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Methods: The study was carried out at the National Homeopathic Hospital of the Secretary of Health, Mexico City, Mexico and included 41 patients: 3 men and 38 women, mean age 54 14.89 years, diagnosed with IBS as defined by the Rome IV Diagnostic criteria. Single individualized medicine was prescribed for each patient, taking into account all presenting symptoms, clinical history, and personality via repertorization using RADAR Homeopathic Software (archibel, Isnes, Belgium). The homeopathic drugs were used at fifty-millesimal (LM) potency per the Mexican Homeopathic Pharmacopoeia starting with 0/1 and increasing every month (0/2, 0/3, 0/6). Severity scales were applied at the beginning of treatment and every month for 4 months of treatment. The evaluation was based on comparing symptom severity scales during treatment.
Results: The results demonstrated that 100% of patients showed some improvement and 63% showed major improvement or were cured. The study showed a significant decrease in severity of symptom scores 3 months after treatment, with the pain score showing a decrease 1 month after treatment. The results highlight the importance of individualized medicine regimens using LM potency, although the early decrease in pain observed could also be due to the fact that Lycopodium clavatum and Nux vomica were the main homeopathic medicine prescribed, and these medicines contain many types of alkaloids, which have shown significant analgesic effects on pain caused by physical and chemical stimulation.
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Several studies examining individualized homeopathic treatment of fatigue in adults have shown promising results in diverse populations7-9 in addition to cancer patients.10,11 If effective, individualized homeopathy may have advantages compared with other interventions. Given the extremely diluted nature of homeopathic substances, there is little chance of drug interaction with chemotherapy. A systematic review evaluating homeopathic medicines used to prevent or treat side effects of cancer treatments concluded that no serious adverse events or interactions with conventional treatment were noted.12 Previous studies have shown that homeopathic treatments are well tolerated in adults and in children.13,14
The study medication was administered in 1 of 2 forms: (1) homeopathic medicine embedded in 2.5-mm-diameter lactose/sucrose globules or (2) 30% ethanol-based liquid homeopathic remedy. The homeopathic remedy was administered as either 1 globule sublingually or 0.2 mL orally (depending on the chosen formulation) up to 3 times per day. The homeopathic remedy or the homeopathic remedy potency could be changed on a daily basis during the course of treatment. However, only 1 homeopathic remedy and potency was administered at a given time.
Participants were asked to take the homeopathic medicine at least a half hour before or after food, beverages, or strong smelling substances. All conventional treatments, including counselling and exercise, and the use of other natural health products (other than homeopathy) were permitted. Participants were asked to refrain from taking other homeopathic substances while receiving study treatments and for 2 weeks following completion of homeopathic treatment.
Our results are consistent with those of Rostock et al,11 who observed a similar significant reduction in fatigue symptoms in the homeopathic care of an adult cancer patient population. Our safety data are also consistent with other studies showing a low incidence of adverse events.12 There were no serious adverse events attributed to homeopathy.
The Clinical Department of the Academia Medico Homeopática de Barcelona (AMHB) launched a study in March 2020 to collect clinical cases of COVID-19 who were treated with homeopathy. The study was conducted by local homeopaths, aiming to determine the homeopathic symptomatic characteristics of the COVID-19 outbreak and to identify a group of epidemic medicines or a genus epidemicus that would be useful to treat most patients. A secondary objective was to analyze the response to the homeopathic treatment.
Cases were collected from the private practices of homeopathic physicians who are the members of the AMHB. On March 13th, 2020 (day 0 of our study), all AMHB members (approximately 190) received an email explaining the study, its objectives, and two checklist documents ([Supplementary Files 1] and [2], available online only) to enable data collection from patients, as well as informing them about the inclusion and exclusion criteria. An email address was also provided to every associate to centralize the case data collection (email and AMHB database).
Data from 107 clinical cases were provided by 19 homeopathic local doctors. All cases came from Spanish individuals, mostly from Catalonia region (98%). Using the WHO COVID-19 disease severity classification,[1] 90 (84.1%) of our cases could be classified as mild (fever, flu-like symptoms, and negative radiology test [Rx]), 13 (12.1%) as moderate (same plus Rx positive and mild hypoxia and dyspnea), two (1.9%) as severe (hypoxia and dyspnea, oxygen needed, and hospitalization), and two (1.9%) as critical (severe acute respiratory syndrome). It should be said that 34 of the cases classified as mild (30% of total) were patients between mild and moderate categories; those patients had dyspnea or breathlessness with no Rx findings or with no Rx performed. Seven patients (6.5%) required hospitalization at some point and two patients died (1.9%).
In order to simplify our data analysis and to enable stronger conclusions on the genus epidemicus or set of homeopathic medicines most likely adequate to treat these patients, we have analyzed the data only from the 103 patients with mild or moderate disease. We have excluded the four patients with severe or critical disease because their small numbers could invalidate the extrapolation of findings.
To our knowledge, this is one of the largest reported collections of COVID-19 cases treated with homeopathy.[16] [17] Besides having some methodological, study sample or data collection bias, the results of the study seem strong enough to be extrapolated to other populations infected with a symptomatically mild or moderate COVID-19 disease, enabling us to postulate a valid genus epidemicus with a candidate set of useful homeopathic medicines that could be helpful in treating or preventing further COVID-19 outbreaks.
On the various factors that could somehow limit the validity of the study, we would like to comment first about the study sample. Even though the study sample is quite heterogeneous, representing all age ranges and both sexes, it is likely to be representative only for mild and moderate cases of COVID-19. We attended only four cases of severe or critical COVID-19. Those latter cases presented with severe respiratory distress and other characteristic symptoms of advanced stages of the disease, with complex systemic involvement established. As the analysis of those four cases might have altered the validity of the results for mild or moderate cases, we decided to exclude them from this analysis. As commented by Waisse et al,[17] the coronaviruses have a large symptomatic range and affect some age groups differently from others, so other studies focusing on severe disease are needed to determine its symptomatic homeopathic characteristics and its genus epidemicus.
Given the previous repertorizations and the results obtained from the remedies used in our collected cases, which we have summarized above, it is difficult to propose just one homeopathic medicine as the genus epidemicus. However, we could probably agree on a group of remedies, as Kent said,[14] with which we might treat nearly all mild and moderate cases of COVID-19 with success. Those medicines would be Bryonia alba, Phosphorus, Sulphur, Camphora and Pulsatilla.
After presenting all the data and conclusions from the collected cases, we firmly believe that we have accomplished our goal, to present a clear symptomatic picture of the mild and moderate COVID-19 disease in our region. We presented also a group of remedies most suitable to treat those cases. Nevertheless, we should reflect that for each case studied and treated, the good homeopathic physician should still always individualize and prescribe the proper homeopathic medicine guided by the Law of Similars, even in treating epidemic disease, as Kent said in his Lectures.[14]
The importance of publishing this work is that its comprehensive homeopathic clinical information can reach as many homeopaths worldwide as possible, and it can be used to inform about the treatment of COVID-19 patients, taking into account that, at the time of the study, there have been no preventive or effective conventional treatments for the disease. We think homeopathy has much to contribute in reducing deaths and morbidity of this disease. Further studies are needed to investigate the role of homeopathy in severe cases of COVID-19 and in critical stages where the involvement of inflammation and hypercoagulability drive the organism to multi-organ failure.
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