I have the same experience using Entourage. I often mistakenly delete
my draft email by pressing the CMD+Delete keys when actually mean to
press Function+Delete to perform a forward moving character deletion.
It's very frustrating when this happens since, I lose all the work
I've done in my draft email. I try to remember to press CMD+S to save
my work occasionally, so that if this does accidentally happen, I
don't lose everything I've typed already.