Last-modified: 10 March 2009
Changes: see part 1 of the FAQ for a list of changes to all parts.
Subject: READ THIS FIRST
Copyright 1993-2009 by Edward Reid. Re-use beyond the fair use provisions
Subject: My diabetic father isn't taking care of himself. What can I do?
We'll assume your father has type 2 diabetes. See separate section for
definition of types.
Type 2 diabetics, and those who care for them, are in a difficult situation.
Type 2 strikes late in life, so personal habits and patterns are already
formed and solidly engrained. Yet in most cases those habits and
exactly what must be changed if a newly-diagnosed diabetic is to care
properly for his or her health. This is a difficult psychological problem.
The cornerstones for treating type 2 diabetes are exercise, weight control,
and diet. A high percentage of type 2 patients who apply these therapies
assiduously can control the disease with these therapies alone, without
insulin or oral hypoglycemic drugs. Naturally these are also some of the
difficult aspects of life to change. There can be no single or simple answer
of how to help or encourage a particular individual find a combination of
therapies which not only controls the disease but also is psychologically
acceptable and which can be incorporated as a lifetime pattern. Helping
depends on knowing the individual's habits, patterns, motivations, desires,
likes and dislikes, and working with all the existing conditions and
everything brought forward from past life.
Doctors and other health care professionals have a choice in treating
patients with type 2 diabetes. They can prescribe drugs (oral hypoglycemics)
and insulin, or they can try to get their patients to make the difficult
lifestyle changes described above. (Many patients need both.) The latter
effort is time consuming and often frustrating, as doctors too often see
patients failing to make any change at all.
Friends and family can help by learning about type 2 diabetes, and doing
you can to encourage your loved one to make diet and lifestyle changes. If
this supports the plan a treatment team is urging the patient to follow, you
will add your support for difficult changes. If the doctor (or the whole
treatment team) falls down on the educational and motivational
can fill in some of the gaps. Your effort is well spent in either case.
In particular, if a doctor has left the impression that drugs and
the only treatments, make sure to counter that impression with information
about the value of exercise, diet, and weight control.
At the same time, it's important to remember that needing oral hypoglycemics
and/or insulin injections as additional tools isn't failure. On the
a patient who's been actively involved in self treatment already has an
excellent chance of using these additional tools successfully. Those who
learned to use the exercise - weight control - diet triumvirate will also be
able to utilize insulin and oral drugs as additional treatments when needed.
Choose the appropriate tools and use them effectively.
These treatment choices can interact in positive ways as well. Bringing
glucose under control often increases the body's sensitivity to insulin. So
ironically, using insulin may decrease the need for insulin. This is a
positive change which can then be reinforced by the other, interacting
You will need far more information than is appropriate for a Usenet FAQ
panel. As a start, call the ADA (see ADA section), get a subscription to
_Diabetes Forecast_ (see journals), and visit a university library and
in the diabetes section in the stacks.
Beyond the generalizations above, a few specifics are usually of value:
Set a good example in your own life. Exercise and eat a good diet.
The recommendations for diabetics are healthy choices for anyone.
Share your example. Serve a tasty, low-fat diet to family and friends
when they are your guests.
Suggest joint activities. Suggest a walk instead of watching a
Make sure your diet and activities are visibly enjoyable so your
guests will accept your invitiation to join you.
Subject: Managing adolescence, including the adult forms
Adolescents have special problems in managing diabetes. These include a
variety of physiological problems related to puberty and rapid growth,
problems related to growing up and the general social pressures of
life, and the psychological turmoil caused by the expectations of
here today to talk about (hey, hold the eggs and tomatoes) expectations.
Actually, this all applies to adults as well, though the subtle points may
The most important thing to remember, for the adolescent, the parent,
health care provider, is
All Blood Glucose Measurements Are Good.
There Are No Bad Blood Glucose Readings.
If that doesn't sound right, then please take two steps. First, learn why it
is true. Then chant it like a mantra until you internalize it, so that you
never give off the slightest vibes to the contrary.
Why is it true?
There are two kinds of adolescents (to simplify life enormously): those who
rebel and those who want to please. Ironically, the rebellious are probably
easier to deal with in treating diabetes. "So my blood sugar is 350, so
what?" Bad? No, that's good: you know what's going on, and so does your
child. The point of blood glucose measurement is to respond -- not to be
or bad -- and only with an accurate report can you and the patient respond.
[Compulsory digression: 350 mg/dl = 20.0 mmol/L.]
Look what can happen to the eager-to-please child:
Child: My blood sugar is 350.
Adult: Oh, that's awful! You must try to be better!
Child: My blood sugar is ... um [to self: I must be good] 140 ...
Adult: Oh, that's great!
In short order, the log book looks great but the HbA1c doesn't jibe.
This all happens with the best of intentions from all parties. The child is
trying to please, and is behaving in exactly the ways that elicit approval.
The adult is trying to care for the child's health in the most natural ways.
And the result is one that neither desires.
Thus the positive mantra to replace the half-negative one above:
All Blood Glucose Measurements Are Good.
Responding To Blood Glucose Readings Is Good.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
An excellent article entitled "Insulin Therapy in the Last Decade: A
Pediatric Perspective", by Julio Santiago, MD, of the St. Louis Children's
Hospital and the Washington University School of Medicine in St. Louis,
Missouri, appears in _Diabetes Care_, volume 16 supplement 3, December 1993,
pp. 143-154. The article discusses many aspects of treating pediatric
diabetes. Santiago spends several pages discussing how to establish
and honest approaches to self-monitoring. I highly recommend the article.
Subject: So-and-so eats sugar! Isn't that poison for diabetics?
This is asked from both sides: the non-diabetic who doesn't understand
diabetes, and the diabetic who gets tired of hearing "I won't put any sugar
on the table" etc etc ad nauseum.
Diabetics should eat a high-quality, healthy diet very similar to that
recommended for everyone. This will include some sugar, and research
indicates that obtaining a moderate amount of carbohydrates in the form of
sugar makes little or no difference in controlling blood glucose levels.
isn't room here to describe all the aspects of diabetes treatment that make
No one has suggested a really good, uniformly satisfying answer to the
know-alls who insist they know more than you do. Feel free to add to this
That was true before insulin treatment became available in 1922.
Fat is more dangerous than sugar because diabetics have a three-fold
higher risk of heart disease.
The whole point of injecting insulin is to balance carbohydrate intake.
All carbohydrates are converted to sugar in the digestive tract anyway.
Subject: Insulin nomenclature
The major types of insulin have both generic designations and brand names
used by the manufacturers. Most of the brand names are close enough to the
generic ones that the correspondence is obvious. Novo uses totally different
names. In those parts of the world where Novo has most of the market, the
Novo brand names are used in place of the generic names. To facilitate
communication between Novo users and others, here is the correspondence:
Generic Novo May also be known as
------- ---- --------------------
Regular Actrapid Soluble
NPH Protophane Isophane
Ultralente Ultratard Zn (Zinc suspension)
The recently developed lispro (generic name) insulin is sold as Humalog by
Eli Lilly. Novo has no comparable insulin as of July 1996, although they
undoubtedly have research in progress.
