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[Bonichris Nice]

What does it look like?
Usually found as a yellow, sometimes waxy, crystal-like substance, occasionally as a powder.
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How is it taken?
Smoked: it can be inhaled through a pipe, and smoked in a joint. This is the preferred method and usually easier to do in the ‘freebase’ form.

Injected: it can be injected only if it is in the acidic salt (fumarate) form, the other form (‘freebase’) cannot be as it does not mix with water.

Snorted: the crystals can be crushed and snorted, similar to other white powders.
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Ingested: in some cultures, the ‘ayahuasca’ beverage contains some DMT. However, when ingesting DMT, an appropriate enzyme inhibitor must be taken (i.e. MAOIs), otherwise the DMT will be inactive.

NB. The fumarate form is water soluble (mixes with water), more stable and less likely to degrade, but is slightly less potent than the ‘freebase’ form. Both forms can look similar in appearance, although the ‘freebase’ form may have a stronger crystal-like appearance.
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POSITIVE EFFECTS OF DMT
A statistically significant and clinically relevant reduction in depressive symptoms two weeks following a dose of SPL026 with supportive therapy, compared to placebo, demonstrating a -7.4 point difference in Montgomery–Åsberg Depression Rating Scale (MADRS) (p=0.02)
Analysis of key secondary endpoints demonstrated a rapid onset of antidepressant effect one-week post-dose, with a statistically significant difference in MADRS score between the active and placebo groups of -10.8 (p=0.002)
Across the 12-week open-label phase, patients who received at least one active dose of SPL026 with supportive therapy reported a durable improvement in depression symptoms. No apparent difference in antidepressant effect was observed between a one and two dose regimen of the intravenous DMT
Clinically meaningful difference in response rates of SPL026 at week one and week two, 44 percent and 35 percent, respectively.
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DMT stands for dimethyltryptamine — it’s one of the simplest psychedelics from a molecular level — but among the most profound in terms of the experience it produces. There are a few different kinds of DMT, but the most common are N,N,DMT and 5-MeO-DMT.
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Other forms exist as well but produce a very different experience — such as 4-AcO-DMT (more similar to psilocybin than DMT), 5-Bromo-DMT (very mild psychoactive effects), and 4-OH-DMT (the chemical name for psilocin). These compounds are technically a form of DMT, but are considered an entirely different class than N,N,DMT or 5-MeO-DMT.

The most common method of using DMT is in the form of ayahuasca (N,N,DMT) or the Bufo alvarius toad (5-MeO-DMT). Both are traditional sources of DMT used by shamans to occasion mystical experiences for the sake of healing and self-exploration.
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