Mali study published in The Lancet Global Health
Steinmetz, Ivo
Dear colleagues and friends,
We are pleased to share with you our recent publication in The Lancet Global Health, which reports on our study of melioidosis in Mali, conducted in collaboration with Médecins Sans Frontières/Doctors Without Borders.
You can access the article via the following link: https://www.sciencedirect.com/science/article/pii/S2214109X25003171
Hopefully another small step towards raising awareness.
Best wishes
Ivo
_____________________________________
Prof. Ivo Steinmetz, MD
Head
R&D Institute of Hygiene, Microbiology and Environmental Medicine
Medical University of Graz
Neue Stiftingtalstraße 6
8010 Graz
Austria
Phone +43 316 385 73700
David Dance
Excellent Ivo, well done and congratulations!
As we said in Darwin, if there is this much melioidosis in children in Mali there must be a lot in adults.
BW
David
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Jeffrey Warner
On 16 Oct 2025, at 6:06 pm, David Dance <davidd...@gmail.com> wrote:
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Excellent Ivo, well done and congratulations!
As we said in Darwin, if there is this much melioidosis in children in Mali there must be a lot in adults.
BW
David
From: <melio...@googlegroups.com> on behalf of Ivo Steinmetz <ivo.st...@medunigraz.at>
Reply to: <melio...@googlegroups.com>
Date: Thursday, 16 October 2025 at 08:57
To: "melio...@googlegroups.com" <melio...@googlegroups.com>
Subject: [Melioidosis] Mali study published in The Lancet Global Health
Dear colleagues and friends,
We are pleased to share with you our recent publication in The Lancet Global Health, which reports on our study of melioidosis in Mali, conducted in collaboration with Médecins Sans Frontières/Doctors Without Borders.
You can access the article via the following link: https://www.sciencedirect.com/science/article/pii/S2214109X25003171
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Hopefully another small step towards raising awareness.
Best wishes
Ivo
_____________________________________
Prof. Ivo Steinmetz, MD
Head
R&D Institute of Hygiene, Microbiology and Environmental Medicine
Medical University of Graz
Neue Stiftingtalstraße 6
8010 Graz
Austria
Phone +43 316 385 73700
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xiaqi...@sina.com
BW
发件人："'Jeffrey Warner' via Melioidosis.info" <melio...@googlegroups.com>
收件人："melio...@googlegroups.com" <melio...@googlegroups.com>
主题：Re: [Melioidosis] Mali study published in The Lancet Global Health
日期：2025年10月16日 16点17分
Bart Currie
Thanks Ivo – what an incredibly important paper and so well presented – well done to the whole team and shows how value adding to the good work of MSF can really improve understanding and management of the infectious diseases in specific locations.
It certainly does raise questions too as noted by Jeff and David:
Ivo – when you extrapolated to estimated rates of melioidosis for the whole population (ie adults and children) did you assume a constant melioidosis rate across all ages?
If the age breakdown of cases was as in Australia (children well under 10% of all cases), then the overall rates would be extremely high, as David notes. Are you aware of adult cases of melioidosis diagnosed from that region of Mali?
If it is more like Western Province PNG as Jeff notes (and as published from NE Brazil by Dionne Rolim), then there would be fewer adult cases than children cases and a particular epidemiological link to swimming in Bp +ve water sources.
Also – have the novel STs you found been deposited to pubMLST and assigned a new ST?
https://pubmlst.org/organisms/burkholderia-pseudomallei
I encourage everyone to continue to get novel STs assigned a number, so the value of this global collaboration continues to be up to date and available to everyone.
Bart Currie
To view this discussion visit
https://groups.google.com/d/msgid/melioidosis/D74794F3-4A92-4430-AF30-753E2B32AAB3%40jcu.edu.au.
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Steinmetz, Ivo
Dear Bart, thanks for your comments!
To answer your questions:
- a step-by-step calculation of our incidence estimates is provided in the appendix 2 (pp3-4) in the Supplementary material. As you will see the estimates are based on a number of assumptions: test sensitivity of 60% (we also provide numbers for a sensitivity of 40%, probably more realistic in small children), a comparable distribution of the age-related incidence as observed in NE Thailand, a comparable risk to acquire melioidosis throughout Mali in the environmentally suitable zones for B pseudomallei.
- We completely agree a Western Province PNG scenario with a disproportionate burden in children might also be true. We are not aware of adult cases in this region, but that doesn’t mean anything, nobody looked at it.
- We feel that our incidence estimates are still rather conservative taking into account that only severe cases were admitted to the clinic, less severe cases are not represented in our study and long distances in the catchment area of the clinic are likely to hinder health-care access
- All novel STs have been deposited to pubMLST (see also Suppl. Material)
Best wishes
Ivo and team
Bart Currie
Thanks Ivo,
That is very comprehensive – what a remarkable story and a lesson in exposing the Iceberg!
Best wishes
Bart
To view this discussion visit https://groups.google.com/d/msgid/melioidosis/e6cbb30456064b16a93a092de3f309ab%40medunigraz.at.
Petras, Julia (CDC/NCIRD/ID)
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Sent: Thursday, October 16, 2025 7:57:42 AM
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Subject: [Melioidosis] Mali study published in The Lancet Global Health