ASETNIOP is a "chord-based" keyboard layout that uses the most frequent letter for each finger on a qwerty keyboard as its foundation.
I wonder how much efficiency could be achieved if one adopted this approach for an ordinary (i.e., non-chord) keyboard. Such a keyboard (call it "6x2") would involve six swaps of keys -- E-D, T-F, N-J, I-K, O-L, and P-;. You're just moving the most frequent letter in each case to the home row. It would seem far easier to transition to such a layout, since there are no finger changes. So, how efficient would it be compared to Minimak or Colemak - would you get more "bang for the buck" even if overall efficiency were a little lower?
Obviously, by definition, such a layout would not address left-right imbalance in qwerty, as no finger changes. But one additional swap (call the resulting keyboard "6+1") could get you there: you could swap the (moved) E and I keys (yielding a home row of ASITGHNEOP) or the E and N keys (ASNTGHEIOP). The former is pretty close to Minimak 12. Both are even closer to qwpr, but avoid moving the E to the right pinky.
I wonder (1) how much additional improvement you would get from this additional move (and, thus, whether it would be worth it), (2) which version of "6+1" would be better (I suspect the former, as both Colemak and Minimak 8 have the NEO combination), and (3) how close 6+1 would come to Minimak or Colemak in terms of overall efficiency.
Best regards.