Dear Thierry;
Yes, this is possible.
The "11 native regions" are only for one specific model (or family of models) used by the IIASA ECE Program, called "MESSAGEix-GLOBIOM".
The MESSAGEix framework, in general, allows to populate the "node"
set/dimension with any values; see the documentation, e.g. the Westeros
and Austria tutorials which each use a single specific region.