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cüneyt ayrık

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Dec 4, 2012, 3:38:36 AM12/4/12
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Dr. Cüneyt

Methemoglobinemia is formed when iron from any one of the four heme rings of the 
hemoglobin structure is oxidized from the ferrous (Fe2+) to its ferric state (Fe3+). Why can’t the cyanosis of MetHb be overcome with oxygen?



The Answer is:

In the ferric state, oxygen is unable to bind to the iron atom of the heme group. Because of the dysfunctional hemoglobin, the cyanosis of MetHb cannot be overcome with oxygen. (Am J EM, 1/12, p. 231).

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