Subject: What is Humalog / LysPro / lispro / ultrafast insulin?
Except as otherwise noted, this info comes from an article on p396 of the
March 1994 _Diabetes_ by researchers at Eli Lilly.
Insulin is a protein. Proteins consist of sequences of amino acids. Human
insulin has the amino acid lysine at position B28 and proline at position
Insulin molecules naturally pair off (like people) and combine into dimers.
The dimers interact with small amounts of zinc and combine into
form sold as "regular" insulin.
From another source, now forgotten: the time required to disassociate the
hexamer into the dimer, and then the dimer into the monomer so that it
can be absorbed, is the main reason for the delay in the action of
insulin and the reason for injecting it 30 to 45 minutes before meals.
Switching the B28 and B29 positions on the protein has no effect on the
normal activity of the insulin but inhibits the formation of the dimer and
the hexamer. Thus the insulin is in monomeric form when injected and can be
The name LysPro comes from the names of the amino acids, lysine and proline,
that occupy the swapped positions. According to an article in the August
Diabetes Forecast, the spelling 'lispro' is now preferred.
Challenges in the development include the biochemical process for
amino acids, and making the result reasonably stable in the monomeric form.
From another source, now forgotten: US FDA approval was not automatic,
the insulin molecule has been modified. In fact, several other amino acid
exchanges have been tried and met with unacceptable side effects.
Some points from the article in the August 1996 Diabetes Forecast:
Patients with gastroparesis, or taking acarbose, should be careful with
lispro. Gastroparesis is a condition caused by neuropathy which causes
the stomach to empty slowly and erratically. (See the section on
gastroparesis later in this section.) Acarbose is a drug which slows
the absorption of carbohydrates from the intestine. Either may result
in lispro insulin acting too quickly.
Response to lispro is variable. Some patients love it, others hate it.
On the average, it does not change bg control either for better or for
worse, but some patients definitely find it one or the other. Eli Lilly
is promoting lispro for convenience, not for better control.
Doctors and patients are still experimenting with the best regimens for
using lispro insulin. "Best" clearly varies from one patient to another.
Typically lispro insulin is injected very close to mealtime.
An obvious concern is that hypoglycemic reactions might be more common
faster acting insulin. A paper presented at the 1996 ADA Scientific Papers
conference studied this possibility:
Reducing the Incidence of Hypoglycemia with a Novel Insulin Formulation
J. Anderson, R. Brunelle, A Pfeutzner et al.
Indianapoils, IN and Bad Homberg, Germany
In fact, they found the rate of hypoglycemic incidents slightly lower among
those using lispro insulin. They found no difference on most other measures,
including especially HbA1c. I've only seen the abstract of the paper, so I
know nothing about their methodology. (They also state the lispro forms
hexamers just like regular insulin but that the hexamers dissociate much
quickly. I don't know who to believe, but from a practical point of view it
Subject: Travelling with insulin
Insulin does not need to be kept cold.
Insulin is stable at body temperature. This is not surprising when you
realize that the beta cells often store the insulin they produce for
days before releasing it. (Specifically, according to Jens Brange's
_Stability of Insulin_, Regular/Actrapid insulin stored at 40C will
lose 5% of its potency after 14 weeks.)
A general guide to how long it is safe to store insulin at various
Refrigerated a few years
Room temperature several months
Body temperature a few weeks
Do not allow insulin to freeze. Do not expose insulin to temperatures
significantly above body temperature. I don't know how much heat is
required to destroy insulin, but leaving it in a closed car in the sun
would be a very bad idea. (Two readers have reported that solidly
frozen and rethawed regular insulin works just fine. I've been unable
to locate any studies documenting the degradation of insulin at extreme
Short of such extremes, degradation is gradual. You should always be
alert for gradual changes in your blood glucose anyway, since
individual sensitivity to insulin changes over time for reasons
unknown. Your normal dosage adjustments will handle minor degradation
that might occur, say, from keeping insulin in a very hot room for
So why do drugstores (pharmacies) keep insulin refrigerated, and why are
"insulin cold packs" advertised? The drugstores are mosty just
following standard procedures. For them, it's a simple precaution not
As for cold packs, as long as anyone thinks they are needed, someone
will sell them. As noted, you do need to protect insulin from extremes
of temperature, and the cold packs can help at both extremes. In many
situations it may be just as effective to pack the insulin next to a
bottle of water, especially during outdoor activities when you are
carrying water anyway.
Always keep your insulin with you! Keep all your medical supplies with
you. Never pack them in checked luggage. Luggage may sit outside in hot
sun or freezing rain. If you are delayed, or your luggage is waylaid,
you could be without supplies packed in luggage.
Meter manufacturers recommend keeping meters and strips from freezing
and extreme heat.
Subject: Injectors: Syringe and lancet reuse and disposal
Disposable syringes can be safely reused as long as you take reasonable
precautions. Recap both ends between uses, and discard the syringe if
dropped, dirty, or damaged (especially if the needle is bent). Discard
it when it becomes uncomfortable to use. This varies a great deal,
being half a dozen uses for some patients and several dozen uses for
others. Comfort depends far less on sharpness than on the silicone
coating applied to the needle at manufacture. Never wipe the needle
with alcohol, as this will remove the silicone coating.
Lancets can also be reused safely with the same caveats.
Syringe disposal has proven controversial. If you want to be
conservative, buy a needle clipper, get a hard plastic bottle designed
for medical waste to put the syringes in, and take the full bottle to a
facility approved for handling medical waste. Your doctor's office, a
local hospital, or a pharmacy may be able to handle it for you.
Intermediate positions use one of these techniques. At the least
conservative, cap the needle carefully and discard in trash which will
not be subject to illicit searching and possible abuse. If you have
trouble capping the needle without sticking yourself, definitely get a
bottle to drop the uncapped syringes in; a bleach bottle may be
Local or state regulations apply in many places and limit your choices.
Know the laws for your area! Where sharps containers are required, the
pharmacy where you purchase the container will probably dispose of the
full container for you.
Subject: Injectors: Pens
A pen injector is a device that holds a small vial of insulin and a
disposable needle, and injects an amount measured with a dial.
Advantages include being compact, convenient, easy to use circumspectly
in public, and accurate and simple in dose measurement. The pen device
clicks for each unit (or two depending on the manufacturer) dialed;
this can help those with impaired vision.
Some pen units only allow setting a multiple of two units of insulin,
which many find inadequate. Get a model which measures a multiple of
one unit, which should be easy to find among current models.
