 mg/dl ... 1.1%
% of glucose levels 54 to 59.9 mg/dl ... 2/10ths of 1%
% of glucose levels < 54 mg/dl ... 0%

HbA1c for the 153 individuals with no DHGC was
average 5.1, range from 4.2 to 5.6.

My recent HbA1c was 5.4.

My last 14 days CGM report used for all of the
following data:
https://prohuman.net/pix2/14dayCGMglucoselevels_asof031421.jpg

I do compare favorably to the above individuals in
my 4/10ths of 1% below 70 mg/dl.

However, I fall far short of what their fully functional
pancreases do in *all* areas 70 mg/dl and above:

my % of glucose levels > 180 mg/dL ... 5.3%, theirs = 0%
my % of glucose levels 160.1 to 180 mg/dl ... 10.9%, theirs = 3/10ths of 1%
my % of glucose levels 140.1 to 160 mg/dl ... 18.3%, theirs = 2.1%
my % of glucose levels 70 to 140 mg/dl ... 65.1%, theirs = 96%
my % of glucose levels 70 to 120 mg/dl ... 40.9%, theirs = 89%

So, that begs the question, how can my HbA1c
be so low despite my percents in all of the 70
to > 180 mg/dl areas being so, well, pitiful
compared to the superb "totally ALWAYS in
CONTROL glucose levels of those with fully
functional pancreases?

I don't know. Perhaps someone has a viable
explanation.

Also, perhaps we with Islit and our doctors are
far too hard on us, what with all the pressure &
guilt-trips inflicted on us to constantly manually
be doing the CONTROL thing, the thing that
everyone with fully functional pancreases does
all-the-time with no effort whatsoever.

The thing that requires manual effort on our
part all the time, 24 x 7 x 365 (366 every leap
year), while awake and while sleeping, no time
off EVER!!!

Oh well, such is life with Islit. Per the following
article, "less than 20% of patients with Islit have
HbA1c of under 7%."
http://www.buffalo.edu/ubnow/briefs/2019/08/diabetes-study.html

CONTROL? Nah, see THE CURE!!! See above
for the best I can do with current technology.

~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~

INSULINITIS (ISLIT)

New SUPERIOR clarifying name for near-
total to total loss of endogenous insulin
https://prohuman.net/pix2/new_superior_clarifying_name_is_INSULINITIS.jpg

The overwhelming majority of Islit caused by
autoimmune attacks on pancreatic beta cells
(Insulitis Islit) but there are

o 13 specific types of rapid onset Islit, a
rare condition (only present in < one-half
of 1% of Americans & in a much lower rate
in most of the world), when present is typ-
ically diagnosed at age under 30
(50% at age < 18, 20% at age 19 to 29)

o 1 slow onset specific type, Latent Autoim-
mune Islit, frequency unknown but per a
recent report, misdiagnosed as Cellosis
(new clarifying name for type 2 diabetes)
almost 40% of the time due to its slow
onset and its occurrence typically at age
over 30

Old outdated anachronistic name for Islit is
type 1 diabetes, confusing in that diabetes
without clarifier is often used to describe
this condition which is 1 of the 7 Disparate
High Glucose Conditions (DHGCs).

That makes figuring out which DHGC is actu-
ally being referred to (and it can be any one,
or some, or all of them when the diabetes
or diabetic word is used without clarifier)
confusing / difficult:
https://prohuman.net/pix2/diabetesdiabeticguessinggame.jpg
https://prohuman.net/pix2/diabetesdiabeticconfusion.jpg
https://prohuman.net/pix2/diabetesdiabeticendingthemisunderstanding.jpg

- - -

Insulin / Insulin Pump / CGM I use

Fiasp Ultra-Fast-Acting Insulin in a
tubeless Omnipod insulin pump catheter
placed into skin / pod with adhesive
stuck onto skin every 80 hours, control
via PDM (Personal Data Manager)
https://prohuman.net/pix2/Fiaspinsulin_tubelessOmnipodDASHinsulinpump.jpg

Dexcom G6 CGM (continuous glucose monitor)
https://prohuman.net/pix2/Dexcom_G6_CGM.jpg

~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~

[_]

Follow-up:

Time in Range

Little-mentioned, when compared to folks
who have a fully functional pancreas (no
Disparate High Glucose Condition), the
widely promoted "time in range" for those
with any of the 7 Disparate High Glucose
Conditions is higher than what folks with ...

