Hi Haley,
I tried this out, and everything worked for me. I'll show you what I did, so you can tell me if you are doing something differently.
This is what I have in the clipboard (triangles are tabs; little Ls lying down are end line characters):
I have a small file with four taxa, and when I choose Make New Matrix from... Clipboard, it shows this dialog:
and gives me this matrix:
This is what I expect.
If instead I have this matrix in Mesquite, with all cells selected:
And then I paste the above matrix in, I end up with this:
This is what I expect. The blank cells in the clipboard don't overwrite the cells in the matrix, but the others do.
Can you give me instructions to match what you do when the problem occurs?
Thanks!
Wayne