The primary disadvantage is cost, up to twice as much per unit of
insulin compared with standard vials. The special vials may be
difficult to obtain in remote areas, and widespread shortages have
occurred occasionally. Falling back to a standard syringe is always an
Also, the special vial can be refilled from a standard vial using a
syringe, making sure the rubber stopper is not damaged, though the
manufacturer will not recommend this. If you do refill, make sure to
use the same concentration of insulin. This is not a problem in the US,
where only U100 concentration is used. In some parts of the world, U40
concentration is common, but pen refills are always U100. Make sure to
match the concentration.
Pens are more popular in Europe than in the US, but are being heavily
promoted in the US.
Subject: Injectors: Jets
A jet injector uses no needles, but instead squirts the substance being
injected through a narrow orifice under high pressure, producing a fine
stream which penetrates the skin as easily as a needle. Jets are popular
with anyone who is simply scared of needles, for any reason. The jet
disperses the insulin more than a needle does, which probably results in
faster absorption. This can be an advantage or a disadvantage, and
requires careful monitoring when first used. Technique is just as
important as with needles, so jets are no more appropriate than needles
for small children. If a jet is used to avoid needles, equipment failure
forcing a fallback to needles may be traumatic. High cost is a major
Subject: Insulin pumps
An insulin pump provides a Continuous Subcutaneous Insulin Infusion, or
via an indwelling needle or catheter. That is, a small needle (similar to
those on insulin syringes) or tube is inserted through the skin and fixed in
place for two or three days at a time. An external box pumps insulin through
the needle steadily.
Pumps don't solve all the problems of treating diabetes for two main
1) The infusion is still subcutaneous, so the insulin still must be
absorbed before it can be used. Insulin from the pancreas goes
into the bloodstream and takes effect much more quickly.
2) Current pumps are open-loop -- that is, there is no feedback from
glucose (bG) to the pump. The patient must still self-monitor bG and
program the pump.
Nonetheless, many patients get much better results with a pump than from
intensive therapy without a pump, and those patients tend to be
extremely happy with the pump. It isn't clear at present how to decide
whether a given patient should use a pump. Different studies have
obtained varying results, ranging from 85% success to 85% dropout!
Unfortunately, no studies seem to have been done since the mid-1980s,
and the manufacturers have little motivation to fund the studies, as
advertising is more cost-effective for them. It is likely that the pumps
and pump therapy have become much more consistently successful since
then. A few important factors seem clear, though:
1) Motivation. A pump takes extra effort and attention.
2) Knowledge. If you aren't already familiar with intensive therapy,
think more than twice before jumping for a pump. You should
probably try intensive therapy with multiple injections first.
3) Treatment team. Successful users are backed by teams of physicians
and educators who are experienced *with pumps*. Don't try a pump on
your own (the manufacturers won't let you anyway), and don't try it
with inexperienced providers -- these are recipes for unnecessary
4) Funding. Pumps represent a nontrivial capital outlay. If you don't
have insurance or other public programs that will pay for the pump,
you will need personal financial resources.
Most or all pump manufacturers allow a trial period, so you can try a pump
without financial risk. You will probably know fairly soon whether you want
to continue with the pump.
I have removed the oudated insulin pump discussion previously posted here.
Subject: Type 1 cures -- beta cell implants
Beta cells can be isolated and implanted, requiring only outpatient surgery
for implantation. But foreign beta cells are quickly rejected without
immunosuppressant drugs. Even with the recent advances in drugs, especially
cyclosporin, using immunosuppressants is much more dangerous than living
diabetes. As a result, beta cell implantation is not currently used to treat
Current research is investigating two general methods of implanting beta
cells without the use of immunosuppressant drugs. The first
encapsulates the beta cells within a barrier so that nutrients, glucose, and
insulin can pass freely through the barrier but the proteins which provoke
the immune response, and the cells which respond, cannot pass. The second
(immunoalteration) involves altering the proteins on the surface of the
which provoke the immune response. The first human trial began early in 1993
on immunoisolated beta cells, and human trials were scheduled to begin late
in 1993 on immunoaltered beta cells. (As of early 1997, I haven't had the
opportunity to try to locate the followup to these trials.)
An article in the Journal of Clinical Investigation, September 1996,
describes a successful experiment which implanted immunoisolated porcine
(pig) islets into monkeys. An accompanying editorial describes the state of
islet transplantation. Both are online in full, linked from the issue
contents page at
In early 2000, a lot of hype appeared about the "Edmonton protocol" trials.
While an important step, this is still only a small step on a long journey.
They made improvements in technique and graft survival, but no progress on
the serious problems of beta cell supply (each patient needed beta cells
from two cadaver donors) or of immunosuppressant use (they used drugs,
Don't expect these treatments to be available on a standard basis any time
soon. I've been reading about this research since the mid-1970s, and the
results are always just around the corner. Serious problems remain to be
solved: safety of the immunoisolated implants, long-term survival,
use beta cells from non-human species or grow usable cells for grafting in
the laboratory, perfection of both techniques -- all
these must be resolved before beta cell implantation moves beyond the
experimental stage. Other problems will likely be encountered along the way,
since this is cutting edge medical research. I'll be surprised if it
of the lab before the year 2005; 2015 is probably a better guess. And it may
fail -- it's always possible that unsolvable problems will yet arise.
Finally, it's not yet clear that even completely normal bG profiles will
all the problems of type 1 diabetes. Some may be related to the autoimmune
reaction that is the immediate cause of diabetes. This question cannot be
answered until it is possible to normalize bG levels for a period of many
Subject: Type 1 cures -- pancreas transplants
Whole pancreas transplants have the same rejection problems as beta
cell implants, and also require major surgery. For these reasons, whole
pancreas transplants are only used 1) in desperate cases in medical
schools with exceptional capabilities, and 2) in conjunction with
Kidney transplants are (relatively) common in diabetics with advanced
complications. A kidney recipient is taking immunosuppressant drugs
anyway, and the same surgery that implants the kidney can stick in a
pancreas with little extra effort or trauma. As a result, the double
transplant is now recommended, at least for consideration, for any
diabetic patient who requires a kidney transplant.
The only disadvantage would seem to be that the pancreas donor must be
dead; whereas a living kidney donor is feasible. Even this is not
strictly true, as a kidney-plus-partial-pancreas transplant from a
living donor is possible, and the partial pancreas contains enough beta
cells to produce insulin for the recipient. However, this procedure is
Combination kidney/pancreas transplants are listed in a different queue
than kidney-only. Since the number of people waiting for donor kidneys
is quite long (anywhere from a few months to seven or eight years), the
kidney/ pancreas list is often a quicker means of receiving a
transplant. For example, in January 1998 there were 38,380 people on
the UNOS [see below] registrations for a kidney transplant. There were
only 355 registrations for a pancreas transplant and 1604 registrations
for a kidney-pancreas transplant. [Based on UNOS Scientific Registry
data as of January 28, 1998.]