... a fully functional pancreas have. Gener-
ally promoted "time in range" for those with
any of the 7 DHGCs is 70 to 180 mg/dl, but
as you can see from the previous post, those
with a fully functional pancreas have

.> % of glucose levels > 180 mg/dL ... 0%
.> % of glucose levels 160.1 to 180 mg/dl ... 3/10ths of 1%
.> % of glucose levels 140.1 to 160 mg/dl ... 2.1%
.> % of glucose levels 70 to 140 mg/dl ... 96%
.> % of glucose levels 70 to 120 mg/dl ... 89%
.> % of glucose levels 60 to 69.9 mg/dl ... 1.1%
.> % of glucose levels 54 to 59.9 mg/dl ... 2/10ths of 1%
.> % of glucose levels < 54 mg/dl ... 0%

Their 70 to 180 mg/dl time in range = 98.7%,
but their 70 to 120 mg/dl = 89% & their
70 to 140 mg/dl = 96%. Surprising, rarely
mentioned, their hypoglycemia = 1.3%.

I don't know if the CGM measurements of
those with a fully functional pancreas erred
in showing 1.3% hypoglycemia -or- if that
reflected individuals who have Hypoglycemia
Uncaused by Treatments for High Glucose
(Hut).

Needless to say, they have something that
none of the individuals any of the -7- DHGCs
has, ZERO hyperglycemia, TRUE CONTROL
with no effort whatsoever!

- - -
June 24 2021

DexCom, Nick Jonas and Leading
DHGCs Nonprofits Launch Initiative
to Help Improve the Lives of People
With any of the 7 DHGCs
https://www.galvnews.com/news_ap/business/article_9647ed09-acb3-5538-be05-77ac0e6fec17.html
- - -

That article, promoting focusing on & improv-
ing (increasing) 70-180 mg/dl (so-called 'time
in range' goal for those with any DHGC). A
specific goal / %, not mentioned.

The above article, flooded with diabetes
without clarifier references -28- times, -1-
use of 'type 1 diabetes' -and- the use of
a rarely used term "insulin-treated diabetes"
-7- times which excludes everyone who has
any non-Islit DHGC and doesn't use ...

... exogenous insulin. That excludes most
DHGC individuals as a recent article, in
2019, stated 5.3% of Cellosis individuals
use exogenous insulin, meaning 94.7% of
Cellosis individuals *don't* use exogenous
insulin.
https://www.bloomberg.com/press-releases/2019-12-13/tandem-diabetes-care-announces-fda-clearance-of-the-t-slim-x2-insulin-pump-with-control-iq-advanced-hybrid-closed-loop

- - -
CGM & Time in Range
https://www.diabetes.org/healthy-living/devices-technology/cgm-time-in-range
- - -

Pertinent excerpt: "... Most people with type 1
(Islit) and type 2 (Cellosis) diabetes should
aim for a time in range of at least 70 percent
of readings—meaning 70 percent of readings,
you should aim for roughly 17 out of 24 hours
each day to be in range (not high or low). ..."

The article indicts hypoglycemia & hypergly-
cemia equally regarding increased risk of
adverse sequelae. However, in actually, hypo-
glycemia risk is extremely low in the over-
whelming majority who don't use any hypo-
glycemia-causing medication, whereas ...

... the long-term adverse sequelae risk of
hyperglycemia is very high for everyone
with any of the 7 DHGCs. The article fails
to mention the fact that hyperglycemia
risk increases the higher one's HbA1c
is (the article doesn't mention HbA1c).

- - -

For reference, my 70-180 mg/dl 'time in
range' over the last 90 days = 91.8% .
Here's my breakdown using the identical
ranges used for those with a fully func-
tional pancreas (FFP):

% of glucose levels > 180 mg/dL ... 6.0% , FFP = 0%
% of glucose levels 160.1 to 180 mg/dl ... 6.8% , FFP = 3/10ths of 1%
% of glucose levels 140.1 to 160 mg/dl ... 13.3% , FFP = 2.1%
% of glucose levels 70 to 140 mg/dl ... 72.2% , FFP = 96%
% of glucose levels 70 to 120 mg/dl ... 50.6% , FFP = 89%
% of glucose levels 60 to 69.9 mg/dl ... 1.1% , FFP = 1.1%
% of glucose levels 54 to 59.9 mg/dl ... 3/10ths of 1% , FFP = 2/10ths of 1%
% of glucose levels < 54 mg/dl ... 3/10ths of 1% , FFP = 0%

As you can clearly see, individuals with
a fully functional pancreas, true control,
have something that even the best man-
aged individual using optimum current
exogenous insulin dosing / glucose CGM
monitoring tools isn't capable of.

