Pfizer Gummies - twice-daily weight-loss Gummies 2024 pulled from clinical trials due to side effects

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Pfizer wants a chunk of the budding weight loss drug market, which it believes could eventually grow to $90 billion.
But analysts said that upcoming data on Pfizer’s experimental obesity pill, danuglipron, will be crucial to how competitive the company can be against Eli Lilly and Novo Nordisk.
Investors want to see Pfizer’s drug cause a similar level of weight loss as a once-daily pill from Eli Lilly in an phase two trial in obese patients with diabetes.

What is Pfizer’s weight-loss drug?

Known as danuglipron, the diabetes and obesity treatment is in a class of drugs called GLP-1 agonists and mimics a hormone the body releases when a person eats food. People have reduced appetite, and when they do eat, they feel full sooner, as TODAY.com previously reported. Semaglutide, the active ingredient in Ozempic and Wegovy, is also in this class of drugs.

Danuglipron comes in pill form. Unlike oral semaglutide, which is currently available as the Type 2 diabetes treatment Rybelsus, it doesn’t require fasting before or after taking the pill.

Danuglipron was being tested as both a twice-daily and once-daily pill. Pfizer announced on Dec. 1 that it was discontinuing phase 3 clinical trials of the twice-daily version due to high rates of adverse side effects. While these were mostly mild, a large percentage of participants, who had obesity, experienced them: up to 73% had nausea; up to 47% had vomiting, and up to 25% had diarrhea. Over half of participants, all adults with obesity, discontinued the medication during the study.

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The company said that it still plans to release data on its once-daily version of danuglipron next year, which will "inform a path forward" regarding pursuing approval for the medication.

The clinical trial did find that twice-daily danuglipron led to "statistically significant" weight loss, the company said: Participants were down between 8% to 13% of their body weight on average after 32 weeks on the medication, and 5% to 9% after 26 weeks.

A previous phase 2 trial in adults with Type 2 diabetes also found that when people took danuglipron twice a day for four months, their body weight was “statistically significantly reduced” compared to a placebo. The results were published in JAMA Network in May 2023.

Study participants who took the highest dose of danuglipron — 120 milligrams, twice daily — lost about 10 pounds in 16 weeks, researchers reported. The paper didn’t directly compare those results to Ozempic or Wegovy, but a phase 3 trial showed patients who received a once-weekly 1 milligram injection of semaglutide lost about 10 pounds in 30 weeks.
Does Pfizer have a weight-loss pill that’s better than Ozempic?

When it comes to effectiveness, it’s a little early to say, McGowan notes.

Danuglipron and semaglutide are different molecules so the dosages can’t be directly compared, but in general, the oral dose required to achieve the same results as an injectable version is significantly higher because the digestive tract is a “more challenging route for absorption,” McGowan says.


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The trials were different studies with different populations so they can’t be directly compared, McGowan says.

“Unless you do a direct head-to-head comparison, you really can’t make any definitive conclusions,” he adds.

“But what we can say is that the results are in the same ballpark as what we’ve seen with Ozempic.”
What are the side effects?

The most common side effects of danuglipron were nausea, diarrhea and vomiting, according to the studies.


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