Kidney/pancreas transplants, while still considered experimental at some
institutions, have been approved by Blue Cross/Blue Shield in the
following centers: University of Iowa Hospitals and Clinics, Iowa City;
University of Minnesota Hospital and Clinic, Minneapolis; Ohio State
University Hospitals, Columbus; and University of Wisconsin Hospital
and Clinics, Madison. Though this is for BC/BS only, other insurance
companies may follow the BC/BS lead if pushed. [Information from January
2000. Check to see whether additional centers have been approved.]
UNOS (United Network of Organ Sharing) has a list of 124 transplant
centers that have pancreas transplant programs. For more information,
contact UNOS at (800)24-DONOR or see their web page at
(See the section on sources for additional contact info.)
The UNOS handles transplant registrations only in the USA, but can
provide contact information for organ-donation agencies around the
world. Organ allocation became a political football in the US in the
late 1990s, and the details of allocation and waiting lists may change.
The transplant mailing list is an excellent resource. See the section on
online resources: mailing lists.
(Thanks to Alexandra Bost for much of the information in this section.)
Subject: Type 2 cures -- barely a dream
The treatments described in the preceding sections apply only to type 1
diabetes. Type 2 diabetes is the result of insulin resistance or other forms
of improper use of insulin within the body, not in general to an absolute
lack of insulin. Type 2 patients usually have normal beta cells at the
with beta cell insufficiency developing later while the insulin use defects
continue. There is nothing on the horizon for type 2 diabetes with promise
comparable to that of beta cell transplants for type 1. The sequencing
human genome, completed in 2000, provides information for research which is
likely to help, but that is for the very long term.
This is distinct from the *treatment* of type 2 diabetes, which has improved
quite significantly even since I first wrote the above paragraph. New drugs
are available which improve insulin sensitivity. The UKPDS directly, and the
DCCT indirectly, have convinced many more doctors that intensive treatment
of type 2 diabetes is worth the trouble and expense. Support and education
programs continue to expand. The UKPDS showed clearly that medical nutrition
therapy (MNT, diet with proper medical team support) helps type 2 diabetics
greatly even without weight loss, and so more doctors are providing the
But all this is treatment, not cure.
Subject: What's a glycemic index? How can I get a GI table for foods?
The glycemic index, or GI, is a measure of how a given food affects
blood glucose (bG). Some complex carbohydrates affect bG much more
drastically than others. Some, such as white bread, affect bG even more
than sugar (sucrose).
This was quite a surprise when the research was first published in 1981.
It really should not have been such a surprise. "Sugar", meaning
sucrose, decomposes in the gut to equal parts of glucose and fructose.
Fructose, as expected, has only a small effect on bG. Even
professionals, it turns out, were swayed in their thinking by the evil
charm of the word "sugar" and failed to take into account the
differences among the many kinds of sugar found in foods.
To use the glycemic index in a real-life diet, you must combine the GI
of various foods using a weighted average. Rick Mendosa's article (see
below) has information on simple calculations for mixed meals, which
recent research has shown to be reliable.
It remains difficult to predict the GI of high fat meals because of the
multiple affects of the fat, especially the way it slows the gut. For
example, a baked potato has a very high GI (one of the famous,
unexpected examples), but adding butter to it lowers the GI greatly.
This is a good reason to reduce dietary fat (if you needed another
reason), since doing so makes the effect of carbohydrates more
If you don't want to go to the effort of full GI calculations, the
important thing is to understand that foods may affect your bG profile
in ways that you wouldn't expect from categorizations such as "simple
sugar" and "complex carbohydrate". Build your knowledge about your own
response to different foods and meals by monitoring and keeping
records, and avoid assumptions.
Rick Mendosa <mendosa(AT)mendosa.com
> has written an excellent and thorough
article about the glycemic index. He also maintains a glycemic index
list. I highly recommend that you check out
[Thanks to Rick for information he provided for this section.]
Subject: Should I take a chromium supplement?
The short answer is "no". I'll quote the ADA's longer answer, from the May
1994 _Diabetes Forecast_, p.73. The ADA's editorial board says:
Some popular books on diabetes have claimed that chromium, which is
found in many common foods such as animal meats, grains, and
brewer's yeast, is good for people with diabetes. Not so. Though
chromium supplements may benefit people who are significantly
malnourished and have an actual chromium deficiency, there is no
significant evidence that consuming extra chromium helps people
with diabetes who are even close to being well nourished.
Taken at the dosages listed on the bottle, however, chromium is not
likely to be harmful. But your money is better spent on more useful
Subject: I beat my wife! (and other aspects of hypoglycemia)
(not yet written)
Subject: Does falling blood glucose feel like hypoglycemia?
Sometimes. Symptoms of hypoglycemia are divided into the adrenergic and the
neuroglycopenic. Adrenergic responses are caused by increased activity of
the autonomic nervous system and may be triggered by a rapid fall in blood
glucose (bG) or by low absolute bG levels; symptoms include
irritability (sound familiar?)
tingling of mouth and fingers
nausea or vomiting (unusual)
The autonomic nervous system activity also causes the secretion of
glucagon, cortisol and growth hormone. The first two are secreted
eliminated rapidly. The second two are secreted slowly and remain
4-6 hours, and may cause reactive hyperglycemia.
Neuroglycopenic responses are caused by decreased activity of the central
nervous system and are triggered only by low absolute bG levels; symptoms
The above information is from Mayer Davidson's _Diabetes Mellitus: Diagnosis
Remember, as always, that individual responses vary greatly. The exact
symptoms encountered will vary. It's not impossible that some of the
will fall in the other category for some individuals.
Subject: Alcohol and Diabetes
This section provided by Peter Stockwell <peter(AT)sanger.otago.ac.nz
Having diabetes does not prevent the consumption of alcoholic drinks,
but there are some considerations:
- Alcohol can metabolised to produce energy and so has dietary
- Alcohol promotes the uptake of blood glucose into liver glycogen
causing a drop in bG.
- Many alcoholic drinks contain sugar, particularly mixed drinks.
- The symptoms of drunkenness and hypoglycaemia are similar - alcohol
may mask the effects of a hypo.
- Diabetics must remain sober enough to care for themselves (perform
injections on schedule, etc).
- Excess alcohol consumption can cause increased serum triglycerides.
Few difficulties arise if following points are observed.
Acceptable in moderation:
- Red wines.
- Dry or medium-dry white wines.
- Dry sherries.
- Dry light beers (lagers, light ales fermented with low residual
- Spirits (whiskey, gin, vodka, etc) with "diet" mixers.
Use with extreme caution due to high sugar content:
- Sweet wines or sherries.
- Heavy or dark sweetened beers (stout, porters, etc which have
high residual sugar).
- Wine coolers.
- Spirits with normal mixers.
Use with extreme caution due to very high alcohol concentration:
- Neat (undiluted) spirits.
- Simple drinks (wine, beer) are more reliable than complex mixed
drinks, especially in company where you have less control over
the contents or concentration.
- Drink with or after food to avoid hypo problems.
- Approach anything with caution if you are in doubt.
- Low alcohol beers are not necessarily preferred - many of them are
- Alcohol provides about 7 cal/g of food energy. Some is lost in the
urine, but most is converted by the liver into forms which can be
used for energy elsewhere in the body or stored as fat.