Granted, my levels place me in a very low
risk category among those who have Islit
-but- the ideal - THE CURE -or- much-im-
proved technology (closed-loop insulin
pump / CGM or artificial pancreas) needed
to achieve the near-perfect glucose levels
of those with a fully functional pancreas.

* * * * * * * * * * * * * * * * * * * * * * * * * * * * *

Pro-Humanist FREELOVER, I got Insulinitis
(Islit) which was caused by Insulitis at age 5
in March 1961, requiring multiple exogenous
insulin doses to try to stay alive. There are
15 specific types of rapid-onset Islit.

There is 1 specific type of slow-onset Islit,
Latent Autoimmune Islit, also unpreventable
& nonreversible (thus far).

- - -

Insulin / Insulin Pump / CGM I use

Fiasp Ultra-Fast-Acting Insulin in a
tubeless Omnipod insulin pump catheter
placed into skin / pod with adhesive
stuck onto skin every 80 hours, control
via PDM (Personal Data Manager)
https://prohuman.net/pix2/Fiaspinsulin_tubelessOmnipodDASHinsulinpump.jpg

Dexcom G6 CGM (continuous glucose monitor)
https://prohuman.net/pix2/Dexcom_G6_CGM.jpg

- - -

C.ure I.nsulinitis A.ssociation
https://prohuman.net/cureinsulinitisassociation.htm

Glucose Anomalies Research regarding
Potential Cures / Improvements in Treatments
https://prohuman.net/glucoseanomaliesresearch.htm

- - -

o Preventable Cellosis is the only specific
type of Disparate High Glucose Condition
that is preventable & reversible (in many,
sometimes it's called type 2 diabetes, often
confusingly called diabetes with no clarifier)

Risk for Preventable Cellosis, Hypertension,
& Cardiovascular Disease increases as one's
weight increases but BMI risk increases at
lower BMI levels in non-white individuals:
https://prohuman.net/pix2/BMI-WaistCircumference-Cellosis&Hypertension&CardiovascularDisease-Risk.jpg
https://medicalxpress.com/news/2021-05-bmi-offs-obesity-diabetes-non-white.html

o PreCellosis (often confusingly called predia-
betes with no clarifier) is the oft-times preven-
table & reversible Cellosis precondition that all-
too-often the overwhelming majority having it
are unaware they have it

o 20 specific types of Cellosis, unpreventable
& nonreversible (thus far, sometimes called
type 2 diabetes, all-too-often confusingly called
diabetes with no clarifier)

- - -

o 4 other Disparate High Glucose Conditions
exist (Gestational Cellosis, Diminosis, Neonatal
Diminosis, Ohiglucons), all 7 DHGCs fully des-
cribed in the following article:

Logic and reasoning behind ceasing using
confusing / misleading / misinforming diabetes
& diabetic & reactive hypoglycemia words and
phrases, replacing all of that with vastly superior
clarifying names:

Diabetes Bubble / Diabetes Bubble Burst
https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

* * * * * * * * * * * * * * * * * * * * * * * * * * * * *

On Sunday, March 14, 2021 at 10:10:34 PM UTC-5, _ wrote:

