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Glucose-responsive, charge-switchable lipid nanoparticles for insulin delivery

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Apr 14, 2023, 8:43:20 PM4/14/23
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April 14 2023
https://phys.org/news/2023-04-glucose-responsive-charge-switchable-lipid-nanoparticles-insulin.html

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Sidenote: For some reason, either because
the developers, Jinqiang Wang and Zhen Gu,
aren't optimistic that the nanoparticles could
be the cure, -or- there's some flaw in the deliv-
ery of insulin that the article failed to mention,
-or- the writer of the article simply didn't ...

... consider the possibility that nanoparticles
could work so well that they, in essence, would
be the cure.

Ideally, this methodology should be able to
be the cure, although the article doesn't indi-
cate the methodology has any automatic
prevention of hypoglycemia capability. Also,
they don't indicate how close this methodol-
ogy might be to the second-by-second ...

... magnificent perfection of a fully functional
pancreas in those having no Disparate High
Glucose Condition.

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~

Pro-Humanist FREELOVER, Insulinitis (Islit)
since age 5, got it in March 1961
https://prohuman.net/pix2/new_superior_clarifying_name_is_INSULINITIS.jpg

C.ure I.nsulinitis A.ssociation
ASAP! https://prohuman.net/cureinsulinitisassociation.htm

Glucose Anomalies Research regarding
Potential Cures / Improvements in Treatments
The Sooner The Better! https://prohuman.net/glucoseanomaliesresearch.htm

- - -

The old confusing way which all-too-often
involves folks using the diabetes / diabetic
words without a clarifier:

diabetes / diabetic without a clarifier,
diabetes / diabetic guessing required
https://prohuman.net/pix2/diabetesdiabeticguessinggame.jpg

- - -

Logic and reasoning behind ceasing using
diabetes & diabetic & reactive hypoglycemia
words and phrases, replacing all that with
vastly superior names, ending diabetes &
diabetic & reactive hypoglycemia confusion,
misleading, & misunderstanding:

Diabetes Bubble / Diabetes Bubble Burst
Splendid! https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

- - -

Disparate High Glucose Conditions,
DHGCs, 7 disparate categories of
unpreventability / nonreversibility
of all-but-one of the specific types
of DHGCs (thus far, research actively
trying to change that):

o 15 specific types of rapid-onset Insul-
initis (Islit), unpreventable & nonrevers-
ible (thus far), the overwhelming majority
with Islit have Insulitis Islit (sometimes
called type 1 diabetes, often confusingly
called diabetes with no clarifier)
https://prohuman.net/pix2/new_superior_clarifying_name_is_INSULINITIS.jpg

14 specific types of Islit are not caused
by Insulitis, present in a small minority
of those with Islit.

o 1 specific type of slow-onset Islit, Latent
Autoimmune Islit, also unpreventable &
nonreversible (thus far) (sometimes called
latent autoimmune diabetes in adults, often
confusingly called diabetes with no clarifier)

o Preventable Cellosis is the only specific
type of DHGC that is preventable & revers-
ible (in many, sometimes it's called type 2
diabetes, often confusingly called diabetes
with no clarifier)

Risk for Preventable Cellosis, Hypertension,
& Cardiovascular Disease increases as one's
weight increases but BMI risk increases at
lower BMI levels in non-white individuals:
https://prohuman.net/pix2/BMI-WaistCircumference-Cellosis&Hypertension&CardiovascularDisease-Risk.jpg
https://medicalxpress.com/news/2021-05-bmi-offs-obesity-diabetes-non-white.html

PreCellosis (often confusingly called pre-
diabetes with no clarifier) is the oft-times
preventable & reversible Cellosis precondi-
tion that all-too-often the overwhelming ma-
jority having it are unaware they have it

o 20 specific types of Cellosis, unpreven-
table & nonreversible (thus far, sometimes
called type 2 diabetes, all-too-often con-
fusingly called diabetes with no clarifier)

o 1 specific type of DHGC only occurring
in the late stage of impregnation in women,
a type that's transient but that increases
risk of later getting Cellosis, that ...

... condition called Gestational Cellosis
(sometimes called gestational diabetes,
sometimes confusingly called diabetes with
no clarifier).

o 11 specific types of Diminosis (new name
created in 2010 for a monogenic condition
> age 6 months that sometimes is called
maturity onset diabetes of the young, some-
times confusingly called diabetes with no
clarifier), unpreventable & non-reversible
(thus far).

o 12 specific types of Neonatal Diminosis
(new name created in 2010 for a monogenic
condition at age < or = 6 months that some-
times is called neonatal diabetes, sometimes
confusingly called diabetes with no ...

... clarifier), 8 types are permanent & unpre-
ventable & nonreversible (thus far); 4 specific
types are transient but can recur.

o 25 specific types of Ohiglucons (new name
created in 2010 for other diabetes mellitus,
but often confusingly called diabetes with
no clarifier).

23 specific types are totally unpreventable.

Hemochromatosis Ohiglucon, is only preventa-
ble if Hemochromatosis is found and treated
before it damages the pancreas.

Immunosuppressants Ohiglucon, caused after
a transplant with the required use of immun-
osuppressants, 50% is temporary, but if it
persists for over a year, most likely the condi-
tion is permanent.

If endogenous insulin production is near-totally
to totally lost & does not recover after immuno-
suppressants dosages reduced, it causes Im-
munosuppressants Islit.

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A mostly Non-Glucose Anomaly, Insipidus, it's
also unpreventable & nonreversible (thus far):

o 6 specific types of Insipidus (new name
created in 2010 for diabetes insipidus, some-
times confusingly called diabetes with no clar-
ifier), 4 specific types don't include high glucose
& are unpreventable & nonreversible (thus far),
2 specific rare types do include high glucose &
are unpreventable & nonreversible (thus far).

- - -

The following condition is apart from the
diabetes confusion problem, but has confu-
sion issues of its own.

A Low Glucose Condition, Hut:

o The 21 specific types of Hut (new name
created in 2010 for Hypoglycemia Uncaused
by Treatments for High Glucose, often con-
fusingly called reactive hypoglycemia, con-
fusing in that it does not occur as a reac-
tion to treatment for High Glucose; one ...

... form sometimes called hyperinsulinism),
some specific types are preventable & rever-
sible, some aren't (thus far).

- - -

Stop Diabetes/Diabetic Confusion
with New Superior Clarifying Terms
https://www.change.org/stopdiabetesdiabeticconfusionwithNewSuperiorClarifyingTerms

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