Clearly these succinct rules are simplified and there are exceptions to
them (for example, there are dry ports) but they are intended as a
general guide. I make no attempt to define the term moderation, this
will depend on the individual.
Subject: Necrobiosis lipoidica diabeticorum
Necrobiosis lipoidica diabeticorum (NLD) consists of oval plaques,
the lower legs. It may start as small red spots or raised areas, which
develop a shiny, porcelain-like appearance. The plaques often turn a light
color due to extracellular fat (the "lipoidica"). They are often itchy or
painful. Typically the spots turn a brownish color, which fades slowly but
NLD is not related to any other complication of diabetes. In particular, NLD
does not presage eye, kidney or vascular problems.
NLD is much more common in diabetics, who account for perhaps 2/3 of all
cases. Many of the remainder develop diabetes, and NLD should be
warning sign of diabetes. Reports vary widely on exactly who is most at
About 1% of diabetics have some degree of NLD ... plus or minus 1%,
on which report you read. Some reports say NLD occurs more often in young
women, but some textbooks disagree.
The real dangers seem to be ulceration, infection, and the stress from the
appearance. Ulceration sometimes occurs spontaneously, and often as a result
Ulceration is often a result of scratching or trauma, and the ulceration
scratching sometimes heals very slowly. Thus avoiding scratching and trauma
decreases the amount of ulceration, though some ulceration will occur
There are some images of NDL lesions at
No particularly good treatment seems to be known. Topical steroids (that is,
creams) are the most common first choice. The ulcerations usually heal if
cared for properly, and drastic measures are not called for in most cases.
William Biggs reports that skin grafts may be necessary in cases of severe
ulceration, but do not tend to give results that are cosmetically
Other treatments reported to help sometimes are oral aspirin,
dipyridamole, locally injected steroids, and systemic steroids. No one
to be able to predict what will work on any given patient, and often not
of anything is effective. However, the ulcers usually heal if given
supportive treatment. Surgery should be avoided. Ineke van der Pol reports
finding relief in Chinese herbal treatments.
STEROID WARNING: locally injected and systemic steroids raise blood glucose
and cause severe problems regulating blood glucose. These should be used
as a last resort. Topical steroids (creams and inhalers) cause no such
Note that treatment is not a medical necessity except for ulcerations and
infections. Otherwise, the purpose of treatment is to prevent ulcerations
and infections, decrease pain and itching, and improve the appearance.
NLD is the subject of occasional articles in scientific journals on diabetes
and on dermatology. Betsy Butler has researched the medical journals,
little beyond what I've reported above -- in her words, "no good answers".
_Therapy for Diabetes Mellitus and Related Disorders_, published by the ADA,
has a section on necrobiosis lipoidica diabeticorum and its treatment.
Ineke van der Pol has started a mailing list about NLD at
I thank the following people, especially Betsy, who posted the information
from which I derived this section:
Betsy Butler Polley (who says sorry, she doesn't have any information
besides what's here)
William Biggs <reddy_biggs(AT)msn.com
Tari M. Birch <tm_birch(AT)pnl.gov
Terence Griffin (who also says he doesn't have any other info)
Bill Barner <barner(AT)mail.loc.gov
Ineke van der Pol <fluo(AT)chello.nl
> (who has no further information
but is happy to correspond about NLD if you wish)
Subject: Has anybody heard of frozen shoulder (adhesive capsulitis)?
Short answers: adhesive capsulitis, aka frozen shoulder, is a painful
condition that limits motion in one shoulder or both. It's not found
exclusively in conjunction with diabetes, but occurs sufficiently more often
with diabetes to be considered a diabetic complication. Don't be surprised,
though, if your doctor isn't aware of this connection. Avoid surgery (which
seldom helps) and cortisone (which plays havoc with blood glucose control);
take physical therapy seriously; expect to take about two years to recover.
Lee Boylan <lboylan(AT)cisco.com
There are three treatments usually offered for frozen shoulder: surgery,
cortisone shots and exercises. Surgery offers the best transfer of
a surgeon but the patient ends up needing to do exercises anyway.
Cortisone offers quick pain relief but not full shoulder relief, so the
patient is told to do exercises. Also, a DMer has drastically changed
insulin requirements after taking a cortisone injection.
Exercise, with alternating hot and cold packs and optional NSAIDs, offers
slow and sometimes painful therapy that gets full or nearly full
restoration of movement. Just don't let it discourage you, because
improvement comes slowly. Keep at it! Eventually, you will have pain-free
motion in your arm.
And I'll re-emphasize what Lee says: DON'T TAKE STEROIDS LIGHTLY. Including
cortisone. This warning should not be necessary, but unfortunately some
doctors are unaware of what steroids do to blood glucose. If your doctor
doesn't understand how serious a problem this is, insist on including an
endocrinologist in your medical team.
Lyle Hodgson <lyle(AT)world.std.com
>, who has been through adhesive
capsulitis in both shoulders, wrote:
I suggest anybody who really wants to know about it who can visit
to see Dr. Gordon Lupien, who used to be an orthopedic surgeon at Joslin
and, according to a couple doctors I asked, knows more about adhesive
capsulitis in diabetics than anyone else, period.
o Diabetics get "frozen shoulder" more than non-diabetics.
o Women get "frozen shoulder" more than men.
o Everybody I talked to who had ever treated "frozen shoulder" said that
every patient they'd seen with it got over it in two years, no matter
whether they did the exercises or not.
o The exercises and ESPECIALLY PHYSICAL THERAPY help tremendously in
retaining what range of motion you still have and in keeping the pain
(which can be incredible) to a minimum.
o The exact cause and pathology is completely unknown, but often adhesive
capsulitis follows an untreated injury, or bursitis or tendonitis
a period of no stretching exercises.
o Adhesive capsulitis is often mis-diagnosed as a torn rotator cuff,
may well be involved but which will heal without the surgery most
orthopedic surgeons prescribe for it. What's more, an often undiscussed
side-effect of the surgery is permanently reduced range of motion,
because tendons are snipped and resewn, and thus shortened.
o If the exact pathology is unknown, it is certain that it involves
scarification of the tissues in the shoulder "capsule", and from what I
understand scar tissue is at least partly caused by glycosulation of
tissues, so good control is (once again) the best prevention .
o Cortisone is often prescribed for non-diabetic patients, and only for
diabetic patients by doctors unfamiliar with the dramatic effect
cortisone has on bloodsugar levels. Dr. Lupien told me cortisone
even really have any long-term effect except to reduce the pain for
awhile, and should be avoided completely since it could also
screw up how your body deals with cortisone.
o Recommended treatment: daily exercises, biweekly physical therapy,
(if possible) swimming, and acetaminephen (Tylenol). Extensive use of
non-steroidal anti-inflammatories is not recommended. These include
aspirin, ibuprofen (Advil/Motrin), and naproxen.