.> - - -
.>
.> Well, don't have much in the way of memories
.> before I got Islit (Insulinitis, near-total to total
.> loss of endogenous insulin) in March, 1961,
.> but I'd wager it was sweet, as in heavenly.
.>
.> Hopefully, some day all of us with any of 5 of
.> the non-transient non-reversible Disparate
.> High Glucose Conditions (DHGCs) will know
.> what it's like again, when THE CURE for each
.> one of our DHGCs arrives.
.>
.> Some of us, those with Preventable Cellosis
.> (the preventable type of type 2 diabetes) can
.> return to that with diet / exercise / weight loss
.> or gastric bypass surgery, but the risk is that
.> won't last if what led to having Cellosis returns
.> again.
.>
.> Some, those with transient Gestational Cellosis
.> (gestational diabetes) will once again know what
.> it's like to have a fully functional pancreas after
.> giving birth, though having had Gestational Cel-
.> losis increases the risk of later getting Cellosis.
.>
.> Most of us with any of over 80 specific types of
.> DHGCs, we can only dream of what it's like to
.> have a fully functional pancreas.
.>
.> Recently, I linked to an article with many differ-
.> ent reports of what it's like to have a fully func-
.> tional pancreas, varying in their accounts, reflec-
.> ting differences in large part due to the manner
.> in which continuous glucose monitors have im-
.> proved from 2009 to 2019 (the years in those
.> reports):
.> https://www.levelshealth.com/blog/what-should-my-glucose-levels-be-ultimate-guide
.>
.> For the latest, here's an impressive recent study,
.> April 25 2019, of Dexcom G6 glucose levels in
.> 153 individuals who have no DHGC, age 7 to 80.
.> https://scholar.google.com/scholar_url?url=https://academic.oup.com/jcem/article-pdf/104/10/4356/33391651/jc.2018-02763.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=H7VOYJz4CKWO6rQPzNu3iAY&scisig=AAGBfm33swcoXccjDG92mseRsRDu6G0_dQ
.>
.> That's a PDF file, if that link doesn't work, the article
.> may be accessed from
.> https://academic.oup.com/jcem/article/104/10/4356/5479355
.>
.> Tables display revealing details, but for a thorough
.> understanding of all 153 individuals' glucose levels,
.> refer to the following information in Table 2:
.>
.> % of glucose levels > 180 mg/dL ... 0%
.> % of glucose levels 160.1 to 180 mg/dl ... 3/10ths of 1%
.> % of glucose levels 140.1 to 160 mg/dl ... 2.1%
.> % of glucose levels 70 to 140 mg/dl ... 96%
.> % of glucose levels 70 to 120 mg/dl ... 89%
.> % of glucose levels 60 to 69.9 mg/dl ... 1.1%
.> % of glucose levels 54 to 59.9 mg/dl ... 2/10ths of 1%
.> % of glucose levels < 54 mg/dl ... 0%
.>
.> HbA1c for the 153 individuals with no DHGC was
.> average 5.1, range from 4.2 to 5.6.
.>
.> My recent HbA1c was 5.4.
.>
.> My last 14 days CGM report used for all of the
.> following data:
.> https://prohuman.net/pix2/14dayCGMglucoselevels_asof031421.jpg
.>
.> I do compare favorably to the above individuals in
.> my 4/10ths of 1% below 70 mg/dl.
.>
.> However, I fall far short of what their fully functional
.> pancreases do in *all* areas 70 mg/dl and above:
.>
.> my % of glucose levels > 180 mg/dL ... 5.3%, theirs = 0%
.> my % of glucose levels 160.1 to 180 mg/dl ... 10.9%, theirs = 3/10ths of 1%
.> my % of glucose levels 140.1 to 160 mg/dl ... 18.3%, theirs = 2.1%
.> my % of glucose levels 70 to 140 mg/dl ... 65.1%, theirs = 96%
.> my % of glucose levels 70 to 120 mg/dl ... 40.9%, theirs = 89%
.>
.> So, that begs the question, how can my HbA1c
.> be so low despite my percents in all of the 70
.> to > 180 mg/dl areas being so, well, pitiful
.> compared to the superb "totally ALWAYS in
.> CONTROL glucose levels of those with fully
.> functional pancreases?
.>
.> I don't know. Perhaps someone has a viable
.> explanation.
.>
.> Also, perhaps we with Islit and our doctors are
.> far too hard on us, what with all the pressure &
.> guilt-trips inflicted on us to constantly manually
.> be doing the CONTROL thing, the thing that
.> everyone with fully functional pancreases does
.> all-the-time with no effort whatsoever.
.>
.> The thing that requires manual effort on our
.> part all the time, 24 x 7 x 365 (366 every leap
.> year), while awake and while sleeping, no time
.> off EVER!!!
.>
.> Oh well, such is life with Islit. Per the following
.> article, "less than 20% of patients with Islit have
.> HbA1c of under 7%."
.> http://www.buffalo.edu/ubnow/briefs/2019/08/diabetes-study.html
.>
.> CONTROL? Nah, see THE CURE!!! See above
.> for the best I can do with current technology.