GRIN lens sources

[Nikolas Karalis]

Does anybody have experience with Thorlabs or Edmund Optics lenses for miniscope (v4) imaging?

[Daniel Aharoni]

From last time I checked, Edmund Optics sells grin lenses manufactured by Grintech, the same company that makes the grin lenses Inscopix sells. The issue is that these lenses have a design wavelength longer than what is used for GCaMP imaging, resulting in their optical characteristics being a bit different than what the site says. We have had reasonably good experience using these lenses, specifically their larger diameter lenses (~1.8 mm) for imaging in rats.

Thorlabs, since producing their Mini2P system, looks to have expanded their grin lens line. They use to only carry grin lenses manufactured by GoPhoton which some reported issues with including tissue toxicity. I'm not sure what has all changed in terms of their manufacturer but they look worth trying.

My lab will order a bunch of these to test and write up our findings as part of the Miniscope project.

On Wed, Mar 11, 2026 at 12:11 PM Nikolas Karalis <nikolas...@gmail.com> wrote:

Does anybody have experience with Thorlabs or Edmund Optics lenses for miniscope (v4) imaging?

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Daniel B. Aharoni, PhD
Associate Professor, Department of Neurology, UCLA
Eleanor Leslie Chair in Innovative Brain Research
DAha...@mednet.ucla.edu
DBAh...@gmail.com