Here's a sort-of-a- self test for adhesive capsulitis:
1. Lay on the floor on your back. Can you raise your arm over your
a 180-degree arc and rest it on the floor without pain or *too* much
2. Stand sideways next to a wall, and walk your fingers up the wall until
you can't reach any more. Can you almost press your armpit to the
If either of these gives you significant trouble -- you can't quite reach
the floor behind your head, you can't touch the wall with your elbow, and
either or both gives you pain -- you may (MAY, MAYBE, MIGHT) have
Two doctors and one physical therapist told me that shoulders tend not to
get the regular stretching that other joints get: a person can go for
periods of time without moving the shoulder much out of its usual hanging
position, and then often the movement doesn't count for much. Hips are
stretched at least a little several or many times a day, even with
sedentary types who only sit, stand, sit, stand, walk a little, sit,
the tissues are still fairly regularly manipulated so that it is much
harder for them to freeze up.
Lyle, who is always interested to hear what else anyone has learned about
this little-studied, little-mentioned condition
J K Drummond (no longer on the net, but well) contributed this section.
Gastroparesis (gastroparesis diabeticorum if a diabetes complication) is
nerve damage caused delayed gastric emptying. This more common than
recognized irregular digestive slowdown interferes with blood glucose
regulation and oral medicine absorption.
Severity ranges from occasionally recurring bothersome symptoms like
nausea, vomiting, constipation and diarrhea to total "stomach paralysis"
-- the inability to consume/absorb any food. This worst stage requires
tube feedings as the sole source of nutrition, IVs for hydration, and
gastric suction for waste elimination. Be aware that "stomach trouble" may
be more serious for one with diabetes and report digestive problems to
your physician. Do not wait until you have had gastroparesis for several
years or end up in the emergency room because you cannot eat. If you
are a health professional, please routinely ask diabetics if they have
Many with gastroparesis are undiagnosed or misdiagnosed and find little
information about it. Often they have been used as guinea pigs in
guessing games of hit or miss treatment trials. The scary quest has
only just begun to find answers, reason, and solutions to this lesser
known and mystifying complication of diabetes. There are people who
have found answers in their lonely struggle with gastroparesis.
Most folks with gastroparesis are female, with type 1 diabetes for 20-25
years and are age 25-45 at onset of gastroparesis.
These incomplete lists of symptoms, treatments, helpful & stressful
foods, and social aspects have been compiled mostly from patient reports.
There is no all-patient guarantee of experience. CHECK WITH YOUR DOCTOR!
S Y M P T O M S
nausea fatigue- muscle weakness
lack of hunger
high stomach acidity
inability to control blood sugars
Symptoms together with gender &/or years of diabetes (clinical intuition)
Gastric Mobility Transit Test
Manometric Motility Study
Diabetics are also subject to all forms of non-diabetic gastropathy so be
aware that tests are necessary to eliminate and/or verify other diagnoses.
NUTRITION - MALNUTRITION Dietitians recommend 6 small meals daily
Foods more easily digested Foods increasing symptoms
fruit juices protein foods - meat, eggs
canned fruits & vegetables raw fruits & vegetables
soft starches (white bread dairy products
& rice, mashed potatoes,
cereals) caffeine, chocolate
soups nuts & seeds
Liquid Nutritional Supplement Drinks
Diabetic: Choice dm (Mead-Johnson), Glucerna (Ross Labs)
Ensure Glucerna OS (Ross Labs)
Non-diabetic: Ensure/Ensure plus, Sustacal (Ross Products Div)
IVs (fluids or TPN)
Tube feedings (eq. Osmolite or Supplena)
PHYSICAL - Remaining upright at least a half hour after eating,
stomach massage, enemas, glycerine suppositories, stool softeners
(for example, psyllium husk powder: Metamucil and other brands)
DRUGS - May have adverse side effects on other conditions. Ask your MD!
Reduce stomach acid: Zantac, Pepcid, Prilosec, Axid, Cytotec
Propulsid (cisapride) (in U.S. only under compassionate use protocol)
domperidone (U.S. availability: compassionate use only, and for
use -- it's used to treat fescue toxicosis in horses)
Zelnorm (tegaserod maleate), labeled in the US as of 2002 to treat
women with irritable bowel syndrome (IBS) dominated by
constipation. Zelnorm increases serotonin activity in the bowel by
activating some 5HT4 receptors, which increases serotonin in the
bowel and increases motility. The percentage of IBS patients who
benefit is small but significant. It's not clear why the labeling
is limited to women, though it seems likely to be a combination of
the fact that 2/3 of IBS patients are women and the clinical
studies barely reached statistical significance. If the effects in
gastroparesis follow those in IBS, a small percentage of patients
will see improvement, and some of those will be helped a lot.
Information from the Zelnorm prescribing information on the
Reduce digestive system spasm: dicyclomine
Diarrhea: immodium, clonidine
Nausea/vomiting: marinol, thorazine, ativan, inapsine, zephran, phenergan
Surgical (physical implants or alterations)
portacath or Hickman - IV hydration or Total Peritoneal Nutrition
jejunostomy - tube feedings
gastrostomy - for stomach suction (PEG tube)
gastric resectioning or stomach removal
gastric pacing - digestive pacemakers (experimental). Enterra Therapy by
Medtronic, gastric electrical stimulation (GES) neurostimulator implants
are approved as a humanitarian use device (HUD) since severe
(refractory to drugs) has less then 4,000 cases per year. More info at
SOCIAL & PSYCHOLOGICAL ASPECTS
Frustration for patient and physician from the difficulty in balancing
insulin dosages and food intake to achieve level blood sugars with
unpredictable slowed digestion.
Additional psychological impact from delayed treatment due to relative
medical unrecognition causing underdiagnosis and even misdiagnosis (ex. as
anorexia nervosa if accompanied by vomiting).
Lack of ostomy education.
If/when eating ability returns following thinking that a normal diet could
never again be eaten it may cause physical & emotional anorexia.
Often felt burden to friends and family.
Most information was collected by the pioneering health professionals of
the defunct Gastroparesis Communication Network, updated by J K Drummond.
There's an excellent web page on gastroparesis at
** If you have been or are out of work pursue Medicare/Medicaid & Social
Security Options IMMEDIATELY!
Subject: Extreme insulin resistance
Mayer Davidson writes several pages about insulin resistance in his
book _Diabetes Mellitus: Diagnosis and Treatment_. Except for what's in
[brackets], the following information is from pp 126-132 of the third
edition or pp 112-119 in the fourth edition. I'd recommend finding a
copy. Most university libraries will have it, even those without
medical schools. It's about $65; if necessary you can order from the
Rittenhouse Medical Bookstore in Philadelphia at 215-545-6072
In this context, "insulin resistance" refers to patients requiring more
than the arbitrary amount of 200 units/day. Davidson uses the term
"insulin antagonism" for the phenomenon which is commonly part of type
Davidson cites ten major causes of insulin resistance. The first eight
are obvious major medical problems that you would immediately suspect
were related, so I won't bother listing those. Rarely, insulin is
destroyed at the subcutaneous injection site; this form can be treated
with normal amounts of insulin administered intravenously or
The most common form of insulin resistance is immune-mediated. Everyone
taking injected insulin develops IgG antibodies to insulin. In most,
the antibody levels are low. In about 1 in 1000, the levels are much
higher, from 5 to over 1000 times higher than usual. In Davidson's
The reason for this markedly enhanced response and the
subsequent decline to normal levels is completely unknown.
