RE: p-value < 0.1 for important outcomes! -- Thanks

[knouri]

I would like to thank you all for providing me with so much fine information on this issue.

I will summarize responses/related papers, and post it to the group.

 

Regards,

Keramat Nourijelyani; PhD Biostat

-----------------------------------------------------------------------------

 

Original query: p-value < 0.1 for important outcomes! 

Recently, a medical doctor colleague sent me the following query:

“Do you have any stats or epidemiology papers that discuss justification of alpha and beta (p values and their interpretation), especially conditions that merit altering them from what is done conventionally? My recollection is that interventions with important primary outcomes (e.g. mortality) and minimal associated adverse effects may mean that one can change p<0.05 to p<0.1 so as not to conclude there are no differences between the arms”.