The antibodies bind to, and neutralize, the insulin.
At one time it was thought that the antibodies resulted from impurities
in the insulin preparations, and that using highly purified
preparations would avoid the problem. This has proven not to be the
case; purified insulin helps but usually does not resolve the problem,
[though it seems to be worth trying].
Also, switching to a different insulin does not help, as the antibodies
bind to beef, pork and human insulin. They may bind to one more than
the others, but the titers of antibody are so high as to neutralize
virtually all of any of the insulins.
Two treatments which are effective are not generally available in the
First, insulin can be treated with sulfuric acid. The modified molecule
retains some biological activity but has reduced affinity for binding
to the IgG antibodies to insulin. This treatment was tested by a
Canadian laboratory in the late 1960s but is available in the US only
by special petition to the FDA. Novo Nordisk Pharmaceutical can provide
information at 609-987-5800
Second, fish insulin works in humans but does not bind to the
antibodies. Cod insulin, for example, differs from human insulin in 33
amino acid positions compared with 3 differences for beef insulin. But
nonmammalian insulins are not available in the US at all.
This leaves the two treatments that are actually used on a regular
basis, and a promising new treatment.
Because this condition is rare, there's been little experience treating
it with lispro insulin (Humalog). That experience is promising; it
appears that the structural change in lispro may inhibit the antibody
binding. If this is borne out by further experience, lispro will be the
treatment of choice for extreme insulin resistance.
Glucorticoids such as prednisone decrease the extreme insulin
resistance, possibly by inhibiting the production of IgG antibodies. As
the antibodies have a half life of 3-4 weeks, the response is delayed,
during which time bg control is even more difficult due to the effects
of the glucocorticoids. After several weeks the dosage can be reduced
to maintenance levels or eliminated, but relapse is common. Since
glucocorticoids have other nasty effects in addition to the problems
listed above, there are significant problems with this course of
Davidson's recommendation is based on The Good News: insulin resistance
is self-limited and only lasts a few months to a year. He simply uses
as much insulin as is needed in the meantime. U-500 concentration is
available for this purpose. The antibodies delay the action, so even
though U-500 is regular insulin it acts like a lente or semilente in
resistant patients. For unknown reasons, much less U-500 is needed than
the equivalent amount of U-100, 50% to 75% less. Since the situation is
difficult to manage and is temporary, Davidson advises not trying for
good bg control, but just avoiding ketosis and the overt symptoms of
hyperglycemia (thirst, excess urination, infections).
When insulin sensitivity returns, it can happen quite suddenly.
Davidson starts reducing the high insulin doses when fasting bg is
under 200 mg/dl (11.0 mmol/L). At these times, large amounts of insulin
previously bound to the antibodies may be released, so avoiding
hypoglycemia is a major concern. The return to normal sensitivity will
take at least several weeks due to the half-life of the antibodies, and
insulin requirements may fluctuate a great deal during this time. A
fast response to U-500 insulin (2-4 hours from injection to measurably
lower bg) may indicate the decline of insulin resistance.
[This was the movie. Now go read the book.]
Subject: What is pycnogenol? Where and how is it sold?
All sections on pycnogenol are written by Laura Clift
Numbers in parentheses refer to the section on "Pycnogenol references".
Pycnogenol, a.k.a. Revenol, is a substance that has been mentioned in
misc.health.diabetes as an aid/cure for several diabetic complications.
Pycnogenol is a bioflavanoid, also identified as an oligomeric
proanthocyanidin (OPC) and a procyanidin, which is found in the bark of
conifers, specifically the maritime pine (_Pinus maritima_) and the Canadian
spruce (_Tsuga canadensis_) and in grape seeds. The substance was
the US (patent 4,698,360) in 1985 by J. Masquelier of France.
Pycnogenol is sold on several web sites in addition to health food
web sites are set up in a pyramid scheme with the claims of quick riches for
new distributors. Most of the sales pitches rely on first-person
"testimonials". Some pitches include a list of published scientific studies
that, according to the pitch, support the claims of the ad. In the following
sections I examine the sales claims, investigate the ad's publication list,
and establish a bottom line.
Subject: What claims do the sales pitches make for pycnogenol?
Written by Laura Clift.
Pycnogenol or Revenol (super-enriched pycnogenol) claim to be the world's
most powerful anti-oxidant (vitamin C and E are anti-oxidants). The ads
pycnogenol is non-toxic, non-mutagenic, has high bioavailability,
blood-brain barrier, enables vitamin C to remain in the body for 3 days as
opposed to 3 hours, increases capillary resistance, decreases capillary
fragility and permeability, decreases lower leg volume, strengthens
and remains active in the body for 72 hours.
Ads make claims that pycnogenol prevents, aids and/or cures the following
arthritis, cancer, AIDs, stomach pains, aches and pains, aging, abnormal
menstrual bleeding, asthma, atherosclerosis, bruises, diabetic
retinopathies, dry skin, edemas, excessive blood sugar, fatigue, hay
heart attacks due to vascular accidents, hemorrhoids, inflamed tissue,
internal bleeding, jet lag, kidney disease, menstrual cramps, phlebitis,
poor circulation, skin elasticity, strokes due to cerebral accidents,
stress, ulcers, varicose veins, multiple sclerosis, prostate problems,
sleep disorders, dog and horse cancers, attention deficit disorders, and
increased physical endurance.
Subject: What's the real published scientific knowledge about pycnogenol?
Written by Laura Clift. (refs) point to "pycnogenol references" section.
In a study examining the anti-oxidant action of several bioflavanoids,
(-)-epicatechin 3-O-gallate and (-)-epigallocatechin 3-O-gallate were both
more potent than pycnogenol against the free radicals DPPH, superoxide
OH, and OOH, although not by much (1).
The toxicity of pycnogenol is not established in published reports.
Proanthocyanidin mutagenicity is tricky, if it is completely pure it is
considered non-mutagenic. However, there is an impurity that is very similar
and hard to remove in the purification of proanthocyanidin that is mutagenic
No published work could be found on the bioavailability of pycnogenol in
particular, but oral ingestion of bioflavanoids in general results in a low
Pycnogenol does cross the blood-brain barrier in rats when given as an
intraperitoneal injection (4). The same study seems to indicate that
pycnogenol can increase capillary resistance and decrease capillary
permeability in rats. A clinical study on 25 patients indicated an increase
in capillary resistance (5). When administered by intraperitoneal injection
to rats, chemically induced edema of the paw was decreased (6).
There are no published studies on pycnogenol's interaction with vitamin
most of the preventions, aids and/or cures claimed. However, procyanidol
oligomers offered no protection for venous disease from hypoxia (lack of
Subject: How reliable is the literature cited by the pycnogenol ads?
Written by Laura Clift.
Masquelier J, Michaud J, Laparra J, Dumon MC. Flavanoids et pycnogenols. Int
J Vit Nutr Res 1979;49(3):307-11.
Article in French. Abstract states that the article describes pycnogenol
chemically designating the compound as "pycnogenol" to distinguish it
the hundreds of other bioflavanoinds.
Uchida S, Edamastu R, Hiramatsu M, et al. Condensed tannins scavenge active
oxygen free radicals. Med Sci Res 1987;15:831-2.
Pycnogenol is a free radical scavenger (anti-oxidant) in vitro
a living animal, or, in a petri plate).
Lagrue G, Oliver-Martin F, Grillot A. Etude des effects des oliomeres du
procyanidol sur la resistance capillaire dans l'hypertension arterielle et
certains nephropathies. La semaine des Hopitaux de Paris 1981; 57:1399-1401.
French article. Abstract states capillary resistance increased in 25
patients. No dose amount or route of administration in the abstract.
Cahn J, Borzeix MG. Etude de l'administration des oligomeres du
procyanidoliques chez le rat: Effets observes sur les alterations de la
permeabilite de la barrier hematoencephalique. La semaine des Hopitaux de
French article. Abstract states that pycnogenol crosses the blood-brain
barrier in the rat and affects capillary permeability. Route and dose not
presented in abstract.
Tixier JM, Godeau G, Rober AM, Hornebeck W. Evidence by in vivo and in vitro
studies that binding of pycnogenols to elastin affects its rate of
degradation by elastases. Biochem Pharmacol 1984;33(24):3933-9.
Study with (+) catechin and pycnogenol (states they are related
but act differently, including the results of this study). Pycnogenol
prevents the break down of elastin in vitro and in rabbits.
Kuttan R, Donnelly PV, DiFerrainte N. Collagen treated with (+)-catechin
becomes resistant to the action of mammalian aollagenase. Experentia
(+) catechin is not pycnogenol (see above). Study does not investigate
Reimann HJ, Lorenz W, Fischer M, et al. Histamine and acute hemorrhagic
lesions in rat gastric mucosa: prevention of stress ulcer formation by
(+)-catechin, an inhibitor of specific histidine decarboxylase in vitro.
Agents and Actions 1977;71:69-72.
(+) catechin is not pycnogenol (see above). Study does not investigate
Markle RA, Hollis TM. Rabbit aortic endothelial and medical histamine
synthesis following short-term cholesterol feeding. Exp Mol Pathol
Markle RA, Hollis TM. Variations in rabbit aortic endothelial and medical
histamine synthesis in pre- and early experimental atherosclerosis. Proc Soc
Exp Biol Med 1977;155:365-8.
Hollis TM, Furniss JV. Relationship between aortic histamine formation and
aortic albumin permeability in atherogenesis. Proc Soc Exp Biol Med
Does not study pycnogenol or any bioflavanoid. Logic may go like this:
pycnogenol is similar to (+) catechin which can effect histamines.
some cardiac/circulatory problems that are affected by histamine.
Therefore, pycnogenol will prevent these diseases. Logic may be OK for a
hypothesis but is flawed as a conclusion, especially since (+)
pycnogenol act differently in most studies (see above).
Feine-Haake G. A new therapy for venous diseases with
3,3,4,4,5,7-hexa-dihydro-flauan. Z Allgemeinmed 1975;51(18):839.
German article, no abstract translation; chemical name implies
Blazso G, Gabor M. Oedema-inhibiting effect of procyanidin. Acta Physiol
Sci Hung 1980;56(2):235-40.
Chemically induced edema of a rat's paw was decreased with
injections of pycnogenol.
Subject: What's the bottom line on pycnogenol?
Written by Laura Clift. (refs) point to "pycnogenol references" section.
All bioflavanoids are anti-oxidants (1,8,9) and may effect capillary
hyperpermeability (8,9), inflammations (3,8), and edemas (8). However, there
is no bioflavanoid deficiency condition, and they have "no accepted
preventive or therapeutic role in vascular purpura, hypertension,
degenerative vascular disease, rheumatic fever, arthritis, cancer, or any
other condition" (9). This was as of 1988; no mention of bioflavanoids is
made in the 1994 edition of this reference. Most pycnogenol studies and/or
claims come from the early 70's to mid 80's. Promising starts are never
followed up on. Most later studies seem negative (both pycnogenol and
bioflavanoids), especially about the oral route. With all but one study
performed in rodents, there is a very definite lack of information on how
this substance acts in humans and what possible side-effects it produces.
The sales pitch seems to be taken from the 1985 patent. Filing a medical
patent doesn't mean the substance is thoroughly studied and its applications
are determined. A patent is filed when preliminary studies look
you try to come up with every possibly use for the compound, no matter how
far out in left field it may be. If you do not hold the patent for the
application, someone else could conceivably use your compound for that
application and owe you nothing or a very reduced royalty.
In short, patent claims have no medical significance.
Subject: Pycnogenol references
Written by Laura Clift. This is the section to which the (refs) point.
1. Uchida S, Edamastu R, Hiramatsu M, et al. Condensed tannins scavenge
oxygen free radicals. Med Sci Res 1987;15:831-2.
2.Yu CL, Swaminathan B. Mutagenicity of proanthocyanidins. Food Chem Toxicol
3. Namgoong SY, Son KH, Chang HW, Kang SS, Kim HP. Effects of naturally
ocurring flavanoids on mitogen-induced lymphocyte proliferation and mixed
lymphocyte culture. Life Sci 1994;54(5):313-20.
4. Cahn J, Borzeix MG. Etude de l'administration des oligomeres du
procyanidoliques chez le rat: Effets observes sur les alterations de la
permeabilite de la barrier hematoencephalique. La semaine des Hopitaux de
5. Lagrue G, Oliver-Martin F, Grillot A. Etude des effects des oliomeres du
procyanidol sur la resistance capillaire dans l'hypertension arterielle et
certains nephropathies. Las semaine des Hopitaux de Paris 1981;
6. Blazso G, Gabor M. Oedema-inhibiting effect of procyanidin. Acta Physiol
Acad Sci Hung 1980;56(2):235-40.
7. Michiels C, Arnould T, Houbion A, Remacle J. A comparative study of the
protective effect of different phlebotonic agents on endothelial cells in
hypoxia. Phlebologie 1991;44(3):779-86.
8. Lonchampt M, Guardiola B, Sicot N et al. Protective effect of a purified
flavanoid fraction against reactive oxygen radicals. in vivo and in vitro
study. Arzneimittelforschung 1989;39(8):882-5.
9. Shils ME. Modern nutrition in health and disease. Philadelphia: Lea and
Febiger, 1988. p472.